307,451 Results Found

Avian reovirus p17 (ARV p17) is a non-structural protein known to activate autophagy, interfere with gene transcription and induce a significant tumor cell growth inhibition in vitro and in vivo. In this study, we show that ARV p17 is capable of exer...

Avian reoviruses (ARV) are a group of poultry pathogens that cause runting and stunting syndrome (RSS), a condition otherwise known as “frozen chicken”, which are characterized by dramatically delayed growth in broilers. It has been known...

Non-Hodgkin lymphoma (NHL) remains the most common malignancy and cause of death among human immunodeficiency virus (HIV-1)-positive individuals, its prevalence remaining even after the introduction of combined antiretroviral therapy (cART). The mech...

Avian reovirus (ARV) causes viral arthritis, chronic respiratory diseases, retarded growth and malabsorption syndrome. However, the precise molecular mechanism remains unclear. Here, we report the host cellular proteins that interact with ARV p17 by...

p17, the human immunodeficiency virus type 1 (HIV-1) matrix protein traditionally associated with viral assembly, has been recently investigated for its extracellular functions linked to vascular damage. This review examines the molecular and pathoge...

In this study, we investigated the long-term evolutionary dynamics of human norovirus GII.17[P17] using the RNA-dependent RNA polymerase (RdRp) region and the VP1 capsid gene, integrating phylogenetics, time-scaled inference, phylodynamics, and struc...

Since 2018, the outbreak and prevalence of the African swine fever virus (ASFV) in China have caused huge economic losses. Less virulent ASFVs emerged in 2020, which led to difficulties and challenges for early diagnosis and control of African swine...

The human immunodeficiency virus (HIV-1) matrix protein p17 (p17) is released from infected cells as a protein capable of deregulating the biological activity of different cells. P17 variants (vp17s), more frequently detected in the plasma of HIV-1⁺...

African swine fever virus (ASFV) causes African swine fever (ASF), a highly lethal disease in pigs. Vietnam has approved two ASF live-attenuated vaccines (LAVs), but their efficacy and safety remain controversial, and no reliable, highly effective co...

African swine fever (ASF) has widely spread around the world in the last 100 years since its discovery. The African swine fever virus (ASFV) particles are made of more than 150 proteins, with the p17 protein encoded by the D117L gene serving as one o...

African swine fever virus (ASFV) is a highly pathogenic large DNA virus that causes African swine fever (ASF) in domestic pigs and wild boars. The p17 protein, encoded by the D117L gene, is a major transmembrane protein of the capsid and the inner li...

To explore whether the p17 protein of oncolytic avian reovirus (ARV) mediates cell migration and invadopodia formation, we applied several molecular biological approaches for studying the involved cellular factors and signal pathways. We found that A...

Although the advent of combined antiretroviral therapy has substantially improved the survival of HIV-1-infected individuals, non-AIDS-related diseases are becoming increasingly prevalent in HIV-1-infected patients. Persistent abnormalities in coagul...

The members of the p53 family comprise p53, p63, and p73, and full-length isoforms of the p53 family have a tumor suppressor function. However, p53, but not p63 or p73, has a high mutation rate in cancers causing it to lose its tumor suppressor funct...

Transforming growth factor-beta (TGFβ1) is considered as a master regulator for many intracellular signaling pathways, including proliferation, differentiation and death, both in health and disease. It further represents an oncogenic factor in a...

Feline oral squamous cell carcinoma (FOSCC) is a highly aggressive head and neck cancer in cats, but the molecular pathogenesis of this cancer is still uncertain. In this study, p16, p53, and pRb proteins were detected and quantified by immunohistoch...

A graph G is said to be perfect if $\omega \left(H\right)=\chi \left(H\right)$ for every induced subgraph H of G, where $\omega \left(H\right)$ and $\chi \left(H\right)$ denote the clique number and the chromatic number of H. We say that a graph G admits a perfect division if its vertex set can be p...

In recent years, $(p,q)$-special polynomials, such as $\left(p,q\right)$-Euler, $\left(p,q\right)$-Genocchi, $\left(p,q\right)$-Bernoulli, and $\left(p,q\right)$-Frobenius-Euler, have been studied and investigated by many mathematicians, as well physicists. It is important that any polynomial have explicit form...

Glioblastoma (GBM), the most common primary brain tumor, is a complex and extremely aggressive disease. Despite recent advances in molecular biology, there is a lack of biomarkers, which would improve GBM’s diagnosis, prognosis, and therapy. He...

According to the United Nations (UN) Refugee Agency, there were 79.5 million forcibly displaced people worldwide by the end of 2019. Evictions from homes and land are often linked to protracted violent conflict. Land administration (LA) can be a smal...

After the observation of the strong near-threshold enhancement of proton-antiproton mass spectrum in $J/\psi \to \gamma p$...

Rising awareness and emergence of smart technologies have inspired new thinking in energy system management. Whilst integration of distributed energy resources in micro-grids (MGs) has become the technique of choice for consumers to generate their en...

The TP53 gene is a critical tumor suppressor and key determinant of cell fate which regulates numerous cellular functions including DNA repair, cell cycle arrest, cellular senescence, apoptosis, autophagy and metabolism. In the last 15 years, the p53...

Given a positive integer n, a finite group G is called quasi-core-n if $⟨x⟩/{⟨x⟩}_G$ has order at most n for any element x in G, where ${⟨x⟩}_G$ is the normal core of $⟨x⟩$ in G....

Applications running over peer-to-peer (P2P) networks have exploded since the late 1990s. Research is needed into many aspects of P2P. These include architecture, application functionality, and the categories of digital works that are shared using P2...

p53-dependent signaling and the integrated stress response (ISR) are major stress response programs that coordinate cellular metabolism and cell fate decisions. While p53 activation often promotes cell cycle arrest and cell death, the ISR can support...

The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all famil...

In this paper, we introduce the $\left(\rho ,q\right)$ -analog of the p-adic factorial function. By utilizing some properties of $\left(\rho ,q\right)$ -numbers, we obtain several new and interesting identities and formulas. We then construct the p-adic $\left(\mathrm{\&rho}\right)$...

Let G be a graph. We denote the chromatic (clique) number of G by $\chi \left(G\right)\left(\omega \right(G\left)\right)$. In this paper, we prove that (i) $\chi \left(G\right)\le 2\omega \left(G\right)$ if G is ($P_3\cup P_2$, kite)-free, (ii) $\chi \left(G\right)\le {\omega }^2\left(G\right)$ if G is ($P_3\cup P_2$, hammer)-free, (iii) $\mathrm{\&chi}$...

The classical tests for combining p-values use suitable statistics $T(P_1,\dots ,P_n)$, which are based on the assumption that the observed p-values are genuine, i.e., under null hypotheses, are observations from independent and identically distributed...

Wind turbines (WTs) are exposed to a dynamic/cyclic load environment, and are subjected to 1P/3P loads under operational conditions. Recent studies introduced the Sommerfeld Effect to explain the dynamic response amplification induced by 1P/3P loads....

Background: This study aimed to investigate the role of ROS/MAPK signaling pathways and the effects of baicalin in LPS-induced inflammatory responses in mice and porcine intestinal epithelial cells (IPEC-J2). Methods: In vivo, 18 male C57BL/6J mice w...

In this review we focus on the major isoforms of the tumor-suppressor protein p53, dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the DNA binding domain, have been regarded as the main cause for p53 inactivati...

This study aimed to investigate the expression of microRNAs (miRNAs) -146b-3p, -221-5p, -222-3p, and -21a-3p and the methylation pattern of the thyroid-stimulating hormone receptor (TSHR) gene in blood plasma samples from papillary thyroid cancer (PT...

Microglia cells represent the immune system of the central nervous system. They become activated by ATP released from damaged and inflamed tissue via purinergic receptors. Ionotropic purinergic P2X4 and P2X7 receptors have been shown to be involved i...

In this article, the $(p,q)$-analogs of the $\alpha$-th fractional Fourier transform are provided, along with a discussion of their characteristics in specific classes of $(p,q)$-generalized functions. Two spaces of infinitely $(p,q)$-differentiable functio...

Inflammatory breast cancer (IBC) is a rare yet aggressive breast cancer variant, associated with a poor prognosis. The major challenge for IBC is misdiagnosis due to the lack of molecular biomarkers. We profiled dysregulated expression of microRNAs (...

Early hepatocellular carcinoma (HCC) diagnosis is challenging. Moreover, for patients with alpha-fetoprotein (AFP)-negative HCC, this challenge is augmented. MicroRNAs (miRs) profiles may serve as potential HCC molecular markers. We aimed to assess p...

S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. It has been hypothesized that the oncogenic function of S100P may involve binding-induced inactivation of p53. We used ¹H-¹⁵N HSQC experiments and molec...

This paper summarizes the results of investigations into heterogeneous P23/P91 welds after long-term creep exposure at temperatures of 500, 550 and 600 °C. Two variants of welds were studied: In Weld A, the filler material corresponded to P91 ste...

Transactivation of p21 (cyclin-dependent kinase inhibitor 1A, CDKN1A) is closely related to the recruitment of transcription cofactors at the p53 responsive elements (p53REs) in its promoter region. Human chromatin remodeling enzyme INO80 can be recr...

Peer-to-peer (P2P) systems are widely used to exchange content over the Internet. Knowledge of pedophile activity in such networks remains limited, despite having important social consequences. Moreover, though there are different P2P systems in use,...

Background: Cardiovascular diseases remain important causes of morbidity and potential premature mortality in children. Although clinical imaging and electrophysiologic testing have advanced, early, minimally invasive biomarkers that can both detect...

Cyclin-dependent kinase inhibitor p16 (CDKN2A) primarily functions as a negative regulator of the retinoblastoma protein (pRb) pathway to prevent pRb phosphorylation, thus playing a critical role in cell cycle arrest. In canine lymphoma cells, methyl...

T-2 mycotoxins are known to induce toxic effects in animals. The kidneys are particularly vulnerable to oxidative stress induced by toxins, resulting in cellular damage, apoptosis, and disruptions to cell cycle regulation. Cyclin-dependent kinase inh...

The regularity of the n-P-V-rings and n-P-V’-rings is systematically investigated in this paper. Employing the notions of quasi-ideals, weakly left (or right) ideals, and generalized weak ideals, we focus on investigating the strong $\pi$-regula...

Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be responsible for MDR and making the treatment regimens ineffective. In th...

In this paper, we study asymptotic semicircular laws induced both by arbitrarily fixed $C^{*}$ -probability spaces, and p-adic number fields ${\left\{{\mathbb{Q}}_p\right\}}_{p\in \mathcal{P}}$ , as p→ ∞ in the set $\mathcal{P}$ of all primes.

Moyamoya angiopathy (MA) is a rare cerebrovascular disorder characterised by the progressive occlusion of the internal carotid artery. Its aetiology is uncertain, but a genetic background seems likely, given the high MA familial rate. To investigate...

Peer-to-peer (P2P) applications have been popular among users for more than a decade. They consume a lot of network bandwidth, due to the fact that network administrators face several issues such as congestion, security, managing resources, etc. Henc...