411,842 Results Found

Background: The potentiator VX-770 (ivacaftor) has been approved as a monotherapy for over 95 cystic fibrosis (CF)-causing variants associated with gating/conductance defects of the CF transmembrane conductance regulator (CFTR) channel. However, desp...

This study was focused on the action of lantibiotic nisin on the phospholipid membranes. Nisin did not produce ion-permeable pores in the membranes composed of DOPC or DOPE. The introduction of DOPS into bilayer lipid composition led to a decrease in...

Many antibiotics are ineffective in killing Gram-negative bacteria due to the permeability barrier of the outer-membrane LPS. Infections caused by multi-drug-resistant Gram-negative pathogens require new antibiotics, which are often difficult to deve...

Legionella pneumophila (Lp) is a common etiological agent of bacterial pneumonia that causes Legionnaires’ disease (LD). The bacterial membrane-associated virulence factor macrophage infectivity potentiator (Mip) exhibits peptidyl-prolyl-cis/tr...

Oncolytic virotherapy, using viruses such as vesicular stomatitis virus (VSVΔ51) and Herpes Simplex Virus-1 (HSV-1) to selectively attack cancer cells, faces challenges such as cellular resistance mediated by the interferon (IFN) response. Dime...

The solution of a quantum periodic potential in solid state physics is relevant because one can understand how electrons behave in a corresponding crystal. In this paper, the analytical solution of the energy formulation for a one-dimensional periodi...

Despite over 90 years of study on the emissive probe, a plasma diagnostic tool used to measure plasma potential, its underlying physics has yet to be fully understood. In this study, we investigated the voltages along the hot filament wire and emitti...

The analytical generalization for N periodic potential wells coupled to a probe rectangular-like potential and a zero potential is extremely important in the study of one-dimensional periodic potentials in solid state physics, e.g., in the calculatio...

The theory of non cooperative games with potential function was introduced by Monderer and Shapley in 1996. Such games have interesting properties, among which is the existence of equilibria in pure strategies. The paper by Monderer and Shapley has i...

ABCB1/P-glycoprotein is an ATP binding cassette transporter that is involved in the clearance of xenobiotics, and it affects the disposition of many drugs in the body. Conformational flexibility of the protein within the membrane is an intrinsic part...

The formation of the substrate surface potential based on the Lennard-Jones two-particle potential is investigated in this paper. A simple atom’s square lattice on the substrate surface is considered. The periodic potential of the substrate ato...

Climate change is expected to affect the quality of soil and water, resulting in a significant impact on soil water balance in various regions around the world. Soil water potential plays a significant role in influencing evapotranspiration (ET), whi...

For nearly a century, screened Coulomb potentials have been of recognized importance in diverse areas of physics and chemistry. A key feature of interest in these potentials is the phenomenon of critical screening. This paper has three main purposes:...

Relativity theory assumes that force fields propagate with the speed of light. We show that such force fields generated by a single source can be described by a pre-potential, which is a complex-valued function on spacetime outside the worldline of t...

Bovine viral diarrhea virus (BVDV) is a pathogen associated with substantial economic losses in the dairy cattle industry. Currently, there are no effective vaccines against BVDV. Melatonin (MT) has been shown to have anti-inflammatory and anti-viral...

In the framework of this study, significant features of the formation of the strategic potential of the enterprise in a circular economy are identified. The characteristics and elements of the strategic potential of the enterprise, which can ensure i...

Exposure to atmospheric particulate matter (PM) has detrimental effects on health, but specific mechanisms of toxicity are still not fully understood. In recent years, there has been a growing evidence that oxidative stress is an important mechanism...

Machine learning potentials, particularly the deep potential (DP) model, have revolutionized molecular dynamics (MD) simulations, striking a balance between accuracy and computational efficiency. To facilitate the DP model’s integration with th...

With the rapid development of high-voltage DC (HVDC) power systems, accurate measurement of surface electrostatic potential on insulating components has become critical for electric field assessment and insulation reliability. This paper proposes an...

The paper investigates resource, technical, economic and market potential of solar energy and its ecology and economic efficiency in Azerbaijan. The authors have distinguished six regions in the territory of Azerbaijan with different levels of solar...

In this work, we investigate the Shannon entropy of four recently proposed hyperbolic potentials through studying position and momentum entropies. Our analysis reveals that the wave functions of the single-well potentials $U_{0,3}$ exhibit greater localiz...

Surface potential and surface charge sensing techniques have attracted a wide range of research interest in recent decades. With the development and optimization of detection technologies, especially nanosensors, new mechanisms and techniques are eme...

We investigate the planar Dirac equation with the most general time-independent contact (singular) potential supported on a circumference. Taking advantage of the radial symmetry, the problem is effectively reduced to a one-dimensional one (the radia...

In this paper, the effects of asymmetrically modulated charged surfaces on streaming potential, velocity field and flow rate are investigated under the axial pressure gradient and vertical magnetic field. In a parallel-plate microchannel, modulated c...

This paper presents a new simplified method for analyzing the availability of photovoltaic potential on roofs. Photovoltaic systems on roofs are widespread as they represent a sustainable and safe investment and, therefore, a means of energy self-suf...

Understanding neuronal firing patterns and long-term potentiation (LTP) induction in studying learning, memory, and neurological diseases is critical. However, recently, despite the rapid advancement in neuroscience, we are still constrained by the e...

Urban areas can be considered high-potential energy producers alongside their notable portion of energy consumption. Solar energy is the most promising sustainable energy in which urban environments can produce electricity by using rooftop-mounted ph...

We investigated the single-electron spectrum of an InAs/GaAs quantum dot (QD) using an effective potential model developed in previous studies. Our objective was to explore the limits of applicability of this model. We conducted numerical simulations...

Global recoverable shale gas reserves are estimated to be 214.5 × 10¹² m³. Estimation methods for shale gas resources, such as volumetric, analog, and genetic approaches, have been widely used in previous studies. However, these approaches have...

The present review discusses the solution of the Heun, confluent, biconfluent, double confluent, and triconfluent equations in terms of polynomial expansions, and applies the results to generate exactly solvable Schrödinger potentials. Although...

Corrosion investigations of steel-reinforced concrete structures are often based on half-cell potential measurements, in which the diffusion potentials can be a significant source of measurement errors. Therefore, the diffusion potentials must be tak...

The present review is addressed to researchers in the field of reading and psycholinguistics who are both familiar with and new to co-registration research of eye movements (EMs) and fixation related-potentials (FRPs) in reading. At the outset, we co...

The agricultural use of sewage sludge has become an economic disposal method used worldwide. However, heavy metals contained in sewage sludge have become the crucial limiting factors for this way of disposal. This study showed that regulatory limit v...

The zeta potential of soils is an electric potential in the double-layer interface and is a physical property exhibited by any particle related to electrochemical attractive forces. On the other hand, the chemical aging phenomenon is seen as the chie...

Wettability determination is of crucial importance for multiphase flow in porous media. Currently available methods are either applied to simplified geometries (sessile drop) or are time-consuming (Amott, USBM) and cost-intensive (micro-CT scanning)....

The dependency of the Nernst potential in an operating proton exchange membrane fuel cell (PEMFC) on the temperature, inlet pressure and relative humidity (RH) is examined, highlighting the synergistic dependence of measured open circuit potential (O...

Background: This study aimed to determine the prevalence of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) and their association with ADR-related hospital admissions in patients aged ≥ 65 years admitted acut...

A transformation method was applied to the biconfluent (BHE), doubly confluent (DHE), and triconfluent (THE) Heun equations to generate and classify exactly solvable quantum mechanical potentials derived from them. With this, the range of potentials...

Bushfire management which incorporates fire potential indices is still in its infancy in Jamaica and the Caribbean. In this study three bushfire potential indices—Keetch–Byram Drought Index (KBDI), Vapour Pressure Deficit (VPD) and Water...

Membrane potential is a fundamental property of biological cells. Changes in membrane potential characterize a vast number of vital biological processes, such as the activity of neurons and cardiomyocytes, tumorogenesis, cell-cycle progression, etc....

Evoked potentials (EPs), including somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs), are used to assess neural conduction in spinal cord injury (SCI) and multiple sclerosis (MS), conditions marked by demyelination, inflammat...

In recent decades, efficiency and intensification have emerged as hot topics within urban industrial land use (UILU) studies in China. However, the measurement and analysis of UILU efficiency and intensification are not accurate and in-depth enough....

Introduction: The aim of this study is a comprehensive analysis of the parameters of exogenous evoked potentials (visual, brainstem auditory, and somatosensory) in patients with myasthenia gravis (MG), a prototype of both neuromuscular junction disea...

The R334W (c.1000C>T, p.Arg334Trp) is a rare cystic fibrosis (CF)-causing mutation for which no causal therapy is currently approved. This mutation leads to a significant reduction of CF transmembrane conductance regulator (CFTR) channel conductan...

The interest in renewable energy to replace fossil fuel is increasing as the problem caused by climate change has become more severe. In this study, small hydropower (SHP) was evaluated as a resource with high development value because of its high en...

The mechanical properties of calcite suspension are predominantly affected by different ions dissolved in solution. In this work, natural and synthetic calcites were employed to investigate the influence of potential-determining ions (PDIs) (Ca²⁺, Mg...

Territorial ecological restoration (TER) is a critical step for promoting the development of an ecological civilization, as well as a significant strategic task relating to national ecological security and the well-being of a population. However, cal...

Intestinal bacteria are crucial for the healthy aquaculture of Litopenaeus vannamei, and the coastal areas of China are important areas for concentrated L. vannamei cultivation. In this study, we evaluated different compositions and structures, key r...

The purpose of this research was to assess the development potential of cities and municipalities in Wałbrzych County, approached from the perspective of social, economic and environmental potential. Comparisons were performed for the periods 2002–20...

At present, the study of the oil and gas potential of poorly explored areas of oil and gas basins in the Russian Federation is of great importance due to the possibility of discovering large hydrocarbon accumulations in them. The Vychegda Trough in t...