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Search Results (3,051)

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18 pages, 695 KB  
Article
Emergency Management in Coal Mining: Developing a Capability-Based Model in Indonesia
by Ajeng Puspitaning Pramayu, Fatma Lestari, Dadan Erwandi and Besral Besral
Safety 2025, 11(4), 96; https://doi.org/10.3390/safety11040096 (registering DOI) - 4 Oct 2025
Abstract
The coal mining sector in Indonesia faces a high level of risk of disasters; however, to date, there is no specific evaluation framework to measure Emergency Management Capability. This research aims to develop a conceptual model of EMC that applies to the context [...] Read more.
The coal mining sector in Indonesia faces a high level of risk of disasters; however, to date, there is no specific evaluation framework to measure Emergency Management Capability. This research aims to develop a conceptual model of EMC that applies to the context of the coal mining industry. Using an exploratory qualitative approach, this study employed regulatory analysis and in-depth interviews, which were then thematically analyzed using the NVivo application. The results identified four challenges to EMC implementation, namely the absence of a minimum index standard for assessment, policy and implementation gaps, illegal mining activities, and risk dynamics. In response to these challenges, three strategic approaches were proposed: utilizing the InaRISK platform, adapting the IKD model, and developing standardized EMC instruments. Furthermore, this research formulates seven main components in the mining sector EMC framework, namely (1) risk and threat identification, (2) physical capacity, (3) human resource capacity, (4) prevention, (5) emergency response capability, (6) evaluation and improvement, and (7) recovery and restoration. This framework is expected to serve as a reference for evaluating the preparedness of mining organizations in a systematic, adaptive, and integrated manner within the national safety management system. Full article
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22 pages, 8701 KB  
Article
A Web-GIS Platform for Real-Time Scenario-Based Seismic Risk Assessment at National Level
by Agostino Goretti, Marta Faravelli, Chiara Casarotti, Barbara Borzi and Davide Quaroni
Geosciences 2025, 15(10), 385; https://doi.org/10.3390/geosciences15100385 - 3 Oct 2025
Abstract
The paper presents the main features of a Web-GIS platform designed to compute real-time scenario-based seismic risk assessments at the national level. Based on the Italian experience, the platform enables DRM scientist and policymakers to readily generate seismic scenarios supporting the entire DRM [...] Read more.
The paper presents the main features of a Web-GIS platform designed to compute real-time scenario-based seismic risk assessments at the national level. Based on the Italian experience, the platform enables DRM scientist and policymakers to readily generate seismic scenarios supporting the entire DRM cycle, including training, emergency planning, calibrating operations during response, and providing seismic risk estimates for National Disaster Risk Assessment or seismic risk reduction programs. The platform is immediately operational, relying on preloaded freeware datasets on exposure and vulnerability, and requiring only basic earthquake parameters to perform real-time analysis. At a later stage, these datasets should be replaced with more detailed and accurate national-level data. The platform generates earthquake impact assessments that include physical damage, economic and human losses, and key emergency response indicators, such as estimated displaced population, required tent camps, and EMT and USAR needs. Its key innovation lies in the ability to operate at the national scale, offering immediate usability with the possibility of further customization. As a web-based service with a user-friendly graphical interface, it is particularly suited for civil protection and DRM experts. Full article
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24 pages, 4192 KB  
Article
Investigation on Dynamic Thermal Transfer Characteristics of Electromagnetic Rail Spray Cooling in Transient Processes
by Shuo Ma and Hongting Ma
Energies 2025, 18(19), 5254; https://doi.org/10.3390/en18195254 - 3 Oct 2025
Abstract
Electromagnetic Railguns Face Severe Ablation and Melting Risks Due to Extremely High Transient Thermal Loads During High-Speed Launching, Directly Impacting Launch Reliability and Service Life. To address this thermal management challenge, this study proposes and validates the effectiveness of spray cooling technology. Leveraging [...] Read more.
Electromagnetic Railguns Face Severe Ablation and Melting Risks Due to Extremely High Transient Thermal Loads During High-Speed Launching, Directly Impacting Launch Reliability and Service Life. To address this thermal management challenge, this study proposes and validates the effectiveness of spray cooling technology. Leveraging its high heat transfer coefficient, exceptional critical heat flux (CHF) carrying capacity, and strong transient cooling characteristics, it is particularly suitable for the unsteady thermal control during the initial launch phase. An experimental platform was established, and a three-dimensional numerical model was developed to systematically analyze the dynamic influence mechanisms of nozzle inlet pressure, flow rate, spray angle, and spray distance on cooling performance. Experimental results indicate that the system achieves maximum critical heat flux (CHF) and rail temperature drop at an inlet pressure of 0.5 MPa and a spray angle of 0°. Numerical simulations further reveal that a 45° spray cone angle simultaneously achieves the maximum temperature drop and optimal wall temperature uniformity. Key parameter sensitivity analysis demonstrates that while increasing spray distance leads to larger droplet diameters, the minimal droplet velocity decay combined with a significant increase in overall momentum markedly enhances convective heat transfer efficiency. Concurrently, increasing spray distance effectively improves rail surface temperature uniformity by optimizing the spatial distribution of droplet size and velocity. Full article
(This article belongs to the Section J: Thermal Management)
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19 pages, 36886 KB  
Article
Topographic Inversion and Shallow Gas Risk Analysis in the Canyon Area of Southeastern Qiongdong Basin Based on Multi-Source Data Fusion
by Hua Tao, Yufei Li, Qilin Jiang, Bigui Huang, Hanqiong Zuo and Xiaolei Liu
J. Mar. Sci. Eng. 2025, 13(10), 1897; https://doi.org/10.3390/jmse13101897 - 3 Oct 2025
Abstract
The submarine topography in the canyon area of the Qiongdongnan Basin is complex, with severe risks of shallow gas hazards threatening marine engineering safety. To accurately characterize seabed morphology and assess shallow gas risks, this study employed multi-source data fusion technology, integrating 3D [...] Read more.
The submarine topography in the canyon area of the Qiongdongnan Basin is complex, with severe risks of shallow gas hazards threatening marine engineering safety. To accurately characterize seabed morphology and assess shallow gas risks, this study employed multi-source data fusion technology, integrating 3D seismic data, shipborne multibeam bathymetry data, and high-precision AUV topographic data from key areas to construct a refined seabed terrain inversion model. For the first time, the spatial distribution characteristics of complex geomorphological features such as scarps, mounds, fissures, faults, and mass transport deposits (MTDs) were systematically delineated. Based on attribute analysis of 3D seismic data and geostatistical methods, the enrichment intensity of shallow gas was quantified, its distribution patterns were systematically identified, and risk level evaluations were conducted. The results indicate: (1) multi-source data fusion significantly improved the resolution and accuracy of terrain inversion, revealing intricate geomorphological details in deep-water regions; and (2) seismic attribute analysis effectively delineated shallow gas enrichment zones, clarifying their spatial distribution patterns and risk levels. This study provides critical technical support for deep-water drilling platform site selection, submarine pipeline route optimization, and engineering geohazard prevention, offering significant practical implications for ensuring the safety of deep-water energy development in the South China Sea. Full article
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26 pages, 12409 KB  
Article
Digital Twin Integration for Active Learning in Robotic Manipulator Control Within Engineering 4.0
by Fernando J. Pantusin, Jessica S. Ortiz, Christian P. Carvajal, Víctor H. Andaluz, Lenin G. Yar, Flavio Roberti and Daniel Gandolfo
Symmetry 2025, 17(10), 1638; https://doi.org/10.3390/sym17101638 - 3 Oct 2025
Abstract
Robotic systems play an increasingly significant role in both education and industry; however, access to physical robots remains a challenge due to high costs and operational risks. This work presents a training platform based on Digital Twins, aimed at active learning in the [...] Read more.
Robotic systems play an increasingly significant role in both education and industry; however, access to physical robots remains a challenge due to high costs and operational risks. This work presents a training platform based on Digital Twins, aimed at active learning in the control of robotic manipulators, with a focus on the UFACTORY 850 arm. The proposed approach integrates mathematical modeling, interactive simulation, and experimental validation, enabling the implementation and testing of control strategies in three virtual scenarios that replicate real-world conditions: a laboratory, a service environment, and an industrial production line. The system relies on kinematic and dynamic models of the manipulator, using maneuverability velocities as input signals, and employs ROS as middleware to link the Unity 2022.2.14 graphics engine with the control algorithms developed in MATLAB R2022a. Experimental results demonstrate the accuracy of the implemented models and the effectiveness of the control algorithms, validating the usefulness of Digital Twins as a pedagogical tool to support safe, accessible, and innovative learning in robotic engineering. Full article
(This article belongs to the Special Issue Applications Based on Symmetry in Control Systems and Robotics)
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27 pages, 19149 KB  
Article
Efficient Autonomy: Autonomous Driving of Retrofitted Electric Vehicles via Enhanced Transformer Modeling
by Kai Wang, Xi Zheng, Zi-Jie Peng, Cong-Chun Zhang, Jun-Jie Tang and Kuan-Min Mao
Energies 2025, 18(19), 5247; https://doi.org/10.3390/en18195247 - 2 Oct 2025
Abstract
In low-risk and open environments, such as farms and mining sites, efficient cargo transportation is essential. Despite the suitability of autonomous driving for these environments, its high deployment and maintenance costs limit large-scale adoption. To address this issue, a modular unmanned ground vehicle [...] Read more.
In low-risk and open environments, such as farms and mining sites, efficient cargo transportation is essential. Despite the suitability of autonomous driving for these environments, its high deployment and maintenance costs limit large-scale adoption. To address this issue, a modular unmanned ground vehicle (UGV) system is proposed, which is adapted from existing platforms and supports both autonomous and manual control modes. The autonomous mode uses environmental perception and trajectory planning algorithms for efficient transport in structured scenarios, while the manual mode allows human oversight and flexible task management. To mitigate the control latency and execution delays caused by platform modifications, an enhanced transformer-based general dynamics model is introduced. Specifically, the model is trained on a custom-built dataset and optimized within a bicycle kinematic framework to improve control accuracy and system stability. In road tests allowing a positional error of up to 0.5 m, the transformer-based trajectory estimation method achieved 94.8% accuracy, significantly outperforming non-transformer baselines (54.6%). Notably, the test vehicle successfully passed all functional validations in autonomous driving trials, demonstrating the system’s reliability and robustness. The above results demonstrate the system’s stability and cost-effectiveness, providing a potential solution for scalable deployment of autonomous transport in low-risk environments. Full article
(This article belongs to the Section E: Electric Vehicles)
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37 pages, 2156 KB  
Review
Experimental Fish Models in the Post-Genomic Era: Tools for Multidisciplinary Science
by Camila Carlino-Costa and Marco Antonio de Andrade Belo
J 2025, 8(4), 39; https://doi.org/10.3390/j8040039 - 2 Oct 2025
Abstract
Fish have become increasingly prominent as experimental models due to their unique capacity to bridge basic biological research with translational applications across diverse scientific disciplines. Their biological traits, such as external fertilization, high fecundity, rapid embryonic development, and optical transparency, facilitate in vivo [...] Read more.
Fish have become increasingly prominent as experimental models due to their unique capacity to bridge basic biological research with translational applications across diverse scientific disciplines. Their biological traits, such as external fertilization, high fecundity, rapid embryonic development, and optical transparency, facilitate in vivo experimentation and real-time observation, making them ideal for integrative research. Species like zebrafish (Danio rerio) and medaka (Oryzias latipes) have been extensively validated in genetics, toxicology, neuroscience, immunology, and pharmacology, offering robust platforms for modeling human diseases, screening therapeutic compounds, and evaluating environmental risks. This review explores the multidisciplinary utility of fish models, emphasizing their role in connecting molecular mechanisms to clinical and environmental outcomes. We address the main species used, highlight their methodological advantages, and discuss the regulatory and ethical frameworks guiding their use. Additionally, we examine current limitations and future directions, particularly the incorporation of high-throughput omics approaches and real-time imaging technologies. The growing scientific relevance of fish models reinforces their strategic value in advancing cross-disciplinary knowledge and fostering innovation in translational science. Full article
(This article belongs to the Special Issue Feature Papers of J—Multidisciplinary Scientific Journal in 2025)
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7 pages, 894 KB  
Commentary
Advancing Peptide-Based Vaccines Against Candida: A Comparative Perspective on Liposomal and Synthetic Formulations
by Hong Xin
J. Fungi 2025, 11(10), 715; https://doi.org/10.3390/jof11100715 - 2 Oct 2025
Abstract
The growing threat of multidrug-resistant fungal pathogens, especially Candida auris, has underscored the need for effective antifungal vaccines. This commentary highlights recent advances in peptide-based vaccination using the SNAP (Spontaneous Nanoliposome Antigen Presentation) platform, focusing on the FM-SNAP vaccine, a bivalent liposomal [...] Read more.
The growing threat of multidrug-resistant fungal pathogens, especially Candida auris, has underscored the need for effective antifungal vaccines. This commentary highlights recent advances in peptide-based vaccination using the SNAP (Spontaneous Nanoliposome Antigen Presentation) platform, focusing on the FM-SNAP vaccine, a bivalent liposomal formulation targeting the surface-expressed peptides fructose bisphosphate aldolase (Fba) and methionine synthase (Met6). Compared to earlier constructs such as MP12, FM-SNAP achieves superior immunogenicity and long-lasting protection at lower antigen doses. It elicits balanced Th1/Th2 cytokine responses and demonstrates durable efficacy in both immunocompetent and complement-deficient mouse models. The platform’s compatibility with clinically approved adjuvants (MPLA and QS-21), modular peptide design, and potential for multi-pathogen applications underscores its translational promise. FM-SNAP exemplifies a next-generation vaccine strategy that is both scalable and adaptable for high-risk immunocompromised populations. Full article
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25 pages, 3236 KB  
Article
A Wearable IoT-Based Measurement System for Real-Time Cardiovascular Risk Prediction Using Heart Rate Variability
by Nurdaulet Tasmurzayev, Bibars Amangeldy, Timur Imankulov, Baglan Imanbek, Octavian Adrian Postolache and Akzhan Konysbekova
Eng 2025, 6(10), 259; https://doi.org/10.3390/eng6100259 - 2 Oct 2025
Abstract
Cardiovascular diseases (CVDs) remain the leading cause of global mortality, with ischemic heart disease (IHD) being the most prevalent and deadly subtype. The growing burden of IHD underscores the urgent need for effective early detection methods that are scalable and non-invasive. Heart Rate [...] Read more.
Cardiovascular diseases (CVDs) remain the leading cause of global mortality, with ischemic heart disease (IHD) being the most prevalent and deadly subtype. The growing burden of IHD underscores the urgent need for effective early detection methods that are scalable and non-invasive. Heart Rate Variability (HRV), a non-invasive physiological marker influenced by the autonomic nervous system (ANS), has shown clinical relevance in predicting adverse cardiac events. This study presents a photoplethysmography (PPG)-based Zhurek IoT device, a custom-developed Internet of Things (IoT) device for non-invasive HRV monitoring. The platform’s effectiveness was evaluated using HRV metrics from electrocardiography (ECG) and PPG signals, with machine learning (ML) models applied to the task of early IHD risk detection. ML classifiers were trained on HRV features, and the Random Forest (RF) model achieved the highest classification accuracy of 90.82%, precision of 92.11%, and recall of 91.00% when tested on real data. The model demonstrated excellent discriminative ability with an area under the ROC curve (AUC) of 0.98, reaching a sensitivity of 88% and specificity of 100% at its optimal threshold. The preliminary results suggest that data collected with the “Zhurek” IoT devices are promising for the further development of ML models for IHD risk detection. This study aimed to address the limitations of previous work, such as small datasets and a lack of validation, by utilizing real and synthetically augmented data (conditional tabular GAN (CTGAN)), as well as multi-sensor input (ECG and PPG). The findings of this pilot study can serve as a starting point for developing scalable, remote, and cost-effective screening systems. The further integration of wearable devices and intelligent algorithms is a promising direction for improving routine monitoring and advancing preventative cardiology. Full article
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22 pages, 1699 KB  
Review
Connected but at Risk: Social Media Exposure and Psychiatric and Psychological Outcomes in Youth
by Giuseppe Marano, Francesco Maria Lisci, Sara Rossi, Ester Maria Marzo, Gianluca Boggio, Caterina Brisi, Gianandrea Traversi, Osvaldo Mazza, Roberto Pola, Eleonora Gaetani and Marianna Mazza
Children 2025, 12(10), 1322; https://doi.org/10.3390/children12101322 - 2 Oct 2025
Abstract
Background: The widespread use of social media among children and adolescents has raised increasing concern about its potential impact on mental health. Given the unique neurodevelopmental vulnerabilities during adolescence, understanding how digital platforms influence psychiatric outcomes is critical. Objectives: This narrative review aims [...] Read more.
Background: The widespread use of social media among children and adolescents has raised increasing concern about its potential impact on mental health. Given the unique neurodevelopmental vulnerabilities during adolescence, understanding how digital platforms influence psychiatric outcomes is critical. Objectives: This narrative review aims to synthesize current evidence on the relationship between social media exposure and key psychiatric symptoms in youth, including depression, anxiety, body image disturbances, suicidality, and emotional dysregulation. Methods: We conducted a comprehensive narrative review of the literature, drawing from longitudinal, cross-sectional, and neuroimaging studies published in peer-reviewed journals. Specific attention was given to moderators (e.g., age, gender, and personality traits) and mediators (e.g., sleep, emotion regulation, and family context) influencing the relationship between social media use and mental health outcomes. Results: Evidence indicates that certain patterns of social media use, especially passive or compulsive engagement, are associated with increased risk of depression, anxiety, body dissatisfaction, and suicidal ideation. Adolescent girls, younger users, and those with low self-esteem or poor emotional regulation are particularly vulnerable. Neuroimaging studies show that social media activates reward-related brain regions, which may reinforce problematic use. Family support and digital literacy appear to mitigate negative effects. Conclusions: Social media use is not uniformly harmful; its psychological impact depends on how, why, and by whom it is used. Multilevel prevention strategies, including media education, parental involvement, and responsible platform design, are essential to support healthy adolescent development in the digital age. Full article
(This article belongs to the Special Issue Advances in Mental Health and Well-Being in Children (2nd Edition))
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46 pages, 2380 KB  
Review
Microalgae in Mitigating Industrial Pollution: Bioremediation Strategies and Biomagnification Potential
by Renu Geetha Bai, Salini Chandrasekharan Nair, Liina Joller-Vahter and Timo Kikas
Biomass 2025, 5(4), 61; https://doi.org/10.3390/biomass5040061 - 2 Oct 2025
Abstract
The rapid growth of the human population and industrialization has intensified anthropogenic activities, leading to the release of various toxic chemicals into the environment, triggering significant risks to human health and ecosystem stability. One sustainable solution to remove toxic chemicals from various environmental [...] Read more.
The rapid growth of the human population and industrialization has intensified anthropogenic activities, leading to the release of various toxic chemicals into the environment, triggering significant risks to human health and ecosystem stability. One sustainable solution to remove toxic chemicals from various environmental matrices, such as water, air, and soil, is bioremediation, an approach utilizing biological agents. Microalgae, as the primary producers of the aquatic environment, offer a versatile bioremediation platform, where their metabolic processes break down and convert pollutants into less harmful substances, thereby mitigating the negative ecological impact. Besides the CO2 sequestration potential, microalgae are a source of renewable energy and numerous high-value biomolecules. Additionally, microalgae can mitigate various toxic chemicals through biosorption, bioaccumulation, and biodegradation. These remediation strategies propose a sustainable and eco-friendly approach to address environmental pollution. This review evaluates the microalgal mitigation of major environmental contaminants—heavy metals, pharmaceuticals and personal care products (PPCPs), persistent organic pollutants (POPs), flue gases, microplastics, and nanoplastics—linking specific microalgae removal mechanisms to pollutant-induced cellular responses. Each section explicitly addresses the effects of these pollutants on microalgae, microalgal bioremediation potential, bioaccumulation process, the risks of trophic transfer, and biomagnification in the food web. Herein, we highlight the current status of the microalgae-based bioremediation prospects, pollutant-induced microalgal toxicity, bioaccumulation, and consequential biomagnification. The novelty of this review lies in integrating biomagnification risks with the bioremediation potential of microalgae, providing a comprehensive perspective not yet addressed in the existing literature. Finally, we identify major research gaps and outline prospective strategies to optimize microalgal bioremediation while minimizing the unintended trophic transfer risks. Full article
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18 pages, 2133 KB  
Article
A Simulation Game in Mineral Exploration: A Mineral Adventure from Exploration to Exploitation
by George Valakas, Daphne Sideri and Konstantinos Modis
J 2025, 8(4), 38; https://doi.org/10.3390/j8040038 - 1 Oct 2025
Abstract
In recent decades, simulation has emerged as a pivotal educational tool, bolstering scientific knowledge and honing decision-making skills across diverse disciplines. Surgery and flight simulators are well-known tools used to practice and train safely in surgeries and piloting. Meanwhile, the development of simulation [...] Read more.
In recent decades, simulation has emerged as a pivotal educational tool, bolstering scientific knowledge and honing decision-making skills across diverse disciplines. Surgery and flight simulators are well-known tools used to practice and train safely in surgeries and piloting. Meanwhile, the development of simulation games advances in other scientific fields, such as economics, management, engineering, and mathematics. These simulations offer learners a risk-free virtual platform to apply and refine their knowledge, leveraging animations, graphics, and interactive environments to enrich the learning experience. In engineering, while simulation is widely utilized as a powerful training tool for heavy equipment and process handling, the creation of strategy games for educational purposes is less frequent. This gap primarily stems from the challenge of converting complex engineering concepts and theories into a user-friendly yet comprehensive setup that preserves the more difficult aspects. This study adopts a design-based research approach to develop and evaluate an educational simulation game aimed at enhancing probabilistic and spatial reasoning in mineral exploration. The application generates random scenarios, within which users deploy strategies based on their knowledge, while accommodating the randomness of physical phenomena. The simulation game is adopted as an educational tool in the course “Introduction to Mineral Exploration” in the School of Mining and Metallurgical Engineering of the National Technical University of Athens. Additionally, we present the outcomes of game analytics and a qualitative evaluation derived from three workshops at higher education institutions in Greece. Full article
(This article belongs to the Special Issue Feature Papers of J—Multidisciplinary Scientific Journal in 2025)
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21 pages, 2975 KB  
Article
ARGUS: An Autonomous Robotic Guard System for Uncovering Security Threats in Cyber-Physical Environments
by Edi Marian Timofte, Mihai Dimian, Alin Dan Potorac, Doru Balan, Daniel-Florin Hrițcan, Marcel Pușcașu and Ovidiu Chiraș
J. Cybersecur. Priv. 2025, 5(4), 78; https://doi.org/10.3390/jcp5040078 - 1 Oct 2025
Abstract
Cyber-physical infrastructures such as hospitals and smart campuses face hybrid threats that target both digital and physical domains. Traditional security solutions separate surveillance from network monitoring, leaving blind spots when attackers combine these vectors. This paper introduces ARGUS, an autonomous robotic platform designed [...] Read more.
Cyber-physical infrastructures such as hospitals and smart campuses face hybrid threats that target both digital and physical domains. Traditional security solutions separate surveillance from network monitoring, leaving blind spots when attackers combine these vectors. This paper introduces ARGUS, an autonomous robotic platform designed to close this gap by correlating cyber and physical anomalies in real time. ARGUS integrates computer vision for facial and weapon detection with intrusion detection systems (Snort, Suricata) for monitoring malicious network activity. Operating through an edge-first microservice architecture, it ensures low latency and resilience without reliance on cloud services. Our evaluation covered five scenarios—access control, unauthorized entry, weapon detection, port scanning, and denial-of-service attacks—with each repeated ten times under varied conditions such as low light, occlusion, and crowding. Results show face recognition accuracy of 92.7% (500 samples), weapon detection accuracy of 89.3% (450 samples), and intrusion detection latency below one second, with minimal false positives. Audio analysis of high-risk sounds further enhanced situational awareness. Beyond performance, ARGUS addresses GDPR and ISO 27001 compliance and anticipates adversarial robustness. By unifying cyber and physical detection, ARGUS advances beyond state-of-the-art patrol robots, delivering comprehensive situational awareness and a practical path toward resilient, ethical robotic security. Full article
(This article belongs to the Special Issue Cybersecurity Risk Prediction, Assessment and Management)
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22 pages, 3094 KB  
Article
Enhanced NO2 Detection in ZnO-Based FET Sensor: Charge Carrier Confinement in a Quantum Well for Superior Sensitivity and Selectivity
by Hicham Helal, Marwa Ben Arbia, Hakimeh Pakdel, Dario Zappa, Zineb Benamara and Elisabetta Comini
Chemosensors 2025, 13(10), 358; https://doi.org/10.3390/chemosensors13100358 - 1 Oct 2025
Abstract
NO2 is a toxic gas mainly generated by combustion processes, such as vehicle emissions and industrial activities. It is a key contributor to smog, acid rain, ground-level ozone, and particulate matter, all of which pose serious risks to human health and the [...] Read more.
NO2 is a toxic gas mainly generated by combustion processes, such as vehicle emissions and industrial activities. It is a key contributor to smog, acid rain, ground-level ozone, and particulate matter, all of which pose serious risks to human health and the environment. Conventional resistive gas sensors, typically based on metal oxide semiconductors, detect NO2 by resistance modulation through surface interactions with the gas. However, they often suffer from low responsiveness and poor selectivity. This study investigates NO2 detection using nanoporous zinc oxide thin films integrated into a resistor structure and floating-gate field-effect transistor (FGFET). Both Silvaco-Atlas simulations and experimental fabrication were employed to evaluate sensor behavior under NO2 exposure. The results show that FGFET provides higher sensitivity, faster response times, and improved selectivity compared to resistor-based devices. In particular, FGFET achieves a detection limit as low as 89 ppb, with optimal performance around 400 °C, and maintains stability under varying humidity levels. The enhanced performance arises from quantum well effects at the floating-gate Schottky contact, combined with NO2 adsorption on the ZnO surface. These interactions extend the depletion region and confine charge carriers, amplifying conductivity modulation in the channel. Overall, the findings demonstrate that FGFET is a promising platform for NO2 sensors, with strong potential for environmental monitoring and industrial safety applications. Full article
(This article belongs to the Special Issue Functionalized Material-Based Gas Sensing)
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13 pages, 446 KB  
Systematic Review
Digital Enablement of Psychedelic-Assisted Therapy in Non-Clinical Settings: A Systematic Review of Safety, Efficacy, and Implementation Models
by Brendan Driscoll and Shaheen E. Lakhan
Psychoactives 2025, 4(4), 35; https://doi.org/10.3390/psychoactives4040035 - 1 Oct 2025
Abstract
Psychedelic-assisted therapy offers rapid and profound benefits for treatment-resistant psychiatric conditions but remains constrained by the need for intensive, clinic-based administration. Concurrently, advances in digital health technologies have introduced scalable tools. This systematic review evaluates the safety, efficacy, and implementation of digitally enabled [...] Read more.
Psychedelic-assisted therapy offers rapid and profound benefits for treatment-resistant psychiatric conditions but remains constrained by the need for intensive, clinic-based administration. Concurrently, advances in digital health technologies have introduced scalable tools. This systematic review evaluates the safety, efficacy, and implementation of digitally enabled psychedelic-assisted therapy delivered in non-clinical settings. A comprehensive search of five databases, registered in PROSPERO (CRD420251020968) and conducted in accordance with PRISMA guidelines, identified six eligible studies including real-world analyses, clinical trials, qualitative research, and case reports, representing a total of 12,731 participants. Most studies examined at-home ketamine or esketamine therapy supported by telehealth platforms or mobile applications. Data were synthesized narratively given the heterogeneity of designs and outcomes. Digital enablement was associated with high response rates (ranging from 56.4% to 62.8% for depression) and rapid symptom improvement, particularly in depression and anxiety. Remote monitoring and digital tools demonstrated feasibility and acceptability, but serious safety concerns—including psychiatric adverse events and one unintentional overdose—underscore the need for strict oversight. Risk of bias was moderate to serious across non-randomized studies, limiting confidence in the findings. One study on virtual ayahuasca rituals highlighted the sociocultural potential and limitations of online practices. Despite promising preliminary findings, the field is marked by low methodological rigor and absence of controlled trials. Digitally supported at-home psychedelic therapy represents a transformative but high-stakes frontier, requiring robust research and safeguards to ensure safe, equitable, and effective implementation. No funding was received for this review, and the authors declare no conflicts of interest. Full article
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