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23 pages, 10836 KiB  
Article
Potential Utilization of End-of-Life Vehicle Carpet Waste in Subfloor Mortars: Incorporation into Portland Cement Matrices
by Núbia dos Santos Coimbra, Ângela de Moura Ferreira Danilevicz, Daniel Tregnago Pagnussat and Thiago Gonçalves Fernandes
Materials 2025, 18(15), 3680; https://doi.org/10.3390/ma18153680 - 5 Aug 2025
Abstract
The growing need to improve the management of end-of-life vehicle (ELV) waste and mitigate its environmental impact is a global concern. One promising approach to enhancing the recyclability of these vehicles is leveraging synergies between the automotive and construction industries as part of [...] Read more.
The growing need to improve the management of end-of-life vehicle (ELV) waste and mitigate its environmental impact is a global concern. One promising approach to enhancing the recyclability of these vehicles is leveraging synergies between the automotive and construction industries as part of a circular economy strategy. In this context, ELV waste emerges as a valuable source of secondary raw materials, enabling the development of sustainable innovations that capitalize on its physical and mechanical properties. This paper aims to develop and evaluate construction industry composites incorporating waste from ELV carpets, with a focus on maintaining or enhancing performance compared to conventional materials. To achieve this, an experimental program was designed to assess cementitious composites, specifically subfloor mortars, incorporating automotive carpet waste (ACW). The results demonstrate that, beyond the physical and mechanical properties of the developed composites, the dynamic stiffness significantly improved across all tested waste incorporation levels. This finding highlights the potential of these composites as an alternative material for impact noise insulation in flooring systems. From an academic perspective, this research advances knowledge on the application of ACW in cement-based composites for construction. In terms of managerial contributions, two key market opportunities emerge: (1) the commercial exploitation of composites produced with ELV carpet waste and (2) the development of a network of environmental service providers to ensure a stable waste supply chain for innovative and sustainable products. Both strategies contribute to reducing landfill disposal and mitigating the environmental impact of ELV waste, reinforcing the principles of the circular economy. Full article
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28 pages, 4437 KiB  
Review
Development and Core Technologies of Long-Range Underwater Gliders: A Review
by Xu Wang, Changyu Wang, Ke Zhang, Kai Ren and Jiancheng Yu
J. Mar. Sci. Eng. 2025, 13(8), 1509; https://doi.org/10.3390/jmse13081509 - 5 Aug 2025
Abstract
Long-range underwater gliders (LRUGs) have emerged as essential platforms for sustained and autonomous observation in deep and remote marine environments. This paper provides a comprehensive review of their developmental status, performance characteristics, and application progress. Emphasis is placed on two critical enabling technologies [...] Read more.
Long-range underwater gliders (LRUGs) have emerged as essential platforms for sustained and autonomous observation in deep and remote marine environments. This paper provides a comprehensive review of their developmental status, performance characteristics, and application progress. Emphasis is placed on two critical enabling technologies that fundamentally determine endurance: lightweight, pressure-resistant hull structures and high-efficiency buoyancy-driven propulsion systems. First, the role of carbon fiber composite pressure hulls in enhancing energy capacity and structural integrity is examined, with attention to material selection, fabrication methods, compressibility compatibility, and antifouling resistance. Second, the evolution of buoyancy control systems is analyzed, covering the transition to hybrid active–passive architectures, rapid-response actuators based on smart materials, thermohaline energy harvesting, and energy recovery mechanisms. Based on this analysis, the paper identifies four key technical challenges and proposes strategic research directions, including the development of ultralight, high-strength structural materials; integrated multi-mechanism antifouling technologies; energy-optimized coordinated buoyancy systems; and thermally adaptive glider platforms. Achieving a system architecture with ultra-long endurance, enhanced energy efficiency, and robust environmental adaptability is anticipated to be a foundational enabler for future long-duration missions and globally distributed underwater glider networks. Full article
(This article belongs to the Section Ocean Engineering)
21 pages, 3733 KiB  
Article
DNO-RL: A Reinforcement-Learning-Based Approach to Dynamic Noise Optimization for Differential Privacy
by Guixin Wang, Xiangfei Liu, Yukun Zheng, Zeyu Zhang and Zhiming Cai
Electronics 2025, 14(15), 3122; https://doi.org/10.3390/electronics14153122 - 5 Aug 2025
Abstract
With the globalized deployment of cross-border vehicle location services and the trajectory data, which contain user identity information and geographically sensitive features, the variability in privacy regulations in different jurisdictions can further exacerbate the technical and compliance challenges of data privacy protection. Traditional [...] Read more.
With the globalized deployment of cross-border vehicle location services and the trajectory data, which contain user identity information and geographically sensitive features, the variability in privacy regulations in different jurisdictions can further exacerbate the technical and compliance challenges of data privacy protection. Traditional static differential privacy mechanisms struggle to accommodate spatiotemporal heterogeneity in dynamic scenarios because of the use of a fixed privacy budget parameter, leading to wasted privacy budgets or insufficient protection of sensitive regions. This study proposes a reinforcement-learning-based dynamic noise optimization method (DNO-RL) that dynamically adjusts the Laplacian noise scale by real-time sensing of vehicle density, region sensitivity, and the remaining privacy budget via a deep Q-network (DQN), with the aim of providing context-adaptive differential privacy protection for cross-border vehicle location services. Simulation experiments of cross-border scenarios based on the T-Drive dataset showed that DNO-RL reduced the average localization error by 28.3% and saved 17.9% of the privacy budget compared with the local differential privacy under the same privacy budget. This study provides a new paradigm for the dynamic privacy–utility balancing of cross-border vehicular networking services. Full article
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31 pages, 5644 KiB  
Article
Mitigation Technique Using a Hybrid Energy Storage and Time-of-Use (TOU) Approach in Photovoltaic Grid Connection
by Mohammad Reza Maghami, Jagadeesh Pasupuleti, Arthur G. O. Mutambara and Janaka Ekanayake
Technologies 2025, 13(8), 339; https://doi.org/10.3390/technologies13080339 - 5 Aug 2025
Abstract
This study investigates the impact of Time-of-Use (TOU) scheduling and battery energy storage systems (BESS) on voltage stability in a typical Malaysian medium-voltage distribution network with high photovoltaic (PV) system penetration. The analyzed network comprises 110 nodes connected via eight feeders to a [...] Read more.
This study investigates the impact of Time-of-Use (TOU) scheduling and battery energy storage systems (BESS) on voltage stability in a typical Malaysian medium-voltage distribution network with high photovoltaic (PV) system penetration. The analyzed network comprises 110 nodes connected via eight feeders to a pair of 132/11 kV, 15 MVA transformers, supplying a total load of 20.006 MVA. Each node is integrated with a 100 kW PV system, enabling up to 100% PV penetration scenarios. A hybrid mitigation strategy combining TOU-based load shifting and BESS was implemented to address voltage violations occurring, particularly during low-load night hours. Dynamic simulations using DIgSILENT PowerFactory were conducted under worst-case (no load and peak load) conditions. The novelty of this research is the use of real rural network data to validate a hybrid BESS–TOU strategy, supported by detailed sensitivity analysis across PV penetration levels. This provides practical voltage stabilization insights not shown in earlier studies. Results show that at 100% PV penetration, TOU or BESS alone are insufficient to fully mitigate voltage drops. However, a hybrid application of 0.4 MWh BESS with 20% TOU load shifting eliminates voltage violations across all nodes, raising the minimum voltage from 0.924 p.u. to 0.951 p.u. while reducing active power losses and grid dependency. A sensitivity analysis further reveals that a 60% PV penetration can be supported reliably using only 0.4 MWh of BESS and 10% TOU. Beyond this, hybrid mitigation becomes essential to maintain stability. The proposed solution demonstrates a scalable approach to enable large-scale PV integration in dense rural grids and addresses the specific operational characteristics of Malaysian networks, which differ from commonly studied IEEE test systems. This work fills a critical research gap by using real local data to propose and validate practical voltage mitigation strategies. Full article
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20 pages, 10605 KiB  
Article
Network Analysis of Outcome-Based Education Curriculum System: A Case Study of Environmental Design Programs in Medium-Sized Cities
by Yang Wang, Zixiao Zhan and Honglin Wang
Sustainability 2025, 17(15), 7091; https://doi.org/10.3390/su17157091 - 5 Aug 2025
Abstract
With deepening global higher education reforms, outcome-based education has emerged as the core paradigm for teaching model innovation. This study investigates the structural dependencies and teaching effectiveness of the Environmental Design curriculum at Hubei Engineering University in medium-sized cities, China, addressing challenges of [...] Read more.
With deepening global higher education reforms, outcome-based education has emerged as the core paradigm for teaching model innovation. This study investigates the structural dependencies and teaching effectiveness of the Environmental Design curriculum at Hubei Engineering University in medium-sized cities, China, addressing challenges of enrollment decline and market contraction critical for urban sustainability. Using network analysis, we construct curriculum support and contribution networks and course temporal networks to assess structural dependencies and teaching effectiveness, revealing structural patterns and optimizing the OBE-based Environmental Design curriculum to enhance educational quality and student competencies. Analysis reveals computer basic courses as knowledge transmission hubs, creating a course network with a distinct core–periphery structure. Technical course reforms significantly outperform theoretical course reforms in improving student performance metrics, such as higher average scores, better grade distributions, and reduced performance gaps, while innovative practice courses show peripheral isolation patterns, indicating limited connectivity with core curriculum modules, which reduces their educational impact. These findings provide empirical insights for curriculum optimization, supporting urban sustainable development through enhanced professional talent cultivation equipped to address environmental challenges like sustainable design practices and resource-efficient urban planning. Network analysis applications introduce innovative frameworks for curriculum reform strategies. Future research expansion through larger sample validation will support urban sustainable development goals and enhance professional talent cultivation outcomes. Full article
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22 pages, 6288 KiB  
Article
The Pontoon Design Optimization of a SWATH Vessel for Resistance Reduction
by Chun-Liang Tan, Chi-Min Wu, Chia-Hao Hsu and Shiu-Wu Chau
J. Mar. Sci. Eng. 2025, 13(8), 1504; https://doi.org/10.3390/jmse13081504 - 5 Aug 2025
Abstract
This study applies a deep neural network (DNN) to optimize the 22.5 m pontoon hull form of a small waterplane area twin hull (SWATH) vessel with fin stabilizers, aiming to reduce calm water resistance at a Froude number of 0.8 under even keel [...] Read more.
This study applies a deep neural network (DNN) to optimize the 22.5 m pontoon hull form of a small waterplane area twin hull (SWATH) vessel with fin stabilizers, aiming to reduce calm water resistance at a Froude number of 0.8 under even keel conditions. The vessel’s resistance is simplified into three components: pontoon, strut, and fin stabilizer. Four design parameters define the pontoon geometry: fore-body length, aft-body length, fore-body angle, and aft-body angle. Computational fluid dynamics (CFD) simulations using STAR-CCM+ 2302 provide 1400 resistance data points, including fin stabilizer lift and drag forces at varying angles of attack. These are used to train a DNN in MATLAB 2018a with five hidden layers containing six, eight, nine, eight, and seven neurons. K-fold cross-validation ensures model stability and aids in identifying optimal design parameters. The optimized hull has a 7.8 m fore-body, 6.8 m aft-body, 10° fore-body angle, and 35° aft-body angle. It achieves a 2.2% resistance reduction compared to the baseline. The improvement is mainly due to a reduced Munk moment, which lowers the angle of attack needed by the fin stabilizer, thereby reducing drag. The optimized design provides cost-efficient construction and enhanced payload capacity. This study demonstrates the effectiveness of combining CFD and deep learning for hull form optimization. Full article
(This article belongs to the Section Ocean Engineering)
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21 pages, 4707 KiB  
Article
A Real-Time Cell Image Segmentation Method Based on Multi-Scale Feature Fusion
by Xinyuan Zhang, Yang Zhang, Zihan Li, Yujiao Song, Shuhan Chen, Zhe Mao, Zhiyong Liu, Guanglan Liao and Lei Nie
Bioengineering 2025, 12(8), 843; https://doi.org/10.3390/bioengineering12080843 (registering DOI) - 5 Aug 2025
Abstract
Cell confluence and number are critical indicators for assessing cellular growth status, contributing to disease diagnosis and the development of targeted therapies. Accurate and efficient cell segmentation is essential for quantifying these indicators. However, current segmentation methodologies still encounter significant challenges in addressing [...] Read more.
Cell confluence and number are critical indicators for assessing cellular growth status, contributing to disease diagnosis and the development of targeted therapies. Accurate and efficient cell segmentation is essential for quantifying these indicators. However, current segmentation methodologies still encounter significant challenges in addressing multi-scale heterogeneity, poorly delineated boundaries under limited annotation, and the inherent trade-off between computational efficiency and segmentation accuracy. We propose an innovative network architecture. First, a preprocessing pipeline combining contrast-limited adaptive histogram equalization (CLAHE) and Gaussian blur is introduced to balance noise suppression and local contrast enhancement. Second, a bidirectional feature pyramid network (BiFPN) is incorporated, leveraging cross-scale feature calibration to enhance multi-scale cell recognition. Third, adaptive kernel convolution (AKConv) is developed to capture the heterogeneous spatial distribution of glioma stem cells (GSCs) through dynamic kernel deformation, improving boundary segmentation while reducing model complexity. Finally, a probability density-guided non-maximum suppression (Soft-NMS) algorithm is proposed to alleviate cell under-detection. Experimental results demonstrate that the model achieves 95.7% mAP50 (box) and 95% mAP50 (mask) on the GSCs dataset with an inference speed of 38 frames per second. Moreover, it simultaneously supports dual-modality output for cell confluence assessment and precise counting, providing a reliable automated tool for tumor microenvironment research. Full article
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17 pages, 5314 KiB  
Article
The Settlement Ratio and Settled Area: Novel Indicators for Analyzing Land Use in Relation to Road Network Functions and Performance
by Giulia Del Serrone, Giuseppe Cantisani and Paolo Peluso
Eng 2025, 6(8), 188; https://doi.org/10.3390/eng6080188 - 5 Aug 2025
Abstract
Land use significantly influences mobility dynamics, affecting both travel behavior and mode choice. Traditional indicators such as the Floor Area Ratio, Land-Use Mix Index, and Built-up Area Ratio are widely used to describe settlement patterns; yet, they often fail to capture their functional [...] Read more.
Land use significantly influences mobility dynamics, affecting both travel behavior and mode choice. Traditional indicators such as the Floor Area Ratio, Land-Use Mix Index, and Built-up Area Ratio are widely used to describe settlement patterns; yet, they often fail to capture their functional impacts on road networks. This study introduces two complementary indicators—Settlement Ratio (SR) and Settled Area (SA)—developed through a spatial analysis framework integrating GIS data and MATLAB processing. SR offers a continuous typological profile of built-up functions along the road axis, while SA measures the percentage of anthropized land within fixed analysis windows. Applied to two Italian state roads, SS14 and SS309, in the Veneto Region, the dual-indicator approach reveals how the intensity (SR) and extent (SA) of settlement vary across different territorial contexts. In suburban segments, SR values exceeding 15–20, together with SA levels between 10% and 15%, highlight the significant spatial impact of isolated development clusters—often not evident from macro-scale observations. These findings demonstrate that the SR–SA framework provides a robust tool for analyzing land use in relation to road function. Although the study focuses on spatial structure and indicator design, future developments will explore correlations with traffic flow, speed, and crash data to support road safety analyses. Full article
(This article belongs to the Special Issue Interdisciplinary Insights in Engineering Research)
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30 pages, 9435 KiB  
Article
Intelligent Fault Warning Method for Wind Turbine Gear Transmission System Driven by Digital Twin and Multi-Source Data Fusion
by Tiantian Xu, Xuedong Zhang and Wenlei Sun
Appl. Sci. 2025, 15(15), 8655; https://doi.org/10.3390/app15158655 (registering DOI) - 5 Aug 2025
Abstract
To meet the demands for real-time and accurate fault warning of wind turbine gear transmission systems, this study proposes an innovative intelligent warning method based on the integration of digital twin and multi-source data fusion. A digital twin system architecture is developed, comprising [...] Read more.
To meet the demands for real-time and accurate fault warning of wind turbine gear transmission systems, this study proposes an innovative intelligent warning method based on the integration of digital twin and multi-source data fusion. A digital twin system architecture is developed, comprising a high-precision geometric model and a dynamic mechanism model, enabling real-time interaction and data fusion between the physical transmission system and its virtual model. At the algorithmic level, a CNN-LSTM-Attention fault prediction model is proposed, which innovatively integrates the spatial feature extraction capabilities of a convolutional neural network (CNN), the temporal modeling advantages of long short-term memory (LSTM), and the key information-focusing characteristics of an attention mechanism. Experimental validation shows that this model outperforms traditional methods in prediction accuracy. Specifically, it achieves average improvements of 0.3945, 0.546 and 0.061 in Root Mean Square Error (RMSE), Mean Absolute Percentage Error (MAPE), and R-squared (R2) metrics, respectively. Building on the above findings, a monitoring and early warning platform for the wind turbine transmission system was developed, integrating digital twin visualization with intelligent prediction functions. This platform enables a fully intelligent process from data acquisition and status evaluation to fault warning, providing an innovative solution for the predictive maintenance of wind turbines. Full article
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23 pages, 3106 KiB  
Article
Preparation of a Nanomaterial–Polymer Dynamic Cross-Linked Gel Composite and Its Application in Drilling Fluids
by Fei Gao, Peng Xu, Hui Zhang, Hao Wang, Xin Zhao, Xinru Li and Jiayi Zhang
Gels 2025, 11(8), 614; https://doi.org/10.3390/gels11080614 - 5 Aug 2025
Abstract
During the process of oil and gas drilling, due to the existence of pores or micro-cracks, drilling fluid is prone to invade the formation. Under the action of hydration expansion of clay in the formation and liquid pressure, wellbore instability occurs. In order [...] Read more.
During the process of oil and gas drilling, due to the existence of pores or micro-cracks, drilling fluid is prone to invade the formation. Under the action of hydration expansion of clay in the formation and liquid pressure, wellbore instability occurs. In order to reduce the wellbore instability caused by drilling fluid intrusion into the formation, this study proposed a method of forming a dynamic hydrogen bond cross-linked network weak gel structure with modified nano-silica and P(AM-AAC). The plugging performance of the drilling fluid and the performance of inhibiting the hydration of shale were evaluated through various experimental methods. The results show that the gel composite system (GCS) effectively optimizes the plugging performance of drilling fluid. The 1% GCS can reduce the linear expansion rate of cuttings to 14.8% and increase the recovery rate of cuttings to 96.7%, and its hydration inhibition effect is better than that of KCl and polyamines. The dynamic cross-linked network structure can significantly increase the viscosity of drilling fluid. Meanwhile, by taking advantage of the liquid-phase viscosity effect and the physical blocking effect, the loss of drilling fluid can be significantly reduced. Mechanism studies conducted using zeta potential measurement, SEM analysis, contact angle measurement and capillary force assessment have shown that modified nano-silica stabilizes the wellbore by physically blocking the nano-pores of shale and changing the wettability of the shale surface from hydrophilic to hydrophobic when the contact angle exceeds 60°, thereby reducing capillary force and surface free energy. Meanwhile, the dynamic cross-linked network can reduce the seepage of free water into the formation, thereby significantly lowering the fluid loss of the drilling fluid. This research provides new insights into improving the stability of the wellbore in drilling fluids. Full article
(This article belongs to the Special Issue Advanced Gels for Oil Recovery (2nd Edition))
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25 pages, 6730 KiB  
Article
Decentralized Coupled Grey–Green Infrastructure for Resilient and Cost-Effective Stormwater Management in a Historic Chinese District
by Yongqi Liu, Ziheng Xiong, Mo Wang, Menghan Zhang, Rana Muhammad Adnan, Weicong Fu, Chuanhao Sun and Soon Keat Tan
Water 2025, 17(15), 2325; https://doi.org/10.3390/w17152325 - 5 Aug 2025
Abstract
Coupled grey and green infrastructure (CGGI) offers a promising pathway toward sustainable stormwater management in historic urban environments. This study compares CGGI and conventional grey infrastructure (GREI)-only strategies across four degrees of layout centralization (0%, 33.3%, 66.7%, and 100%) in the Quanzhou West [...] Read more.
Coupled grey and green infrastructure (CGGI) offers a promising pathway toward sustainable stormwater management in historic urban environments. This study compares CGGI and conventional grey infrastructure (GREI)-only strategies across four degrees of layout centralization (0%, 33.3%, 66.7%, and 100%) in the Quanzhou West Street Historic Reserve, China. Using a multi-objective optimization framework integrating SWMM simulations, life-cycle cost (LCC) modeling, and resilience metrics, we found that the decentralized CGGI layouts reduced the total LCC by up to 29.6% and required 60.7% less green infrastructure (GI) area than centralized schemes. Under nine extreme rainfall scenarios, the GREI-only systems showed slightly higher technical resilience (Tech-R: max 99.6%) than CGGI (Tech-R: max 99.1%). However, the CGGI systems outperformed GREI in operational resilience (Oper-R), reducing overflow volume by up to 22.6% under 50% network failure. These findings demonstrate that decentralized CGGI provides a more resilient and cost-effective drainage solution, well-suited for heritage districts with spatial and cultural constraints. Full article
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22 pages, 982 KiB  
Article
Cross-Cultural Adaptation and Validation of the Spanish HLS-COVID-Q22 Questionnaire for Measuring Health Literacy on COVID-19 in Peru
by Manuel Caipa-Ramos, Katarzyna Werner-Masters, Silvia Quispe-Prieto, Alberto Paucar-Cáceres and Regina Nina-Chipana
Healthcare 2025, 13(15), 1903; https://doi.org/10.3390/healthcare13151903 - 5 Aug 2025
Abstract
Background/Objectives: The social importance of health literacy (HL) is widely understood, and its measurement is the subject of various studies. Due to the recent pandemic, several instruments for measuring HL about COVID-19 have been proposed in different countries, including the HLS-COVID-Q22 questionnaire. The [...] Read more.
Background/Objectives: The social importance of health literacy (HL) is widely understood, and its measurement is the subject of various studies. Due to the recent pandemic, several instruments for measuring HL about COVID-19 have been proposed in different countries, including the HLS-COVID-Q22 questionnaire. The diversity of cultures and languages necessitates the cross-cultural adaptation of this instrument. Thus, the present study translates, adapts, and validates the psychometric properties of the HLS-COVID-Q22 questionnaire to provide its cross-cultural adaptation from English to Spanish (Peru). Methods: As part of ensuring that the final questionnaire accommodates the cultural nuances and idiosyncrasies of the target language, the following activities were carried out: (a) a survey of 40 respondents; and (b) a focus group with 10 participants, followed by expert approval. In addition, the validity and reliability of the health instrument have been ascertained through a further pilot test administered to 490 people in the city of Tacna in southern Peru. Results: The resulting questionnaire helps measure HL in Peru, aiding better-informed decision-making for individual health choices. Conclusions: The presence of such a tool is advantageous in case of similar global health emergencies, when the questionnaire can be made readily available to support a promotion of strategies towards better self-care. Moreover, it encourages other Latin American stakeholders to adjust the instrument to their own cultural, language, and socio-economic contexts, thus invigorating the regional and global expansion of the HL study network. Full article
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23 pages, 9844 KiB  
Article
Mechanistic Exploration of Aristolochic Acid I-Induced Hepatocellular Carcinoma: Insights from Network Toxicology, Machine Learning, Molecular Docking, and Molecular Dynamics Simulation
by Tiantaixi Tu, Tongtong Zheng, Hangqi Lin, Peifeng Cheng, Ye Yang, Bolin Liu, Xinwang Ying and Qingfeng Xie
Toxins 2025, 17(8), 390; https://doi.org/10.3390/toxins17080390 - 5 Aug 2025
Abstract
This study explores how aristolochic acid I (AAI) drives hepatocellular carcinoma (HCC). We first employ network toxicology and machine learning to map the key molecular target genes. Next, our research utilizes molecular docking to evaluate how AAI binds to these targets, and finally [...] Read more.
This study explores how aristolochic acid I (AAI) drives hepatocellular carcinoma (HCC). We first employ network toxicology and machine learning to map the key molecular target genes. Next, our research utilizes molecular docking to evaluate how AAI binds to these targets, and finally confirms the stability and dynamics of the resulting complexes through molecular dynamics simulations. We identified 193 overlapping target genes between AAI and HCC through databases such as PubChem, OMIM, and ChEMBL. Machine learning algorithms (SVM-RFE, random forest, and LASSO regression) were employed to screen 11 core genes. LASSO serves as a rapid dimension-reduction tool, SVM-RFE recursively eliminates the features with the smallest weights, and Random Forest achieves ensemble learning through decision trees. Protein–protein interaction networks were constructed using Cytoscape 3.9.1, and key genes were validated through GO and KEGG enrichment analyses, an immune infiltration analysis, a drug sensitivity analysis, and a survival analysis. Molecular-docking experiments showed that AAI binds to each of the core targets with a binding affinity stronger than −5 kcal mol−1, and subsequent molecular dynamics simulations verified that these complexes remain stable over time. This study determined the potential molecular mechanisms underlying AAI-induced HCC and identified key genes (CYP1A2, ESR1, and AURKA) as potential therapeutic targets, providing valuable insights for developing targeted strategies to mitigate the health risks associated with AAI exposure. Full article
(This article belongs to the Section Plant Toxins)
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20 pages, 4095 KiB  
Article
Integrated Explainable Diagnosis of Gear Wear Faults Based on Dynamic Modeling and Data-Driven Representation
by Zemin Zhao, Tianci Zhang, Kang Xu, Jinyuan Tang and Yudian Yang
Sensors 2025, 25(15), 4805; https://doi.org/10.3390/s25154805 - 5 Aug 2025
Abstract
Gear wear degrades transmission performance, necessitating highly reliable fault diagnosis methods. To address the limitations of existing approaches—where dynamic models rely heavily on prior knowledge, while data-driven methods lack interpretability—this study proposes an integrated bidirectional verification framework combining dynamic modeling and deep learning [...] Read more.
Gear wear degrades transmission performance, necessitating highly reliable fault diagnosis methods. To address the limitations of existing approaches—where dynamic models rely heavily on prior knowledge, while data-driven methods lack interpretability—this study proposes an integrated bidirectional verification framework combining dynamic modeling and deep learning for interpretable gear wear diagnosis. First, a dynamic gear wear model is established to quantitatively reveal wear-induced modulation effects on meshing stiffness and vibration responses. Then, a deep network incorporating Gradient-weighted Class Activation Mapping (Grad-CAM) enables visualized extraction of frequency-domain sensitive features. Bidirectional verification between the dynamic model and deep learning demonstrates enhanced meshing harmonics in wear faults, leading to a quantitative diagnostic index that achieves 0.9560 recognition accuracy for gear wear across four speed conditions, significantly outperforming comparative indicators. This research provides a novel approach for gear wear diagnosis that ensures both high accuracy and interpretability. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
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17 pages, 1152 KiB  
Article
PortRSMs: Learning Regime Shifts for Portfolio Policy
by Bingde Liu and Ryutaro Ichise
J. Risk Financial Manag. 2025, 18(8), 434; https://doi.org/10.3390/jrfm18080434 - 5 Aug 2025
Abstract
This study proposes a novel Deep Reinforcement Learning (DRL) policy network structure for portfolio management called PortRSMs. PortRSMs employs stacked State-Space Models (SSMs) for the modeling of multi-scale continuous regime shifts in financial time series, striking a balance between exploring consistent distribution properties [...] Read more.
This study proposes a novel Deep Reinforcement Learning (DRL) policy network structure for portfolio management called PortRSMs. PortRSMs employs stacked State-Space Models (SSMs) for the modeling of multi-scale continuous regime shifts in financial time series, striking a balance between exploring consistent distribution properties over short periods and maintaining sensitivity to sudden shocks in price sequences. PortRSMs also performs cross-asset regime fusion through hypergraph attention mechanisms, providing a more comprehensive state space for describing changes in asset correlations and co-integration. Experiments conducted on two different trading frequencies in the stock markets of the United States and Hong Kong show the superiority of PortRSMs compared to other approaches in terms of profitability, risk–return balancing, robustness, and the ability to handle sudden market shocks. Specifically, PortRSMs achieves up to a 0.03 improvement in the annual Sharpe ratio in the U.S. market, and up to a 0.12 improvement for the Hong Kong market compared to baseline methods. Full article
(This article belongs to the Special Issue Machine Learning Applications in Finance, 2nd Edition)
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