Search Results (109)

This article presents a diagnostic study on the characterization of community and walkable rooftops in Barcelona’s historic district. The study aims to evaluate the potential for efficient improvement solutions that align with contemporary regulations for safety, accessibility, and energy efficiency. It is part of the REVTER project, which seeks to recover flat roofs as non-public collective areas in densely populated environments. The research emphasizes the importance of understanding the technical aspects of these rooftops before interventions, focusing on construction and performance to establish guidelines for future improvements. The methodology includes cartographies, on-site inspections, and performance evaluations, aiming to create a district-level overview, characterize roofing solutions chronologically, assess current technical performance, and identify deficiencies to develop intervention guidelines. Key findings highlight the evolution of construction practices across three distinct periods, revealing significant shifts in materials and techniques. The research underscores the necessity of data-driven technical characterization and proposes a systematic approach for evaluating historic architectural spaces. By selecting a broad study sample and using a GIS approach, the study sets a precedent for understanding and improving the technical characteristics of urban rooftops, contributing significantly to sustainable urban development and heritage conservation within Ciutat Vella. Full article

From the 9th century onwards, Tāmdult was one of the three major caravan ports in the Western Maghreb, alongside Sijilmāssa and Nūl Lamṭa. By the mid-20th century, the remains of dwellings, metallurgical production sites and fortifications had been located a few kilometres south of the present-day oasis of Aqqa, which is irrigated by the resurgence of the wadi of the same name. In 1999, our research, which was based on field surveys and aerial photographs, revealed exceptionally well-preserved traces of a large-scale agricultural system and an irrigation canal network adjacent to the ruins. This completed the picture of this pre-Saharan oasis. An initial study was published in 2011. However, the question of the chronological relationship between the two oases, Tāmdult and Aqqa, remained unresolved. Processing recent satellite images (Airbus © 2023) of these two oases and creating a WebGIS interface now enables us to refine and correct our observations from 1999. This new data largely confirms our initial proposals, such as the joint development of an urban settlement and an agricultural area with an irrigation network. Furthermore, these new images show the branching structure of the various water distribution channels, the regularity of the agricultural land parcels and the existence of interstitial rural settlements. They thus reveal a hierarchy in this distribution that was perhaps insufficiently explored in our initial publication. Given the limited historical sources available, we can now make more informed arguments regarding the possibility of the two oases coexisting over time. We can also propose initial hypotheses about the main reasons for the abandonment of one of the oases and discuss the identity of their founders, which could be local tribal groups and/or branches of the Idrisid dynasty. The central issue of the dossier to which our contribution is addressed—‘The Role of Urban Elites in the Construction of Rural Landscape’—is adapted here to the specific characteristics of the pre-Saharan context in terms of both climate and settlement structure. Full article

This study empirically analyzed changes in the representation of older adults in Korean digital media from 2020 to 2024. As Korea enters a super-aged society, social perceptions of aging and older adults are rapidly evolving through digital platforms. This study aimed to identify how public discourse about older adults has shifted in emotional tone and thematic structure within online media environments. Approximately 200,000 text data points were collected from news and YouTube comments containing keywords related to older adults. Text mining techniques—including Latent Dirichlet Allocation (LDA) topic modeling, sentiment analysis, and time-series analysis—were applied to examine annual trends and emotional transitions. The findings revealed a clear shift in thematic emphasis from “health,” “care,” and “vulnerability” toward “participation,” “self-management,” and “digital activity.” Negative sentiments decreased (from 58.3% in 2020 to 37.8% in 2024), while positive sentiments increased (from 22.5% to 42.7%). These results indicate that the image of older adults in digital discourse has transformed from that of passive care recipients to active and independent participants in society. The study supports the ongoing policy debate in Korea on redefining the age threshold for “older adults” from 65 to 70 years, emphasizing capability over chronological age. Digital media play a critical role in shaping these changing perceptions, highlighting the need for intergenerational media literacy education and policy interventions that promote inclusive and age-positive communication. Full article

Background/Objectives: Gastroschisis is a congenital abdominal wall defect characterized by herniation of bowel loops without a covering membrane and typically located to the right of the umbilical cord. Although contemporary management is well established, its historical study development has not been comprehensively synthesized. This review examines the chronological evolution of focus of interest in gastroschisis and highlights how research priorities shifted across eras, shaping current anatomical understanding, diagnostic strategies, and surgical management. Methods: A structured literature search was performed in PubMed, Web of Science, and Scopus. Studies in English, Spanish, Turkish, and Arabic were included. Titles, abstracts, and full texts were screened independently. Eligible publications addressed historical descriptions, differentiation from omphalocele, advancements in imaging, surgical techniques, or experimental modeling. Results: Sixty-eight studies met the inclusion criteria. Early reports from the sixteenth to eighteenth centuries provided descriptive accounts without distinguishing gastroschisis from omphalocele. The nineteenth century introduced the term “gastroschisis,” and definitive clinical differentiation was achieved in the mid twentieth century. Surgical innovation progressed from primary closure in the 1940s to the development of preformed and spring-loaded silos, which improved physiologic tolerance and survival. Animal models clarified mechanisms of bowel injury, including the effects of amniotic exposure and delayed maturation of interstitial cells of Cajal. Advances in ultrasound and magnetic resonance imaging facilitated prenatal risk stratification and shifted research attention toward predicting complex gastroschisis and optimizing perinatal planning. Conclusions: The historical trajectory of studies about gastroschisis demonstrates a coherent pattern in which developments in anatomical definition, surgical innovation, and mechanistic research sequentially enabled modern prenatal diagnostic and prognostic strategies. Recognizing these temporal shifts provides important context for current practice and highlights opportunities to improve prenatal markers of bowel compromise and refine individualized postnatal care. Full article

Background: Socioeconomic disparities may affect COVID-19 booster vaccination uptake, potentially undermining public health efforts. This study assessed the association between first booster dose coverage and municipal socioeconomic deprivation in the Apulia region of southern Italy. A secondary objective was to evaluate whether SARS-CoV-2 incidence modified this relationship. Methods: We conducted a retrospective observational study including Apulian residents aged ≥5 years from 1 January 2021, to 31 December 2022. First booster doses were identified using an algorithm based on dose chronology and national guidelines. Vaccination and infection data were retrieved from regional databases. Socioeconomic deprivation was measured using the Social and Material Vulnerability Index (SMVI) developed by the Italian National Institute of Statistics (ISTAT). Booster coverage was calculated at the municipal level. A multivariable Poisson’s regression model was used to estimate the association between SMVI and booster uptake, adjusting for age group, primary vaccine type, SARS-CoV-2 incidence, and municipal vaccination rates. Analyses were stratified by sex. Results: A total of 2,732,258 individuals received a first booster dose. Booster coverage decreased with increasing SMVI. Among females, a significant reduction was observed in the highest deprivation category (RR > 102 vs. <99: 0.95; 95% CI: 0.94–0.97) and it was similar in males (RR: 0.95; 95% CI: 0.93–0.96). A significant interaction between age and deprivation was found in both sexes, with a sharper decline in younger individuals. Municipal vaccination rates were positively associated with booster uptake. SARS-CoV-2 incidence was positively associated with uptake only in males. Conclusions: The analysis revealed a significant association between lower socio-cultural level and lower adherence to the first booster dose of the COVID-19 vaccine. The decline is more pronounced among subjects younger than 50 years with high levels of vulnerability. The findings of this study suggest that to overthrow vaccine hesitancy, knowledge of the social setting allows for targeted communications to the different groups in the population. Further research is needed to define different approaches in the different social groups. Full article

Rescue operations involving baleen whales trapped in dammed environments are difficult to perform successfully, yet increasingly relevant under growing coastal development. We report on a two-day (9–10 February 2023) rescue of a juvenile humpback whale trapped upstream of the Rance Tidal Power Station (TPS) in Brittany, France, providing rare peer-review evidence on response strategies in highly engineered estuaries. A collaborative, non-invasive strategy was implemented by adjusting water levels and creating artificial tidal currents to prevent the whale from stranding and to guide the individual back to open water. Approximately 100 people were mobilized as part of the rescue operation. This paper describes a detailed spatiotemporal account of the whale’s movements and a chronological record of the actions taken by the rescue team. After several attempts to guide it out, rescue efforts enabled its successful exit from the estuary on the second day of operations, and it was not subsequently reported stranded along the French coast. This case demonstrates the value of rapid multidisciplinary coordination between the French National Stranding Network (composed of marine scientists, veterinarians and local correspondents), local organizations, the local marine biology station, international marine mammal experts, national institutions, authorities and a tidal energy operator. Beyond documenting an unusual event, this paper provides operational lessons, highlighting (i) the adaptative management of a TPS as a guidance tool, (ii) the prioritization of animal welfare and responders’ safety, (iii) the effective public and media management and (iv) the involvement of trained volunteers during the rescue, promoting environmentally responsible behavior. These insights are transferable to other cases to inform future baleen whales rescue protocols in anthropogenic environments. Full article

This study investigates Leonardo da Vinci’s long-standing interest in milling technologies through the digital reconstruction of a pendulum-driven mill illustrated in the Codex Atlanticus. By tracing the chronological development of Leonardo’s ideas across multiple sheets, this research highlights the continuity and evolution of his conceptual approach to energy transmission and mechanical automation. This work adopts a systematic design methodology to interpret and visualize the structural logic of the machine, integrating historical sources with engineering reasoning. The resulting CAD model reconstructs the key components (such as the gear train, escapement system, and pendulum) within a coherent architectural framework inspired by Leonardo’s sketches. While the digital model remains a preliminary interpretation, it offers a historically grounded basis for future refinements. In particular, it lays the groundwork for potential physical reconstructions intended for museum display and public engagement. This study contributes to the broader understanding of Renaissance mechanical culture and the role of digital tools in heritage preservation and dissemination. Full article

Background: Despite growing recognition of vaccination social science as essential to immunization strategies, the field’s evolution, geographic distribution, and research patterns remain poorly characterized. This study provides the first comprehensive mapping of the social science literature on vaccination over eight decades. Methods: We conducted a bibliometric analysis of peer-reviewed publications indexed in PubMed from their inception, using a systematic search strategy that combined vaccination and social science terms. Publications were analyzed using the Bibliometrix R package (version 5.0) to examine temporal trends, author productivity, institutional contributions, geographic distribution, and thematic evolution globally. Results: We retrieved 8005 eligible publications. Analysis highlighted three chronological research phases: sporadic early work (1945–1980, n = 85), sustained growth (1981–2019, n = 2743), and unprecedented expansion since the COVID-19 era (2020–2024, n = 4563). Annual publications reached a peak in 2022 (n = 1686). Research spans 146 countries but remains concentrated in high-income countries, with the United States (n = 10,230), China (n = 3796), and Canada (n = 2288) leading production. The top 20 institutions were from the United States (n = 8), United Kingdom (n = 4), and Canada (n = 3), with a few institutions from African countries. International collaboration was moderate (19.44%). Thematic analysis revealed a clear evolution from biological science (1963–1999) to socio-behavioural science, with an emphasis on vaccine hesitancy, trust, communication, and health equity (2015–2024). Conclusions: Vaccination social science has grown steadily over the decades, with a sharp rise in research during the COVID-19 pandemic. Most studies were from high-income countries, underscoring the need for enhanced social science capacity in low- and middle-income countries. As the focus of immunization efforts shifts toward issues like vaccine hesitancy and trust, broader collaboration and inclusion will be key to improving vaccine uptake worldwide. Full article

This review analyzed the epidemiology and impact of HPAI (H5N1 and H5N8) in migratory birds and poultry in Kazakhstan, with a special focus on outbreaks from 2005 to 2024. A comprehensive bibliographic analysis of publications on avian influenza in Kazakhstan over the past 20 years was performed. This review mainly included epidemiological studies of virus detections in wild and poultry in Kazakhstan. Migratory wild birds, in particular, played a key role in the spread of the virus. An analysis of the migration chronology of HPAIV-carrying birds prior to their entry into Kazakhstan was conducted, as well as a comparative analysis of seasonal and water landscape characteristics in previous habitats. The complexity and risks associated with the virus, together with the limited number of current scientific studies in Kazakhstan, require further research to reduce its impact on animals and the ecosystem as a whole. Full article

The electronic judicial evidence preservation systems face various challenges including regulatory control, data exchange, poor credibility, etc. To address these issues, a blockchain-based judicial evidence preservation framework, JudicBlock, is proposed in the present study. It combines the scalability of the Interplanetary File System with the transparency and security of public blockchain. By decentralizing data management and using cryptographic integrity, the system ensures reliable chronological tracking of investigative changes. Unlike traditional approaches, JudicBlock incorporates smart contracts and advanced consensus mechanisms to enforce strict access controls with secure collaboration among the stakeholders. The simulation results show that JudicBlock provides better results over traditional ELR (electronic law records) storage schemes in terms of mining cost, query fetching time, block processing IPFS (Interplanetary file systems) throughput, etc. At a USD 6 mining cost, it appends an average of 23,601 transactions. For 25 blocks, the average query fetching time is 0.852 ms with the cache support of 32 KB. The proposed scheme achieves an average ELR uploading latency improvement of 6.79% over traditional schemes. The results indicate the efficacy of the proposed scheme over the conventional schemes. Full article

Although giant viruses have introduced new perspectives on the definition and evolution of viruses and are increasingly recognized for their significant biological roles within marine ecosystems, systematic evaluations of development trends and scientific contributions in this research field remain limited. This study conducted a bibliometric analysis of the global academic literature on marine giant viruses (MGVs), focusing on nucleocytoplasmic large DNA viruses (NCLDVs), from 1996 to 2024. Using the Web of Science Core Collection, 1544 publications related to giant viruses were identified. After filtering using marine-related keywords and manual review, 300 studies specifically addressing marine giant viruses were selected for the final analysis. This study comprehensively examined the structural characteristics and evolutionary trends in this field by analyzing annual publication productivity, citation patterns, contributions by countries and institutions, author collaboration networks, and keyword co-occurrence patterns. The results show that research on MGVs has steadily increased since the mid-2000s, with a notable surge after 2018 driven by advancements in metagenomics, next-generation sequencing technologies, and global ocean exploration initiatives. The United States and France have taken leading positions in terms of research productivity and impact, with key institutions such as the CNRS (Centre National de la Recherche Scientifique) and Aix-Marseille Université playing central roles. A multipolar network of international collaborations between countries and institutions has been formed. Research topics have evolved from an early focus on virus classification and genome analysis to more diverse themes, including interactions with marine microbiota, viral ecological functions, infection dynamics, virophage research, and metagenome-based ecosystem-level studies. This study provides an overview of the chronological and structural evolution of the marine giant virus research field by systematically presenting key research themes and collaborative networks. The results provide a valuable foundation for determining future academic directions and planning strategic research initiatives. Furthermore, it is expected to facilitate interdisciplinary research in marine biology, environmental science, systems biology, and artificial intelligence-based functional predictions. Full article

Despite the current level of public immunity to SARS-CoV-2, the early inflammatory events associated with respiratory distress in COVID-19 patients are not fully elucidated. Syrian golden hamsters, facultative hibernators, recapitulate the phenotype of SARS-CoV-2-induced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—induced severe acute lung injury seen in patients. In this study, we describe the predominance of the innate immune response in hamsters inoculated with four different SARS-CoV-2 variants, underscoring phenotypic differences among them. Severe inflammatory lung injury was chronologically associated with acute and significant weight loss, mainly in animals inoculated with A.2 and Delta variants. Omicron-infected animals had lower overall histopathology scores compared to other variants. We highlight the central role of endothelial injury and activation in the pathogenesis of experimental SARS-CoV-2 infection in hamsters, characterised by the presence of proliferative type I and type II pneumocytes with abundant surfactant expression, thereby maintaining hyperinflated alveolar fields. Additionally, there was evidence of intrapulmonary lymphatic vessel proliferation, which was accompanied by a lack of detectable microthrombosis in the lung parenchyma. However, white microthrombi were observed in lymphatic vessels. Our findings suggest that the physiological compensatory mechanisms that maintain respiratory homeostasis in Golden Syrian hamsters prevent severe respiratory distress and death after SARS-CoV-2 infection. Full article

Inclusive Education aims to ensure equitable learning opportunities for all students, including those with special educational needs (SEN) and disabilities, by promoting accessible teaching practices and supportive learning environments. Although its importance for fostering the academic and social development of diverse learners has been widely recognized in international policy and research, its practical implementation is still under investigation, particularly within the Greek primary education system. This study investigates (a) Greek primary school teachers’ perspectives, focusing on their attitudes, knowledge, challenges, and perceived needs in Inclusive Education for SEN students and (b) research trends relating to these perspectives, focusing on publication trends and methodological characteristics, through a systematic literature review using the PRISMA methodology. The analysis revealed a shift in Greek primary teachers’ attitudes towards Inclusive Education for SEN students, trending towards neutral or negative responses, alongside limited knowledge, various challenges, and an absence of targeted support mechanisms. The analysis also highlighted chronological gaps between the identified studies in international journals and a variability in methodological approaches and sample characteristics. These insights point to a pressing need for further targeted and ongoing research on Greek primary teachers’ perspectives and professional development initiatives to enable effective and inclusive practices for SEN students in Greek primary education. Full article

Colorectal cancer (CRC) incidence increases markedly with age, yet chronological age is an inadequate proxy for the complex biological processes involved. Colon aging, the intrinsic biological aging of the colonic tissue, is emerging as a crucial, active driver of CRC development. This review comprehensively analyzes the interplay between colon aging and CRC pathogenesis by examining fundamental hallmarks of aging—such as altered tissue homeostasis, epigenetic dysregulation, and microenvironmental shifts including chronic inflammation (inflammaging), gut microbiome dysbiosis, and extracellular matrix remodeling—manifest specifically within the aging colon to synergistically foster a pro-tumorigenic environment. Key findings synthesized from the literature highlight the critical roles of impaired colonic stem cell function, epithelial barrier disruption (“leaky gut”), persistent low-grade inflammation, and altered microbial communities and their metabolites in promoting CRC initiation and progression. Translating this mechanistic understanding holds significant promise: insights from colon aging research can inform novel biomarkers for improved early detection and risk stratification, guide the development of personalized preventative strategies and therapeutic interventions targeting aging pathways, and underpin public health initiatives focused on healthy colon aging. Ultimately, recognizing colon aging as a modifiable contributor to CRC offers a powerful avenue to potentially reduce CRC incidence and enhance patient outcomes, particularly in the vulnerable aging population. Full article

This review provides a comprehensive overview of the closed-form expressions developed for estimating the soil water retention curve (SWRC) from 1964 to the present. Since the concept of the SWRC was introduced in 1907, numerous closed-form functions have been proposed to describe the relationship between soil matric suction and volumetric water content, each with distinct strengths and limitations. Given the variability in SWRC shapes influenced by soil texture, structure, and organic matter, models in the form of sigmoidal, multi-exponential, lognormal, hyperbolic, and hybrid functions have been designed to fit experimental SWRC data. Based on the number of adjustable parameters, these models are categorized into three main groups: three-, four-, and five-parameter models. They can also be classified as one-, two-, or three-segment functions depending on their structural complexity. A review of the developed models indicates that most are effective in representing the SWRC between the residual and saturated water content range. To capture the full range of the SWRC, hybrid functions have been proposed by combining traditional models. This review presents and discusses these models in chronological order of publication. Full article