Search Results (2,694)

This study investigated whether black soldier fly larvae meal (BSFL; Hermetia illucens L.) produced on polyphenol-rich agro-industrial by-products could enhance broiler meat lipid quality and oxidative stability during refrigerated storage. A total of 200 one-day-old Arbor Acres broilers were allocated to five dietary treatments: control diet, 5% standard full-fat BSFL meal, 10% standard full-fat BSFL meal, 10% full-fat BSFL meals produced on olive leaf and spent tea residues, and 10% defatted BSFL meal. Compared with standard full-fat BSFL meal, the olive leaf–spent tea BSFL meal showed markedly higher total phenolic content (6.74 vs. 1.82 mg GAE/g DM), DPPH radical-scavenging activity (54.80 vs. 22.40%) and ABTS antioxidant capacity (38.20 vs. 15.60 umol TE/g DM), together with lower peroxide value (1.46 vs. 2.38 meq O₂/kg lipid) and TBARS (0.24 vs. 0.39 mg MDA/kg meal). Also, when compared with 10% standard full-fat BSFL meal, the olive leaf–spent tea BSFL meal improved final body weight (2592.8 vs. 2511.6 g) and feed conversion ratio (1.53 vs. 1.58). Breast meat from this group contained higher oleic acid (40.52 vs. 37.48%) and a-linolenic acid (1.72 vs. 1.29%), while showing a lower n-6/n-3 ratio (11.81 vs. 14.49) and thrombogenicity index (0.78 vs. 0.92). After 10 days of refrigerated storage, breast meat from birds fed the polyphenol-enriched BSFL meal showed markedly lower oxidative deterioration, as indicated by reduced TBARS values (0.60 vs. 1.12 mg MDA/kg), protein carbonyl formation (2.16 vs. 3.35 nmol/mg protein) and hexanal abundance (5.10 vs. 11.90 a.u.; internal-standard-normalized peak area). This treatment also better-preserved redness, as reflected by higher CIE values (3.52 vs. 2.40), compared to the control group. Overall, these results suggest that substrate-tailored BSFL meal may serve as a functional feed ingredient for improving the lipid quality of broilers’ breast meat and delaying oxidation-driven quality deterioration during refrigerated storage. Full article

This study aimed to develop a spray-dried tahini-based powder enriched with pea protein and coconut milk powder and to comprehensively characterize its plant bioactive composition, antioxidant potential, nutritional properties, and bioaccessibility following the standardized INFOGEST in vitro static gastrointestinal digestion protocol. A stable oil-in-water emulsion containing tahini (50%), pea protein (30%), and coconut milk powder (20%) was prepared by microfluidization and converted into powder by spray drying. The resulting powder exhibited considerable total phenolic content and antioxidant activity, together with distinct amino acid and fatty acid profiles. Simulated gastrointestinal digestion significantly altered the phenolic profile and antioxidant capacity, while several key bioactive compounds showed measurable in vitro bioaccessibility in the intestinal fraction. The formulation also contained high levels of protein (52.69%), lipid (26.42%), and dietary fiber (8.28%) with low moisture (2.28%). Phosphorus, potassium, calcium, and magnesium were the predominant minerals, whereas oleic and linoleic acids were the major fatty acids. Overall, the developed spray-dried tahini-based powder represents a nutritionally valuable plant-derived functional ingredient combining antioxidant potential with the bioaccessibility of essential nutrients. Full article

This study aimed to evaluate the effects of milk replacer (MR) feeding on carcass characteristics, meat quality, and fatty acid profile in suckling goat kids through a meta-analysis. The electronic databases Scopus, Web of Science, PubMed, and Google Scholar were used to identify the articles required for the meta-analysis using the PRISMA methodology. The data used in this meta-analysis were obtained from 13 English-language articles published in peer-reviewed journals between January 2005 and May 2026. All data were analyzed using random-effects models. Feeding with MR did not affect (p > 0.05) body weight at slaughter, hot carcass weight, or hot carcass yield of suckling kids. However, a lower renal fat weight (p < 0.05) was observed in kids fed MR. On the other hand, feeding with MR did not affect (p > 0.05) meat pH at 24 h, lightness (L*), redness (a*), yellowness (b*), Chroma (C*), Hue (H°), Warner-Bratzler shear force, or the moisture, protein, fat, collagen, and ash content in the meat of suckling kids. Nevertheless, a lower water-holding capacity (p < 0.05) was observed in the meat of kids fed MR. Feeding with MR did not affect (p > 0.05) the concentration of caproic, caprylic, lauric, myristic, myristoleic, palmitoleic, heptadecanoic, oleic, alpha-linolenic, arachidonic acid, behenic acids, total saturated fatty acids, total monounsaturated fatty acids, and total polyunsaturated fatty acids. However, lower concentrations (p < 0.05) of capric, pentadecanoic, palmitic, stearic, and arachidic acids were observed in the meat of suckling kids fed MR. In contrast, higher concentrations (p < 0.05) of linoleic acid were observed in the meat of suckling kids fed MR. In conclusion, the use of milk replacer in suckling kids preserves growth, carcass traits, and most meat quality attributes, while reducing renal fat deposition and selectively modifying the fatty acid composition toward a higher linoleic acid content. Full article

The growing demand for sustainable protein sources has increased interest in edible insects and their potential role within circular bioeconomy strategies. This study evaluated the suitability of brewer’s spent grain (BSG), cocoa bean shell (CBS), and banana peel (BP) as alternative substrates for Tenebrio molitor rearing and assessed the valorization of the resulting biomass through pilot-scale supercritical CO₂ extraction (CO₂-SFE). Larvae reared on BSG-based and BP-based diets achieved growth performances comparable to those obtained with a conventional wheat bran diet, whereas CBS-based diet resulted in lower weight gain and feed intake. No significant differences in feed conversion ratio were observed among diets. Substrate composition also affected biomass nutritional quality, with larvae reared on the BSG-based diet exhibiting the highest protein content (60.4%), whereas larvae reared on CBS-based diet exhibited the highest lipid content (29.3%). CO₂-SFE generated protein-enriched meals and lipid-rich extracts, yielding 12.9–15.4% oil depending on the substrate. Following extraction, protein content increased to 68.5%, 50.3%, and 60.2% in BSG-, CBS-, and BP-derived meals, respectively. The extracted oils were characterized by high levels of unsaturated fatty acids, with oleic acid (42.4–47.6%) as the predominant component. Overall, the results demonstrate that agro-industrial by-products can be effectively converted into valuable insect-derived ingredients and highlight the potential of integrating substrate selection with green extraction technologies within insect biorefinery systems. Full article

Oxidative stress is a major physiological constraint on industrial lager yeast, compromising fermentation efficiency and flavor quality. Unsaturated fatty acids are known to influence membrane fluidity, but whether exogenous fatty acid supplementation can actively reprogram the yeast defense system, beyond serving as a passive membrane component, remains unclear. Here, we compared the effects of four fatty acids (palmitic, palmitoleic, oleic, and linoleic acid) on oxidative stress tolerance and fermentation performance in industrial lager yeast, under a defined chemical oxidative challenge (2.0 mM H₂O₂) in 15 °P wort, combining physiological assays with targeted gene-expression and untargeted metabolomic analyses; the dose was selected from a 0–2.0 mM gradient, with an ethanol-vehicle control included throughout. Among the fatty acids tested, palmitoleic acid (POA) most markedly enhanced oxidative stress tolerance, maintaining 91% cell viability, restoring intracellular pH to 6.1 by 24 h after transient acidification, and reducing ROS accumulation by 41.2%. Mechanistically, POA upregulated the antioxidant system, increasing catalase and glutathione peroxidase activities by 35.6% and 85.5%, respectively, and restoring glutathione levels by 35.5%. Metabolic profiling revealed a global reconfiguration, including a 2.6-fold increase in the stress-protectant proline and elevated pantothenate and coenzyme A levels, accompanied by a shift in the volatile profile toward esters, which rose from 26.1% to 60.3% of the total pool, alongside a 52.1% increase in total volatiles that did not reach significance after correction for multiple testing (q = 0.070); sensory evaluation confirmed higher fruity-estery intensity and lower soapy and staling notes in the POA beer. These findings identify POA as an active metabolic modulator, not merely a passive structural lipid, pointing to a non-transgenic nutritional strategy whose industrial value now requires validation under high-gravity, pilot-scale, and serial-repatching conditions. Full article

Background/Objectives: Tumor-associated macrophages (TAMs) are critical mediators for immunosuppressive ovarian tumor microenvironments. However, the lipid metabolic features of macrophages at different stages of ovarian tumor development remain poorly understood. Methods: Here, we performed LC-MS-based lipidomic profiling of CD11b⁺/F4/80⁺ macrophages isolated from ID8 tumor-bearing C57/BL6 mice at Days 10, 40, and 80 following tumor cell inoculation. Results: Principal component analysis and hierarchical clustering revealed stage-associated differences in macrophage lipid profiles. Phosphatidylethanolamine (PE), phosphatidylserine (PS), and lysophosphatidylcholine (LPC) were relatively more abundant at earlier time points, whereas triglyceride (TG) species were more abundant in macrophages isolated at Day 80. Detailed analysis revealed an increased abundance of TG species with greater total numbers of double bonds at Day 80. Pathway analysis identified enrichment of glycerolipid metabolism at Day 80. Consistent with these lipidomic findings, macrophages at Day 80 exhibited increased expression of lipogenic regulators, including Fasn, Pparg, and Srebp1, together with a gene expression profile associated with a pro-tumoral macrophage state. Supplementation of oleic acid to macrophages increased expression of selected genes associated with this macrophage state, supporting a potential relationship between altered lipid metabolism and macrophage gene expression changes. Conclusions: These findings identify stage-associated TG accumulation and alterations in macrophage lipid metabolism and provide a basis for future studies to determine whether macrophage lipid metabolism contributes to a pro-tumoral macrophage state. Full article

Phytochemicals modulate lipid metabolism, but it remains unclear whether phytochemical-rich cactus fruits have a similar effect. Accordingly, the effects of Etcho (Pachycereus pecten-aboriginum) fruit juice on lipid accumulation and on the expression of CD36 and ADIPOR1 were investigated, and the potential interactions between its major betalains and the CD36 and ADIPOR1 receptors were predicted. Phytochemical content was determined by spectrophotometry. Human adipocytes were stimulated with a 2:1 (molar) oleic/palmitic acid mixture and then treated with Etcho fruit juice/its hydroethanolic extract/betanin. Lipid accumulation was measured by Oil Red O staining, and CD36 and ADIPOR1 expression were quantified by qPCR. Molecular docking was performed to assess the binding affinities and molecular interactions of betanin, indicaxanthin, and phyllocactin with CD36 and ADIPOR1. All treatments reduced long-chain fatty acid–induced lipid accumulation (p < 0.05). The juice decreased CD36 mRNA and increased ADIPOR1 mRNA levels (p < 0.05), and molecular docking revealed that its betalains bind strongly to the CD36 extracellular domain and the ADIPOR1 orthosteric pocket triad. Etcho fruit juice is a source of phenolics and betalains. It reduces lipid accumulation in human adipocytes and modulates the expression of CD36 and ADIPOR1. The juice’s major betalains may target CD36 and ADIPOR1. Full article

Objective: Ablative fractional laser (AFL) therapy impairs epidermal barrier integrity through the disruption of stratum corneum lipids and keratinocyte differentiation, resulting in increased transepidermal water loss (TEWL) and delayed functional recovery. This study aims to develop a more effective barrier repair strategy and evaluate the efficacy of topical safflower seed oil (SSO) in promoting post-AFL barrier restoration. Methods: An optimized murine AFL model (20 W, 0.5 ms pulse delay, and 0.7 mm spot spacing) was established to investigate skin repair mechanisms. SSO composition was characterized by gas chromatography–mass spectrometry (GC-MS). Epidermal repair was assessed using confocal laser scanning microscopy, while Oil Red O staining and immunofluorescence were employed to evaluate lipid formation and the expression of lipid synthesis-related genes, respectively. Results: GC-MS analysis identified SSO as a rich natural source of linoleic acid (69.1%) and oleic acid (18.7%). Over the 7-day period of AFL exposure alone, TEWL rose by 4–6 fold in mouse skin, accompanied by a near-complete loss of epidermal lipid synthesis. However, upon SSO administration, a marked reduction in TEWL was observed from day 1, and epidermal lipid synthesis recovered by day 7. Moreover, SSO treatment significantly upregulated epidermal PPARγ expression in AFL-injured skin. Pharmacological inhibition of PPARγ (T0070907) largely abrogated the lipid synthesis and barrier repair effects of SSO, while PPARα antagonism (GW6471) showed no obvious interference with SSO’s therapeutic efficacy, suggesting a potential association between PPARγ signaling modulation and SSO-mediated skin barrier restoration. Conclusions: These findings suggest that SSO is a promising natural agent for post-AFL skin care, which improves AFL-impaired skin barrier function by remodeling lipid metabolism, at least in part through PPARγ signaling, and warrants further preclinical and clinical investigation. Full article

Pecan oil is a valuable source of unsaturated fatty acids and bioactive compounds whose recovery and stability may be influenced by the extraction process. This study compared Soxhlet extraction (SE), ultrasound-assisted extraction (UAE), and supercritical CO₂ extraction (sCO₂) in terms of extraction yield, fatty acid profile, physicochemical properties, total phenolic content (TPC), antioxidant activity, and oxidative stability. SE achieved the highest extraction yield (69.21%), followed by sCO₂ (52.89%) and UAE (48.68%). The fatty acid profile was relatively stable among extraction methods, although differences were observed in the relative proportions of oleic and linolenic acids. UAE produced oil with the highest TPC (32.55 µg GAE/g oil), whereas sCO₂ showed the highest initial antioxidant activity (2681 µmol TE/100 g oil). After 12 days, UAE oil exhibited the lowest peroxide value (10.49 meq O₂/kg) and the highest TPC retention, whereas sCO₂ oil showed the greatest peroxide accumulation (28.16 meq O₂/kg) and the largest decrease in TPC. These results demonstrate that extraction conditions differently affect oil recovery, antioxidant-related properties, and oxidative stability. Under the conditions evaluated, UAE showed particular advantages in preserving TPC and limiting primary oxidation during accelerated storage, despite its lower extraction yield. Full article

Aim: In this study, the phytochemical composition of the seeds of twelve different local grape (Vitis vinifera L.) varieties traditionally cultivated in the Southeastern Anatolia Region (Diyarbakır, Türkiye) was investigated using a holistic approach. The main objective of the study was to evaluate the associations of the effects of berry skin colour, the ripening stage and utilization type on the fatty acid profile, tocopherol and phytosterol contents, vitamin K and D levels, antioxidant capacity (DPPH) and lipid peroxidation (MDA) of grape seeds. Method: The seeds of grape varieties belonging to four different colour groups, grown on their own roots, were harvested during the 2017 growing season and analysed. Fatty acid composition was determined by gas chromatography (GC), vitamin and phytosterol contents by HPLC-UV, MDA content by the thiobarbituric acid reactive substance (TBARS) method, and antioxidant capacity by the DPPH radical scavenging assay. Findings: Linoleic acid was identified as the predominant fatty acid in all varieties (53.68–67.06%), followed by oleic acid (13.80–27.32%). α-Tocopherol was identified as the predominant tocopherol form (1.597–4.703 mg kg⁻¹), whilst β-sitosterol was the phytosterol component present at the highest level (915.67–3340.42 µg g⁻¹). Statistically significant varietal differences were detected for most measured phytochemical parameters. Group-wise differences associated with berry skin colour and ripening stage were observed for selected traits. Overall, varietal differences appeared to be more pronounced than those associated with berry skin colour or ripening stage. It was observed that the differences in phytochemical composition between the various commercial classifications of grapes were very limited. Result: The findings reveal that the seeds of the local grape varieties studied exhibit a rich phytochemical profile and represent an important source of bioactive compounds that could be utilised, particularly in the functional food, nutraceutical and cosmetics industries. The ‘Tahannebi’ variety stood out as the one with the highest values across many parameters. Differences observed among samples of the same cultivar collected from different vineyards suggest that vineyard-specific conditions may contribute to variation in selected phytochemical traits. Future multi-year and multi-location studies are needed to confirm the stability of these phytochemical profiles and to further clarify genotype × environment interactions. Full article

Flax is an important food and industrial crop. Linolenic acid (LIN) content of linseed oil differs greatly among varieties, ranging from 2% to 70%. In addition to genetic factors, environmental conditions can also significantly impact the fatty acid composition of linseed oil. Our study aimed to compare the effects of different temperature and watering conditions on the fatty acid composition of oil from nine flax varieties with diverse LIN content induced by genotype. Elevated temperature with reduced watering resulted in increased oleic acid (OLE) levels in all varieties. Decreases in linoleic acid (LIO) and LIN were also observed, though these trends were less pronounced in genotypes with low LIN content. Using our previously obtained transcriptomic data for seeds of the same flax varieties grown under the same conditions, we found that elevated temperature with reduced watering caused the maximum expression levels to shift to earlier development stages and shortened the period of high expression for the key fatty acid desaturase (FAD) genes: FAD2a-1, FAD2a-2, and FAD2b-2 (OLE to LIO desaturation) as well as FAD3a and FAD3b (LIO to LIN desaturation). However, low-LIN flax genotypes have inactivating mutations in FAD3a and FAD3b, so FAD3d-1, FAD3d-2, FAD3c-1, and FAD3c-2 were likely the major contributors to LIN synthesis in these varieties. These FAD3 genes had low but relatively stable expression levels during seed development compared to FAD3a and FAD3b, which may explain why growth conditions had less effect on LIN content in low-LIN genotypes. High temperature with optimal watering also led to a significant increase in OLE content in flax seeds. Thus, the fatty acid composition of linseed oil is significantly altered at high temperature, which is associated with a shift to earlier stages and narrowing of the expression peaks of key FAD genes in seeds. These findings should be considered when cultivating flax and producing pharmaceuticals, food, paints, and other products from its seeds. Full article

This study developed an oleic acid (OA)-functionalized, bio-derived calcium carbonate (Bio-CaCO₃) filler recovered from Asian green mussel (Perna viridis) shell waste for incorporation into a hydroxypropyl methylcellulose (HPMC)-glycerol (Gro) matrix as a hydrophobic composite coating for reducing pesticide deposition on mandarin surfaces. Aragonite-rich Bio-CaCO₃ was extracted through a combined chemical treatment and mechanical pulverization process. The extracted Bio-CaCO₃ was characterized by scanning electron microscopy, X-ray diffraction, laser diffraction, and ATR FT-IR spectroscopy. At the optimal OA concentration, surface functionalization yielded OA-functionalized Bio-CaCO₃ (OA-Bio-CaCO₃) powder beds that exhibited apparent superhydrophobicity; successful functionalization was confirmed by X-ray photoelectron spectroscopy. The resulting HPMC-Gro-OA-Bio-CaCO₃ coating dispersion (CD-OA) formed hydrophobic composite films (f-CD-OA), as demonstrated by water contact-angle measurements and surface-morphology analysis. The CD-OA coating formulation was successfully applied to mandarin surfaces by a dip-coating process. Colorimetric screening indicated that organophosphate pesticide residues on coated mandarins did not exceed hazardous levels, even at 20 times the manufacturer-recommended application rate. Quantitative LC-MS/MS and GC-MS/MS analyses demonstrated that the optimized CD-OA coating formulation provided substantial short-term protection against acetamiprid and chlorothalonil with pesticide-deposition reductions of 89% and ≥96%, respectively, after 1 d relative to pristine mandarins. These findings advance the functional reuse of biogenic CaCO₃ and offer a simple, water-based dip-coating approach that provides temporary surface protection for citrus production and food-safety management. Full article

The argan tree (Argania spinosa) is an endemic Moroccan species known for its primary product, argan oil, which possesses exceptional nutritional and medicinal properties. The current study aimed to evaluate and compare the antidiabetic and antioxidant activities of argan oil obtained from the introduced and native argan tree in eastern Morocco, to analyze its chemical composition using HPLC-DAD and GC-MS, and to investigate the molecular mechanisms behind the obtained pharmacological activities through an in silico pharmacological networking and molecular docking study. The results revealed that argan oil from all three regions of Morocco (Oujda, Agadir, and Chouihya) is rich in oleic and linoleic acids as major constituents, along with the presence of significant tocopherols. Regarding the antioxidant assays, including DPPH radical scavenging and iron-reducing power tests, argan oil from Oujda exhibited the highest activity, with the lowest IC₅₀ values of 15.25 ± 0.022 mg/mL and 28.5 ± 1.7 mg/mL, respectively. Concerning the antidiabetic activity, we found that oil from Chaouihya showed the strongest α-amylase inhibition, while Oujda oil had the highest antiglycation activity, indicating that even introduced argan trees retain potent bioactivity. The results of the in silico investigation suggested that tocopherols may contribute to the antioxidant and antidiabetic potential of argan oil, showing predicted antioxidant activity (Pa = 0.843–0.967) and favorable binding affinities toward iNOS (ΔG = −9.3 kcal mol⁻¹) and α-glucosidase (ΔG = −8.2 kcal mol⁻¹). The identified fatty acids also showed predicted insulin-promoting activity (Pa = 0.59–0.75) and moderate enzyme-binding potential. Pharmacological network analysis identified 51 shared genes associated with antioxidant, antidiabetic, and argan-related targets, with enrichment of the AGE–RAGE signaling pathway. These computational findings provide possible molecular associations that may help explain the observed biological activities, although they remain predictive and require experimental validation. Overall, the in silico analysis suggests that tocopherols could be among the contributors to the multi-target profile of Argania spinosa oil, while fatty acids may provide complementary effects related to glycemic regulation. Full article

The sun-dried merguez sausage (DM) is deeply rooted in the Tunisian culinary culture. It is characterized by a distinctive composition and an energy-saving process. Unlike fermented or mechanically dried meats, sun-dried merguez is produced through a single, natural solar dehydration step lasting 8–12 days. Limited information is available regarding its physicochemical properties, chemical composition, and nutritional profile. To address this gap, changes in physicochemical properties during drying were monitored, and the chemical composition and microbiological flora of fresh merguez (FM) and DM were analyzed. Results showed that sun-drying contributed to a significant decrease in moisture (17.0%), water activity (0.675), and pH (5.56), ensuring microbiological stability and safety. DM was rich in lactic acid (1865 mg.kg⁻¹) and other low-molecular-weight organic acids, as well as minerals, particularly iron (13.5 mg per 100 g), with an enhanced fatty acid profile—specifically oleic acid—due to tail fat. The distinctive composition of DM, enriched with 15% spices and herbs, yielded a volatile profile dominated by terpenes (67%), which imparts its characteristic flavor and may contribute to health benefits. The current study underscored the nutritional and nutritive value of DM, offering valuable insights for stakeholders to enhance and protect this cultural heritage. Full article

Background: Myelodysplastic neoplasms (MDSs) are clonal hematopoietic stem cell disorders associated with ineffective hematopoiesis, chronic inflammation, and increased cardiovascular morbidity. Although metabolic dysregulation has been implicated in MDS pathogenesis, systemic metabolic alterations remain incompletely characterized. Methods: Plasma samples from treatment-naïve patients with MDS or chronic myelomonocytic leukemia (CMML) and age-matched healthy controls were analyzed using quantitative nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Metabolomic profiles were compared using unsupervised and supervised multivariate analyses, validated in an independent external MDS cohort, and integrated with re-analysis of publicly available RNA-sequencing datasets from purified CD14⁺ CMML monocytes. Results: Patients with MDS and CMML exhibited broad reductions in circulating lipoprotein-associated metabolites, including HDL-, LDL-, IDL-, and apolipoprotein-associated fractions, indicating disturbed systemic lipoprotein homeostasis. Within the discovery cohort, CMML samples showed higher concentrations of the ketone bodies 3-hydroxybutyrate and acetoacetate, as well as succinate. LC-MS analysis demonstrated selective increases in C18:1 acylcarnitine, oleic and isopalmitic acids, whereas free carnitine abundance remained unchanged. Elevated 3-hydroxybutyrate levels were not associated with mutational burden, hematologic parameters, disease risk, or immunophenotypic features. Re-analysis of public CMML monocyte transcriptomes demonstrated increased expression of genes involved in lipid uptake and intracellular lipid trafficking, including FABP5, APOE, LPL, and SLC27A2, without coordinated activation of fatty acid oxidation pathways. External cohort analysis confirmed the overall MDS-associated plasma metabolomic profile. Conclusions: MDSs and CMML are associated with reproducible alterations in systemic lipid metabolism characterized by reduced circulating lipoprotein-associated metabolites, while CMML showed more pronounced ketone body- and acylcarnitine-associated metabolic phenotype accompanied by changes in lipid-handling transcriptional programs. These findings support altered systemic lipid metabolism and carnitine-dependent fatty acid handling as characteristic features of myeloid neoplasms and provide a rationale for future functional studies investigating lipid metabolism in disease pathogenesis. Full article