Search Results (26)

Acupuncture is a medical tool in which a sterile needle is used to penetrate and stimulate a certain body area (acupoint), inducing a series of sensations such as numbness, dullness, or aching, often referred to as de-qi. But is that all? In this article, we adopt a Bayesian perspective to explore the cognitive and affective aspects of acupuncture beyond needling, specifically, how the body integrates bottom-up sensory signals with top-down predictions of acupuncture perception. We propose that the way in which we discern acupuncture treatment is the result of predictive coding, a probabilistic, inferential process of our brain. Active inference from both prior experience and expectations of acupuncture, when integrated with incoming sensory signals, creates a unique, individual internal generative model of our perception of acupuncture. A Bayesian framework and predictive coding may, therefore, aid in elucidating and quantifying the cognitive components of acupuncture and facilitate understanding of their differential interactions in determining individual expectations of treatment. Thus, a perception-based Bayesian model of acupuncture presented in this article may expand on how we perceive acupuncture treatment, from simply inserting needles into our body to one that encompasses a complex healing process supported by belief and hope of regaining health. By exploring how cognitive factors influence individual responsiveness to acupuncture treatment, this review sheds light on why acupuncture treatment is more effective in some individuals than in others. Full article

Background: Drug-induced gingival enlargement is a commonly documented adverse effect in patients administered with calcium antagonist medications. Nifedipine is the medicine most frequently linked to instances of gingival enlargement; nevertheless, amlodipine, likewise a calcium antagonist, can elicit this adverse effect. This case report aims to detail a case of amlodipine-induced gingival hyperplasia, emphasizing the significance of a multidisciplinary approach and outlining its therapy across various surgical phases. Methods: A 48-year-old hypertensive patient using amlodipine therapy presents with aberrant gingival tissue growth in the upper arch. Intraoral examination reveals localized inflammation and tissue enlargement in the papillae areas of the upper arch gingiva, leading to partial covering of the dental crowns. The patient experienced painful sensations and episodes of spontaneous bleeding in the enlarged gingival tissue. Following an initial professional dental hygiene treatment, which included root planning in the upper quadrants, and in consultation with the referring cardiologist, it was determined to discontinue amlodipine and initiate a replacement therapy with olmesartan medoxomil. Fifteen days following the cessation of amlodipine, surgical excision of the thickened interdental gingival tissues in the anterior region was conducted to obtain biopsies for histological confirmation of the observed pathological condition. Results: Histopathological examination validated the diagnosis of drug-induced gingival enlargement, characterized by chorion fibrosis and significant lymphoplasmacytic infiltration. Specifically, parakeratotic and acanthotic characteristics were seen in the gingival epithelium. Adjacent to the inflammatory regions, fibrosis was noted, along with the presence of cytoid bodies, which are typically linked to pathological diseases driven by inflammatory processes. These histological characteristics were consistent with the diagnosis of drug-induced gingival enlargement. Conclusions: A multidisciplinary approach involving the treating physician, dentist, and hygienist, incorporating drug replacement and targeted oral hygiene sessions, is crucial for the management and resolution of calcium channel blocker-induced gingival enlargement. Full article

As one of the most widely used appliances in home and office scenarios over recent decades, electrical fans and their use in built environments have garnered considerable research interest. However, current methods are insufficient to reflect the overall characteristics of different types of fan equipment. This study conducted airflow field tests for six typical electrical fans and human comfort experiments across background temperature conditions of 26 °C, 28 °C, and 30 °C. The airflow test results showed the following: (1) for the mechanical airflow generated by fans, the mean airflow speed (MAS) had a strong negative correlation with turbulence intensity (Tu) and the power spectral index (β), which made Tu and β have a complementary distribution with airflow speed, meaning that areas with a higher airflow speed had lower dynamic characteristics; and (2) the form of the fan mainly affected the flow field distribution in the near-fan area (within 2 m), where tower fans and vaneless fans with elongated outlets had a mainstream airflow area that spread to about 0.2 m in width but 0.6 m in height at a distance of 0.25 m from the fan. The airflow speed distribution shape of axial-flow fans with circular outlets was circular on the test surface at the same position, with a radius of about 0.1–0.2 m. The human comfort experiment revealed that, at 28 °C, in the low-airflow-speed area (v < 1.5 m/s), the increased Tu and power spectral β of the airflow near the head and chest could reduce the thermal sensation vote (TSV). Additionally, this improvement slightly increased as the room temperature rose. When the airflow speed was high, the dynamic characteristics were generally low, and at this time, airflow speed played a leading role in reducing thermal sensation. The results of this paper have certain reference value for the improvement of comfortable dynamic characteristics and functional flow field design in subsequent fan product development. Full article

Background: Many studies, for example, on taste-visual dissonance, have shown that the influence of the visual cortex on taste sensation is enormous. The presented work aims to investigate, using fNIRS, whether a taste stimulus, in this case, the taste of bitter, also causes stimulation of the visual cortex in the fNIRS study. Methods: fNIRS was used to examine 51 participants (204 examinations, 9996 records), collecting signals from the left hemisphere. Differences between the maximum and minimum changes in oxyHb concentrations (ΔoxyHb) for the areas of the brain cortex considered responsible for recording visual and gustatory signals were analyzed. Protocols I, II, III, and IV—activation with distillate water, coffee with lower concentration, reference (no stimulation), and coffee with higher concentration, respectively, were used. Results: We recorded high signals for teste activation on channels covering the gustatory cortex, which confirms the correctness of the choice of research method. As expected, a significant statistical difference was observed between protocols I, II, and IV and reference III (without stimulation). What seems important is the fact that we also received high signals for the channels 45–49, which cover the visual cortex. The statistical analysis shows no differences between protocols I, II, and IV (different taste activation—water, coffee A, and coffee B) for specific channels for analyzing regions of interest. As a result of the analysis of the correlation between the subjective bitterness assessment solutions and the signal ΔoxyHb height, it was observed that a statistically significant correlation, although weak, occurs only for 14 and gustatory channels, only for coffee with a higher concentration. Additionally, the only statistically significant difference between women and men was observed in Protocol I (water), where the ΔoxyHb signal was twice as high in women compared to men. Conclusions: In conclusion, we can clearly state that the senses of sight and taste work closely together. Moreover, this cooperation is not one-sided: while visual activation influences taste perception, interestingly, a taste stimulus can also generate a hemodynamic response, activating the visual cortex. Full article

Bodily self-consciousness (BSC), a subject of interdisciplinary interest, refers to the awareness of one’s bodily states. Previous studies have noted the existence of individual differences in BSC, while neglecting the underlying factors and neural basis of such individual differences. Considering that BSC relied on integration from both internal and external self-relevant information, we here review previous findings on individual differences in BSC through a three-level-self model, which includes interoceptive, exteroceptive, and mental self-processing. The data show that cross-level factors influenced individual differences in BSC, involving internal bodily signal perceptibility, multisensory processing principles, personal traits shaped by environment, and interaction modes that integrate multiple levels of self-processing. Furthermore, in interoceptive processing, regions like the anterior cingulate cortex and insula show correlations with different perceptions of internal sensations. For exteroception, the parietal lobe integrates sensory inputs, coordinating various BSC responses. Mental self-processing modulates differences in BSC through areas like the medial prefrontal cortex. For interactions between multiple levels of self-processing, regions like the intraparietal sulcus involve individual differences in BSC. We propose that diverse experiences of BSC can be attributed to different levels of self-processing, which moderates one’s perception of their body. Overall, considering individual differences in BSC is worth amalgamating diverse methodologies for the diagnosis and treatment of some diseases. Full article

A large number of people in China still live in rural villages. The indoor environment of these rural dwellings directly affects the quality of life of the occupants. Nevertheless, constrained by the quality of dwelling construction, rural buildings have poorer indoor environments and, at the same time, have a higher operating energy consumption. However, inadequate attention has been given to the summer thermal environment in cold regions. This work has been carried out around the thermal environment of rural residences in cold regions during summer. Field measurements, questionnaires, and data analysis were used in this study. We recorded the indoor and outdoor thermal environment parameters on a typical summer day in the Linyi rural area. Moreover, the subjective sensations and thermal adaptive behaviors of the participants were recorded in detail with a questionnaire. Linear regression showed that the neutral temperature for residents in summer was 27.52 °C, with acceptable temperatures ranging from 25.14 °C to 29.9 °C. Age and gender differences were found to affect the occupants’ sensation of thermal comfort and humidity, as well as their thermal adaptive behavior. In addition, a thermal adaptive model has been constructed in the study, which will further enrich the thermal adaptive investigation and provide a scientifically sound reference for the renovation and development of the local rural areas. Full article

Escalating global climate change and the intensification of urban heatwaves have led to an increase in summer air conditioning cooling energy consumption. This phenomenon is particularly critical in tropical regions, as it may trigger an energy crisis. The rational setting of indoor thermal design parameters can help conserve energy to the maximum extent while ensuring thermal comfort for occupants. This study selected Haikou City, a unique tropical city in China, as the research location. Indoor environment measurements and a questionnaire survey were conducted with participants, and the outdoor thermal environment sensitivity, population attributes and differences in thermal sensation, thermal neutral temperature, and comfort range were calculated and analyzed. The following results were obtained. Based on the overall population, long-term residence, and temporary residence classification, the indoor thermal comfort needs of residents in tropical cities in Haikou were effectively identified. The actual thermal neutral temperature of the overall population is 25.7 °C, and 90% of the acceptable thermal comfort temperature range is 23.2 °C–28.0 °C. The actual thermal neutral temperature of the regular residents is 27.3 °C, and 90% of the acceptable thermal comfort temperature range is 23.3 °C–31.4 °C. The actual thermal neutral temperature of the temporary population is 25.5 °C, and 90% of the acceptable thermal comfort temperature range is 23.0 °C–28.0 °C. These research results have an important reference value for improving the setting of the temperature of air conditioning in tropical areas in summer and further reducing energy consumption, which is conducive to sustainable development. Full article

Heat transfer coefficients between shower water and human skin could significantly impact occupants’ thermal sensation and energy consumption during showering. A recent study found that heat transfer coefficients varied considerably among showerhead patterns. However, the specific effects of the showering heat transfer process on the showerhead patterns have yet to be determined. Two experiments were conducted to quantify the spray patterns during showering, and the impacts of the patterns’ parameters on the heat transfer coefficient were examined using different statistical methods. Five showerheads with 18 spray patterns were tested in this study. The resistance factor, water supply pressure, and nozzle area ratio of these patterns were measured to qualify their shower performance. The results indicated that all the tested parameters significantly impacted the heat transfer coefficient in general, and using resistance factor and nozzle area ratio could accurately predict the heat transfer performance of the showerhead pattern. Additionally, this study demonstrated that changing to a showerhead with a higher heat transfer coefficient could save considerable energy while maintaining the same thermal sensation during showering. The influence of water spray patterns on the heat transfer coefficient could provide residents with scientific references when selecting showerheads in their bathrooms. Full article

Designs of active prostheses attempt to compensate for various functional losses following amputation. Integration of sensory feedback with the functional control re-enables sensory interaction with the environment through the prosthetic. Besides the functional and sensory loss, amputation induces anatomical and physiological changes of the sensory neural pathways, both peripherally and centrally, which can lead to phantom limb pain (PLP). Additionally, referred sensation areas (RSAs) likely originating from peripheral nerve sprouting, regeneration, and sensory reinnervation may develop. RSAs might provide a non-invasive access point to sensory neural pathways that project to the lost limb. This paper aims to report on the sensory input features, elicited using non-invasive electrical stimulation of RSAs that over time alleviated PLP in two upper-limb amputees. The distinct features of RSAs and sensation evoked using mechanical and electrical stimuli were characterized for the two participants over a period of 7 and 9 weeks, respectively. Both participants received transradial and transhumeral amputation following traumatic injuries. In one participant, a relatively low but stable number of RSAs provided a large variety of types of evoked phantom hand (PH) sensations. These included non-painful touch, vibration, tingling, stabbing, pressure, warmth/cold as well as the perception of various positions and movements of the phantom hand upon stimulation. Discomforting and painful sensations were induced with both mechanical and electrical stimuli. The other participant had a relatively large number of RSAs which varied over time. Stimulation of the RSAs provided mostly non-painful sensations of touch in the phantom hand. Temporary PLP alleviation and a change in the perception of the phantom hand from a tight to a more open fist were reported by both participants. The specificity of RSAs, dynamics in perception of the sensory input, and the associated alleviation of PLP could be effectively exploited by designs of future active prostheses. As such, techniques for the modulation of the sensory input associated with paradigms from interaction with the environment may add another dimension of protheses towards integrating personalized therapy for PLP. Full article

Low temperatures and high humidity often occur in the northern basins and mountainous regions of China. This research reveals a common winter indoor environment in this rural areas characterized by low-temperature and high-humidity indoor thermal conditions. Improving this environment directly with equipment would inevitably result in significant energy consumption. Therefore, comprehending the thermal performance mechanisms of different structural building materials is of vital importance as it provides crucial baseline values for environmental improvement. This study conducted a survey utilizing user questionnaires, resulting in the collection of 214 valid responses. Additionally, a local experiment regarding thermal comfort was conducted. Simultaneously, this study monitored the indoor physical environments of these houses (a sample of 10 rooms was taken from earth houses and 12 rooms from brick houses). Parameters measured on site included air temperature, relative humidity, light illumination, and CO₂. The results showed that the humidity inside the earth houses is more stable and regression models can be developed between thermal sensations and temperature for long-term residents. The residents of these earth houses are more sensitive to temperature step. In contrast, the residents of brick houses, experiencing greater environmental variability, demonstrated lower sensitivity and greater adaptability to temperature changes. In addition, heating from bottom to top is more comfortable and healthier for the residents of brick houses in Gansu. Moreover, it is more favorable for the inhabitants’ livelihood to regulate the temperature steps to a maximum of 4 °C. This study provides valuable reference information for the future design of houses in low-temperature and high-humidity environments. Full article

Background and Objectives: Thermal skin injuries are a prevalent cause of skin damage, potentially leading to severe morbidity and significant mortality. In this study, we intended to estimate the effects of HBO (hyperbaric oxygen treatment) and antioxidant supplementation with Filipendula ulmaria extract, individually and simultaneously, in the treatment of thermal skin injuries. Materials and Methods: As a thermal skin injury experimental model, we used two-month-old male Wistar albino rats. Thermal injuries were made with a solid aluminium bar at a constant temperature of 75 °C for 15 s. Hyperbaric oxygen treatment was performed in a specially constructed hyperbaric chamber for rats (HYB-C 300) for seven consecutive days (100% O₂ at 2.5 ATA for 60 min). Antioxidant supplementation was performed with oral administration of Filipendula ulmaria extract dissolved in tap water to reach a final concentration of 100 mg/kg b.w. for seven consecutive days. Results: Simultaneous administration of hyperbaric oxygen therapy and antioxidant supplementation with Filipendula ulmaria extract significantly ameliorated the macroscopic and histopathological characteristics of the wound area and healing. Also, this therapeutic approach decreased the local expression of genes for proinflammatory mediators and increased the expression of the μ-opioid receptor and the MT1 and MT2 receptors in the wound area and spinal cord, with a consequent increase in reaction times in behavioural testing. Conclusions: In conclusion, the presented results of our study allow evidence for the advantages of the simultaneous employment of HBO and antioxidant supplementation in the treatment of thermal skin injuries, with special reference to the attenuation of painful sensations accompanied by this type of trauma. Full article

In this study, typical open spaces were selected in the urban area of Lanzhou, China, with varying distances from the Yellow River and different plant configuration spaces. Then, the thermal perception of respondents was investigated through meteorological measurements, thermal comfort questionnaires, and parametric modeling. The findings indicate the following: (1) Wind speed decreases significantly as the distance from the Yellow River increases in the three open green spaces. (2) The cold lake effect of the Yellow River dominates the wind environment. (3) The closest site to the Yellow River exhibits the strongest correlation between wind speed and the respondents’ thermal sensation. (4) There is a strong positive correlation between the model output and different spatial measurement values. (5) There is a certain discrepancy between the UTCI values and the actual measurements, but the fit is high and consistent with an R-squared value of 0.936. This study quantitatively evaluated the thermal comfort and perception in typical spaces and validated the reliability of parameterized modeling for such spaces, providing a reference basis for thermal environment planning in these spaces. Full article

With relatively high temperatures and evenly distributed precipitation throughout the year, outdoor thermal comfort is important in Taiwan. Thus, we discuss thermal comfort in different density areas with A: a low density (average buildings height/Street width ratio: 1.3, SVF: 0.28), B: a mid density (H/W: 2.75, SVF: 0.14), and C: a high density (H/W: 6.88, SVF: 0.11). Data were acquired through field meteorological measurements from the three sites on typical summer days from 15 to 17 July 2022. Around the Wanhua district of Taipei City, thermal comfort was obtained through the calculation of thermal comfort indices: physiological equivalent temperature (PET) and Universal Thermal Climate Index (UTCI). Results showed that different urban density areas had different thermal comforts; streets in A were more exposed to sunlight, causing the mean radiant temperature to be the highest; C had lower solar radiation and stronger wind with the highest comfort level; and B had higher air temperature but lower radiation than A. PET contributed to uncomfortableness in A. Thermal sensation vote results showed that B had the most “uncomfortable” votes because wind speed in B was the lowest. Medium-density urban areas had enough solar exposure on the pedestrian level, but not enough wind to dissipate the heat. PET was more sensitive to mean radiant temperature. These findings provide a guideline and technical reference for urban designers to mitigate the high temperatures of summer in urban areas and improve thermal comfort to create a healthy environment and encourage people to utilize outdoor environments. Full article

Social exclusion refers to the experience of rejection by one or more people during a social event and can induce pain-related sensations. Cyberball, a computer program, is one of the most common tools for analyzing social exclusion. Regions of the brain that underlie social pain include networks linked to the dorsal lateral prefrontal cortex (DLPFC). Specifically, self-directed negative socially induced exclusion is associated with changes in DLPFC activity. Direct manipulation of this area may provide a better understanding of how the DLPFC can influence the perception of social exclusion and determine a causal role of the DLPFC. Transcranial magnetic stimulation (TMS) was applied to both the left and right DLPFC to gauge different reactions to the Cyberball experience. It was found that there were elevated exclusion indices following right DLPFC rTMS; participants consistently felt more excluded when the right DLPFC was excited. This may relate to greater feelings of social pain when the right DLPFC is manipulated. These data demonstrate that direct manipulation of the DLPFC results in changes in responses to social exclusion. Full article

In China, the post-Winter Olympics era has seen the rapid development and promotion of ice rinks with air-supported membrane structures. With the rise of large indoor spectator areas in ice rinks, thermal comfort needs in spectator areas are receiving more and more attention. The satisfaction of thermal comfort needs is crucial to people’s health and well-being, so further study of the issue of thermal comfort in such spectator areas is needed. Unfortunately, models currently used to evaluate the thermal comfort of traditional building envelopes are not applicable to air-supported membrane-envelope ice rinks. Researchers need to focus on the internal thermal comfort needs of air-supported membrane envelopes for spectator areas. The aim of this research was to establish a thermal comfort model to provide exact temperature-range recommendations for spectator areas in air-supported membrane ice rinks. The indoor thermal-environment parameters of the ice rink in Harbin were measured from 2 January to 15 January 2023. To elicit data on spectators’ actual thermal sensations in the ice rink, a field questionnaire was administered. By modifying the expectancy factor, an extended predicted thermal comfort model was established. The results suggested that the operative temperature required to meet spectators’ thermal comfort needs in the case study ice rink ranged from 17 °C to 26 °C. The results of the study offer specific insights into the indoor thermal comfort needs of air-supported ice rinks and provide a more accurate temperature-setting reference for the healthy and energy-efficient development of such rinks. Full article