Search Results (2,839)

This article compares selected fire safety regulatory systems in Japan, China, the United States, and the EU/UK, interpreted through the lens of responsive architecture and the implementation of digital technologies—building information modelling (BIM), digital twins (DTs), artificial intelligence (AI), and the Internet of Things (IoT). The study adopts a qualitative approach based on a structured review of legal acts, technical standards, public-sector reports, and the scientific and professional literature, organised using a common analytical framework. First, the analysis identifies shared foundations across regimes: the primacy of life safety, mandatory detection and alarm functions, fire compartmentation, requirements for protected means of exit, and the increasing importance of documenting the operational status of protection measures. Then, it contrasts key differences, including the permissibility of performance-based design (PBD), the degree to which digital documentation is formally recognised, organisational enforcement models, and cybersecurity approaches for integrated fire alarm/voice alarm/building management/IoT ecosystems. Japan and selected Chinese cities combine stringent requirements with openness to dynamic solutions and urban-scale data platforms. The USA relies on a decentralised code-based ecosystem with a strong role for professional and industry bodies, while the EU/UK continues to strengthen harmonised standards and digital building registers, reinforced by lessons after the Grenfell Tower fire. Against this background, Poland is discussed as broadly aligned in goals and baseline technical requirements yet lagging behind in implementing PBD pathways, digital registers, formal BIM/DT integration, and minimum cybersecurity requirements. The proposed directions for change aim to create a more predictable regulatory and technical framework for the development of responsive architecture and dynamic fire safety systems in Poland. The study contributes to the sustainability literature by framing regulatory readiness for digital fire safety as a lifecycle resilience strategy, directly relevant to safe, resource-efficient, and inclusive built environments. Full article

Atherosclerosis remains the leading cause of death worldwide and imposes a major healthcare burden. Physiologically, elimination of cholesterol from the arterial wall depends on reverse cholesterol transport (RCT). RCT requires access to HDL and apolipoprotein A-I (ApoA-I) to lesional macrophages/foam cells. The endothelial glycocalyx is a dynamic and injury-sensitive layer of proteoglycans and glycosaminoglycans (including hyaluronan). It contributes to vascular barrier properties, leukocyte adhesion, mechanotransduction, and macromolecular transport. In atherosclerosis, glycocalyx structure and function are altered; this may facilitate entry/retention of atherogenic lipoproteins and may also alter transport conditions relevant to cholesterol efflux pathways. This article presents a mechanistic hypothesis: short, transient, systemic hyaluronidase exposure could temporarily remodel glycocalyx/extracellular matrix components and thereby facilitate conditions permissive for regulated transport processes relevant to RCT. However, the proposed link between glycocalyx remodeling and improved lesional cholesterol efflux remains theoretical. Direct in vivo evidence that the endothelial glycocalyx is a dominant barrier limiting HDL- or ApoA-I-mediated cholesterol efflux from plaque macrophages is currently limited. Moreover, glycocalyx degradation is widely associated with endothelial dysfunction, increased permeability, inflammation, and thrombosis, all of which could aggravate rather than ameliorate atherosclerosis. Human pharmacokinetic data indicate a very short plasma half-life of circulating hyaluronidase activity, suggesting that any systemic enzymatic effect is brief. Nevertheless, the biological consequences of repeated degradation–regeneration cycles, especially in high-risk states such as diabetes, inflammation, oxidative stress, or chronic kidney disease, remain incompletely understood. Evidence supporting clinical benefit in atherosclerosis is currently limited to heterogeneous animal experiments, historical uncontrolled reports, and a small number of anecdotal case observations, whereas randomized trials have only been performed in other settings such as acute myocardial infarction and do not establish efficacy for plaque regression. We therefore provide a balanced evaluation of knowns, uncertainties, alternative interpretations, potential risks, dosing unknowns, and a translational research agenda including mechanistic preclinical studies, biomarker development, imaging, and carefully designed early-phase clinical investigation. Full article

This paper explores the ethical dimensions of violence in sporting contexts, proposing that violence can be a virtue when characterized by controlled physicality. While society often views violence negatively, the paper argues that within rule-governed sports, certain forms of violence are morally permissible, strategically valuable, and essential to upholding the integrity of the game. Drawing on Suitsian terms and Kantian ethics, the paper develops a theory of lusory violence, distinguishing it from uncontrolled physicality or unmitigated violence. By examining the roles of enforcers in hockey, the development of MMA, and the ethics of sport jiu-jitsu, the paper suggests that violence is acceptable within a lusory framework only when it is purposive, strategically relevant, and constrained by rules that prioritize technical skill over raw damage. Ultimately, the paper argues that the ability to modulate violent behaviour represents a form of moral development, framing virtuous violence as a necessary tool for maintaining natural justice and personal excellence within specific sporting environments. Yet, virtuous violence is subordinate to technique, justice, and other defining elements of sports. Full article

Infectious complications remain a principal determinant of late morbidity and mortality following major thermal injury, reflecting a convergence of barrier disruption, microbial adaptation, and host immune dysfunction. The post-burn environment creates a uniquely permissive niche for pathogen persistence, characterized by altered tissue perfusion, biofilm formation, and dynamic shifts in microbial ecology toward multidrug-resistant organisms. Concurrently, profound and evolving changes in host immunity and metabolism reshape both susceptibility to infection and response to therapy. This review integrates current evidence across pathophysiology, microbiology, diagnostics, and treatment, with a focus on challenges that limit effective infection control in burn patients. Particular attention is given to diagnostic uncertainty arising from overlap between sterile inflammation and true infection, the clinical implications of biofilm-associated tolerance, and the impact of burn-specific pharmacokinetic variability on antimicrobial efficacy. We further examine emerging diagnostic and therapeutic innovations, including host-response profiling, rapid molecular detection platforms, and next-generation anti-infective strategies targeting microbial virulence, biofilm structure, and host immune pathways. Despite substantial scientific advances, translation into clinical practice remains constrained by limited burn-specific trials, heterogeneous definitions, and systemic barriers to antimicrobial development. Collectively, these challenges underscore the need for integrated, precision-based approaches that combine early source control, individualized antimicrobial optimization, and advanced diagnostic frameworks. Future progress will depend on coordinated efforts to standardize definitions, generate high-quality multicenter data, and align innovation with clinical applicability across diverse healthcare settings. Full article

Cultured meat holds the potential to reduce environmental impacts and offer ethical advantages while replicating the nutritional, taste, and texture attributes of conventional meat. To date, most research on consumer acceptance of meat has focused on European and North American markets. In contrast, Muslim-majority countries remain underexplored, particularly regarding the compatibility of cultured meat with Islamic dietary laws. These societies are experiencing rising meat consumption, and countries such as Saudi Arabia and Malaysia rely heavily on meat imports. This narrative perspective article aims to systematically examine how specific stages of cultured meat production align with, or challenge, Islamic dietary (halal) principles. To this end, we adopt a stage-based analytical approach, mapping key technological steps in cultured meat production onto core requirements of Islamic jurisprudence. To this end, we critically and comprehensively examine the intersection between cultured meat production methods and the Islamic concept of halal, which extends beyond ingredient permissibility to encompass ethical, spiritual, and hygienic dimensions of food production. Key challenges to halal certification include the origin and status of starter cells, whether donor animals were slaughtered according to Islamic law, the permissibility of biopsied tissue, and the use of fetal bovine serum in growth media. The analysis indicates that while halal-compliant cultured meat is scientifically feasible, its adoption remains constrained by unresolved religious interpretations, regulatory fragmentation, and limited availability of halal-certified inputs. We emphasize the need for interdisciplinary collaboration among Islamic scholars, food scientists, certification bodies, and policymakers. From a policy perspective, harmonized halal standards, targeted investment in serum-free and animal-free culture media, and early regulatory engagement with Islamic authorities are essential to facilitate responsible market entry. Therefore, we suggest a multi-level governance and stage-gated halal decision framework for cultured meat. Proactive regulation and open dialogue with religious leaders are vital to ethically introduce cultured meat into Muslim markets, aligning innovation with Islamic values while supporting national sustainability and food security goals. Full article

Heavy metal contamination in drinking water remains a pervasive global challenge with significant consequences for environmental quality and human health. This review synthesizes findings from recent studies examining heavy metal concentrations in different sources of drinking water, including municipal tap water, groundwater, surface water, and bottled/sachet water across various geographical regions. The study used a systematic review of studies published from 2015 to 2024. The result showed a variation in the concentrations of heavy metals from all the sources, with tap water generally exhibiting lower heavy metal levels. Pb, Fe, Mn, and other metals persist in different sources and from many regions with levels above the permissible limits recommended by the World Health Organization (WHO) in some instances, which were sometimes linked to aging distribution systems and other pollution sources. Bottled and sachet water, commonly regarded as safer alternatives, also showed some levels of heavy metals such as Pb, Cd, and Cr, reflecting inconsistent packaging or production oversight. Surface waters display variability with heavy metals pollution, driven by industrial discharge, mining activities, agricultural runoff, and urban wastewater inputs. Groundwater sources, although naturally shielded, frequently contained elevated concentrations of As, Hg, and Ni due to both geological and anthropogenic factors. Pb concentrations were below detection limit in some of the published papers; however, the values reported in this study ranged from ND to 260.0 µg/L (tap water), ND to 0.259 mg/L (surface water), ND to 0.791 mg/L (groundwater), and ND to 123.15 µg/L (bottled water). Arsenic (As) concentrations ranged from ND to 692 µg/L from different sources, with the highest concentration from groundwater. Collectively, these patterns underscore the need for strengthened monitoring frameworks, improved water treatment technologies, and integrated pollution-prevention strategies. Addressing heavy metal contamination in drinking water requires coordinated policy approach and continuous monitoring to reduce human exposure and safeguard global public health. Full article

Epstein–Barr virus (EBV) establishes lifelong infection in most humans, yet its biology in immunocompetent hosts is commonly framed as a binary alternation between latency and productive lytic replication. Accumulating molecular and single-cell evidence challenges this view, indicating that EBV frequently enters abortive forms of lytic reactivation that do not culminate in virion production. Here, we propose a conceptual framework in which EBV persistence is governed by feedback-regulated interactions and permissive conditions for reactivation rather than a strictly sequential life cycle. Immediate-early and early gene expression can be repeatedly induced by inflammatory signaling, cellular stress, and epigenetic changes. However, progression to viral DNA replication represents a highly functional barrier that likely requires the coordinated convergence of multiple viral and host conditions. Failure to reach this threshold arrests reactivation before late gene expression, generating a stable partial lytic state characterized by sustained immunomodulatory viral protein expression without the production of infectious particles. Immune surveillance reinforces this bottleneck by eliminating cells undergoing full lytic replication while sparing those stalled in early phases. We argue that EBV persistence reflects a dynamic equilibrium shaped by regulatory interactions between viral gene expression and host immunity, with implications for biomarker interpretation and therapeutic strategies in chronic inflammatory and autoimmune disease. Full article

Environmental factors are suspected of triggering rheumatoid arthritis (RA). One such factor is oxidative stress (OS), which is a step in ecotoxin detoxification and a damaging factor. The linkage of ecotoxin-triggered OS with clinical and laboratory RA indices in patients and individuals at the pre-RA stage was studied in patients with early (e) (n = 35) and advanced (a) stages of RA (n = 25) and individuals at pre-RA stages (FDR-First-Degree Relative(s), pre-RA, n = 72) in comparison with 52 healthy individuals without autoimmune and immunoinflammatory diseases in their family history (Controls). Ecotoxins within permissible concentration limits were associated with serum levels of OS markers in all cohorts, including Controls. Serum oxidized low-density lipoprotein (oxLDL) levels in pre-RA and eRA cohorts exceeded Control values. Significant differences were found in anti-oxLDL antibody correlations and OS markers. In pre-RA and both RA cohorts, a relationship was found with regards to serum antibodies to cyclic citrullinated peptide (ACCP) levels. Thus, ecotoxin-induced OS likely triggers pathogenic mechanisms at the pre-RA stage and RA onset. Full article

The mental health of children/adolescents is closely related to family functioning. However, there are factors that impair family functioning, such as parental psychopathology, parenting styles, and beliefs about physical punishment, which may require intervention by psychology and psychiatry. Given the lack of literature, the main objectives of this research are: to explore the association between parenting styles and the personality traits that constitute the Dark Triad, to analyze the association between beliefs about physical punishment and the personality traits that make up the Dark Triad, and to test the mediating effect of beliefs about physical punishment between the traits of the Dark Triad and parenting styles. The sample consisted of 290 parents of school-age children/adolescents between 7 and 16 years old, consisting of 231 female and 59 male participants. The main results suggest that Machiavellianism and narcissism are positively associated with authoritarian and permissive parenting styles and psychopathy with authoritarian; personality traits are associated with beliefs about physical punishment, and beliefs about physical punishment influence the relationship between the Dark Triad and parenting styles. In short, parental psychopathology seems to have an influence on the way parents educate their children and on their beliefs about physical punishment. Full article

Message Queuing Telemetry Transport (MQTT) is a lightweight publish–subscribe protocol widely deployed in Internet of Things (IoT) systems. Although MQTT defines authentication and authorization mechanisms, their enforcement accuracy, configuration sensitivity, and operational cost under controlled misconfiguration conditions remain insufficiently quantified. This study experimentally quantifies authentication enforcement behavior and Access Control List (ACL) misconfiguration impact within a standards-compliant MQTT deployment under controlled laboratory conditions. Rather than benchmarking a specific software product, the work measures protocol-defined security behavior—including authentication success rate, false acceptance rate (FAR), false rejection rate (FRR), privilege-boundary preservation, authentication latency, and broker CPU utilization—across systematically constructed operational and failure scenarios. Username/password and mutual TLS authentication were evaluated under valid and stress-induced connection conditions, alongside structured ACL policies incorporating wildcard over-permission. Across repeated trials, username/password authentication achieved higher observed connection reliability (≈0.95), while TLS-based authentication provided stronger cryptographic identity assurance at the cost of increased authentication latency (≈42.6 ms vs. 14.8 ms) and higher CPU utilization (≈23.7% vs. 9.4%). No false acceptances were observed within 100 unauthorized trials per configuration, corresponding to a 95% confidence upper bound of <3% for FAR under a binomial model. Under controlled ACL misconfiguration, 22 of 100 evaluated authorization operations accessed topics beyond the originally intended least-privilege scope, yielding a reproducible privilege expansion rate of 0.22. This expansion resulted from wildcard policy semantics rather than an enforcement malfunction. The results provide controlled empirical quantification of reliability–security trade-offs and configuration-driven privilege-boundary behavior within a standards-compliant MQTT deployment. While the findings reflect enforcement behavior as realized in the evaluated implementation and laboratory environment, the proposed measurement framework establishes reproducible criteria for assessing MQTT security enforcement accuracy under controlled conditions. Full article

Mini-roundabouts are increasingly implemented as compact, low-cost alternatives to conventional roundabouts and signalized intersections, especially at low-speed, space-constrained urban locations where safety is a concern. Their design emphasizes speed management, reduced conflict severity, and operational simplicity, contributing to safer mobility for all road users. This paper reviews U.S., German, and UK design guidelines and synthesizes empirical safety evidence from before-and-after studies of mini-roundabout conversions. In terms of design, the U.S. practice typically relies on a single large design vehicle and more permissive geometry, whereas the German guidance adopts a multi-vehicle approach with tighter curvature and stronger compactness to enforce lower speeds, affecting crash risk and driver behavior. The UK guidance is distinguished by its flush or slightly domed central marking and flexible application approach. Conversions from two-way stop-controlled (TWSC) or one-way stop-controlled (OWSC) intersections yield substantial reductions in injury and severe crashes, with total crash reductions of 17–42%. Conversions from all-way stop-controlled (AWSC) intersections present more variable outcomes, including increases in total crashes, because drivers are still reacting based on the previous control and may not adjust their expectations quickly. Modular roundabouts are also examined as alternative compact interventions for constrained or high-risk sites, with early evidence indicating reductions in severe crashes and improved speed control while minimizing construction costs and right-of-way impacts. Full article

Water scarcity compels wastewater reuse, but lax discharge standards generate a regulatory mirage, misleading the public about safety. Here, “regulatory mirage” refers to situations where formal compliance with discharge standards creates a false perception of safety while ecological risks and degradation persist. Despite formal compliance, treated effluent severely harms Iran’s effluent-dependent Kashaf River, driving eutrophication, salinization, and the downstream transport of unregulated contaminants of emerging concern, including fluorinated substances (PFAS) and pharmaceuticals. These pressures extend beyond the river channel to adjacent natural wetlands, which act as de facto nature-based treatment systems yet are progressively transformed into sacrificial sinks for excess nutrients, salts, heavy metals, and micropollutants. By benchmarking the Iranian Wastewater Discharge Standards (IWDS) against international guidelines (WHO, EU, FAO), this study quantifies a “Permissibility Gap” frequently greater than 10 for key parameters such as BOD₅, nutrients, and trace metals, revealing how concentration-based limits ignore cumulative mass load and mixture toxicity at the basin scale. The Kashaf River case demonstrates that current end-of-pipe regulation undermines both natural wetlands and planned nature-based solutions, including constructed wetlands, in arid regions where effluent reuse is unavoidable. The study argues that aligning discharge standards with global benchmarks, adopting mass-based permits, and explicitly regulating contaminants of emerging concern are prerequisites for truly safe wastewater reuse and for protecting wetland ecosystems in effluent-dependent basins. This study shows that permissive, concentration-based discharge standards in effluent-dependent basins create a regulatory mirage that accelerates river and wetland degradation, and that stricter, mass-based limits are essential for safe wastewater reuse. Full article

Cutaneous T-cell lymphoma (CTCL) comprises a heterogeneous group of extranodal non-Hodgkin lymphomas. With the publication of the fifth edition of the World Health Organization Classification of Hematolymphoid Tumors, the diagnostic framework for CTCL has shifted from primarily morphologic phenotypes toward an emphasis on molecular drivers. Current research suggests that malignant clones may arise from somatic mutations at the hematopoietic stem cell stage and may follow a continuous hematogenous dissemination model with bidirectional trafficking between the skin and systemic circulation. At the molecular level, genomic instability, often associated with somatic copy-number variations, may promote activation of the janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling pathway through gene-dosage effects. In parallel, chromatin remodeling linked to EZH2 overexpression and reduced special SATB1 expression may support a Th2-polarized program. This phenotype may contribute to epidermal barrier impairment via cytokines such as Interleukins-4 (IL-4) and IL-13, potentially creating conditions permissive for Staphylococcus aureus colonization. Microbial superantigens and exotoxins may further contribute to tumor progression and therapeutic resistance by reinforcing JAK/STAT signaling, particularly STAT3, and reducing CD8+ T-cell–mediated immune surveillance. In the dermis, reprogramming of cancer-associated fibroblasts and polarization of macrophages toward an M2 phenotype may collectively contribute to an immunosuppressive niche. Emerging biomarkers, including CD74, and acquired resistance mechanisms after anti-C-C chemokine receptor 4 therapy further extend the translational relevance of recent pathologic findings. Overall, CTCL evolution appears to be a systemic process shaped by interactions between tumor-intrinsic genetic alterations and the skin microenvironment. Full article

The impact of anesthetic technique on long-term oncologic outcomes remains controversial. While early observational data suggested that regional anesthesia might reduce cancer recurrence, large randomized trials have failed to demonstrate consistent survival benefits. This apparent contradiction may not reflect biological neutrality, but rather a mismatch between trial design and the inflammatory biology of the perioperative period. Surgical resection provokes an acute and intense inflammatory surge characterized by sympathetic activation, cytokine release, neutrophil extracellular trap formation, endothelial activation, and transient suppression of cellular immunity. During this perioperative inflammatory window, circulating tumor cells encounter a biologically permissive microenvironment that may facilitate immune evasion, adhesion, and early metastatic niche establishment. The magnitude of this inflammatory response varies across patients and may represent a critical, yet under-recognized, determinant of tumor–host dynamics. Anesthetic and analgesic strategies influence this inflammatory cascade. By attenuating nociceptive signaling and sympathetic activation, regional anesthesia may modulate perioperative immune and immunometabolic pathways. However, it should not be framed as an anti-cancer therapy per se, but rather as a potential regulator of the transient inflammatory milieu that shapes early oncologic biology. We propose that prior neutral trials may reflect methodological misalignment, including heterogeneous tumor populations, absence of inflammatory stratification, and reliance on distant survival endpoints without mechanistic correlates. Future investigations should integrate perioperative immune phenotyping, inflammatory biomarkers, and tumor subtype stratification to determine whether modulation of acute surgical inflammation meaningfully alters early tumor–host interactions. Reconceptualizing the perioperative period as a biologically active inflammatory interface may refine the anesthesiologist’s role within perioperative oncology and open new avenues for precision-based perioperative modulation. Full article

Universities play a dual role as sites of learning and as institutions that certify student competence through assessment. The rapid diffusion of generative artificial intelligence (GenAI) challenges this certification function by altering the conditions under which assessment evidence is produced. When powerful AI tools are widely available, grades may increasingly reflect a combination of individual understanding and external cognitive support rather than solely independent competence. This study examines how changes in assessment format interact with GenAI availability to reshape observable performance outcomes in higher education. Using exam grade data from a compulsory undergraduate course delivered over five years (2021–2025; N = 1066), the study exploits a naturally occurring change in assessment conditions as a natural experiment. From 2021 to 2024, the course was assessed using an AI-permissive take-home examination, while in 2025 the assessment shifted to an AI-restricted, supervised in-person examination. Course content, intended learning outcomes, grading criteria, examiner continuity, and the structural design of the examination tasks remained stable across cohorts. The results reveal a pronounced shift in grade distributions coinciding with the format change. Failure rates increased sharply in 2025, mid-range grades declined, and the proportion of top grades remained largely unchanged. Statistical analysis indicates a significant association between examination period and grade outcomes (χ²(5, N = 1066) = 60.62, p < 0.001), with a small-to-moderate effect size (Cramér’s V = 0.24), driven primarily by the increase in failing grades. These findings suggest that AI-permissive and AI-restricted assessment formats may not be measurement-equivalent under conditions of widespread GenAI use. The results raise concerns about construct validity and the credibility of grades as signals of independent competence, while also highlighting tensions between certification credibility and assessment authenticity. Full article