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Article

16 Citations

8,968 Views

13 Pages

Phenylmethimazole Blocks dsRNA-Induced IRF3 Nuclear Translocation and Homodimerization

Maria C. Courreges,
Noriko Kantake,
Douglas J. Goetz,
Frank L. Schwartz and
Kelly D. McCall

Molecules2012, 17(10), 12365-12377;https://doi.org/10.3390/molecules171012365

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22 October 2012

Previous studies revealed that phenylmethimazole (C10) inhibits IRF3 signaling, preventing dsRNA-induction of type 1 interferon gene expression, production, and downstream signaling. In the present study, we investigated the molecular basis for C10 i...

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Article

13 Citations

6,428 Views

18 Pages

Phenylmethimazole Suppresses dsRNA-Induced Cytotoxicity and Inflammatory Cytokines in Murine Pancreatic Beta Cells and Blocks Viral Acceleration of Type 1 Diabetes in NOD Mice

Kelly D. McCall,
Martin J. Schmerr,
Jean R. Thuma,
Calvin B. L. James,
Maria C. Courreges,
Fabian Benencia,
Ramiro Malgor and
Frank L. Schwartz

Molecules2013, 18(4), 3841-3858;https://doi.org/10.3390/molecules18043841

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27 March 2013

Accumulating evidence supports a role for viruses in the pathogenesis of type 1 diabetes mellitus (T1DM). Activation of dsRNA-sensing pathways by viral dsRNA induces the production of inflammatory cytokines and chemokines that trigger beta cell apopt...

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