Search Results (3,032)

Objectives: Although sex differences have been emphasized in stroke and congenital heart disease, there has been limited investigation into their role in patent foramen ovale (PFO) closure for secondary prevention of stroke. We aimed to explore differences by sex in baseline profiles, procedural characteristics, and short-term outcomes of patients undergoing transcatheter PFO closure. Methods: A retrospective analysis was conducted on 458 consecutive patients (265 women and 193 men) treated with PFO closure at Centro Cardiologico Monzino in Milan between 2006 and 2011. Baseline information included demographic characteristics, medical history, diagnostic and procedural information, and periprocedural complications. Post-closure outcomes were assessed at index hospitalization and during the first follow-up. Results: The indications for PFO closure were as follows: cryptogenic stroke/TIA in 78% of women vs. 88% of men (p = 0.04). Positive thrombophilic screening was observed in 16% of women vs. 19% of men (non-significant). We observed age-matched (mean age 44 ± 12 years) patients without sex-related differences in baseline and procedural characteristics, with the exception of greater arterial hypertension in women. The mean follow-up time was 13 years for both groups. Recurrent stroke was observed in 0.1% and TIA observed in 0.4% of the ‘cryptogenic stroke/TIA’ group; in the ‘other indications’ group, 1.4% experienced stroke and no TIA was reported. No significant differences were present between sexes. Conclusions: There were no differences in procedural and short-term outcomes between males and females undergoing transcatheter PFO closure, but significant baseline differences in risk factors were identified. There is a critical need for long-term, systematic studies to understand sex and gender differences in the PFO population. Full article

Global warming threatens sustainable human development, and carbon emission rights trading (CERT) has emerged as a key market-based tool for reducing emissions. Yet evidence on how CERT affects corporate green innovation—especially high-quality, substantive innovation—remains mixed and fragmented. Using unbalanced panel data on Chinese A-share listed firms from 2007 to 2016 and applying fixed-effect, DID, and PSM-DID models, this study examines the impact of China’s CERT pilot policy on quota-managed firms’ green innovation. The results show that the policy primarily stimulates substantive green innovation, reflected in green invention patents, with limited influence on strategic, low-novelty patents. Its effects are stronger for firms in central and western pilot regions, in non-high-tech industries, and at more mature stages of development, and differ between firms that anticipated regulation and those brought under quota management unexpectedly. Overall, the findings indicate that a well-designed carbon trading mechanism can reallocate resources to incentivize high-quality green innovation, offering micro-level support for Coasian market-based approaches to environmental externalities and informing the further development of China’s national carbon market. Full article

The past decade has witnessed an unprecedented transformation in breast cancer management, driven by parallel advances in targeted therapies, immunomodulation, drug-delivery technologies, and molecular diagnostic tools. This review summarizes the key achievements of 2015–2025, encompassing all major biological subtypes of breast cancer as well as technological innovations with substantial clinical relevance. In hormone receptor-positive (HR+)/HER2− disease, the integration of CDK4/6 inhibitors, modulators of the PI3K/AKT/mTOR pathway, oral Selective Estrogen Receptor Degraders (SERDs), and real-time monitoring of Estrogen Receptor 1 (ESR1) mutations has enabled clinicians to overcome endocrine resistance and dynamically tailor treatment based on evolving molecular alterations detected in circulating biomarkers. In HER2-positive breast cancer, treatment paradigms have been revolutionized by next-generation antibody–drug conjugates, advanced antibody formats, and technologies facilitating drug penetration across the blood–brain barrier, collectively improving systemic and central nervous system disease control. The most rapid progress has occurred in triple-negative breast cancer (TNBC), where synergistic strategies combining selective cytotoxicity via Antibody-Drug Conjugates (ADCs), DNA damage response inhibitors, immunotherapy, epigenetic modulation, and therapies targeting immunometabolic pathways have markedly expanded therapeutic opportunities for this historically challenging subtype. In parallel, photodynamic therapy has emerged as an investigational and predominantly local phototheranostic approach, incorporating nanocarriers, next-generation photosensitizers, and photoimmunotherapy capable of inducing immunogenic cell death and modulating antitumor immune responses. A defining feature of the past decade has been the surge in patent-driven innovation, encompassing multispecific antibodies, optimized ADC architectures, novel linker–payload designs, and advanced nanotechnological and photoactive delivery systems. By integrating data from clinical trials, molecular analyses, and patent landscapes, this review illustrates how multimechanistic, biomarker-guided therapies supported by advanced drug-delivery technologies are redefining contemporary precision oncology in breast cancer. The emerging therapeutic paradigm underscores the convergence of targeted therapy, immunomodulation, synthetic lethality, and localized immune-activating approaches, charting a path toward further personalization of treatment in the years ahead. Full article

With rising demand for clean energy and uncertainty surrounding large-scale renewable deployment, ammonia has emerged as a viable carrier for hydrogen storage and transportation. This study conducts a global patent-based analysis of ammonia-to-hydrogen production technologies to determine technological maturity, dominant design pathways, and emerging innovation trends. A statistically robust retrieval, screening, and classification process, based on the PRISMA guidelines, was employed to screen, sort, and analyze 708 relevant patent families systematically. Patent families were categorized according to synthesis processes, catalyst types, and technological fields. The findings indicate that electrochemical, plasma-based, photocatalytic, and hybrid systems are being increasingly investigated as alternatives to low-temperature processes. At the same time, thermal catalytic cracking remains the most established and widely used method. Significant advances in reactor engineering, system integration, and catalyst design have been observed, especially in Asia. While national hydrogen initiatives, such as those in Brunei, highlight the policy importance of ammonia-based hydrogen systems, the findings primarily provide a global overview of technological maturity and innovation trajectories, thereby facilitating long-term transitions to cleaner hydrogen pathways. Full article

Background: Human Immunodeficiency Virus type 1 (HIV-1) remains a major global health challenge. Despite advances in antiretroviral therapy, new prevention strategies are needed, particularly topical microbicides capable of blocking the earliest steps of viral entry. HIV-1 attachment relies on interactions with heparan sulfate proteoglycans on host cell surfaces; therefore, sulfated heparan-mimetic polymers have been explored as antiviral agents. In this context, sulfated chitosan microparticles are designed to mimic natural glycosaminoglycan receptors, acting as biomimetic decoys that prevent viral attachment and entry. Methods: Low-molecular-weight sulfated chitosan (LMW Chi-S) microparticles were synthesized and characterized (SEM, EDS, DLS, FTIR) following US Patent No. 11,246,839 B2. Their antiviral activity was evaluated by incubating the microparticles with high-viral-load HIV-1-positive plasma (~3.5 × 10⁶ copies/mL) to enable viral binding and removal by pull-down. The performance of the synthesized Chi-S microparticles was compared with established heparinoid controls, including soluble heparin and heparin microparticles. Results: Chi-S microparticles exhibited stronger virus-binding and neutralizing capacity than all heparinoid comparators, achieving up to 70% reduction in viral load relative to untreated HIV-1 plasma. In comparison, soluble heparin and heparin microparticles reduced viral load by approximately 53% and 60%, respectively. Subsequent evaluation across multiple tested concentrations confirmed a consistent antiviral effect, indicating that the synthesized Chi-S microparticles maintain robust virus–particle interactions throughout the concentration range examined. Conclusions: These findings demonstrate that LMW Chi-S microparticles possess potent antiviral properties and outperform classical heparinoid materials, supporting their potential application as topical microbicides targeting early HIV-1 entry mechanisms. Full article

Intracardiac echocardiography (ICE) is increasingly recognized as a valuable imaging modality in structural heart interventions, offering high-resolution, real-time visualization from within the cardiac chambers. Originally developed for electrophysiologic procedures, ICE has expanded its use across a broad spectrum of structural interventions, including atrial septal defect (ASD) and patent foramen ovale (PFO) closure, left atrial appendage occlusion (LAAO), transseptal puncture guidance, transcatheter edge-to-edge repair (TEER), balloon mitral valvuloplasty, and both mitral and tricuspid valve therapies. This review outlines the current role and technical principles of ICE, with an emphasis on catheter design, image acquisition protocols, and the emerging potential of 3D ICE. Comparisons with transesophageal echocardiography (TEE) and fluoroscopy are discussed, highlighting ICE’s ability to support minimally invasive, sedation-sparing procedures while maintaining procedural precision. We provide a focused analysis of ICE-guided applications in specific clinical scenarios, emphasizing its role in anatomical assessment, device navigation, and intra-procedural monitoring. Data from recent clinical studies and registries are reviewed to assess safety, feasibility, and outcomes. Practical considerations including operator learning curve, workflow integration, and limitations such as cost and field of view are also addressed. Lastly, we explore future directions including advanced 3D imaging, fusion imaging, artificial intelligence integration, and robotic catheter systems. Full article

This paper reports part of the research results carried out within the National Centre for Sustainable Mobility (MOST—CN4)—Spoke 5 “Light Vehicle and Active Mobility”—funded by the Italian National Recovery and Resilience Plan (PNRR). Specifically, it presents the design of a bicycle frame based on the pursuit of maximum modularity and adaptability. The research investigates multi-level modularity as a strategic design lever to improve flexibility, usability, and production efficiency in light vehicles. A design-driven and interdisciplinary methodology combined a systematic analysis of 76 patents with a qualitative cross-comparison of 15 case-study products and collaborative co-design activities involving domain experts. The resulting insights informed the development of a modular bike frame prototype, enabling evaluation of user-centered adaptability, production-oriented modularity, and functional transformations such as e-bike integration and cargo configurations. Findings provide evidence-based, qualitative insights and practical design exploration for modular light vehicle development, offering an operational framework and laying the groundwork for a structured, generalized framework to guide future research and industrial applications. Full article

Salmonella spp. is a pathogenic microorganism linked to eggs and egg products. In-shell eggs are not required to be pasteurized in any country before they reach the consumer. The use of an emerging technology known as radio frequency has been successfully used to inactivate this pathogen inside in-shell eggs and claim pasteurization standards (5 - log reduction). The objective of this manuscript was to conduct the engineering cost of egg processing using a radio frequency pasteurizer and compare the processing cost to conventional thermal pasteurization for in-shell eggs. The ARS-patented radio frequency pasteurizer was used (40.68 MHz, 35 W) to pasteurize eggs in 24.5 min. The conventional thermal pasteurization (56.7 °C) required 60 min for the same level of inactivation. The techno-economic analysis (TEA) included information from stakeholders, egg processors and equipment manufacturers and was used together with energy balances and some key assumptions. Calculations for the engineering cost were made based on the required energy for each system, showing that the radio frequency required a third of the total cost of electricity to pasteurize eggs in a year compared with thermal, based on utilities costs in PA. Other utilities such as water and steam were also minor for radio frequency pasteurization. After two years of operation, the projected additional cost of processing is ~USD 0.19 per egg for the radio frequency system, compared with USD 0.22 per egg for conventional thermal treatment, largely due to volume-based amortization of capital costs and lower annual operating costs for the RF process. Radio frequency thus could be an option to pasteurize eggs in farms from PA and potentially in other states, using the system developed by our research team, while reducing energy consumption and increasing return on investment. Full article

Usually, gluten-free “beers” are produced by replacing cereals containing gluten with substitutes that do not contain it or, alternatively, through enzymatic, precipitation, and/or clarification steps. The research was aimed at increasing the concentration of antioxidant compounds and improving the sensory quality of gluten-free craft beers produced from gluten-containing raw materials according to a patented brewing method that represented the starting point of the research. The experiments were organized to evaluate the effects of original combinations of four brewing procedures (Strong, Light, Very Light, Ultra-Light—differing from each other by grains/water ratio, hops/water ratio, protein rest, and boiling time), three yeast strains (M21, K97, S33), and a possible dry hopping. The beer gluten contents ranged from <5 to 13.90 mg/L. The maximum total phenolic content (200 mg/L) was detected in beers produced by combining the Light procedure, inoculation with M21 strain, and dry hopping. The highest overall sensory quality scores (4.0) were assigned to the beers obtained through the Light and Ultra-Light procedures, fermented by M21 and S33 strains, and dry hopped. Dry hopping was the main factor capable of differentiating the beers, increasing antioxidant content and improving perlage, foam characteristics, the intensity of many olfactory and gustatory characteristics, and the overall sensory quality. The brewing procedure affected all the physico-chemical indices and most sensory characteristics, except for color, citrous and spicy flavors, sweetness, effervescence, and body. The use of different yeasts did not impart significant differences for most of the variables considered. Full article

Background/Objectives: Although the outcomes of endoluminal lacrimal duct recanalization (ELDR) for nasolacrimal duct (NLD) obstruction are associated with the obstruction length, NLD obstruction has not been quantified. In this study, we aimed to quantify the obstruction length using a calibrated dacryoendoscope and investigate its relationship with surgical outcomes following endoscopic recanalization of the lacrimal passage. Methods: We retrospectively analyzed the eyes of patients who underwent ELDR using a calibrated dacryoendoscope at our institution between January 2023 and February 2025. Patients with dacryocystitis detected during preoperative irrigation testing were excluded. A lacrimal tube was placed for 2 months after recanalization, and we used the calibrated dacryoendoscope to measure the obstruction length. The 3-month postoperative outcomes were determined using irrigation testing, subjective symptoms, and cotton thread testing. Results: A total of 31 eyes of 26 patients (6 eyes of 5 males; 25 eyes of 21 females; mean age, 68.8 ± 10.5 years) were included in this study. The mean obstruction length was 10.8 mm (range: 1–30 mm). The nasolacrimal duct was patent, showed reflux, and was obstructed in 12, 16, and 3 eyes, respectively, at 3 months. The symptoms resolved, improved, and remained unchanged in 18, 11, and 2 eyes, respectively. Trend analysis revealed a significant relationship between the obstruction length and irrigation outcomes. However, no significant association was observed with the symptoms. The obstruction length was significantly correlated with the 3-month postoperative cotton thread test results. Conclusions: The NLD obstruction length was associated with the 3-month postoperative irrigation test results, and longer obstruction was associated with poorer postoperative outcomes. Full article

The economic and legal framework is transforming with the change in the globalization paradigm, accompanied by structural and quantitative changes in intellectual property assessment. This study aims to justify commercialization and analyze the innovation management of intellectual property as a fundamental socio-economic institution and improve theoretical perspectives on its current development processes. This study surveyed 100 companies to identify the factors determining intellectual property use and its commercialization. The analysis of the structure of intellectual property revealed a 14% decrease in trademark applications and a 2% increase in patent applications. This research highlights the specifics of intellectual property generation through machine learning: mass creation of new objects, reduction in innovation product development cycles, increased accuracy of market demand forecasting, and adaptive problem solving. An analysis of budget expenditures on intellectual property in the EU based on the specific value of patent activity identified five classification groups (ranging from 0.17 to 0.23% to 1.23–2.26% of GDP), each exhibiting different economic activities and innovation intensity. Full article

Pharmaceutical cocrystals are a well-established class of solid-state forms that can modulate the solubility, dissolution, stability, and bioavailability of active pharmaceutical ingredients without altering their molecular identity. Although traditional oral formulations have demonstrated translational potential, recent research has emphasized the importance of integrating cocrystals into emerging drug-delivery technologies. This review systematically analyzes recent advances in conventional and innovative cocrystal-based platforms, critically evaluating their therapeutic relevance. A comprehensive literature search was conducted, focusing on publications from the last decade, with emphasis on studies from 2020 to 2025, including peer-reviewed articles, patents, and regulatory documents. Evidence was organized into traditional oral, inhalable, intranasal, and transdermal formulations, followed by emerging platforms such as 3D printing, nano-cocrystals, and microneedles. Case studies and preclinical/clinical data were critically assessed to identify strengths, limitations, and future directions. Advancements in formulation science and novel delivery technologies are allowing pharmaceutical cocrystals to transition from laboratory innovations to clinical applications. Despite challenges in scalability, stability, and regulatory clarity, the application of cocrystals into emerging platforms highlights their potential as transformative tools in next-generation therapeutics. Full article

Background/Objectives: Aneurysmal subarachnoid hemorrhage (aSAH) involves a sudden onset of a perfusion-pressure injury from the initial insult combined with a secondary injury phase produced by delayed cerebral ischemia, cerebrospinal fluid circulation disturbances, and generalized instability of the patient’s physiological state. The situation may be further complicated when there has been rupture of the aneurysm at the site of the carotid–posterior communicating (PCom) artery junction that occurs in conjunction with a fetal configuration of the posterior cerebral artery (fPCA), thereby making definitive treatment dependent on preserving the critical nature of the branches of the posterior circulation since the aneurysm’s neck plane coincides with the dominant posterior circulation conduit. Case Presentation: A 65-year-old female patient who was obese (Grade III BMI = 42), had chronic bronchial asthma, and arterial hypertension experienced a “thunderclap” type of headache in the right retro-orbital area followed by a syncopal episode and developed acute confusion with agitation. Upon admission to the hospital, her Glasgow Coma Scale (GCS) was 13, her FOUR score was 15, her Montreal Cognitive Assessment (MoCA) score was 12/30, her Hunt–Hess grade was 3, WFNS grade 2, and Fisher grade 4 SAH with intraventricular extension. Digital subtraction angiography (DSA) and three-dimensional rotational angiography revealed a posteriorly directed right carotid communicating aneurysm that had a relatively compact neck (approximately 2.5 mm) and sac size of approximately 7.7 × 6.6 mm, with the fPCA originating at the neck plane. Microsurgical treatment was performed with junction-preserving reconstruction with skull base refinement, temporary occlusion of the internal carotid artery for a few minutes, placement of clips reconstructing the carotid–PCom interface, and micro-Doppler verification of patent vessel. Postoperatively, the blood pressure was kept within the range of 110–130 mmHg with nimodipine and closely monitored. The neurological recovery was sequential (GCS of 15 by POD 2; MoCA of 22 by POD 5). By POD 5 CT scan, the clip remained positioned in a stable fashion without evidence of infarct, hemorrhage, or hydrocephalus; at three months she was neurologically intact (mRS 0; Barthel 100; MoCA 28/30), and CTA confirmed persistent exclusion of the aneurysm and preservation of fPCA flow. Conclusions: In cases where the ruptured aneurysm is located at the carotid communicating junction with the PCom artery in a configuration of the posterior cerebral artery that is described as fetal, clip treatment should be viewed as a form of branch-preserving junction reconstruction of the carotid–PCom junction supported by adherence to controlled postoperative physiology and close ppostoperativesurveillance. Full article

Developing a deep understanding of the evolutionary driving mechanisms of university–industry collaborative innovation networks among Chinese cities is of great significance for advancing sustainable urban development. Based on university–industry collaborative patent data from 275 prefecture-level and above cities in China during the period 2004–2020, this study constructs an intercity university–industry collaborative innovation network and employs the temporal exponential random graph model to analyze its evolutionary driving mechanisms. The results indicate that the network structure has become increasingly complex over time and exhibits pronounced small-world characteristics in the later stages. Network formation is distinctly non-random and is jointly shaped by endogenous structural effects and exogenous factors. Diffusion, connectivity, and closure effects are all significant, while intercity collaborative ties are influenced by multidimensional proximity, including economic, geographic, and organizational proximity. Moreover, the network structure demonstrates strong temporal stability. In the context of high-intensity collaboration, cities place greater emphasis on economic and organizational proximity, and cities with higher levels of economic development and prior experience in high-intensity collaboration are more likely to establish collaborative ties. Furthermore, eastern cities tend to collaborate with partners at similar levels of economic development, whereas cities in central and western regions display a more pronounced core–periphery pattern. Overall, from the perspective of intercity university–industry collaborative innovation networks, this study provides new empirical evidence and insights for promoting coordinated regional innovation capacity and sustainable urban development. Full article

This work focuses on testing and validating a prototype device for measuring mass transfer phenomena in biomass drying processes, patented by the Universitat Politècnica de València (UPV) and Escuela Politécnica del Litoral (ESPOL), WO2025/109237 A1. The first step involved evaluating and calibrating the sensors of the measuring device to ensure accurate and consistent measurements. Subsequently, extensive tests were conducted to validate the prototype’s functionality for obtaining mass diffusivity and the mass transfer coefficient by convection at the solid-air interface. Finally, the results obtained were compared with those provided by existing predictive theoretical models in the literature. Areas for improvement in the theoretical models were identified, and adjustments were made to optimize prediction. The study highlights that the theoretical Sherwood method for estimating the mass transfer coefficient shows discrepancies with experimental data, mainly due to the assumption that the transfer coefficient remains constant during drying, whereas it actually varies with the material’s moisture content. This leads to inaccuracies that affect the efficiency of industrial drying systems. The prototype proved effective in measuring both diffusivity and mass transfer coefficient, validating the method. Full article