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Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis
- Mohammad El-Nablaway,
- Hany M. A. Sonpol,
- Yaser Hosny Ali Elewa,
- Mohamed A. M. Ali,
- Mohamed Adel,
- Eman Serry Zayed,
- Maha Alhelf,
- Manar A. Didamoony,
- Amal Fahmy Dawood and
- Wesam S. El-Saeed
- + 2 authors
Background: The cardiotoxic effects of doxorubicin (DOX), a powerful chemotherapeutic drug, are widely recognized. Cuproptosis, a unique copper-dependent form of controlled cell death, may be involved in DOX-induced cardiomyopathy, according to recen...