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12 pages, 2038 KiB  
Communication
Total Synthesis of Surfactant-Mimetic Nanocolloids via Regioselective Silica Deposition on Bottlebrush Polymers
by Junyi Zeng, Linlin Li, Li Ai, Kai Song, Heng Zhai and Chenglin Yi
Appl. Sci. 2025, 15(15), 8766; https://doi.org/10.3390/app15158766 (registering DOI) - 7 Aug 2025
Abstract
Molecular-mimetic nanocolloids (MMNCs) are promising for advanced materials, yet self-assembly fabrication faces challenges in purity and programmability. We report a total synthesis strategy for surfactant-mimetic nanocolloids (SMNCs), an amphiphilic MMNC subclass. SMNCs consist of a ~5 nm silica nanoparticle head and a bottlebrush [...] Read more.
Molecular-mimetic nanocolloids (MMNCs) are promising for advanced materials, yet self-assembly fabrication faces challenges in purity and programmability. We report a total synthesis strategy for surfactant-mimetic nanocolloids (SMNCs), an amphiphilic MMNC subclass. SMNCs consist of a ~5 nm silica nanoparticle head and a bottlebrush polymer tail. Regioselective silica deposition on linear-block-brush polymers via the modified sol–gel method enables precise control. This strategy is versatile and can be adapted to synthesize other MMNCs with different components. It offers a more controlled alternative to self-assembly methods, advancing MMNC synthesis and enabling their broader use in emerging technologies. Full article
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35 pages, 21105 KiB  
Review
A Review: The Beauty of Serendipity Between Integrated Circuit Security and Artificial Intelligence
by Chen Dong, Decheng Qiu, Bolun Li, Yang Yang, Chenxi Lyu, Dong Cheng, Hao Zhang and Zhenyi Chen
Sensors 2025, 25(15), 4880; https://doi.org/10.3390/s25154880 (registering DOI) - 7 Aug 2025
Abstract
Integrated circuits are the core of a cyber-physical system, where tens of billions of components are integrated into a tiny silicon chip to conduct complex functions. To maximize utilities, the design and manufacturing life cycle of integrated circuits rely on numerous untrustworthy third [...] Read more.
Integrated circuits are the core of a cyber-physical system, where tens of billions of components are integrated into a tiny silicon chip to conduct complex functions. To maximize utilities, the design and manufacturing life cycle of integrated circuits rely on numerous untrustworthy third parties, forming a global supply chain model. At the same time, this model produces unpredictable and catastrophic issues, threatening the security of individuals and countries. As for guaranteeing the security of ultra-highly integrated chips, detecting slight abnormalities caused by malicious behavior in the current and voltage is challenging, as is achieving computability within a reasonable time and obtaining a golden reference chip; however, artificial intelligence can make everything possible. For the first time, this paper presents a systematic review of artificial-intelligence-based integrated circuit security approaches, focusing on the latest attack and defense strategies. First, the security threats of integrated circuits are analyzed. For one of several key threats to integrated circuits, hardware Trojans, existing attack models are divided into several categories and discussed in detail. Then, for summarizing and comparing the numerous existing artificial-intelligence-based defense strategies, traditional and advanced artificial-intelligence-based approaches are listed. Finally, open issues on artificial-intelligence-based integrated circuit security are discussed from three perspectives: in-depth exploration of hardware Trojans, combination of artificial intelligence, and security strategies involving the entire life cycle. Based on the rapid development of artificial intelligence and the initial successful combination with integrated circuit security, this paper offers a glimpse into their intriguing intersection, aiming to draw greater attention to these issues. Full article
(This article belongs to the Collection Integrated Circuits and Systems for Smart Sensor Applications)
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18 pages, 6388 KiB  
Article
Spatial–Temporal Hotspot Management of Photovoltaic Modules Based on Fiber Bragg Grating Sensor Arrays
by Haotian Ding, Rui Guo, Huan Xing, Yu Chen, Jiajun He, Junxian Luo, Maojie Chen, Ye Chen, Shaochun Tang and Fei Xu
Sensors 2025, 25(15), 4879; https://doi.org/10.3390/s25154879 (registering DOI) - 7 Aug 2025
Abstract
Against the backdrop of an urgent energy crisis, solar energy has attracted sufficient attention as one of the most inexhaustible and friendly types of environmental energy. Faced with long service and harsh environment, the poor performance ratios of photovoltaic arrays and safety hazards [...] Read more.
Against the backdrop of an urgent energy crisis, solar energy has attracted sufficient attention as one of the most inexhaustible and friendly types of environmental energy. Faced with long service and harsh environment, the poor performance ratios of photovoltaic arrays and safety hazards are frequently boosted worldwide. In particular, the hot spot effect plays a vital role in weakening the power generation performance and reduces the lifetime of photovoltaic (PV) modules. Here, our research reports a spatial–temporal hot spot management system integrated with fiber Bragg grating (FBG) temperature sensor arrays and cooling hydrogels. Through finite element simulations and indoor experiments in laboratory conditions, a superior cooling effect of hydrogels and photoelectric conversion efficiency improvement have been demonstrated. On this basis, field tests were carried out in which the FBG arrays detected the surface temperature of the PV module first, and then a classifier based on an optimized artificial neural network (ANN) recognized hot spots with an accuracy of 99.1%. The implementation of cooling hydrogels as a feedback mechanism achieved a 7.7 °C reduction in temperature, resulting in a 5.6% enhancement in power generation efficiency. The proposed strategy offers valuable insights for conducting predictive maintenance of PV power plants in the case of hot spots. Full article
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19 pages, 3601 KiB  
Article
Study on Correction Methods for GPM Rainfall Rate and Radar Reflectivity Using Ground-Based Raindrop Spectrometer Data
by Lin Chen, Huige Di, Dongdong Chen, Ning Chen, Qinze Chen and Dengxin Hua
Remote Sens. 2025, 17(15), 2747; https://doi.org/10.3390/rs17152747 (registering DOI) - 7 Aug 2025
Abstract
The Dual-frequency Precipitation Radar (DPR) aboard the Global Precipitation Measurement (GPM) mission provides valuable three-dimensional precipitation structure data on a global scale and has been widely used in hydrometeorological research. However, due to its spatial resolution limitations and inherent algorithmic assumptions, the accuracy [...] Read more.
The Dual-frequency Precipitation Radar (DPR) aboard the Global Precipitation Measurement (GPM) mission provides valuable three-dimensional precipitation structure data on a global scale and has been widely used in hydrometeorological research. However, due to its spatial resolution limitations and inherent algorithmic assumptions, the accuracy of GPM precipitation estimates can exhibit systematic biases, especially under complex terrain conditions or in the presence of variable precipitation structures, such as light stratiform rain or intense convective storms. In this study, we evaluated the near-surface precipitation rate estimates from the GPM-DPR Level 2A product using over 1440 min of disdrometer observations collected across China from 2021 to 2023. Based on three years of stable stratiform precipitation data from the Jinghe station, we developed a least squares linear correction model for radar reflectivity. Independent validation using national disdrometer data from 2023 demonstrated that the corrected reflectivity significantly improved rainfall estimates under light precipitation conditions, although improvements were limited for convective events or in complex terrain. To further enhance retrieval accuracy, we introduced a regionally adaptive R–Z relationship scheme stratified by precipitation type and terrain category. Applying these localized relationships to the corrected reflectivity yielded more consistent rainfall estimates across diverse conditions, highlighting the importance of incorporating regional microphysical characteristics into satellite retrieval algorithms. The results indicate that the accuracy of GPM precipitation retrievals is more significantly influenced by precipitation type than by terrain complexity. Under stratiform precipitation conditions, the GPM-estimated precipitation data demonstrate the highest reliability. The correction framework proposed in this study is grounded on ground-based observations and integrates regional precipitation types with terrain characteristics. It effectively enhances the applicability of GPM-DPR products across diverse environmental conditions in China and offers a methodological reference for correcting satellite precipitation biases in other regions. Full article
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29 pages, 2129 KiB  
Review
Advances in Thermal Management of Lithium-Ion Batteries: Causes of Thermal Runaway and Mitigation Strategies
by Tiansi Wang, Haoran Liu, Wanlin Wang, Weiran Jiang, Yixiang Xu, Simeng Zhu and Qingliang Sheng
Processes 2025, 13(8), 2499; https://doi.org/10.3390/pr13082499 (registering DOI) - 7 Aug 2025
Abstract
With the widespread use of lithium-ion batteries in electric vehicles, energy storage systems, and portable electronic devices, concerns regarding their thermal runaway have escalated, raising significant safety issues. Despite advances in existing thermal management technologies, challenges remain in addressing the complexity and variability [...] Read more.
With the widespread use of lithium-ion batteries in electric vehicles, energy storage systems, and portable electronic devices, concerns regarding their thermal runaway have escalated, raising significant safety issues. Despite advances in existing thermal management technologies, challenges remain in addressing the complexity and variability of battery thermal runaway. These challenges include the limited heat dissipation capability of passive thermal management, the high energy consumption of active thermal management, and the ongoing optimization of material improvement methods. This paper systematically examines the mechanisms through which three main triggers—mechanical abuse, thermal abuse, and electrical abuse—affect the thermal runaway of lithium-ion batteries. It also reviews the advantages and limitations of passive and active thermal management techniques, battery management systems, and material improvement strategies for enhancing the thermal stability of batteries. Additionally, a comparison of the principles, characteristics, and innovative examples of various thermal management technologies is provided in tabular form. The study aims to offer a theoretical foundation and practical guidance for optimizing lithium-ion battery thermal management technologies, thereby promoting their development for high-safety and high-reliability applications. Full article
(This article belongs to the Section Energy Systems)
44 pages, 4024 KiB  
Review
Exploring Purpose-Driven Methods and a Multifaceted Approach in Dam Health Monitoring Data Utilization
by Zhanchao Li, Ebrahim Yahya Khailah, Xingyang Liu and Jiaming Liang
Buildings 2025, 15(15), 2803; https://doi.org/10.3390/buildings15152803 (registering DOI) - 7 Aug 2025
Abstract
Dam monitoring tracks environmental variables (water level, temperature) and structural responses (deformation, seepage, and stress) to assess safety and performance. Structural health monitoring (SHM) refers to the systematic observation and analysis of the structural condition over time, and it is essential in maintaining [...] Read more.
Dam monitoring tracks environmental variables (water level, temperature) and structural responses (deformation, seepage, and stress) to assess safety and performance. Structural health monitoring (SHM) refers to the systematic observation and analysis of the structural condition over time, and it is essential in maintaining the safety, functionality, and long-term performance of dams. This review examines monitoring data applications, covering structural health assessment methods, historical motivations, and key challenges. It discusses monitoring components, data acquisition processes, and sensor roles, stressing the need to integrate environmental, operational, and structural data for decision making. Key objectives include risk management, operational efficiency, safety evaluation, environmental impact assessment, and maintenance planning. Methodologies such as numerical modeling, statistical analysis, and machine learning are critically analyzed, highlighting their strengths and limitations and the demand for advanced predictive techniques. This paper also explores future trends in dam monitoring, offering insights for engineers and researchers to enhance infrastructure resilience. By synthesizing current practices and emerging innovations, this review aims to guide improvements in dam safety protocols, ensuring reliable and sustainable dam operations. The findings provide a foundation for the advancement of monitoring technologies and optimization of dam management strategies worldwide. Full article
(This article belongs to the Section Construction Management, and Computers & Digitization)
12 pages, 5808 KiB  
Article
A High-Precision Hydrogen Sensor Array Based on Pt-Modified SnO2 for Suppressing Humidity and Oxygen Interference
by Meile Wu, Zhixin Wu, Hefei Chen, Zhanyu Wu, Peng Zhang, Lin Qi, He Zhang and Xiaoshi Jin
Chemosensors 2025, 13(8), 294; https://doi.org/10.3390/chemosensors13080294 (registering DOI) - 7 Aug 2025
Abstract
Humidity and oxygen have significant impacts on the accuracy of hydrogen detection, especially for metal oxide semiconductor sensors at room temperature. Addressing this challenge, this study employs a screen-printed 1 × 2 resistive sensor array made from an identical 1 wt.% platinum-modified tin [...] Read more.
Humidity and oxygen have significant impacts on the accuracy of hydrogen detection, especially for metal oxide semiconductor sensors at room temperature. Addressing this challenge, this study employs a screen-printed 1 × 2 resistive sensor array made from an identical 1 wt.% platinum-modified tin oxide nanoparticle material. Fabrication variability between the two sensing elements was intentionally leveraged to enhance array output differentiation and information content. Systematic hydrogen-sensing tests were conducted on the array under diverse oxygen and moisture conditions. Three distinct feature types—the steady-state value, resistance change, and area under the curve—were extracted from the output of each array element. These features, integrated with their quotient, formed a nine-feature vector matrix. A multiple linear regression model based on this array output was developed and validated for hydrogen prediction, achieving a coefficient of determination of 0.95, a mean absolute error of 125 ppm, and a mean relative standard deviation of 7.07%. The combined information of the array provided significantly more stable and precise hydrogen concentration predictions than linear or nonlinear models based on individual sensor features. This approach offers a promising path for mass-producing highly interference-resistant, precise, and stable room-temperature hydrogen sensor arrays. Full article
(This article belongs to the Section Materials for Chemical Sensing)
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12 pages, 707 KiB  
Article
Characteristics of Varicella Breakthrough Cases in Jinhua City, 2016–2024
by Zhi-ping Du, Zhi-ping Long, Meng-an Chen, Wei Sheng, Yao He, Guang-ming Zhang, Xiao-hong Wu and Zhi-feng Pang
Vaccines 2025, 13(8), 842; https://doi.org/10.3390/vaccines13080842 (registering DOI) - 7 Aug 2025
Abstract
Background: Varicella remains a prevalent vaccine-preventable disease, but breakthrough infections are increasingly reported. However, long-term, population-based studies investigating the temporal and demographic characteristics of breakthrough varicella remain limited. Methods: This retrospective study analyzed surveillance data from Jinhua City, China, from 2016 [...] Read more.
Background: Varicella remains a prevalent vaccine-preventable disease, but breakthrough infections are increasingly reported. However, long-term, population-based studies investigating the temporal and demographic characteristics of breakthrough varicella remain limited. Methods: This retrospective study analyzed surveillance data from Jinhua City, China, from 2016 to 2024. Varicella case records were obtained from the China Information System for Disease Control and Prevention (CISDCP), while vaccination data were retrieved from the Zhejiang Provincial Immunization Program Information System (ISIS). Breakthrough cases were defined as infections occurring more than 42 days after administration of the varicella vaccine. Differences in breakthrough interval were analyzed across subgroups defined by dose, sex, age, population category, and vaccination type. A bivariate cubic regression model was used to assess the combined effect of initial vaccination age and dose interval on the breakthrough interval. Results: Among 28,778 reported varicella cases, 7373 (25.62%) were classified as breakthrough infections, with a significant upward trend over the 9-year period (p < 0.001). Most cases occurred in school-aged children, especially those aged 6–15 years. One-dose recipients consistently showed shorter breakthrough intervals than two-dose recipients (M = 62.10 vs. 120.10 months, p < 0.001). Breakthrough intervals also differed significantly by sex, age group, population category, and vaccination type (p < 0.05). Regression analysis revealed a negative correlation between the initial vaccination age, the dose interval, and the breakthrough interval (R2 = 0.964, p < 0.001), with earlier and closely spaced vaccinations associated with longer protection. Conclusions: The present study demonstrates that a two-dose varicella vaccination schedule, when initiated at an earlier age and administered with a shorter interval between doses, provides more robust and longer-lasting protection. These results offer strong support for incorporating varicella vaccination into China’s National Immunization Program to enhance vaccine coverage and reduce the public health burden associated with breakthrough infections. Full article
(This article belongs to the Section Epidemiology and Vaccination)
22 pages, 541 KiB  
Article
Patent Licensing Strategy for Supply Chain Reshaping Under Sudden Disruptive Events
by Jianxin Zhu, Xinying Wang, Nengmin Zeng and Huijian Zhong
Systems 2025, 13(8), 672; https://doi.org/10.3390/systems13080672 (registering DOI) - 7 Aug 2025
Abstract
Supply chains are increasingly exposed to sudden disruptive events (SDEs) such as natural disasters and trade wars. We develop a multi-stage game-theoretical model to investigate a novel coping mechanism: when a firm is forced to exit the market because of SDEs, the firm [...] Read more.
Supply chains are increasingly exposed to sudden disruptive events (SDEs) such as natural disasters and trade wars. We develop a multi-stage game-theoretical model to investigate a novel coping mechanism: when a firm is forced to exit the market because of SDEs, the firm can regain profits by licensing its proprietary production tech to a competitor. We find that, compared with the scenario before SDEs, such events can even increase the profit of each manufacturer under certain conditions. Under certain conditions, the cooperative strategy (i.e., supply chain reshaping) yields a higher supply chain system profit than the non-cooperative strategy. After SDEs, the common manufacturer may either accept or reject cooperation, depending on the customer transfer rate and the cooperation cost. Notably, under the cooperation strategy, the high-tech manufacturer extracts part of the common manufacturer’s profit through patent licensing, and the existence of cooperation cost further contributes to a misalignment between the common manufacturer’s optimal decision and the supply chain system optimum. These findings contribute to the literature by identifying a novel supply chain reshaping mechanism driven by patent licensing and offer strategic guidance for firms and policymakers navigating SDE-induced market exits. Full article
(This article belongs to the Special Issue Operation and Supply Chain Risk Management)
24 pages, 4458 KiB  
Review
Selenium-Enriched Microorganisms: Metabolism, Production, and Applications
by Lin Luo, Xue Hou, Dandan Yi, Guangai Deng, Zhiyong Wang and Mu Peng
Microorganisms 2025, 13(8), 1849; https://doi.org/10.3390/microorganisms13081849 (registering DOI) - 7 Aug 2025
Abstract
Microorganisms, as abundant biological resources, offer significant potential in the development of selenium-enrichment technologies. Selenium-enriched microorganisms not only absorb, reduce, and accumulate selenium efficiently but also produce various selenium compounds without relying on synthetic chemical processes. In particular, nano-selenium produced by these microorganisms [...] Read more.
Microorganisms, as abundant biological resources, offer significant potential in the development of selenium-enrichment technologies. Selenium-enriched microorganisms not only absorb, reduce, and accumulate selenium efficiently but also produce various selenium compounds without relying on synthetic chemical processes. In particular, nano-selenium produced by these microorganisms during cultivation has garnered attention due to its unique physicochemical properties and biological activity, making it a promising raw material for functional foods and pharmaceutical products. This paper reviews selenium-enriched microorganisms, focusing on their classification, selenium metabolism, and transformation mechanisms. It explores how selenium is absorbed, reduced, and transformed within microbial cells, analyzing the biochemical processes by which inorganic selenium is converted into organic and nano-selenium forms. Finally, the broad applications of selenium-enriched microbial products in food, medicine, and agriculture are explored, including their roles in selenium-rich foods, nano-selenium materials, and disease prevention and treatment. Full article
(This article belongs to the Special Issue Exploring the Diversity of Microbial Applications)
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22 pages, 681 KiB  
Article
Unlocking the Nexus: Personal Remittances and Economic Drivers Shaping Housing Prices Across EU Borders
by Maja Nikšić Radić, Siniša Bogdan and Marina Barkiđija Sotošek
World 2025, 6(3), 112; https://doi.org/10.3390/world6030112 (registering DOI) - 7 Aug 2025
Abstract
This study examines the impact of personal remittances on housing prices in European Union (EU) countries, while also accounting for a broader set of macroeconomic, demographic, and structural variables. Using annual data for 27 EU countries from 2007 to 2022, we employ a [...] Read more.
This study examines the impact of personal remittances on housing prices in European Union (EU) countries, while also accounting for a broader set of macroeconomic, demographic, and structural variables. Using annual data for 27 EU countries from 2007 to 2022, we employ a comprehensive panel econometric approach, including cross-sectional dependence tests, second-generation unit root tests, pooled mean group–autoregressive distributed lag (PMG-ARDL) estimation, and panel causality tests, to capture both short- and long-term dynamics. Our findings confirm that remittances significantly and positively influence long-term housing price levels, underscoring their relevance as a demand-side driver. Other key variables such as net migration, GDP, travel credit to GDP, economic freedom, and real effective exchange rates also contribute to housing price movements, while supply-side indicators, including production in construction and building permits, exert moderating effects. Moreover, real interest rates are shown to have a significant long-term negative effect on property prices. The analysis reveals key causal links from remittances, FDI, and net migration to housing prices, highlighting their structural and predictive roles. Bidirectional causality between economic freedom, housing output, and prices indicates reinforcing feedback effects. These findings position remittances as both a development tool and a key indicator of real estate dynamics. The study highlights complex interactions between international financial flows, demographic pressures, and domestic economic conditions and the need for policymakers to consider remittances and migrant investments in real estate strategies. These findings offer important implications for policymakers seeking to balance housing affordability, investment, and economic resilience in the EU context and key insights into the complexity of economic factors and real estate prices. Importantly, the analysis identifies several causal relationships, notably from remittances, FDI, and net migration toward housing prices, underscoring their predictive and structural importance. Bidirectional causality between economic freedom and house prices, as well as between housing output and pricing, reflects feedback mechanisms that further reinforce market dynamics. These results position remittances not only as a developmental instrument but also as a key signal for real estate market performance in recipient economies. Full article
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21 pages, 1609 KiB  
Article
Exploring Residual Clays for Low-Impact Ceramics: Insights from a Portuguese Ceramic Region
by Carla Candeias, Sónia Novo and Fernando Rocha
Appl. Sci. 2025, 15(15), 8761; https://doi.org/10.3390/app15158761 (registering DOI) - 7 Aug 2025
Abstract
This study investigates the potential of residual clays from a traditional ceramic-producing region in southern Portugal as raw materials for red ceramic applications. This work aims to support more sustainable ceramic practices through the local valorization of naturally available, underutilized clay resources. A [...] Read more.
This study investigates the potential of residual clays from a traditional ceramic-producing region in southern Portugal as raw materials for red ceramic applications. This work aims to support more sustainable ceramic practices through the local valorization of naturally available, underutilized clay resources. A multidisciplinary approach was employed to characterize clays, integrating mineralogical (XRD), chemical (XRF), granulometric, and thermal analyses (TGA/DTA/TD), as well as technological tests on plasticity, extrusion moisture, shrinkage, and flexural strength. These assessments were designed to capture both the intrinsic properties of the clays and their behavior across key ceramic processing stages, such as shaping, drying, and firing. The results revealed a broad diversity in mineral composition, particularly in the proportions of kaolinite, smectite, and illite, which strongly influenced plasticity, water demand, and thermal stability. Clays with higher fine fractions and smectitic content exhibited excellent plasticity and workability, though with increased sensitivity to drying and firing conditions. Others, with coarser textures and illitic or feldspathic composition, demonstrated improved dimensional stability and lower shrinkage. Thermal analyses confirmed expected dehydroxylation and sintering behavior, with the formation of mullite and spinel-type phases contributing to densification and strength in fired bodies. This study highlights that residual clays from varied geological settings can offer distinct advantages when matched appropriately to ceramic product requirements. Some materials showed strong potential for direct application in structural ceramics, while others may serve as additives or tempering agents in formulations. These findings reinforce the value of integrated characterization for optimizing raw material use and support a more circular, resource-conscious approach to ceramic production. Full article
21 pages, 926 KiB  
Article
Identification of Bottlenecks in Passenger Handling Processes Using Data-Driven Tools
by Edina Jenčová, Tatiana Gajdušková, Martin Jezný and Pavol Hudák
Appl. Sci. 2025, 15(15), 8760; https://doi.org/10.3390/app15158760 (registering DOI) - 7 Aug 2025
Abstract
The paper focuses on the identification of “bottlenecks” in the passenger handling process at the airports. In the current era of digital transformation and the emergence of Industry 4.0 and 5.0 concepts, optimizing passenger flows through data-driven tools is becoming an essential part [...] Read more.
The paper focuses on the identification of “bottlenecks” in the passenger handling process at the airports. In the current era of digital transformation and the emergence of Industry 4.0 and 5.0 concepts, optimizing passenger flows through data-driven tools is becoming an essential part of intelligent airport management. While many solutions focus on high-end software or AI-based systems, this study demonstrates the value of preparatory models built in widely accessible platforms such as Microsoft Excel. A simulation model was developed to analyze check-in and security screening, integrating discrete event simulation (DES), queueing theory, and elements of Monte Carlo simulation. The model enables the segmentation of the handling process into key events, including probabilistically generated arrivals and service durations. Although the model is built in a basic environment, it serves as a prototype platform for potential integration into broader digitalization strategies, offering a preparatory framework for future implementation in more sophisticated systems. Full article
25 pages, 7934 KiB  
Article
An Improved InTEC Model for Estimating the Carbon Budgets in Eucalyptus Plantations
by Zhipeng Li, Mingxing Zhou, Kunfa Luo, Yunzhong Wu and Dengqiu Li
Remote Sens. 2025, 17(15), 2741; https://doi.org/10.3390/rs17152741 (registering DOI) - 7 Aug 2025
Abstract
Eucalyptus has become a major plantation crop in southern China, with a carbon sequestration capacity significantly higher than that of other species. However, its long-term carbon sequestration capacity and regional-scale potential remain highly uncertain due to commonly applied short-rotation management practices. The InTEC [...] Read more.
Eucalyptus has become a major plantation crop in southern China, with a carbon sequestration capacity significantly higher than that of other species. However, its long-term carbon sequestration capacity and regional-scale potential remain highly uncertain due to commonly applied short-rotation management practices. The InTEC (Integrated Terrestrial Ecosystem Carbon) model is a process-based biogeochemical model that simulates carbon dynamics in terrestrial ecosystems by integrating physiological processes, environmental drivers, and management practices. In this study, the InTEC model was enhanced with an optimized eucalyptus module (InTECeuc) and a data assimilation module (InTECDA), and driven by multiple remote sensing products (Net Primary Productivity (NPP) and carbon density) to simulate the carbon budgets of eucalyptus plantations from 2003 to 2023. The results indicated notable improvements in the performance of the InTECeuc model when driven by different datasets: carbon density simulation showed improvements in R2 (0.07–0.56), reductions in MAE (5.99–28.51 Mg C ha−1), reductions in RMSE (8.1–31.85 Mg C ha−1), and improvements in rRMSE (12.37–51.82%), excluding NPPLin. The carbon density-driven InTECeuc model outperformed the NPP-driven model, with improvements in R2 (0.28), MAE (−8.15 Mg C ha−1), RMSE (−9.43 Mg C ha−1), and rRMSE (−15.34%). When the InTECDA model was employed, R2 values for carbon density improved by 0–0.03 (excluding ACDYan), with MAE reductions between 0.17 and 7.22 Mg C ha−1, RMSE reductions between 0.33 and 12.94 Mg C ha−1 and rRMSE improvements ranging from 0.51 to 20.22%. The carbon density-driven InTECDA model enabled the production of high-resolution and accurate carbon budget estimates for eucalyptus plantations from 2003 to 2023, with average NPP, Net Ecosystem Productivity (NEP), and Net Biome Productivity (NBP) values of 17.80, 10.09, and 9.32 Mg C ha−1 yr−1, respectively, offering scientific insights and technical support for the management of eucalyptus plantations in alignment with carbon neutrality targets. Full article
14 pages, 3230 KiB  
Article
CFAP300 Loss-of-Function Mutations with Primary Ciliary Dyskinesia: Evidence from Ex Vivo and ALI Cultures
by Anna G. Demchenko, Tatiana A. Kyian, Elena I. Kondratyeva, Elizaveta E. Bragina, Oksana P. Ryzhkova, Roman V. Veiko, Aleksandra G. Nazarova, Vyacheslav B. Chernykh, Svetlana A. Smirnikhina and Sergey I. Kutsev
Int. J. Mol. Sci. 2025, 26(15), 7655; https://doi.org/10.3390/ijms26157655 (registering DOI) - 7 Aug 2025
Abstract
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by impaired mucociliary clearance due to defects in motile cilia. This study investigates the impact of loss-of-function mutations in the CFAP300 gene on the ciliary structure and function in three PCD patients. Using [...] Read more.
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by impaired mucociliary clearance due to defects in motile cilia. This study investigates the impact of loss-of-function mutations in the CFAP300 gene on the ciliary structure and function in three PCD patients. Using a multimodal approach, we integrated molecular genetic testing, transmission electron microscopy, the high-speed video microscopy assay and immunofluorescence staining to analyze ciliary motility and protein expression in both ex vivo and in vitro-obtained ciliary cells. Our results revealed that the pathogenic variant c.198_200delinsCC (p.Phe67ProfsTer10) in CFAP300 led to the absence of the functional CFAP300 protein, the complete loss of outer and inner dynein arms and immotile cilia. Air–liquid interface (ALI)-cultured cells from patients exhibited no ciliary beating, contrasting with healthy controls. Immunostaining confirmed the absence of CFAP300 in patient-derived cilia, underscoring its critical role in dynein arm assembly. These findings highlight the diagnostic utility of ALI cultures combined with functional and protein analyses for PCD, offering a clinically actionable framework that can be readily incorporated into standard diagnostic workflows. Full article
(This article belongs to the Special Issue Molecular and Cellular Therapeutics for Respiratory Diseases)
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