Search Results (13,788)

The transition to circular models in fashion and textiles requires changes that go beyond technical innovation. The literature recognises that systemic change depends on the transformation of shared meanings around consumption and production, and that spaces for co-design and collaborative learning are crucial to generating this transformation. This article documents how Living Labs operate in this capacity, analysing the Madeback Circular Fashion Festival (May–November 2025), a pilot project of the Fashion & Textile Living Lab at the Politecnico di Milano. The study employs the Living Lab Integrative Process (LLIP) as both a design framework and an analytical lens. Adopting a qualitative and participatory method, the study documents how the three spaces of the LLIP—Problem Space, Solution Space and Implementation Space—simultaneously structured both design innovation and empirical analysis. The results point to three main contributions: (i) Living Labs can function as cultural infrastructures in which performative and narrative dimensions may contribute to the gradual normalisation of alternative practices; (ii) the Quadruple Helix operates as a living process characterised by distributed intentionality and emerging trust; and (iii) transformative learning appears through the co-production of knowledge in embodied and relational practices. The article identifies contextual factors that enabled the project—from its location in a design university to its multi-year funding—and the related constraints on transferability, concluding that Living Labs are promising infrastructures for sustainable transitions when they consciously integrate performative, cultural and relational dimensions. Full article

Trypanosoma vivax is a hemoprotozoan parasite of major veterinary importance affecting domestic ungulates in Africa and the Americas. While traditionally addressed within cattle-centered paradigms, accumulating evidence indicates that water buffaloes (Bubalus bubalis) are both clinically susceptible and epidemiologically significant hosts. This structured narrative review provides a host-centered synthesis of global evidence on T. vivax infection in buffaloes, integrating pathogenesis, transmission biology, epidemiology, diagnostics, chemotherapy, and integrated control. The analysis encompasses literature from 2000 to 2025 and incorporates seminal experimental studies published prior to 2000 that established buffalo susceptibility and reservoir competence. Evidence from cyclical (tsetse-mediated) and mechanical transmission systems is comparatively interpreted to clarify host–parasite dynamics. The Amazon biome is discussed as a model system for high-density buffalo production under mechanical vector pressure, offering case-based contextualization without geographic restriction. Particular attention is given to immunopathological mechanisms, chronic low-parasitemia carriage, diagnostic sensitivity in subclinical infections, emerging trypanocide resistance, and ecological constraints on vector control. Controversies and buffalo-specific knowledge gaps are highlighted throughout. By adopting a buffalo-centered analytical framework, this review supports translational diagnostics, targeted surveillance, and sustainable control strategies for trypanosomiasis in tropical livestock systems. Full article

Emerging contaminants (ECs) comprise diverse pollutant classes that are increasingly detected in remote environments due to their persistence and long-range transport potential. In cold regions, atmospheric cold-trapping processes favour their accumulation in high-altitude and high-latitude snow and ice, which act as sensitive archives and secondary sources of contamination. While previous studies have addressed individual environmental compartments (e.g., snowpack, glacier ice, meltwater), focusing on specific contaminant classes, a systematic review integrating the occurrence, behaviour and impacts of major EC groups in polar and alpine snow and ice is still lacking. To fill this gap, this work synthesised current knowledge on the environmental fate of three key EC categories in the cryosphere: metals and metalloids (MMs), industrial chemicals and by-products (ICBs), and pharmaceuticals and personal care products (PPCPs). PRISMA guidelines were accurately followed for research, which was based on a Google Scholar search combining keywords on cryospheric matrices (snow, firn, ice cores), geographical regions (Arctic, Antarctic, Alps, high mountains), and contaminant classes. Of 350 records initially identified, 300 met the eligibility criteria (post-industrial snow, firn, or ice cores studies) after excluding studies focused on aerosol or meltwater-only, method-focused papers, pre-industrial datasets, urban-only investigations, and duplicates. Risk of bias was qualitatively assessed through manual screening, evaluating matrix eligibility, temporal consistency, analytical methods, detection limits, and duplicate data, with particular attention to inconsistencies in ECs classification. Strict operational definitions were therefore applied to ensure methodological coherence. Concentration data were harmonised into a standardised database, and findings were synthesised through a structured narrative supported by tabulated datasets organised by matrix and site. Overall, the evidence indicates widespread occurrence of ECs in the global cryosphere, with spatial variability linked to emission sources, long-range transport pathways, and snow physicochemical properties. Climate-change-driven alterations of snow dynamics, glacier retreat and permafrost thaw are expected to modify partitioning equilibria and enhance the secondary release of legacy and contemporary contaminants. However, significant limitations persist, including geographical gaps, variability in analytical sensitivity, lack of long-term monitoring for certain EC classes, and inconsistencies in contaminant classification frameworks. Despite these constraints, the synthesis highlights consistent emerging patterns and underscores the need to strengthen existing environmental protocols to mitigate potential risks to ecosystems and human health. Full article

The process of ensuring the safety of the food supply is dynamic. Both the possibility of contamination and the effectiveness of safety precautions are impacted by changes in the kinds of food consumed, the geographical origins of food products, and the methods by which these foods are processed. For instance, compared to earlier generations, consumers’ general understanding of safe food preparation and handling techniques has decreased due to a higher reliance on prepackaged convenience foods. Nowadays, consumers depend increasingly on other people to make sure the food they eat is safe. Growing consumption of minimally processed foods and growing imports of fresh products from other nations have resulted from changes in consumer tastes and food processing technologies. This review aims to critically synthesize existing knowledge on microbial risks in food, focusing on their sources, mechanisms of contamination, risk evaluation methodologies, and implementation of food safety measures. Major foodborne pathogens, including Salmonella, Escherichia coli, Listeria monocytogenes, and Norovirus, are discussed alongside factors influencing their survival and transmission. Today Clostridium botulinum, Staphylococcus aureus, and Salmonella spp. remain among the major foodborne pathogens, but during the last two decades food-borne diseases such as shigellosis, listeriosis, campylobacteriosis, and diseases caused by pathogenic strains of Escherichia coli have become increasingly salient. These new concerns necessitate continued investment in research and technology development to improve the safety of the food supply. The review highlights current approaches to microbiological risk assessment, regulatory frameworks, and control strategies, while also addressing emerging challenges such as antimicrobial resistance, biofilms, and ready-to-eat foods. By integrating risk evaluation with practical implementation strategies, this review provides valuable insights for researchers, regulators, and food industry stakeholders seeking to strengthen food safety systems and reduce the burden of foodborne diseases. Full article

Fluorescent dyes are commonly used as tracers in hydrological investigations to quantify transport pathways, residence times, mixing behavior, and connectivity in surface water, groundwater, and coastal systems. Despite their long history of application, the ecological implications of deliberate dye releases are not well understood. This review synthesizes current knowledge on the physico-chemical characteristics, environmental behavior, and ecotoxicological effects of major dye classes, with emphasis on rhodamines, fluorescein derivatives, and sulfonated xanthene dyes commonly used in water tracing studies. Toxicity data for algae, cyanobacteria, invertebrates, and fish show large inter-specific variability. Some dyes, particularly rhodamine B and eosin Y, show acute or sub-lethal effects at concentrations detected during poorly controlled applications. By contrast, dyes with high polarity and extensive sulfonation (e.g., rhodamine WT, sulforhodamine B, pyranine, and fluorescein) show consistently low toxicity and minimal bioaccumulation potential. Environmental fate processes, including photolysis, sorption, and transformation into potentially more reactive products, influence exposure dynamics, especially in clear, shallow, or slow-moving systems. This review also evaluates regulatory frameworks and operational guidance for safe use, identifies gaps in toxicological and fate data, and proposes recommendations for minimizing environmental impact through dye selection, mass optimization, injection design, and monitoring. The findings support the continued use of fluorescent dyes but highlight the need for more systematic assessment of transformation products, chronic and sub-lethal responses, and cumulative exposure in sensitive environments. Full article

The residues of veterinary drugs in the food chain are a global concern for food safety, including questions about the origin of these residues, exposure pathways, health impacts, methods for their dissolution, and accurate monitoring methods. In recent years, numerous professional studies have addressed the above concerns from various perspectives. However, these studies are relatively scattered and cannot provide a systematic and comprehensive understanding of recent developments. In this systematic review, we aim to provide a comprehensive synthesis of the current state of knowledge concerning the residues of veterinary drugs in the food chain through critical examination of their origins, exposure pathways, and associated health/environmental hazards. Investigating creative mitigation techniques to lower such residues in food products is given special attention. In summary, this research proposes a paradigm that balances the development of animal production with strict food safety governance to address productivity, consumer health, and international standards. Full article

This research aims to record hotel owners’ perceptions as subjective measures of the degree of integration of local traditional cheese varieties in the hospitality sector. Within the context of cheese tourism, this specific type of alternative tourism is operationalized through B2B co-creation among tourism businesses and cheese factories, serving as a framework for perceived business development. Specifically, this study fills a gap in the literature by exploring the managerial views on the current state of cheese tourism in relation to the entrepreneurship strengthening, the opportunities, and challenges that could favor cooperation between the two sectors. Descriptive and inductive statistics were conducted, collecting primary data from hotels in the Peloponnese, Greece, which has a long tradition of cheese production. Regional tradition and star rating determine the integration of local cheese. While 4–5-star hotels leverage cheese heritage for differentiation and experiential services, lower-end hotels face cost and supply chain barriers, requiring supporting strategies and cross-sector partnerships. The study offers original knowledge for the development of specific strategic proposals for the use of cheese tourism through co-creation for business development of hotels. Future research is recommended to record the views of all stakeholders and correlate them with objective financial performance. Full article

Extended Reality (XR) technologies are rapidly reshaping human–computer interaction; however, persistent ambiguity in the use of core terms (VR, AR, MR) hampers cumulative knowledge building, cross-study comparability, and technical standardisation. This review evaluates the XR conceptual landscape across four primary dimensions: the historical evolution of core definitions, the synthesis of contemporary theoretical frameworks, the critical extensions of the Reality-Virtuality (RV) Continuum, and the alignment between academic taxonomies and industry practices. This review evaluates the XR conceptual landscape across four primary dimensions: the historical evolution of core definitions, the synthesis of contemporary theoretical frameworks, the critical extensions of the Reality-Virtuality (RV) Continuum, and the alignment between academic taxonomies and industry practices. To address this issue, we conducted a PRISMA-guided systematic literature review across four major databases (IEEE Xplore, ACM Digital Library, Scopus, and Web of Science), complemented by seminal and industry sources. Of the 173,677 retrieved records, 59 studies were included in the synthesis. Using thematic synthesis, we mapped the historical evolution of definitions and conceptual models and identified recurring analytical dimensions. The results indicate a clear paradigm shift from Milgram’s one-dimensional Reality–Virtuality continuum—originally grounded in visual display technology—towards a multidimensional conceptual space that integrates subjective user-experience constructs (e.g., coherence and plausibility) with objective system characteristics. The included studies cover 1968–2025, with marked acceleration in the 2020s: 2022 alone accounts for the highest annual count (9 studies), and nearly half of the corpus (47.5%) was published in 2021–2025. We further show that industry actors pragmatically re-bound these academic concepts for product and market positioning, leading to systematic divergences between academic and industrial definitions. By distilling key turning points and synthesising core analytical dimensions into a structured lens, this review provides a historically grounded, actionable understanding of the XR conceptual landscape to support terminological alignment across research and practice. Full article

Maintaining stable research productivity is critical for sustainable knowledge production, yet institutional mobility—an increasingly common form of organizational transition in higher education—may disrupt scientists’ output trajectories. This study examines how mobility direction shapes sustainable research productivity and how co-authorship network structure conditions these effects. Using curriculum vitae records and 74,336 Web of Science publications for 531 preliminary candidates for Chinese Academy of Sciences academicians (2005–2019), we estimate random-effects negative binomial models to assess the quantity and quality dimensions of sustainable research productivity in the third-to-fifth years after mobility events. Downward mobility to lower-ranked institutions is associated with significant declines in both dimensions, whereas upward mobility shows no detectable effect within the same window. Network structure matters: higher co-authorship network density buffers the adverse effect of downward mobility, while higher betweenness centrality amplifies it. These findings suggest that cohesive collaboration structures help sustain knowledge production under adverse transitions, whereas brokerage-oriented positions may increase vulnerability when collaborations are reconfigured. By conceptualizing post-mobility outcomes as sustainable research productivity, this study extends the talent mobility literature and offers implications for universities and science policy on supporting high-level scientists during institutional transitions. Full article

As the “flagship” unit of the petrochemical industry, the operational status of ethylene cracking furnaces directly impacts the stability and efficiency of the entire production chain. During long-term operation under extreme temperatures and complex reaction environments, cracking furnace tubes face core bottlenecks primarily related to thermal and coking effects, such as coke deposition, tube metal overheating, and associated creep damage, which restrict the long-term, safe, and efficient operation of the unit. This paper systematically reviews the key technologies for condition monitoring of cracking furnace tubes, providing an in-depth analysis of various monitoring methods—from traditional infrared thermometry and acoustic emission to emerging optical fiber sensing—covering their working principles, application status, and inherent limitations. Furthermore, it elaborates on the evolution from mechanism-based “white-box” models to data-driven “black-box” models, and further to “gray-box” intelligent diagnostic models that integrate expert knowledge. Industrial application cases of integrated monitoring and diagnostic systems are also introduced. Finally, the paper critically addresses the current severe challenges in data fusion, model generalization, real-time performance, and cost-effectiveness, while outlining future development trends toward digital twins, cross-modal fusion, edge intelligence, and self-evolving systems. The aim is to provide valuable references for technological innovation and engineering applications in this field. Full article

Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of peripheral T-cell lymphoma (PTCL) and is frequently associated with autoimmune phenomena. Clinically, AITL shows an aggressive disease course and poor prognosis with currently available treatment strategies. We here report the case of a 64-year-old female patient who was diagnosed with AITL and showed a complicated clinical course due to concurrent immune-mediated thrombotic thrombocytopenic purpura (iTTP). To our knowledge, the presented case highlights a previously unreported association of both conditions. Treatment, including chemotherapy and iTTP-directed treatments, resulted in rapid clinical improvement and sustained remission of both the AITL and the concurrent iTTP. In AITL, transformed T-follicular helper cells (TFHs) are particularly thought to mediate hypersecretion of cytokines and excessive autoantibody production. Immunological disturbances to large parts mediated through these transformed TFHs are thought to trigger autoimmune conditions, as seen with iTTP in this patient. At 36 months post-treatment, the patient remains in complete remission for both AITL and iTTP. This case highlights the complex immunopathological relationship between AITL and autoimmune disorders possibly impeding diagnosis and treatment in a timely manner. Full article

Fusarium head blight (FHB) is one of the most significant diseases in wheat globally, affecting about 200 million tons of grain per year through mycotoxin contamination. Besides yield losses, mycotoxin contamination is a major concern. FHB resistance in wheat is partial and polygenic, and since the efficacy of plant protection measures is generally weak-to-moderate, an integrated approach is needed for successful control. We evaluated a more comprehensive methodology for improved protection; in this two-year study, five registered organic products and six conventional products were compared under artificial and natural infection conditions. The disease index (DI), Fusarium-damaged kernels (FDKs) and deoxynivalenol (DON) contamination were evaluated. The stability of the fungicides was also evaluated based on 10 epidemic conditions. The organic fungicides showed much lower efficacy than the conventional ones, although significant reductions in symptoms and DON contamination were observed. In each group, significant variability was detected. The best fungicides for DON contamination showed the lowest variance (highest stability) between 10 and 20 (Verben, Prosaro, Ascra Xpro). The organic fungicides were much less stable; the least stable showed a variance of 141 (Fusarium control: 264). The best organic fungicide was the Bordeaux mixture supported by sulfur addition (variance: 54). The DI and FDK values presented very similar trends. For the more resistant cultivar GK Pilis, the combined DON reduction exceeded 90% for all fungicides. For the most susceptible cultivar, GK Békés, the values were between 30 and 83%, respectively. High resistance to FHB and toxin contamination is the key to controlling FHB in both organic and conventional production. For efficient fungicide control, stable resistance to disease and toxin accumulation are equally required. Principal component analysis (PCA) verified the importance of considering all traits to identify the fungicidal “fingerprint” and demonstrated the differences between fungicides regardless of their organic or conventional nature. PC response differs for traits and fungicides, supporting the complex evaluation of plant and fungicide behavior. Knowledge of resistance levels, in addition to improving mycotoxin control, aids in disease forecasting and epidemic management. The results are applicable to both organic and conventional production systems. Due to the variability in resistance and fungicidal effects, there is an opportunity to improve food safety in both organic and conventional wheat production. Full article

Bactrian camels (Camelus bactrianus) have long been recognized in China as key agents of long-distance connectivity, based largely on iconographic and textual evidence, while osteological data have rarely been incorporated into discussion. Because these data have seldom been examined within a unified analytical framework, current knowledge of the development and shifting patterns of camel–human relationships remains fragmentary. To address this gap, the present study provides a detailed analysis of available camel osteological material from archaeological contexts in northern China and integrates it with broader archaeological and historical evidence. Our results identify diverse forms of interaction across time and space, including camel exploitation for transport and labor, consumption, funerary practices, and craft production. Spatiotemporal patterns indicate a persistent concentration of osteological remains in China’s northern frontier zones, whereas the record remains sporadic in central regions despite increasing camel representations in material culture and texts. This enduring distribution reflects ecological suitability and sustained economic integration in arid zones. The absence of such conditions in Central China meant that camels were never fully incorporated into local everyday life; instead, they primarily operated within imperial logistical and political systems and came to be culturally important through their role in broader exchange networks. Full article

While many consumers regard meat as an important part of the diet, thanks to its complete protein and nutrient content and its sensory qualities, others choose to forego it for various reasons and replace it with plant-based meat alternatives (PBMAs). The aim of this review is to synthesise the current state of knowledge on PBMAs, particularly with regard to their impact on health and the environment and their ability to meet consumer nutritional and sensory expectations. This holistic overview also aims to identify critical interdisciplinary research gaps often overlooked in segmented reviews. The literature used in the study was identified by a search of PubMed, Web of Science, Google Scholar and Scopus databases using defined keywords. Given the growth in population and demand for meat, PBMAs can make a significant contribution to sustainable food production, provided that they can meet three key criteria: appearance, nutritional value and consumer safety. However, while PBMAs can represent a valuable source of essential amino acids, their overall nutritional value varies with regard to product type and protein source; furthermore, relatively little is known of the effect of the additives and production methods on consumer health. Plant-based meat alternatives can effectively support human health and environmental sustainability, but further research is needed on their safety and quality. Full article

Prenatal exposure to aflatoxin B₁ (AFB₁) poses a significant risk to fetal development and is associated with reduced birth weight in humans. Experimental studies consistently show that AFB₁ induces fetal abnormalities, with skeletal malformations and ossification defects being the most common. However, the specific impact of AFB₁ on fetal osteogenesis remains unclear. Given this knowledge gap, this study aimed to review the existing literature concerning the pathogenesis of AFB₁ and its potential influence on bone development. The primary mechanisms implicated in AFB₁’s impact on bone include dysfunction in vitamin D and calcium metabolism, alterations in parathyroid hormone production and function, induction of inflammatory responses, and oxidative stress. Collectively, these mechanisms have the potential to impair osteoblast and osteoclast function and, consequently, compromise ossification. Based on these findings, studies should explore and elucidate the effects of AFB₁. Elucidating these mechanisms is crucial for mitigating the deleterious impacts of AFB₁ on fetal skeletal development. Full article