Search Results (2,784)

Disability Certification is an instrument that can contribute to the identification of persons with disabilities who are potential beneficiaries of social protection programmes. In Colombia, the disability certification process was changed in 2020 to include a human rights perspective. However, little information exists on how far the process aligns with the recommendations made by the Convention on the Rights of Persons with Disabilities or to what extent it provides useful information for the operation of the country’s social protection system. This study aims to analyse how the changes implemented in 2020 have contributed to the identification and determination of persons with disabilities in social protection programmes in Colombia. This research uses an analytical-descriptive design, in which legal documents related to the social protection programme and disability certification were analysed. In addition, we conducted semi-structured interviews in Colombia with people with disabilities, professionals conducting the certification, and with key stakeholders, and we analysed the information using thematic analysis. Colombia changed its certification process in 2020, moving from a capacity-to-work assessment to a process of assessing functioning capacity and participation limitations following the International Classification of Functional Disability and Health. However, the new certification process has not provided an instrument to contribute to determining persons with disabilities who should be prioritised or receive social benefits in Colombia. The certification does not establish the support needs of people with disabilities, does not recommend reasonable adjustments to support their participation in society, and has not been used systematically in social protection programmes. Finally, individuals with disabilities commented that the disability certification is a process that does not open up opportunities to receive social benefits and social transfers, and in most cases, it is an expensive and lengthy process. Disability certification in Colombia is not an instrument that determines the needs of people with disabilities, nor the reasonable accommodations that they require in order to participate in society. Full article

A refined version of the q-Hermite–Hadamard inequalities for strongly convex functions is introduced in this paper, utilizing both left and right q-integrals. Tighter bounds and more accurate estimates are derived by incorporating strong convexity. New q-trapezoidal and q-midpoint estimates are also presented to enhance the precision of the results. The improvements in the results compared to previous work are demonstrated through numerical examples in terms of precision and tighter bounds, and the advantages of using strongly convex functions are showcased. Full article

Traditional seed supply chains face several hidden risks. Certain regulatory departments tend to focus primarily on entity circulation while neglecting the origin and accuracy of data in seed quality supervision, resulting in limited precision and low credibility of traceability information related to quality and safety. Blockchain technology offers a systematic solution to key issues such as data source distortion and insufficient regulatory penetration in the seed supply chain by enabling data rights confirmation, tamper-proof traceability, smart contract execution, and multi-node consensus mechanisms. In this study, we developed a system that integrates blockchain and neural networks to provide seed traceability services. When uploading seed traceability information, the neural network models are employed to verify the authenticity of information provided by humans and save the tags on the blockchain. Various neural network architectures, such as Multilayer Perceptron, Recurrent Neural Network, Fully Convolutional Neural Network, and Long Short-term Memory model architectures, have been tested to determine the authenticity of seed traceability information. Among these, the Long Short-term Memory model architecture demonstrated the highest accuracy, with an accuracy rate of 90.65%. The results demonstrated that neural networks have significant research value and potential to assess the authenticity of information in a blockchain. In the application scenario of seed quality traceability, using blockchain and neural networks to determine the authenticity of seed traceability information provides a new solution for seed traceability. This system empowers farmers by providing trustworthy seed quality information, enabling better purchasing decisions and reducing risks from counterfeit or substandard seeds. Furthermore, this mechanism fosters market circulation of certified high-quality seeds, elevates crop yields, and contributes to the sustainable growth of agricultural systems. Full article

Hydrogel films receive significant attention among researchers because they combine increased stimuli responsiveness and faster responses to the already excellent properties of their component materials. However, their preparation is complex and requires that many difficulties are overcome. The present work presents a new study regarding the preparation of pure and nanoparticle-loaded alginate-based films by spin-coating. Two-microliter solutions of sodium alginate and calcium chloride with different concentrations were deposited on a glass substrate and subjected to rapid rotations of between 100 and 1000 RPM. Film formation can be achieved by optimizing the ratio between the viscosity of the solutions, depending on their concentrations and the rotation speed. When these conditions are in the right range, a homogeneous film is obtained, showing good adherence to the substrate and uniform thickness. Films containing silver nanoparticles were prepared, exploiting the reaction between sodium borohydride and silver nitrate. The two reagents were added to the sodium alginate and calcium nitrate solution, respectively. Their concentration is the driving force for the formation of a uniform film: particles of about 50 nm that are well-dispersed throughout the film are obtained using AgNO₃ at 4 mM and NaBH₄ at 2 or 0.2 mM; meanwhile, at higher concentrations, one can also obtain the precipitation of inorganic crystals. Full article

Aside from a few passages addressing animals or the environment, Confucian philosophy appears to lack an environmental ethics perspective. Li Zhehou’s (李澤厚) contemporary work in Confucian philosophy continues this lacuna by limiting his understanding of community to the human realm. Using the common liberal humanism that limits moral actions to the interpersonal human realm misses the importance of inclusive moralities such as animal rights and environmental ethics. I propose that if we return to the original shared common cultural roots of Confucian and Daoist philosophy that a Confucian understanding of the natural world can embrace the non-human environment within the scope of Confucian morality. Extricating ideas from the Yijing, the Shijing, Xunzi, Dong Zhongshu, Wang Chong, and later scholars, the concept of the mutual resonance and response (ganying 感應) between the natural world and humans developed into the unity of heaven and humanity (tianren heyi 天人合一). An inclusive Confucian depth ecology opens new ways of thinking that can be deployed to envision deeper dimensions for understanding the self’s inner life, its connections to the outer life of the self–other relationship, and its extension to a kin relationship with the environment. This paper explores how these old and new ways of thinking can change our behavior and change our moral interactions with others including the environment and thereby enhancing freedom as an achievement concept derived from graceful moral action. Full article

Pulmonary hypertension (PH) is broadly defined as a mean pulmonary arterial pressure (mPAP) exceeding 20 mm Hg at rest. Pulmonary arterial hypertension (PAH) is a specific subset of PH characterized by a normal pulmonary arterial wedge pressure (PAWP), combined with elevated mPAP and increased pulmonary vascular resistance (PVR), without other causes of pre-capillary hypertension such as lung diseases or chronic thromboembolic pulmonary hypertension. The majority of PAH cases are idiopathic; other common etiologies include connective tissue disease-associated PAH, congenital heart disease, and portopulmonary hypertension. To a lesser extent, genetic and familial forms of PAH can also occur. The pathophysiology of PAH involves the following four primary pathways: nitric oxide, endothelin-1, prostacyclin, and activin/bone morphogenetic protein (BMP). Dysregulation of these pathways leads to a progressive vasculopathy marked by vasoconstriction, vascular proliferation, elevated right heart afterload, and ultimately right-sided heart failure. Diagnosing PAH is challenging and often occurs at advanced stages. The gold standard for diagnosis remains invasive right heart catheterization. Along with invasive hemodynamic measurements, several noninvasive imaging modalities such as echocardiography and ventilation-perfusion scanning are key adjunct techniques. Also, recent advancements in cardiac magnetic resonance (CMR) have opened a new era for PAH management. Additionally, CMR and echocardiography not only enable diagnosis but also aid in evaluating disease severity and monitoring treatment responses. Current PAH treatments focus on targeting molecular pathways, reducing inflammation, and inhibiting right-sided heart failure. Integrating imaging with basic science techniques is crucial for enhanced patient diagnosis, and precision medicine is emerging as a key strategy in PAH management. Additionally, the incorporation of artificial intelligence into both molecular and imaging approaches holds significant potential. There is a growing need to integrate new imaging modalities with high resolution and reduced radiation exposure into clinical practice. In this review, we discuss the molecular pathways involved in PAH, the imaging modalities utilized for diagnosis and monitoring, and current targeted therapies. Advances in molecular understanding and imaging technologies, coupled with precision medicine, could hold promise in improving patient outcomes and revolutionizing the management of PAH patients. Full article

The making of a land patrimony for the benefit of religious missions is profoundly linked to territorial construction in the colonies but is rarely examined from the angle of ecclesiastical governmentality over the ceded lands. This analysis highlights three complementary processes for understanding the role of religious mission land heritage in territorial reconfigurations. First, this article examines the process of “land sanctuarization”, which materializes territorial anchoring through the crystallization of land rights granted to religious missions over customary lands previously presumed to be “vacant”. Next, it explores the formation of an “ecclesiastical dominium”, manifested in the dismantling of state missions and their free transfer, explicit or tacit, to religious missions under concession or agreement regimes. This reveals the exercise of state power over the land heritage of religious missions, positioning them as structuring axes and administrative intermediaries for public services, thus giving rise to an ecclesiastical governmentality that drives territorial production and reconfiguration. Finally, postcolonial dynamics reveal the resurgence of new spatial polarities shaped by the complexity of evolving religious actors along the center–periphery axis of a recomposing territorialization. This study underscores the importance of a transversal approach to better govern the land legacies of religious missions, fostering a pluralistic reterritorialization of postcolonial societies in central Africa. Full article

This work studies the issue of distributed fault-tolerant control for a vehicle platoon with actuator faults, saturation, and external disturbances. As the degrees of wear, age, and overcurrent of a vehicle actuator might change during the working process, it is more practical to consider the actuator faults to be time-varying rather than constant. Considering a situation in which actuator faults may cause partial actuator effectiveness loss, a novel adaptive updating mechanism is developed to estimate this loss. A new nonlinear observer is proposed to estimate external disturbances without requiring us to know their upper bounds. Since non-zero initial spacing errors (ISEs) may cause instability of the vehicle platoon, a novel exponential spacing policy (ESP) is devised to mitigate the adverse effects of non-zero ISEs. Based on the developed nonlinear observer, adaptive updating mechanism, radial basis function neural network (RBFNN), and the ESP, a novel nonlinear observer-based distributed adaptive fault-tolerant control strategy is proposed to achieve the objectives of platoon control. Lyapunov theory is utilized to prove the vehicle platoon’s stability. The rightness and effectiveness of the developed control strategy are validated using a numerical example. Full article

Job advertisements play a key role in human resource management as they are the first contact between employers and potential employees. A well-written job advertisement communicates not only the requirements and expectations of the position but also the culture, values, and goals of the organisation. Transparent and attractive advertisements increase the number of applicants and help to select the right candidates, leading to more efficient recruitment and selection processes in the long run. From a human resource management perspective, effective job advertising can give organisations a competitive advantage. Continuous changes in the labour market and technological developments require new competencies. Digitalisation, automation, and data-driven decision-making have brought IT, analytical, and communication skills to the fore. There is a growing emphasis on soft skills such as problem solving, flexibility, and teamwork, which are essential in a fast-changing work environment. Job advertisements should reflect these expectations so that candidates are aware of the competencies and skills required for the position. The aim of the study is to carry out a cross-country comparative analysis for a few pre-selected jobs based on data extracted from the CEDEFOP database as it is assumed that there are differences between countries in the European Union in terms of the expectations of workers for the same jobs. Full article

In this study, we report for the first time a brand-new protocol for the multigram-scale synthesis of 5-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylic and 2,8-dimethylimidazo[1,2-b]pyridazine-6-carboxylic acids, without the utilization of metal-complex catalysts. The developed technology for the production of the aforementioned acids is of great importance for two reasons. Firstly, these acids serve as intermediates in the synthesis of risdiplam, the first small-molecule drug approved for the treatment of spinal muscular atrophy. Secondly, they themselves are valuable building blocks right from a broader medicinal chemistry perspective. The synthesis of risdiplam was carried out using a modified synthetic protocol, utilizing the acids indicated above as the key intermediates. The protocols presented in this study enable the production of target compounds with high purity and an acceptable yield. Full article

This article examines how governance structures and procedural timing influence the effectiveness of Territorial Management Instruments (TMIs) in Portugal. Anchored in a comparative analysis of two key legal reforms (Decree-Law No. 380/1999 and Decree-Law No. 80/2015), the study explores the tensions between democratic legitimacy and regulatory complexity. While the 1999 framework emphasized vertical coordination and participatory rights, it often led to procedural rigidity and institutional inertia. Conversely, the 2015 reform promoted digital tools and streamlined processes but introduced new governance gaps, reduced stakeholder diversity, and compressed consultation timelines. Drawing on a qualitative analysis of legal texts, policy documents, and technical documentation, the article introduces the concept of temporal governance, the idea that planning time is not merely a constraint but a governable resource. Through this lens, planning delays are reframed as either pathological (caused by inefficiency and fragmentation) or productive (used strategically to enhance environmental assessment and stakeholder engagement). A new conceptual framework is proposed to classify types of planning time, differentiate delays, and support temporal calibration in governance design. Findings show that effective planning outcomes hinge not only on legal architecture or participatory norms but also on the institutional ability to balance speed with deliberation and strategic foresight with procedural pragmatism. The paper concludes by calling for adaptive governance models that integrate time as a dynamic dimension of spatial planning, with implications for environmental resilience, democratic value, and, above all, institutional trust. Full article

The promotion of sustainable schools is an important criterion for the promotion of ecological protection and the transformation of today’s society into a more sustainable one. The early childhood environment is believed to provide the ideal foundation for fostering values and attitudes related to sustainable education and promoting pro-environmental behaviors. The main goal of this study is to explore educators’ perceptions and expectations regarding the role of sustainable schools in shaping the environmental awareness and behavior of young children. A pilot study was carried out in the context of quantitative research on Preschool Teachers of Primary Education. Research results indicate that a Sustainable School (SS), beyond the curriculum, must promote issues of environmental awareness, culture, equality, natural resource management, and human rights. Also, it was seen that a modern school should provide Educators with new training opportunities in teaching methods that are based on sustainability principles and promote sustainability skills. Students’ acquisition of environmental knowledge can positively influence pro-environmental behavior and increase the likelihood of engaging in sustainable practices to protect the environment. Full article

This study introduces Edible Streets as a distinct and scalable model of community-led urban food growing, specifically investigating the drivers and barriers to the initiative. Unlike traditional urban food-growing initiatives, Edible Streets explores the integration of edible plants into street verges and footpaths with direct community involvement of the people who live/work in a street. This study contributes new knowledge by evaluating Edible Streets through the COM-B model of behavioural change, through policy and governance in addition to behaviour change, and by developing practical frameworks to facilitate its implementation. Focusing on Oxford, the research engaged residents through 17 in-person interviews and 18 online surveys, alongside a stakeholder workshop with 21 policymakers, community leaders, and NGO representatives. Findings revealed strong motivation for Edible Streets, driven by values of sustainability, community resilience, and improved well-being. However, capability barriers, including knowledge gaps in gardening, land-use policies, and food preservation, as well as opportunity constraints related to land access, water availability, and environmental challenges, hindered participation. To address these, a How-to Guide was developed, and a pilot Edible Street project was launched. Future steps include establishing a licensing application model to facilitate urban food growing and conducting a Post-Use Evaluation and Impact Study. Nationally, this model could support Right to Grow policies, while globally, it aligns with climate resilience and food security goals. Locally grown food enhances biodiversity, reduces carbon footprints, and strengthens social cohesion. By tackling key barriers and scaling solutions, this study provides actionable insights for policymakers and practitioners to create resilient, equitable urban food systems. Full article

This article identifies the nature of Traditional Owners’ interests in Sea Country and addresses issues associated with all offshore energy projects—gas and wind. Exploring the impacts of offshore development on First Nations’ cultural heritage, the article proposes integration of free, prior and informed consent (FPIC) and the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP), into the regulatory and legislative offshore environment. In the Australian context, this particularly regards administrative and regulatory reforms to overcome uncertainty arising from recent decisions in the Federal Court. The international focus on new energy has fast-tracked many processes that sideline First Nations’ rights, hitherto understood within the onshore minerals extraction regimes. The reforms proposed in this article recognise an international commitment to enact the principles contained in the UNDRIP and other relevant international law. Full article

Current treatment strategies for partial tendon tears often lack the capacity to promote true tissue regeneration and improve long-term clinical outcomes. This study tested the hypothesis that treatment of a partial defect in the rabbit common calcaneus tendon (CCT) with uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) enables regenerative healing without scar formation. A full-thickness, 3 mm defect was produced in the midsubstance of the right gastrocnemius tendon, a component of the CCT, in adult female New Zealand white rabbits. Animals received either an injection of 28.3 × 10⁶ UA-ADRCs in 0.5 mL Ringer’s lactated solution (RLS) or saline, or RLS or saline alone as sham treatment. Tendons were analyzed 4 or 12 weeks post-treatment using histology, immunohistochemistry and non-destructive biomechanical testing. UA-ADRC-treated tendons showed newly formed connective tissue consistent with tendon regeneration, whereas sham-treated tendons developed scar tissue. Biomechanical testing showed significantly higher percent relaxation in UA-ADRC-treated tendons compared to sham controls (p < 0.05), indicating greater viscoelasticity characteristic of healthy or well-integrated tissue. Together, these findings suggest that UA-ADRC therapy may provide a regenerative, structure-modifying treatment for partial tendon tears. Full article