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16 pages, 3228 KiB  
Article
Wettability of Two-Dimensional Carbon Allotropes from Molecular Simulations
by Margaret E. Thornton, Serban G. Zamfir and Dusan Bratko
Molecules 2025, 30(15), 3296; https://doi.org/10.3390/molecules30153296 - 6 Aug 2025
Abstract
Force-field Monte Carlo and Molecular Dynamics simulations are used to compare wetting behaviors of model carbon sheets mimicking neat graphene, its saturated derivative, graphane, and related planar allotropes penta-graphene, γ-graphyne, and ψ-graphene in contact with aqueous droplets or an aqueous film [...] Read more.
Force-field Monte Carlo and Molecular Dynamics simulations are used to compare wetting behaviors of model carbon sheets mimicking neat graphene, its saturated derivative, graphane, and related planar allotropes penta-graphene, γ-graphyne, and ψ-graphene in contact with aqueous droplets or an aqueous film confined between parallel carbon sheets. Atomistic and area-integrated surface/water potentials are found to be essentially equivalent in capturing moderate differences between the wetting free energies of tested substrates. Despite notable differences in mechanical and electric properties of distinct allotropes, the predicted allotrope/water contact angles span a narrow window of weakly hydrophilic values. Contact angles in the range of 80 ± 10° indicate modest hydration repulsion incapable of competing with van der Waals attraction between carbon particles. Poor dispersibility in neat water is hence a common feature of studied materials. Full article
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13 pages, 2698 KiB  
Article
Study of the Stress–Strain State of the Structure of the GP-50 Support Bushing Manufactured by 3D Printing from PLA Plastic
by Almat Sagitov, Karibek Sherov, Didar Berdimuratova, Ainur Turusbekova, Saule Mendaliyeva, Dinara Kossatbekova, Medgat Mussayev, Balgali Myrzakhmet and Sabit Magavin
J. Compos. Sci. 2025, 9(8), 408; https://doi.org/10.3390/jcs9080408 - 1 Aug 2025
Viewed by 217
Abstract
This article analyzes statistics on the failure of technological equipment, assemblies, and mechanisms of agricultural (and other) machines associated with the breakdown or failure of gear pumps. It was found that the leading causes of gear pump failures are the opening of gear [...] Read more.
This article analyzes statistics on the failure of technological equipment, assemblies, and mechanisms of agricultural (and other) machines associated with the breakdown or failure of gear pumps. It was found that the leading causes of gear pump failures are the opening of gear teeth contact during pump operation, poor assembly, wear of bushings, thrust washers, and gear teeth. It has also been found that there is a problem related to the restoration, repair, and manufacture of parts in the conditions of enterprises serving the agro-industrial complex of the Republic of Kazakhstan (AIC RK). This is due to the lack of necessary technological equipment, tools, and instruments, as well as centralized repair and restoration bases equipped with the required equipment. This work proposes to solve this problem by applying AM technologies to the repair and manufacture of parts for agricultural machinery and equipment. The study results on the stress–strain state of support bushings under various pressures are presented, showing that a fully filled bushing has the lowest stresses and strains. It was also found that bushings with 50% filling and fully filled bushings have similar stress and strain values under the same pressure. The difference between them is insignificant, especially when compared to bushings with lower filling. This means that filling the bushing by more than 50% does not provide a significant additional reduction in stresses. In terms of material and printing time savings, 50% filling may also be the optimal option. Full article
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39 pages, 8119 KiB  
Article
Magmatic Redox Evolution and Porphyry–Skarn Transition in Multiphase Cu-Mo-W-Au Systems of the Eocene Tavşanlı Belt, NW Türkiye
by Hüseyin Kocatürk, Mustafa Kumral, Hüseyin Sendir, Mustafa Kaya, Robert A. Creaser and Amr Abdelnasser
Minerals 2025, 15(8), 792; https://doi.org/10.3390/min15080792 - 28 Jul 2025
Viewed by 324
Abstract
This study explores the magmatic and hydrothermal evolution of porphyry–skarn–transitional Cu-Mo-W-Au systems within the Nilüfer Mineralization Complex (NMC), located in the westernmost segment of the Eocene Tavşanlı Metallogenic Belt, NW Türkiye. Through integration of field data, whole-rock geochemistry, Re–Os molybdenite dating, and amphibole–biotite [...] Read more.
This study explores the magmatic and hydrothermal evolution of porphyry–skarn–transitional Cu-Mo-W-Au systems within the Nilüfer Mineralization Complex (NMC), located in the westernmost segment of the Eocene Tavşanlı Metallogenic Belt, NW Türkiye. Through integration of field data, whole-rock geochemistry, Re–Os molybdenite dating, and amphibole–biotite mineral chemistry, the petrogenetic controls on mineralization across four spatially associated mineralized regions (Kirazgedik, Güneybudaklar, Kozbudaklar, and Delice) were examined. The earliest and thermally most distinct phase is represented by the Kirazgedik porphyry system, characterized by high temperature (~930 °C), oxidized quartz monzodioritic intrusions emplaced at ~2.7 kbar. Rising fO2 and volatile enrichment during magma ascent facilitated structurally focused Cu-Mo mineralization. At Güneybudaklar, Re–Os geochronology yields an age of ~49.9 Ma, linking Mo- and W-rich mineralization to a transitional porphyry–skarn environment developed under moderately oxidized (ΔFMQ + 1.8 to +0.5) and hydrous (up to 7 wt.% H2O) magmatic conditions. Kozbudaklar represents a more reduced, volatile-poor skarn system, leading to Mo-enriched scheelite mineralization typical of late-stage W-skarns. The Delice system, developed at the contact of felsic cupolas and carbonates, records the broadest range of redox and fluid compositions. Mixed oxidized–reduced fluid signatures and intense fluid–rock interaction reflect complex, multistage fluid evolution involving both magmatic and external inputs. Geochemical and mineralogical trends—from increasing silica and Rb to decreasing Sr and V—trace a systematic evolution from mantle-derived to felsic, volatile-rich magmas. Structurally, mineralization is controlled by oblique fault zones that localize magma emplacement and hydrothermal flow. These findings support a unified genetic model in which porphyry and skarn mineralization styles evolved continuously from multiphase magmatic systems during syn-to-post-subduction processes, offering implications for exploration models in the Western Tethyan domain. Full article
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11 pages, 1292 KiB  
Article
Flotation Behaviours of Ilmenite and Associated Solution Chemistry Properties Using Saturated Fatty Acids as the Collector
by Jihua Zhai, Hao He, Pan Chen, Lin Song, Xiaohai Yao and Hongxian Zhang
Separations 2025, 12(8), 191; https://doi.org/10.3390/separations12080191 - 24 Jul 2025
Viewed by 172
Abstract
A series of homologous saturated fatty acids were introduced and evaluated as collectors for ilmenite flotation using a combination of micro-flotation tests and surface tension measurements. The results showed that ilmenite exhibited good flotation behaviour when decanoic and dodecanoic acids were used as [...] Read more.
A series of homologous saturated fatty acids were introduced and evaluated as collectors for ilmenite flotation using a combination of micro-flotation tests and surface tension measurements. The results showed that ilmenite exhibited good flotation behaviour when decanoic and dodecanoic acids were used as collectors; however, saturated fatty acids with shorter or longer carbon chains were not suitable for ilmenite flotation (caused either by poor collection ability or limited solubility in water). The optimum flotation pH range was also dependent on the carbon chain length of saturated fatty acids, and the solution surface tension did not always match well with the ilmenite flotation behaviour when using a series of saturated fatty acids as the collector. The associated solution chemistry properties under series saturated fatty acid flotation systems were discussed, and the adsorption mechanism of decanoic acid onto the ilmenite surface was also investigated via FTIR, zeta potential, and contact angle measurements. Full article
(This article belongs to the Section Separation Engineering)
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17 pages, 3023 KiB  
Article
Slip-Resistance Performance of Basketball Shoes Tread Patterns on Common Courts
by Pramod Yadav, Shubham Gupta, Dishant Sharma and Arnab Chanda
Appl. Mech. 2025, 6(3), 54; https://doi.org/10.3390/applmech6030054 - 24 Jul 2025
Viewed by 400
Abstract
Basketball requires intense movements like jumping and sudden changes in direction, increasing the risk of slips and falls due to poor shoe–court traction. Therefore, a significant demand is for good traction performance in basketball shoes, particularly in the heel region on different court [...] Read more.
Basketball requires intense movements like jumping and sudden changes in direction, increasing the risk of slips and falls due to poor shoe–court traction. Therefore, a significant demand is for good traction performance in basketball shoes, particularly in the heel region on different court surfaces, to prevent slipping. This study examined the traction performance of fifteen common basketball shoe designs that were considered and developed using thermoplastic polyurethane to assess the available coefficient of friction (ACOF) on popular floorings (hardwood, synthetic, and polyurethane) under dry and wet conditions using a robotic slip tester. Results indicate that the hardwood flooring provided better traction, followed by the synthetic flooring, while the polyurethane flooring showed reduced friction. The study also examined the traction with apparent contact areas. Shoes with herringbone and circular tread patterns demonstrated the highest traction on all flooring in dry conditions. This research is anticipated to help basketball shoemakers choose safer shoes for player safety and performance, providing a foundation for future research on shoe flooring interaction in basketball. Full article
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18 pages, 3346 KiB  
Article
Influence of Membrane Salt Rejection Properties on Cake-Enhanced Concentration Polarization Effects During Colloidal Fouling of Nanofiltration Membranes
by Oranso Themba Mahlangu and Bhekie Brilliance Mamba
Membranes 2025, 15(7), 215; https://doi.org/10.3390/membranes15070215 - 19 Jul 2025
Viewed by 450
Abstract
The build-up of a fouling layer on the membrane surface is believed to deteriorate flux and salt rejection by hindering back-diffusion of rejected salts, a phenomenon called cake-enhanced concentration polarization (CECP). Nevertheless, CECP effects have not been linked to the salt rejection properties [...] Read more.
The build-up of a fouling layer on the membrane surface is believed to deteriorate flux and salt rejection by hindering back-diffusion of rejected salts, a phenomenon called cake-enhanced concentration polarization (CECP). Nevertheless, CECP effects have not been linked to the salt rejection properties of the membrane. Furthermore, the decline in salt rejection during fouling has not been related to the decreasing flux, to elucidate the effects of flux on solution rejection as described by the solution-diffusion (SD) model. Therefore, this work examined whether CECP is substantial in membranes with poor salt-rejection properties. Fouling was performed using sodium alginate, Al2O3, latex, and SiO2. The effects of fouling on salt rejection were studied using two nanofiltration (NF) membranes, namely NF270 membrane (46% NaCl rejection) and NF90 membrane (>97% NaCl rejection). The measured flux and salt rejection profiles were compared to those predicted by the CECP and SD models. Overall, the flux declined more (30–60%) for the NF90 membrane (contact angle: 50 ± 3°) compared to the NF270 membrane (10–55%, contact angle: 39 ± 2°) under similar hydrodynamic conditions. Moreover, fouling had more effects on NaCl rejection for the NF90 membrane (2–45% decline) compared to the NF270 membrane (10–30% decline). The decrease in NaCl rejection for the NF90 membrane was ascribed to CECP effects and declining flux. Contrary, CECP effects were less important for the NF270 membrane, and rejection declined due to reduction in flux as predicted by the SD model, indicating that CECP may not be predominant in membranes that poorly reject salts. Full article
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27 pages, 2729 KiB  
Review
Polymer Composite-Based Triboelectric Nanogenerators: Recent Progress, Design Principles, and Future Perspectives
by Geon-Ju Choi, Sang-Hyun Sohn, Se-Jin Kim and Il-Kyu Park
Polymers 2025, 17(14), 1962; https://doi.org/10.3390/polym17141962 - 17 Jul 2025
Viewed by 456
Abstract
The escalating consumption of fossil fuels and the rapid development of portable electronics have increased interest in alternative energy solutions that can sustainably self-power wearable devices. Triboelectric nanogenerators (TENGs), which convert mechanical energy into electricity through contact electrification and electrostatic induction, have emerged [...] Read more.
The escalating consumption of fossil fuels and the rapid development of portable electronics have increased interest in alternative energy solutions that can sustainably self-power wearable devices. Triboelectric nanogenerators (TENGs), which convert mechanical energy into electricity through contact electrification and electrostatic induction, have emerged as a promising technology due to their high voltage output, lightweight design, and simple fabrication. However, the performance of TENGs is often limited by a low surface charge density, inadequate dielectric properties, and poor charge retention of triboelectric materials. To address these challenges, recent research has focused on the use of polymer composites that incorporate various functional fillers. The filler materials play roles in improving dielectric performance and enhancing mechanical durability, thereby boosting triboelectric output even in harsh environments, while also diminishing charge loss. This review comprehensively examines the role of polymer composite design in TENG performance, with particular emphasis on materials categorized by their triboelectric polarity. Tribo-negative polymers, such as PDMS and PVDF, benefit from filler incorporation and phase engineering to enhance surface charge density and charge retention. By contrast, tribo-positive materials like nylon and cellulose have demonstrated notable improvements in mechanical robustness and environmental stability through composite strategies. The interplay between material selection, surface engineering, and filler design is highlighted as a critical path toward developing high-performance, self-powered TENG systems. Finally, this review discusses the current challenges and future opportunities for advancing TENG technology toward practical and scalable applications. Full article
(This article belongs to the Special Issue Advances in Polymer Composites for Nanogenerator Applications)
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26 pages, 2715 KiB  
Systematic Review
Hepatitis E Virus (HEV) Infection in the Context of the One Health Approach: A Systematic Review
by Sophie Deli Tene, Abou Abdallah Malick Diouara, Sarbanding Sané and Seynabou Coundoul
Pathogens 2025, 14(7), 704; https://doi.org/10.3390/pathogens14070704 - 16 Jul 2025
Viewed by 437
Abstract
Hepatitis E virus (HEV) is a pathogen that has caused various epidemics and sporadic localized cases. It is considered to be a public health problem worldwide. HEV is a small RNA virus with a significant genetic diversity, a broad host range, and a [...] Read more.
Hepatitis E virus (HEV) is a pathogen that has caused various epidemics and sporadic localized cases. It is considered to be a public health problem worldwide. HEV is a small RNA virus with a significant genetic diversity, a broad host range, and a heterogeneous geographical distribution. HEV is mainly transmitted via the faecal–oral route. However, some animals are considered to be natural or potential reservoirs of HEV, thus elucidating the zoonotic route of transmission via the environment through contact with these animals or consumption of their by-products. Other routes of human-to-human transmission are not negligible. The various human–animal–environment entities, taken under one health approach, show the circulation and involvement of the different species (mainly Paslahepevirus balayani and Rocahepevirus ratti) and genotypes in the spreading of HEV infection. Regarding P. balayani, eight genotypes have been described, of which five genotypes (HEV-1 to 4 and HEV-7) are known to infect humans, while six have been reported to infect animals (HEV-3 to HEV-8). Furthermore, the C1 genotype of the rat HEV strain (HEV-C1) is known to be more frequently involved in human infections than the HEV-C2 genotype, which is known to infect mainly ferrets and minks. Contamination can occur during run-off, flooding, and poor sanitation, resulting in all of these genotypes being disseminated in the environment, contaminating both humans and animals. This systematic review followed the PRISMA guidelines and was registered in PROSPERO 2025 CRD420251071192. This research highlights the importance of investigating the transmission routes and major circulating HEV genotypes in order to adopt a holistic approach for controlling its emergence and preventing future outbreaks. In addition, this article outlines the knowledge of HEV in Africa, underlining the absence of large-scale studies at the environmental, human, and animal levels, which could improve HEV surveillance on the continent. Full article
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17 pages, 14423 KiB  
Article
The Influence of the Dispersion and Covalent Functionalization of CNTs on Electrical Conduction Under an Electric Field in LDPE/CNT Composites
by Xiaoli Wu, Ting Yin, Yi Yang, Wenyan Liu, Danping Wang, Libo Wan and Yijun Liao
Polymers 2025, 17(14), 1940; https://doi.org/10.3390/polym17141940 - 15 Jul 2025
Viewed by 344
Abstract
In this study, we comprehensively compare electrical conduction behavior under an applied electric field and electrical conductivity variation with temperature in low-density polyethylene (LDPE)/CNT composites with different dispersions and covalent functionalizations. Composites with different dispersions were prepared using solution and melt mixing processes. [...] Read more.
In this study, we comprehensively compare electrical conduction behavior under an applied electric field and electrical conductivity variation with temperature in low-density polyethylene (LDPE)/CNT composites with different dispersions and covalent functionalizations. Composites with different dispersions were prepared using solution and melt mixing processes. The solution-mixed composites exhibited better dispersion and higher electrical conductivity compared to the melt-mixed composites. At a high critical content (beyond the percolation threshold), the current–voltage (I–V) curve of the solution-mixed composites exhibited linear conduction behavior due to the formation of a continuous conductive network. In contrast, the melt-mixed composites exhibited nonlinear conduction behavior, with the conductive mechanism attributed to the field emission effect caused by poor interfacial contact between the CNTs. Additionally, LDPE/CNT-carboxyl (LDPE/CNT-COOH) and LDPE/CNT-hydroxy (LDPE/CNT-OH) composites demonstrated better dispersion but displayed lower electrical conductivity and similar nonlinear conduction behavior when compared to unmodified ones. This is attributed to the surface defects caused by the modification process, which lead to an increased energy barrier and a decreased transition frequency in the field emission effect. Furthermore, the temperature-dependent electrical conductivity results indicate that the variation trend in current with temperature differed among LDPE/CNT composites with different dispersions and covalent functionalizations. These differences were mainly influenced by the gap width between CNTs (mainly affected by dispersion and aspect ratio of CNTs), as well as the electrical conductivity of CNTs (mainly influenced by surface modification and intrinsic electrical conductivity of CNTs). Full article
(This article belongs to the Special Issue Application and Characterization of Polymer Composites)
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16 pages, 3138 KiB  
Article
Analysis of Vibration Characteristics of Angular Contact Ball Bearings in Aviation Engines Under Changing Conditions
by Yanfang Dong, Zibo Yan, Jianyong Sun, Wei Yu, Hai Zhang, Wenbo Zhou and Jihao Jin
Aerospace 2025, 12(7), 623; https://doi.org/10.3390/aerospace12070623 - 11 Jul 2025
Viewed by 308
Abstract
This paper addresses the vibration characteristics of angular contact ball bearings in aircraft engines under variable load conditions. Based on multibody dynamics theory, a dynamic model of the bearing was established. Vibration data under actual operating conditions were obtained using an experimental test [...] Read more.
This paper addresses the vibration characteristics of angular contact ball bearings in aircraft engines under variable load conditions. Based on multibody dynamics theory, a dynamic model of the bearing was established. Vibration data under actual operating conditions were obtained using an experimental test platform. This study systematically investigated the influence of rotational speed, axial load, and radial load on the vibration acceleration level of the bearing outer ring. Through a comparison of simulation and experimental data (with an error rate below 10%), the reliability of the model was validated. The results indicate that the bearing vibration acceleration level exhibits a nonlinear increasing relationship with rotational speed. An increase in radial load significantly amplifies the amplitude of acceleration-level fluctuations, while appropriately increasing axial load can reduce bearing vibration intensity. Under variable load coupling conditions, the dynamic interaction between axial and radial forces results in complex nonlinear vibration responses, with a 2 s acceleration time achieving the optimal balance between vibration suppression and efficiency (steady-state average of 70.4 dB). Additionally, the morphological characteristics of the cage center-of-gravity trajectory (such as trajectory disorder and poor smoothness) are closely related to vibration characteristics, revealing the critical role of dynamic load changes in bearing stability. The research results provide a theoretical basis for optimizing the operating conditions, vibration control, and reliability design of aircraft engine bearings. Full article
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13 pages, 2559 KiB  
Article
Effects of Sand–Cement Columns on Primary Consolidation Settlement
by Benjamin Abankwa, Mehrdad Razavi, Richard Otoo, Abraham Armah and Sandra Donkor
Appl. Sci. 2025, 15(14), 7690; https://doi.org/10.3390/app15147690 - 9 Jul 2025
Viewed by 218
Abstract
The rapid increase in population and the corresponding increase in developments have necessitated the stabilization of areas with poor soil conditions. Due to consolidation settlement, the soft grounds available are deemed unsuitable for such structures. This paper presents the use of cement additives [...] Read more.
The rapid increase in population and the corresponding increase in developments have necessitated the stabilization of areas with poor soil conditions. Due to consolidation settlement, the soft grounds available are deemed unsuitable for such structures. This paper presents the use of cement additives to build sand–cement columns in saturated clayey soils. The approach significantly reduces consolidation settlement and increases the bearing capacity, providing a viable solution to foundation problems. Consolidation tests were conducted on saturated clay specimens and sand–cement columns arranged in various patterns. A 5% cement content by the dry weight of the sand was used in building sand–cement columns. The results showed that the consolidation settlement rate was high due to the extra drainage formed by the widened pores in the sand–cement columns. The extra drainage caused more water to leave the specimen in a given time. However, after full contact between the loading platen and sand–cement columns, the rate of consolidation settlement decreased. At this stage, sand–cement participated in carrying the load. Additionally, the effect of vertical drainage on speeding up consolidation at higher stress levels was minimal, as the widened pores in the sand–cement columns began to close. Full article
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16 pages, 1236 KiB  
Communication
Chemoradiation-Altered Micromilieu of Glioblastoma Cells Particularly Impacts M1-like Macrophage Activation
by Mona Shojaei, Benjamin Frey, Florian Putz, Rainer Fietkau, Udo S. Gaipl and Anja Derer
Int. J. Mol. Sci. 2025, 26(14), 6574; https://doi.org/10.3390/ijms26146574 - 8 Jul 2025
Viewed by 448
Abstract
Glioblastoma is a highly aggressive brain tumor with an overall poor prognosis due to its immunosuppressive tumor microenvironment (TME). Microglia and tumor-associated macrophages (TAMs) with pro-tumorigenic properties are dominant populations of immune cells in the glioblastoma TME. To date, several studies targeting TAMs [...] Read more.
Glioblastoma is a highly aggressive brain tumor with an overall poor prognosis due to its immunosuppressive tumor microenvironment (TME). Microglia and tumor-associated macrophages (TAMs) with pro-tumorigenic properties are dominant populations of immune cells in the glioblastoma TME. To date, several studies targeting TAMs to fight tumor progression in different tumor entities have been initiated. However, the impact of standard therapy schemes of glioblastoma cells on macrophage polarization, activation, and phagocytosis remains controversial. The same applies to the relevance of PD-1/PD-L1 blockade in the interaction between macrophages and tumor cells. Our study, therefore, investigated patient-oriented treatment of GLIOBLASTOMA by examining the phagocytic capacity of polarized M1- and M2-like macrophages using GL261-luc2 tumor cells as a preclinical model system. Additionally, we analyzed the expression of activation and immune checkpoint markers on these macrophage subtypes following contact with tumor cells and their microenvironment. These factors were also determined after PD-1 blockade was initiated. The analyses revealed that the immunoregulatory M2-like macrophages generally exhibited a higher phagocytosis rate than the pro-inflammatory M1-like macrophages; however, this was not influenced by the pretreatment of glioblastoma cells with chemo- or radiotherapy. This could not be improved by blocking the PD-1 receptor. Furthermore, there were no modulations in the expression of differentiation, activation, or immune checkpoint molecules of M1- and M2-like macrophages after cell-to-cell contact with glioblastoma cells. But the medium conditioned by tumor cells strongly altered M1-like macrophages toward a more activated state, whereas M2-like cells were only mildly influenced. This was further enhanced by tumor cell treatment, with the most prominent effect after irradiation. These results suggest that conventional GLIOBLASTOMA tumor cell treatment affects the immunogenic status of macrophage subtypes, which is relevant for enhancing the anti-tumor immune response in brain tumors. Full article
(This article belongs to the Special Issue The Role of Macrophages in Cancers)
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18 pages, 1034 KiB  
Article
Preparation and Characterization of Efficient and Safe Rotenone Solid Nanodispersion by Self-Emulsifying Technique
by Yunfei Zhang, Xuesheng Lin, Yunlong Qian, Mingda Qin, Shujing Zhang, Lanying Wang and Yanping Luo
Nanomaterials 2025, 15(14), 1056; https://doi.org/10.3390/nano15141056 - 8 Jul 2025
Viewed by 378
Abstract
Self-emulsifying solid nanodispersion technology is emerging as an attractive strategy to prepare new eco-friendly and efficient nano-formulations due to its simple, energy efficient and easy scale-up process. However, it is still unknown whether this technology can be employed to cope with the drawbacks [...] Read more.
Self-emulsifying solid nanodispersion technology is emerging as an attractive strategy to prepare new eco-friendly and efficient nano-formulations due to its simple, energy efficient and easy scale-up process. However, it is still unknown whether this technology can be employed to cope with the drawbacks of botanical insecticides including poor water solubility, rapid photodegradation and limited targeting efficiency. In this study, rotenone (Rot) was selected as a model of botanical insecticides, and its solid nanodispersion (Rot–SND) was prepared by a self-emulsifying method combined with parameter optimization. Our target nano-formulation, consisting of 5% Rot, 20% surfactant complexes of 8% Ethylan 992 and 12% EL–80, and 75% lactose, exhibited excellent storage stability and significantly improved the pseudo-solubility of Rot by at least 250 times. The average particle size and polydispersity index (PDI) of Rot–SND were determined to be 101.19 nm and 0.21, respectively. Rot–SND displayed smaller contact angles and greater retention on both cucumber and cabbage leaves than those of a commercial emulsifiable concentrates (ECs). Rot–SND was also more resistant to photodegradation, with a degradation rate reduced by 27.01% as compared with the ECs. In addition, the toxicity of Rot–SND towards Aphis gossypii was 3.01 times that of the ECs, with a median lethal concentration (LC50) of 1.45 µg a.i./mL. Under the field conditions, Rot–SND showed a prolonged duration for A. gossypii control, with a significantly higher control efficacy (88.10%) on the 10th day than that of the ECs (77.02%). Moreover, a 2.34-fold decline in the toxicity towards nontarget mosquito larvae was observed for Rot–SND as compared with the EC. Overall, for the first time, our results indicate the role of Rot–SND as an eco-friendly and efficient way to improve the solubility, foliar affinity, photostability, bioactivity and eco-safety of Rot. This research also provided a feasible strategy to prepare more eco-friendly botanical pesticide formulations of high efficiency. Full article
(This article belongs to the Section Environmental Nanoscience and Nanotechnology)
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20 pages, 3465 KiB  
Article
Phase-Controlled Closing Strategy for UHV Circuit Breakers with Arc-Chamber Insulation Deterioration Consideration
by Hao Li, Qi Long, Xu Yang, Xiang Ju, Haitao Li, Zhongming Liu, Dehua Xiong, Xiongying Duan and Minfu Liao
Energies 2025, 18(13), 3558; https://doi.org/10.3390/en18133558 - 5 Jul 2025
Viewed by 423
Abstract
To address the impact of insulation medium degradation in the arc quenching chambers of ultra-high-voltage SF6 circuit breakers on phase-controlled switching accuracy caused by multiple operations throughout the service life, this paper proposes an adaptive switching algorithm. First, a modified formula for [...] Read more.
To address the impact of insulation medium degradation in the arc quenching chambers of ultra-high-voltage SF6 circuit breakers on phase-controlled switching accuracy caused by multiple operations throughout the service life, this paper proposes an adaptive switching algorithm. First, a modified formula for the breakdown voltage of mixed gases is derived based on the synergistic effect. Considering the influence of contact gap on electric field distortion, an adaptive switching strategy is designed to quantify the dynamic relationship among operation times, insulation strength degradation, and electric field distortion. Then, multi-round switching-on and switching-off tests are carried out under the condition of fixed single-arc ablation amount, and the laws of voltage–current, gas decomposition products, and pre-breakdown time are obtained. The test data are processed by the least squares method, adaptive switching algorithm, and machine learning method. The results show that the coincidence degree of the pre-breakdown time obtained by the adaptive switching algorithm and the test value reaches 90%. Compared with the least squares fitting, this algorithm achieves a reasonable balance between goodness of fit and complexity, with prediction deviations tending to be randomly distributed, no obvious systematic offset, and low dispersion degree. It can also explain the physical mechanism of the decay of insulation degradation rate with the number of operations. Compared with the machine learning method, this algorithm has stronger generalization ability, effectively overcoming the defects of difficult interpretation of physical causes and the poor engineering adaptability of the black box model. Full article
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21 pages, 750 KiB  
Review
Targeting Ocular Biofilms with Plant-Derived Antimicrobials in the Era of Antibiotic Resistance
by Monika Dzięgielewska, Michał Tomczyk, Adrian Wiater, Aleksandra Woytoń and Adam Junka
Molecules 2025, 30(13), 2863; https://doi.org/10.3390/molecules30132863 - 5 Jul 2025
Cited by 1 | Viewed by 685
Abstract
Microbial biofilms present a formidable challenge in ophthalmology. Their intrinsic resistance to antibiotics and evasion of host immune defenses significantly complicate treatments for ocular infections such as conjunctivitis, keratitis, blepharitis, and endophthalmitis. These infections are often caused by pathogens, including Staphylococcus aureus, [...] Read more.
Microbial biofilms present a formidable challenge in ophthalmology. Their intrinsic resistance to antibiotics and evasion of host immune defenses significantly complicate treatments for ocular infections such as conjunctivitis, keratitis, blepharitis, and endophthalmitis. These infections are often caused by pathogens, including Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans, particularly in patients using contact lenses or intraocular implants—devices that serve as surfaces for biofilm formation. The global rise in antimicrobial resistance has intensified the search for alternative treatment modalities. In this regard, plant-derived antimicrobials have emerged as promising candidates demonstrating broad-spectrum antimicrobial and antibiofilm activity through different mechanisms from those of conventional antibiotics. These mechanisms include inhibiting quorum sensing, disrupting established biofilm matrices, and interfering with microbial adhesion and communication. However, the clinical translation of phytochemicals faces significant barriers, including variability in chemical composition due to environmental and genetic factors, difficulties in standardization and reproducibility, poor water solubility and ocular bioavailability, and a lack of robust clinical trials evaluating their efficacy and safety in ophthalmic settings. Furthermore, regulatory uncertainties and the absence of unified guidelines for approving plant-derived formulations further hinder their integration into evidence-based ophthalmic practice. This review synthesizes the current knowledge on the pathogenesis and treatment of biofilm-associated ocular infections, critically evaluating plant-based antimicrobials as emerging therapeutic agents. Notably, resveratrol, curcumin, abietic acid, and selected essential oils demonstrated notable antibiofilm activity against S. aureus, P. aeruginosa, and C. albicans. These findings support the potential of phytochemicals as adjunctive or alternative agents in managing biofilm-associated ocular infections. By highlighting both their therapeutic promise and translational limitations, this review contributes to the ongoing discourse on sustainable, innovative approaches to managing antibiotic-resistant ocular infections. Full article
(This article belongs to the Special Issue Research Progress of New Antimicrobial Drugs)
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