Search Results (5,805)

(1) Polycystic ovary syndrome (PCOS) is one of the most common endocrinological disorders worldwide; its complex etiopathology remains poorly understood. PCOS is associated with a broad spectrum of abnormalities, including irregular menses, androgen excess, and increased risk of metabolic, endocrinological, and cardiovascular disorders. This narrative review focuses on structural and functional changes in the uterus associated with polycystic ovary syndrome and hyperandrogenism. (2) The review was performed by searching PubMed, Medline, Embase, Google Scholar, and Cochrane Library electronic databases on records published between 1964 and 2025. The authors included studies on (i) the uterus in clinical settings of PCOS patients, (ii) the uterus in PCOS models, and (iii) the pregnant uterus in patients with PCOS. Multiple animal and human studies describe a potential impact of PCOS on uterine blood flow, morphology, and thickness of the uterine muscle, indicating a possible functional impairment in pregnant and non-pregnant women. The scope of available knowledge regarding functional and structural uterine changes in PCOS is scarce; new studies are warranted. Future research should focus on hyperandrogenism associated with PCOS and explore the link between the morphology and function of the uterus. Full article

Although opioids are effective in treating pain, they cause serious side effects. The use of regional anesthesia, although effective in the perioperative period, may not be suitable if mobility and lack of numbness is desired. Hence, there is a clear need for novel pain therapies. Low-voltage activated (T-type) calcium channels (Ca_V3.2 isoform) could be a promising therapeutic target for the development of novel pain therapies. Indeed, our published findings suggest that novel neuroactive steroid (NAS) analogs that modulate the activity of Ca_V3.2 channels have unique anti-nociceptive properties. However, the concern with current NASs appears to be their hypnotic/sedative properties, thus potentially hindering the future development of NASs for novel pain therapies. Hence, we developed a new line of NASs that are effective blockers of neuronal Ca_V3.2 channels in pain pathways while having more favorable pharmacodynamic properties, i.e., lack of sedative/hypnotic side effects. We present two promising novel analogs of NASs—B372 ((3β,5α,17β)-3-Hydroxyandrostan-17-carbonitrile) and YX23 ((3β,5α,17β)-3-Methoxyestran-17-ol). Using an in vitro approach, we show that B372 and YX23 are effective in blocking Ca_V3.2 channels. Using an in vivo approach, we show that they are effective anti-nociceptives in wild-type but not Ca_V3.2 knock-out mice. Importantly, we show that they lack sedative/hypnotic effects. Full article

Background/Objectives: Food protein-induced enterocolitis syndrome (FPIES) is a food-related hypersensitivity disorder characterized by delayed repeated vomiting that typically presents within the first years of life. Although FPIES has traditionally been considered a pediatric condition, it has more recently been observed also in teenagers and adults. Adult FPIES may be a continuation of childhood-onset disease or new-onset forms developing later in life. This review aims to describe the peculiarities of FPIES across the lifespan and to provide an update from the last years on the studies focused on FPIES in adolescence. Methods: Papers focusing on FPIES in adolescents, in English and published in PubMed, were reviewed. Results: There is less data available in the literature on FPIES in adolescents. Multiple sensitizations to food can compromise nutritional status in patients with FPIES. Several potential diagnostic biomarkers related to genomic susceptibility, altered immunologic response, mucosal inflammation and intestinal microbiota are under study/validation. The lack of age-specific diagnostic algorithms makes it difficult to understand the clinical features of persistent forms of FPIES. Conclusions: Shared transition medicine protocols tailored to adolescents could help us better understand the clinical, pathophysiological, diagnostic, and therapeutic characteristics of this delicate phase of life. Full article

Background: The use of neuromodulation for the treatment of psychiatric disorders has become increasingly common, but this emerging treatment modality comes with ethical concerns. This scoping review aims to synthesize the neuroethical discourse from the past 10 years on the use of neurotechnologies for psychiatric conditions. Methods: A total of 4496 references were imported from PubMed, Embase, and Scopus. The inclusion criteria required a discussion of the neuroethics of neuromodulation and studies published between 2014 and 2024. Results: Of the 77 references, a majority discussed ethical concerns of patient autonomy and informed consent for neuromodulation, with neurotechnologies being increasingly seen as autonomy enablers. Concepts of changes in patient identity and personality, especially after deep brain stimulation, were also discussed extensively. The risks and benefits of neurotechnologies were also compared, with deep brain stimulation being seen as the riskiest but also possessing the highest efficacy. Concerns about equitable access and justice were raised regarding the rise of private transcranial magnetic stimulation clinics and the current experimental status of deep brain stimulation. Conclusions: Neuroethics discourse, particularly for deep brain stimulation, has continued to focus on how post-intervention changes in personality and behavior influence patient identity. Multiple conceptual frameworks have been proposed, though each faces critiques for addressing only parts of this complex phenomenon, prompting calls for pluralistic models. Emerging technologies, especially those involving artificial intelligence through brain computer interfaces, add new dimensions to this debate by raising concerns about neuroprivacy and legal responsibility for actions, further blurring the lines for defining personal identity. Full article

Background: Eco-anxiety and solastalgia are psychological responses to environmental degradation and climate change. This study examines how these concepts are represented in Spanish-language digital media, considering both emotional dimensions and the profiles of content producers. Methods: We conducted an inductive qualitative content analysis of 120 Spanish-language items (online news articles and selected posts from digital platforms) published between October 2023 and March 2024. Items were identified using a Boolean search strategy and initially filtered by LIWC to detect high emotional-and-anxiety term density; final coding followed grounded-theory procedures, resulting in four thematic categories. Results: The most frequent theme was environmental activism (41%), followed by catastrophic thinking (29%), coping strategies (25%), and loss of meaningful places (6%). Among content producers, citizen participants represented 40%, youth activists 25%, and scientists 15%. Digital media function both as sources of anxiety-inducing content and as spaces for awareness-raising and support. Conclusions: While eco-anxiety is not a clinical diagnosis, it exerts a significant psychological impact—particularly on youth and vulnerable groups. Spanish-language digital platforms play an ambivalent role, amplifying distress yet enabling resilience and collective action. Future interventions should leverage these channels to foster environmental awareness, emotional resilience, and civic engagement. Full article

Today, cathinone and its synthetic derivatives are among the most popular narcotics in the world. Their different cytotoxic activities on humans are increasingly and rapidly being published in forensic reports and the scientific literature. New studies demonstrate that these compounds target the apoptosis of some human cancer cell lines. These results could potentially open a new perspective for cathinones’ use as potential therapeutic agents. Even so, the psychostimulant effects of these compounds require testing their activity in the form of drug delivery systems. In our work, we report on the first theoretical studies concerning the potential use of functionalised carbon nanotubes (CNTs) as carriers in the targeted transport of cathinones. Using density functional theory (DFT), we predicted cathinone–CNT interaction energies in environments with different polarity, as well as the stability of complexes in simplified models of healthy and cancer tissue. The results of the current work provide first-step insights into cathinone–CNT non-covalent complex formation in neutral and acidified environments. This study may serve as the theoretical basis for further experimental works on the possibility of using cathinone–CNT complexes in targeted anticancer therapy. Full article

Background: Over the past two decades, the Copenhagen Psychosocial Questionnaire (COPSOQ) has been established as a valid instrument to measure psychosocial stress at work. Currently, the COPSOQ international network is responsible for monitoring and improving the COPSOQ. In 2019, a new questionnaire was published, and the Greek version is now being validated. The aim of the current study was to assess the reliability and validity of the psychometric properties of the Greek long version of the Copenhagen Psychosocial Questionnaire III (COPSOQ-III-GR). Methods: The measurement qualities of the Greek COPSOQ III have been explored in accordance with the usual requirements of a validation study, as defined by DIN EN ISO 10075-3. A sample of observations from 2189 participants surveyed with the COPSOQ in Greece was used to validate the current version with appropriate statistical analyses. Exploratory factor analysis was used to assess the statistical relationships for many scales. Results: With its 108 items and 40 scales, the Greek COPSOQ III includes all internationally validated psychosocial workplace factors that remain comparable (~72%) with the COPSOQ III German version content. In addition to the primary results, congruence with widely used theoretical approaches such as the demand–control (−support) model (DCM) or the job demands–resources model (JDR) is generally satisfactory. In summary, our validation study for the Greek COPSOQ III version showed adequate reliability and validity, which is in line with the findings of the COPSOQ III questionnaire from other European countries, and it is also compatible with the validation of the German COPSOQ III. Our regression analysis revealed that 34 psychosocial workplace factors (34 “context” scales) could adequately predict the scores of the satisfactory and health scales (6 “outcome” scales). The analysis also revealed the top five predictors (context variables) for each of the six “effect” scales (outcome variables). Conclusions: With the launch of COPSOQ III in Greece, current and new workplace psychosocial aspects could be explored, since COPSOQ III (GR) appears to be a valid and reliable instrument for enterprise research and risk assessment. Full article

Background/Objectives: Introducing new transformative surgical technology involves navigating a complex process from design to implementation, often hindered by various barriers that delay the transition into clinical practice. This review critically examines the barriers, proposes a unified guide for medical device implementation in the Australian healthcare system utilising the validated Medtech Innovation Guide, and compares regulatory frameworks in Australia, the United Kingdom, and the United States of America. Methods: We conducted a literature review using MEDLINE and EMBASE with MeSH terms or emtree terms and keywords “new OR novel” AND “surgical device OR medical device OR health technology OR surgical technology OR surgical instrument OR transformative technology OR technological innovation OR technological change” AND “implementation OR adoption OR innovation adoption” AND “surgery OR surgical” AND “Australia”. We also assessed governmental websites (gov.au) and documents as well as the Royal Australasian College of Surgeons (RACS) website, policies, and position statements. Furthermore, Australian medical technology start-up companies were asked for any published roadmaps. Results: Four key stakeholder groups were identified: medical professionals, government, hospitals, and patients/consumers. Barriers include surgeon scepticism, regulatory hurdles (e.g., Australian Register of Therapeutic Goods), hospital clearance processes, and meeting patient expectations. To address these challenges, we propose a five-phase system: surgical device development (phase one), compliance with regulatory processes (phase two), research and experimentation (phase three), finalisation for product launch (phase four), and product launch and assessment (phase five). Conclusions: By following our five-phase guide, innovators may better navigate the complexities of integrating transformative surgical technologies into Australian healthcare. Although there are limitations, this approach is based on the validated Medtech Innovation Guide and may help both experienced and inexperienced practitioners better implement innovative technology; however, real-world validation is required. Full article

Although he first published fiction during the fin de siècle with John Lane, publisher of The Yellow Book, Arthur Machen denied a Decadent heritage for his work; nonetheless, echoes of Decadent interests and imagery carried through his fiction long after the 1890s, through to his final novel, The Green Round. Decades later, M. John Harrison’s Viriconium series of novels and stories nodded to and wrestled with the Decadent legacy, while his interest in Machen became explicit with the short story “The Great God Pan” (the title taken from one of Machen’s most famous tales) and the novel The Course of the Heart, built from the earlier story. Harrison was an initiator of the New Weird literary tendency at the turn of the millennium, and one of the books central to that tendency is K.J. Bishop’s 2003 novel The Etched City, which openly drew on Decadent writings and on Harrison’s own use of Decadent material. Attending to writings by Machen, Harrison, and Bishop, we can see ways that Decadent aesthetics and imagery carried forward, finding a home a century later, not in the literary mainstream but in an experimental corner of the science fiction, fantasy, and horror genres. Full article

The metallogenic process of gold deposits is typically characterized by multi-stage mineralization and complex tectonic evolution. Precise determination of metallogenic age is thus critical yet challenging for establishing ore-forming models and tectonic evolutionary frameworks. The Koka gold deposit in Eritrea represents the largest gold discovery to date in the area, though its metallogenic age and tectonic evolution remain debated. This study employs in situ micro-analysis techniques to investigate major/trace elements and U-Pb geochronology of hydrothermal monazite coexisting with gold mineralization, providing new constraints on the metallogenic timeline and tectonic setting. Petrographic observations reveal well-crystallized monazite with structural associations to pyrite and native gold, indicating near-contemporaneous formation. Trace element geochemistry shows peak formation temperatures of 270–340 °C for monazite, consistent with fluid inclusion data. Genetic diagrams confirm a hydrothermal origin, enabling metallogenic age determination. Monazite Tera–Wasserburg lower intercept ages and weighted mean ²⁰⁸Pb/²³³Th ages yield 586 ± 8.7 Ma and 589 ± 2.3 Ma, respectively, overlapping error ranges with published sericite ⁴⁰Ar/³⁹Ar ages. This confirms Ediacaran gold mineralization, unrelated to the Koka granite (851 ± 2 Ma). Statistical analysis of reliable age data reveals a three-stage tectonic evolution model: (1) 1000–875 Ma, Rodinia supercontinental rifting, with depleted mantle-derived mafic oceanic crust formation and Mozambique Ocean spreading; (2) 875–630 Ma, subduction-driven crustal accretion and Koka granite emplacement; and (3) 630–570 Ma, post-collision crustal/lithospheric remelting, with mixed metamorphic–magmatic fluids and meteoric water input driving gold precipitation. Full article

Lord Byron’s life and poetic works have inspired musical compositions across genres even during his lifetime. The English author’s fictional characters and themes impressed nineteenth-century European composers, especially since his Byronic heroes were often conflated with their creators’ own melancholy and revolutionary personas. In contrast to Byron-inspired songs and operas, instrumental programme music has raised doubts towards a direct correlation with its poetic sources. While epigraphs help direct listeners to specific ideas, their absence has prompted dismissals of intermedial relationships, even those proposed by the composers themselves. This essay explores major connections between Hector Berlioz’s Harold in Italy, a Symphony in Four Parts with Viola Obbligato (premiered 1834), and Byron’s semi-autobiographical narrative poem Childe Harold’s Pilgrimage: A Romaunt (published 1812–1818). Although Berlioz’s titles and memoirs partially identify Byron’s Childe Harold as his inspiration, other references, including his visits to the Abruzzi mountains, his fascination with Italian folk music, his reuse of earlier material, and his reflections on brigands and solitude, have fuelled ongoing debates about the work’s programmatic content. Combining historical-biographical research, melopoetics, and musical semiotics, this essay clarifies how indefinite elements were transmitted from poetic source to musical target. Particular focus is placed on the “Harold theme”, which functions as a Byronic microcosm: a structural, thematic, and gestural condensation of Byron’s poem into music. Observing the interactions between microcosmic motifs and macrocosmic forms in Berlioz’s symphony and their poetic analogues, this study offers a new reading of how Byron’s legacy is encoded in musical terms. Full article

In the context of digital transformation and Industry 4.0, the engineering profession is evolving rapidly, demanding new skill sets to maintain employability and support career development. This study identifies the competencies engineers must acquire to meet these challenges, addressing concerns from employers who perceive graduates as underprepared for real-world demands. A systematic literature review was conducted in accordance with PRISMA guidelines, using the Methodi Ordinatio technique to select and rank 59 peer-reviewed articles published between 2014 and 2024. The review identified 47 key competencies, which were organized into a comprehensive framework of seven dimensions: 4 transversal, 9 social, 15 personal, 4 cognitive, 7 digital, 3 green, and 5 technical skills. The results highlight that, while technical expertise remains essential, soft skills—such as leadership, teamwork, communication, and adaptability—are increasingly critical for success in the digital era. The proposed framework offers insights for curriculum development, corporate training, and policymaking, contributing to aligning education and professional development with the evolving demands of Industry 4.0. Future research will focus on the empirical validation of the framework to reinforce its applicability across academic and professional settings. Full article

Background/Objectives: Heart failure with preserved ejection fraction (HFpEF) has increased in prevalence as the population ages and associated comorbidities increase. Remote ischemic preconditioning (RIPC) has been shown to provide protection against ischemic injury to the heart and other organs. Therefore, the aim of this project will be to analyse the effectiveness of RIPC in terms of arterial stiffness, endothelial function, diastolic function, and exercise capacity in patients with HFpEF. Methods: The PIRIC-FEp study will be a parallel, randomised controlled trial with two groups conducted at the Faculty of Nursing in Cuenca, University of Castilla-La Mancha. Individuals who are diagnosed with HFpEF and are older than 40 years, with a left ventricular ejection fraction ≥50% and a sedentary lifestyle, will be included. The exclusion criteria will include, among others, patients with noncardiac causes of heart failure symptoms, significant pulmonary disease, diabetes, peripheral vascular disease, or myocardial infarction within the previous three months. A sample size of 48 patients was estimated, with 24 for each group. Participants will be randomly allocated (1:1) to either the RIPC intervention group or the control group to evaluate the effects on arterial stiffness, endothelial function, diastolic function, and exercise capacity. Assessments will be conducted at baseline and after a three-month follow-up period. Results: The findings will be published in a peer-reviewed journal article. Conclusions: This study is important for daily clinical practice because it provides a new approach for the treatment of HFpEF patients via RIPC. Full article

Background: The aim of this review is to summarize and evaluate the properties of antibacterial polysaccharides for application in dental implantology to identify knowledge gaps and provide new research ideas. Methods: The electronic databases PubMed, Medline, ProQuest, and Google Scholar were used to search for peer-reviewed scientific publications published between 2018 and 2025 that provide insights to answer research questions on the role of antibacterial polysaccharides in combating pathogens in dental implantology without triggering immune reactions and inflammation. Further research questions relate to the efficacy against various dental pathogens and the understanding of the antibacterial mechanism, which may enable the development of functionalized polysaccharides with long-term antibacterial activity. Results: Biomedical implants have revolutionized medicine but also increased the risk of infections. Implant infections are a major problem in implantology and lead to implant failure and replacement. An antibacterial coating could be an excellent strategy to extend the lifespan of implants and improve the quality of the patient’s life. Bacterial resistance to antibiotics poses significant challenges for researchers, forcing them to search for new ways to prevent bacterial infections in implantology. Antibacterial natural polymers have recently received considerable research attention due to their long-term antibacterial activity. Polysaccharides from marine sources, such as chitosan and alginate, or pectin, xanthan, etc., from various plants, appear to be promising biopolymers for such applications in implantology due to their antibacterial activity, biocompatibility, and osteogenic properties. The antibacterial activity of these natural biopolymers depends on their chemical and physical properties. Nanopolysaccharides exhibit higher antibacterial activity than conventional polysaccharides, but their toxicity to human cells must be considered. Their antibacterial activity is based on the disruption of bacterial DNA or RNA synthesis, increased cell wall permeability, membrane disruption, and cytoplasmic leakage. Conclusions: Polysaccharides are a class of natural polymers with a broad spectrum of biological activities. They exhibit antioxidant, immunomodulatory, anticoagulant, anticancer, anti-inflammatory, antibacterial, and antiviral activity. Furthermore, polysaccharides are non-cytotoxic and exhibit good biocompatibility with osteogenic cells. Bactericidal polysaccharides are attractive new antibacterial materials against implant infections and open up new perspectives in implantology. Full article

Allergic contact dermatitis (ACD) is an immunologic reaction to a dermal chemical exposure that, once triggered in an individual, will result in an allergic response following subsequent encounters with the allergen. Air Force epidemiological consultations have indicated that aircraft structural maintenance workers may experience ACD at elevated rates compared to other occupations. We aimed to better understand the utility of non-animal testing methods in characterizing the sensitization potential of chemicals used during Air Force operations by evaluating the skin sensitization hazard of Air Force-relevant chemicals using new approach methodologies (NAMs) in a case study. We also evaluated the use of NAM data to develop preliminary candidate surface guidelines (PCSGs, maximum concentrations of chemicals on workplace surfaces to prevent induction of dermal sensitization) for chemicals identified as sensitizers. NAMs for assessing skin sensitization, including in silico models and experimental assays, were leveraged into an integrated approach to predict sensitization hazard for 19 chemicals. Local lymph node assay effective concentration values were predicted from NAM assay data via previously published quantitative models. The derived values were used to calculate PCSGs, which can be used to compare the presence of these chemicals on work surfaces to better understand the risk of Airmen developing ACD from occupational exposures. Full article