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Article

10 Citations

4,291 Views

20 Pages

Zinc Modulation of Neuronal Calcium Sensor Proteins: Three Modes of Interaction with Different Structural Outcomes

Viktoriia E. Baksheeva,
Philipp O. Tsvetkov,
Arthur O. Zalevsky,
Vasiliy I. Vladimirov,
Neonila V. Gorokhovets,
Dmitry V. Zinchenko,
Sergei E. Permyakov,
François Devred and
Evgeni Yu. Zernii

Biomolecules2022, 12(7), 956;https://doi.org/10.3390/biom12070956

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8 July 2022

Neuronal calcium sensors (NCSs) are the family of EF-hand proteins mediating Ca2+-dependent signaling pathways in healthy neurons and neurodegenerative diseases. It was hypothesized that the calcium sensor activity of NCSs can be complemented by sens...

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Article

6 Citations

4,255 Views

22 Pages

A Novel Approach to Bacterial Expression and Purification of Myristoylated Forms of Neuronal Calcium Sensor Proteins

Vasiliy I. Vladimirov,
Viktoriia E. Baksheeva,
Irina V. Mikhailova,
Ramis G. Ismailov,
Ekaterina A. Litus,
Natalia K. Tikhomirova,
Aliya A. Nazipova,
Sergei E. Permyakov,
Evgeni Yu. Zernii and
Dmitry V. Zinchenko

Biomolecules2020, 10(7), 1025;https://doi.org/10.3390/biom10071025

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10 July 2020

N-terminal myristoylation is a common co-and post-translational modification of numerous eukaryotic and viral proteins, which affects their interaction with lipids and partner proteins, thereby modulating various cellular processes. Among those are n...

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