Search Results (2,865)

Pelvic organ prolapse (POP) is a prevalent condition, affecting women all over the world, and is commonly treated through surgical interventions that present limitations such as recurrence or complications associated with synthetic meshes. In this study, biodegradable poly($ϵ$-caprolactone) (PCL) cog threads are proposed as a minimally invasive alternative for vaginal wall reinforcement. A custom cutting tool was developed to fabricate threads with varying barb angles (90°, 75°, 60°, and 45°), which were produced via Melt Electrowriting. Their mechanical behavior was assessed through uniaxial tensile tests and validated using finite element simulations. The results showed that barb orientation had minimal influence on tensile performance. In simulations of anterior vaginal wall deformation under cough pressure, all cog thread configurations significantly reduced displacement in the damaged tissue model, achieving values comparable to or even lower than those of healthy tissue. A ball burst simulation using an anatomically accurate model further demonstrated a 13% increase in reaction force with cog thread reinforcement. Despite fabrication limitations, this study supports the biomechanical potential of 3D-printed PCL cog threads for POP treatment, and lays the groundwork for future in vivo validation. Full article

Common bean (Phaseolus vulgaris L.) is a critical protein-rich legume supporting food and nutritional security globally. However, Fusarium wilt, caused by Fusarium solani, remains a major constraint to production, with yield losses reaching up to 84%. While biocontrol strategies have been explored, most microbial agents are sourced from mesophilic environments and show limited effectiveness under abiotic stress. Here, we report the isolation and characterization of extremophilic Bacillus spp. from the hypersaline Lake Bogoria, Kenya, and their biocontrol potential against F. solani. From 30 isolates obtained via serial dilution, 9 exhibited antagonistic activity in vitro, with mycelial inhibition ranging from 1.07-1.93 cm 16S rRNA sequencing revealed taxonomic diversity within the Bacillus genus, including unique extremotolerant strains. Molecular screening identified genes associated with the biosynthesis of antifungal metabolites such as 2,4-diacetylphloroglucinol, pyrrolnitrin, and hydrogen cyanide. Enzyme assays confirmed substantial production of chitinase (1.33–3160 U/mL) and chitosanase (10.62–28.33 mm), supporting a cell wall-targeted antagonism mechanism. In planta assays with the lead isolate (B7) significantly reduced disease incidence (8–35%) and wilt severity (1–5 affected plants), while enhancing root colonization under pathogen pressure. These findings demonstrate that extremophile-derived Bacillus spp. possess robust antifungal traits and highlight their potential as climate-resilient biocontrol agents for sustainable bean production in arid and semi-arid agroecosystems. Full article

Deep marine shale is the primary carrier of shale gas resources in Southwestern China. Because the occurrence and gas content of methane vary with burial conditions, understanding the microscopic mechanism of methane occurrence in deep marine shale is critical for effective shale gas exploitation. The temperature and pressure conditions in deep shale exceed the operating limits of experimental equipment; thus, few studies have discussed the microscopic occurrence mechanism of shale gas in deep marine shale. This study applies molecular simulation technology to reveal the methane’s microscopic occurrence mechanism, particularly the main controlling factor of adsorbed methane in deep marine shale. Two types of simulation models are also proposed. The Grand Canonical Monte Carlo (GCMC) method is used to simulate the adsorption behavior of methane molecules in these two models. The results indicate that the isosteric adsorption heat of methane in both models is below 42 kJ/mol, suggesting that methane adsorption in deep shale is physical adsorption. Adsorbed methane concentrates on the pore wall surface and forms a double-layer adsorption. Furthermore, adsorbed methane can transition to single-layer adsorption if the pore size is less than 1.6 nm. The total adsorption capacity increases with rising pressure, although the growth rate decreases. Excess adsorption capacity is highly sensitive to pressure and can become negative at high pressures. Methane adsorption capacity is determined by pore size and adsorption potential, while accommodation space and adsorption potential are influenced by pore size and mineral type. Under deep marine shale reservoir burial conditions, with burial depth deepening, the effect of temperature on shale gas occurrence is weaker than pressure. Higher temperatures inhibit shale gas occurrence, and high pressure enhances shale gas preservation. Smaller pores facilitate the occurrence of adsorbed methane, and larger pores have larger total methane adsorption capacity. Deep marine shale with high formation pressure and high clay mineral content is conducive to the microscopic accumulation of shale gas in deep marine shale reservoirs. This study discusses the microscopic occurrence state of deep marine shale gas and provides a reference for the exploration and development of deep shale gas. Full article

In order to study the problem of obvious wall thinning in the wellbore caused by proppant backflow and sand production under throttling conditions in tight gas wells. Based on the gas-phase control equation, particle motion equation, and erosion model, the wellbore erosion model is established. The distribution law of pressure, temperature, and velocity trace fields under throttling conditions is analyzed, and the influences of different throttling pressures, particle diameters, and particle mass flows on wellbore erosion are analyzed. The flow field at the nozzle changes drastically, and there is an obvious pressure drop, temperature drop, and velocity rise. When the surrounding gas is completely mixed, the physical quantity gradually stabilizes. The erosion shape of the wellbore outlet wall has a point-like distribution. The closer to the throttle valve outlet, the more intense the erosion point distribution is. Increasing the inlet pressure and particle mass flow rate will increase the maximum erosion rate, and increasing the particle diameter will reduce the maximum erosion rate. The particle mass flow rate has the greatest impact on the maximum erosion rate, followed by the particle diameter. The erosion trend was predicted using multiple regression model fitting of the linear interaction term. The research results can provide a reference for the application of downhole throttling technology and wellbore integrity in tight gas exploitation. Full article

The presented research examines the performance characteristics of Brazed Plate Heat Exchangers through computational fluid dynamics (CFD), focusing on pressure drop calculations for single-phase flow within full channels of plates featuring dimpled corrugation. This work aims to bridge gaps in the literature, particularly regarding the underexplored behavior near the ports for the studied technology and establishing a framework for future conjugate heat transfer studies. A methodology for the domain generation was developed, integrating a preliminary forming simulation to reproduce the complex plate geometry. Comprehensive sensitivity analyses were conducted to evaluate the influence of different parameters and identify the optimal settings for obtaining reliable results. The findings indicate that the $k-\epsilon$ realizable turbulence model with enhanced wall treatment offers superior accuracy in predicting pressure drops, with errors within ±4.4%. Additionally, leveraging the information derived from CFD, a strategy to estimate contributions from different channel sections without a direct reliance on those simulations was developed, offering practical implications for plate design. Full article

Maintaining the required relative humidity values in the vehicle cabin is an important HVAC task, along with considerations related to the temperature, velocity, air pressure and noise. Deviation from the optimal values worsens the psycho-physiological state of the driver and affects the energy efficiency of the train. In this study, a model of liquid film formation on and removal from various cabin surfaces was constructed using the fundamental Navier–Stokes hydrodynamic equations. A special transport model based on the liquid vapor diffusion equation was used to simulate the air environment inside the cabin. The evaporation and condensation of surface films were simulated using the Euler film model, which directly considers liquid–gas and gas–liquid transitions. Numerical results were obtained using the RANS equations and a turbulence model by means of the finite volume method in Ansys CFD. Conjugate fields of temperature, velocity and moisture concentration were constructed for various time intervals, and the dependence values for the film thicknesses on various surfaces relative to time were determined. The verification was conducted in comparison with the experimental data, based on the protocol for measuring the microclimate indicators in workplaces, as applied to the train cabin: the average ranges encompassed temperature changes from 11% to 18%, and relative humidity ranges from 16% to 26%. Comparison with the results of other studies, without considering the phase transition and condensation, shows that, for the warm mode, the average air temperature in the cabin with condensation is 12.5% lower than without condensation, which is related to the process of liquid evaporation from the heated walls. The difference in temperature values for the model with and without condensation ranged from −12.5% to +4.9%. We demonstrate that, with an effective mode of removing condensate film from the window surface, including recirculation modes, the energy consumption of the climate control system improves significantly, but this requires a more accurate consideration of thermodynamic parameters and relative humidity. Thus, considering the moisture condensation model reveals that this variable can significantly affect other parameters of the microclimate in cabins: in particular, the temperature. This means that it should be considered in the numerical modeling, along with the basic heat transfer equations. Full article

Span-wise homogeneous supersonic cavity flows display complicated structures due to shear layer breakdown, flow acoustic resonance, and even non-linear hydrodynamic-acoustic interactions. In practical applications, such as aircraft bays, the cavity is of finite width and has doors, both of which introduce distinctive phenomena that couple with the shear layer at the cavity lip, further modulating shear layer bifurcations and tonal mechanisms. In particular, asymmetric states manifest as ‘tornado’ vortices with significant practical consequences on the design and operation. Both inward- and outward-facing leading-wedge doors, resulting in leading edge shocks directed into and away from the cavity, are examined at select opening angles ranging from $22.5°$ to $90°$ (fully open) at Mach 1.6. The computational approach utilizes the Reynolds-Averaged Navier–Stokes equations with a one-equation model and is augmented by experimental observations of cavity floor pressure and surface oil-flow patterns. For the no-doors configuration, the asymmetric results are consistent with a long-time series DDES simulation, previously validated with two experimental databases. When fully open, outer wedge doors (OWD) yield an asymmetric flow, while inner wedge doors (IWD) display only mildly asymmetric behavior. At lower door angles (partially closed cavity), both types of doors display a successive bifurcation of the shear layer, ultimately resulting in a symmetric flow. IWD tend to promote symmetry for all angles observed, with the shear layer experiencing a pitchfork bifurcation at the ‘critical angle’ ($67.5°$). This is also true for the OWD at the ‘critical angle’ ($45°$), though an entirely different symmetric flow field is established. The first observation of pitchfork bifurcations (‘critical angle’) for the IWD is at $67.5°$ and for the OWD, $45°$, complementing experimental observations. The back wall signature of the bifurcated shear layer (impingement preference) was found to be indicative of the 3D cavity dynamics and may be used to establish a correspondence between 3D cavity dynamics and the shear layer. Below the critical angle, the symmetric flow field is comprised of counter-rotating vortex pairs at the front and back wall corners. The existence of a critical angle and the process of door opening versus closing indicate the possibility of hysteresis, a preliminary discussion of which is presented. Full article

Hernia is a physiological condition that significantly impacts patients’ quality of life. Surgical treatment for hernias often involves the use of specialized meshes to support the abdominal wall. While this method is highly effective, it frequently leads to complications such as pain, infections, inflammation, adhesions, and even the need for revision surgeries. According to the Food and Drug Administration (FDA), hernia recurrence rates can reach up to 11%, surgical site infections occur in up to 21% of cases, and chronic pain incidence ranges from 0.3% to 68%. These statistics highlight the urgent need to improve mesh technologies to minimize such complications. The design and material composition of meshes are critical in reducing postoperative complications. Moreover, integrating drug-eluting properties into the meshes could address issues like infections and inflammation by enabling localized delivery of antibiotics and anti-inflammatory agents. Mesh design is equally important, with innovative structures like auxetic designs offering enhanced mechanical properties, flexibility, and tissue integration. These advanced designs can distribute stress more evenly, reduce fatigue, and improve performance in areas subjected to high pressures, such as during intense coughing, sneezing, or heavy lifting. Technological advancements, such as 3D printing, enable the precise fabrication of meshes with tailored designs and properties, providing new opportunities for innovation. By addressing these challenges, the development of next-generation mesh implants has the potential to reduce complications, improve patient outcomes, and significantly enhance quality of life for individuals undergoing hernia repair. Full article

To meet the rapid maneuverability and lightweight demands of micro-nano satellites, a space micro solid thruster using 3D-printed short glass fiber reinforced polyamide 6 (PA6GF) composites was developed. Thruster shells with wall thicknesses of 4, 3, and 2.5 mm were designed, and ground ignition tests were conducted to monitor chamber pressure and shell temperature. Compared with conventional metallic thrusters, PA6GF composites have exhibited excellent thermal insulation and sufficient mechanical strength. Under 8 MPa and 2773 K ignition conditions, the shell thickness was reduced to 2.5 mm and could withstand pressures up to 10.37 MPa. These results indicate that PA6GF composites are well-suited for space micro solid thrusters with inner diameters of 15–70 mm, offering new possibilities for lightweight space propulsion system design. Full article

Creating a comfortable microclimate in the premises of buildings is currently becoming one of the priorities in the field of architecture, construction and engineering systems. The increased attention from the scientific community to this topic is due not only to the desire to ensure healthy and favorable conditions for human life but also to the need for the rational use of energy resources. This area is becoming particularly relevant in the context of global challenges related to climate change, rising energy costs and increased environmental requirements. Practice shows that any technical solutions to ensure comfortable temperature, humidity and air exchange in rooms should be closely linked to the concept of energy efficiency. This allows one not only to reduce operating costs but also to significantly reduce greenhouse gas emissions, thereby contributing to sustainable development and environmental safety. In this connection, this study presents a parametric assessment of the influence of climatic and geometric factors on the aerodynamic characteristics of the air cavity, which affect the heat exchange process in the ventilated layer of curtain wall systems. The assessment was carried out using a combined analytical calculation method that provides averaged thermophysical parameters, such as mean air velocity ($V_s$), average internal surface temperature ($t_{in.s}^{av}$), and convective heat transfer coefficient (${\alpha }_s$) within the air cavity. This study resulted in empirical average values, demonstrating that the air velocity within the cavity significantly depends on atmospheric pressure and façade height difference. For instance, a 10-fold increase in façade height leads to a 4.4-fold increase in air velocity. Furthermore, a three-fold variation in local resistance coefficients results in up to a two-fold change in airflow velocity. The cavity thickness, depending on atmospheric pressure, was also found to affect airflow velocity by up to 25%. Similar patterns were observed under ambient temperatures of +20 °C, +30 °C, and +40 °C. The analysis confirmed that airflow velocity is directly affected by cavity height, while the impact of solar radiation is negligible. However, based on the outcomes of the analytical model, it was concluded that the method does not adequately account for the effects of solar radiation and vertical temperature gradients on airflow within ventilated façades. This highlights the need for further full-scale experimental investigations under hot climate conditions in South Kazakhstan. The findings are expected to be applicable internationally to regions with comparable climatic characteristics. Ultimately, a correct understanding of thermophysical processes in such structures will support the advancement of trends such as Lightweight Design, Functionally Graded Design, and Value Engineering in the development of curtain wall systems, through the optimized selection of façade configurations, accounting for temperature loads under specific climatic and design conditions. Full article

This paper presents a neural network model, PINN-AeroFlow-U, for reconstructing full-field aerodynamic quantities around three-dimensional compressor blades, including regions near the wall. This model is based on structured CFD training data and physics-informed loss functions and is proposed for direct 3D compressor flow prediction. It maps flow data from the physical domain to a uniform computational domain and employs a U-Net-based neural network capable of capturing the sharp local transitions induced by fluid acceleration near the blade leading edge, as well as learning flow features associated with internal boundaries (e.g., the wall boundary). The inputs to PINN-AeroFlow-U are the flow-field coordinate data from high-fidelity multi-geometry blade solutions, the 3D blade geometry, and the first-order metric coefficients obtained via mesh transformation. Its outputs include the pressure field, temperature field, and velocity vector field within the blade passage. To enhance physical interpretability, the network’s loss function incorporates both the Euler equations and gradient constraints. PINN-AeroFlow-U achieves prediction errors of 1.063% for the pressure field and 2.02% for the velocity field, demonstrating high accuracy. Full article

To address the challenges associated with deep ground pressure control at the Sanshandao Gold Mine, a pre-controlled top-to-middle and deep-hole upper and lower-wall goaf subsequent filling mining method was proposed. Three distinct downward mining schemes were designed, the excavation procedure is systematically designed with 18 steps, and the temporal and spatial evolution characteristics of stress and displacement were analyzed using FLAC3D. The results revealed that stress concentration occurred during excavation steps 1–3. As excavation progressed to steps 4–9, the stress concentration area shifted primarily to the filling zones of partially excavated and filled sections. By steps 10–12, the stress concentration in these areas was alleviated. Upon completion of all excavation and filling steps, a small plastic zone was observed, accompanied by an alternating distribution of high and low stress within the backfill. Throughout the excavation process, vertical displacement ranged from 4.42 to 22.73 mm, while horizontal displacement ranged from 1.72 to 3.69 mm, indicating that vertical displacement had a more significant impact on stope stability than horizontal displacement. Furthermore, the fuzzy comprehensive evaluation method was applied to optimize the selection among the three schemes, with Scheme 2 identified as the optimal. Field industrial trials subsequently confirmed the technical rationality and practical applicability of Scheme 2 under actual mining conditions. Full article

Microalgae proteins are increasingly recognized in the food and nutraceutical industries for their functional versatility and high nutritional value. Mild alkaline treatment is commonly used for cell wall degradation and intracellular protein solubilization, consequently enhancing the protein extraction yield. The findings of this study reveal that alkaline treatment alone, even at higher NaOH concentration (up to 0.3 M) and treatment time (up to 90 min), was ineffective (max. 2.4% yield) for the extraction of protein from Auxenochlorella protothecoides biomass. This challenge was significantly reduced through synergistic application of mechanical cell disruption using high-pressure homogenization (HPH) and alkaline solubilization. Single-pass HPH (35 k psi) alone without alkaline treatment led to 52.3% protein solubilization from wet biomass directly harvested from culture broth, while it was only 18.5% for spray-dried biomass. The combined effect of HPH and alkaline (0.1 M NaOH) treatment significantly increased protein extraction yield to 68.0% for a spray-dried biomass loading of 50 g L⁻¹. Through replacing spray-dried biomass with wet biomass, the requirement of NaOH was reduced by 5-fold to 0.02 M to achieve a similar yield of 68.1%. The process integration of HPH with the mild alkaline solubilization and utilization of wet biomass from culture broth showed high potential for industrialization of microalgae protein extraction. This method achieves high extraction yield while reducing alkaline waste and eliminating the need for energy-consuming drying of biomass, thereby minimizing the environmental impact. Full article

Natural vaporization in LPG (liquefied petroleum gas) tanks refers to the process where liquid LPG is converted to vapor naturally due to ambient heat. This natural vaporization process relies on ambient heat from the surroundings, which is transferred through the walls of the LPG tank. The natural vaporization rate depends on several factors, such as the ambient temperature, the surface area of the tank in contact with the liquid (i.e., the filling fraction), the exact composition of LPG, and the design and positioning of the LPG tank. When natural vaporization rates cannot meet the gas demand, as in the case of colder climates and large commercial applications, an additional LPG vaporizer will be necessary. The obtained results revealed that pure propane at an operating pressure of 1.75 bar achieves specific vaporization rates per unit of tank surface area of 0.7 kg/h/m², which decreases to 0.4 and 0.25 kg/h/m² for LPG mixtures with 20% and 40% butane, respectively. For a lower operating pressure of 1.10 bar, the specific vaporization rate per unit of tank surface area is 1.0 kg/h/m² for pure propane, 0.85 kg/h/m² for 20% butane, and 0.70 kg/h/m² for 40% butane. Full article

Spinal cord injury (SCI) frequently leads to neurogenic lower urinary tract dysfunction, for which appropriate bladder management is essential. While clinical care relies on continuous low-pressure drainage in the acute phase, rat models commonly use twice-daily manual bladder expression—a method known to generate high intravesical pressures and retention. This study evaluated the impact of this standard practice on bladder tissue remodeling by comparing it to continuous drainage via high vesicostomy in a rat SCI model. 32 female Lewis rats underwent thoracic contusion SCI and were assigned to either manual expression or vesicostomy-based bladder management. Over eight weeks, locomotor recovery, wound healing, and bladder histology were assessed. Vesicostomy proved technically simple but required tailored wound care and calibration. Results showed significantly greater bladder wall thickness, detrusor muscle hypertrophy, urothelial thickening, collagen deposition, and mast cell infiltration in the manual expression group compared to both vesicostomy and controls. In contrast, vesicostomy animals exhibited near-control levels across most parameters. These findings highlight that commonly used bladder emptying protocols in rat SCI models may overestimate structural bladder changes and inflammatory responses. Refined drainage strategies such as vesicostomy can minimize secondary damage and improve the translational relevance of preclinical SCI research. Full article