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19 pages, 18485 KiB  
Article
Astronomical Forcing of Fine-Grained Sedimentary Rocks and Its Implications for Shale Oil and Gas Exploration: The BONAN Sag, Bohai Bay Basin, China
by Jianguo Zhang, Qi Zhong, Wangpeng Li, Yali Liu, Peng Li, Pinxie Li, Shiheng Pang and Xinbiao Yang
J. Mar. Sci. Eng. 2025, 13(6), 1080; https://doi.org/10.3390/jmse13061080 - 29 May 2025
Viewed by 390
Abstract
Fine-grained sedimentary rocks are ideal carriers for astronomical cycle analysis as they can record and preserve significant astronomical cycle signals. Spectral analysis using the Multi-taper Method (MTM) and Evolutionary Harmonic Analysis (EHA) using the Fast Fourier Transform (FFT) were conducted on natural gamma [...] Read more.
Fine-grained sedimentary rocks are ideal carriers for astronomical cycle analysis as they can record and preserve significant astronomical cycle signals. Spectral analysis using the Multi-taper Method (MTM) and Evolutionary Harmonic Analysis (EHA) using the Fast Fourier Transform (FFT) were conducted on natural gamma data from key wells in the Es3l sub-member in the Bonan Sag, Bohai Bay Basin, China. Gaussian bandpass filtering was applied using a short eccentricity cycle of 100 ka, and a “floating” astronomical time scale for the Es3l sub-member (Lower 3rd sub-member of Shahejie Formation in Eocene) was established using magnetic stratigraphic ages as boundaries. Stratigraphic divisions were made for single wells in the Es3l of the Bonan Sag, and a stratigraphic framework was established based on correlations between key wells. The research results indicate the following: Firstly, the Es3l of the Bonan Sag records significant astronomical cycle signals, with an optimal sedimentation rate of 8.39 cm/ka identified. Secondly, the cyclical thicknesses corresponding to long eccentricity, short eccentricity, obliquity, and precession cycles are 38.9 m, 9.7 m, 4.6–3.4 m, and 1.96–1.66 m, respectively. Thirdly, the Es3l sub-member stably records 6 long eccentricity cycles and 26 short eccentricity cycles, and the short eccentricity curve is used as a basis for stratigraphic division for high-precision stratigraphic correlations. Fourthly, the quality of sandstone-interbedded mudrock is jointly controlled by the short eccentricity and precession. Eccentricity maximum values result in thicker sandstone interlayers, while minimum precession values promote the thickness of sandstone interlayers. Through astronomical cycle analysis, the depositional evolution mechanism of sandstone-interbedded mudrock is revealed. Combined with the results of high-precision stratigraphic division, this can provide a basis for fine evaluation and “sweet spot” prediction of lacustrine shale oil reservoirs. Full article
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13 pages, 5874 KiB  
Article
Fano Resonance Mach–Zehnder Modulator Based on a Single Arm Coupled with a Photonic Crystal Nanobeam Cavity for Silicon Photonics
by Enze Shi, Guang Chen, Lidan Lu, Yingjie Xu, Jieyu Yang and Lianqing Zhu
Sensors 2025, 25(10), 3240; https://doi.org/10.3390/s25103240 - 21 May 2025
Viewed by 689
Abstract
Recently, Fano resonance modulators and photonic crystal nanobeam cavities (PCNCs) have attracted more and more attention due to their superior performance, such as high modulation efficiency and high extinction ratio (ER). In this paper, a silicon Fano resonance Mach–Zehnder modulator (MZM) based on [...] Read more.
Recently, Fano resonance modulators and photonic crystal nanobeam cavities (PCNCs) have attracted more and more attention due to their superior performance, such as high modulation efficiency and high extinction ratio (ER). In this paper, a silicon Fano resonance Mach–Zehnder modulator (MZM) based on a single arm coupled with a PCNC is theoretically analyzed, designed, and numerically simulated. By optimizing the coupling length, lattice constant, coupling gap, and the number of holes in the mirror/taper region, the ER of our MZM can achieve 34 dB. When the applied voltage of the MZM is biased at 4.3 V and the non-return-to-zero on–off keying (NRZ-OOK) signal at a data rate of 10 Gbit/s is modulated, the sharpest asymmetric resonant peak and the most remarkable Fano line shape can be obtained around a wavelength of 1550.68 nm. Compared with the traditional nanobeam cavities, along with the varying radii, our PCNC design has holes with a fixed radius of 90 nm, which is suitable to be fabricated by a 180 nm passive silicon photonic multi-project wafer (MPW). Therefore, our compacted lab-on-chip, resonance-based silicon photonic MZM that is coupled with a PCNC has the advantages of superior performance and easy fabrication, which provide support for photonic integrated circuit designs and can be beneficial to various silicon photonic application fields, including photonic computing, photonic convolutional neural networks, and optical communications, in the future. Full article
(This article belongs to the Special Issue Advances in Microwave Photonics)
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17 pages, 3522 KiB  
Article
The Changes in Annual Precipitation in the Forest–Steppe Ecotone of North China Since 1540
by Xiaodong Wang, Jinfeng Ma, Long Fei, Xiaohui Liu and Xiaoqiang Li
Forests 2025, 16(5), 847; https://doi.org/10.3390/f16050847 - 19 May 2025
Viewed by 440
Abstract
Understanding precipitation changes over a long period of time can provide valuable insights into global climate change. Taking the forest–steppe ecotone of North China as the research area, based on the tree ring width index of Carya cathayensis Sarg (Carya cathayensis), [...] Read more.
Understanding precipitation changes over a long period of time can provide valuable insights into global climate change. Taking the forest–steppe ecotone of North China as the research area, based on the tree ring width index of Carya cathayensis Sarg (Carya cathayensis), the relationship between tree growth and climate factors is analyzed, and the annual precipitation is reconstructed from data from the nearest five weather stations from AD 1540 to 2019. The results show that the growth of trees was affected by the changes in precipitation. The precipitation was divided into three dry periods and three wet periods over 480 years, based on wavelet analysis. There were 328 years of precipitation within the mean plus or minus one standard deviation (SD) (accounting for 68.3% of 480 years), indicating that relatively stable climate conditions exist in the study area, which has become one of the main agricultural areas in China. Each period lasted 2–7 years according to the multi-taper method, indicating that precipitation change was closely related to the El Niño–Southern Oscillation (ENSO) on a short time scale and affected by the Atlantic Multidecadal Oscillation (AMO) on a medium time scale during the period of 60–80 years based on wavelet analysis. Full article
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33 pages, 11917 KiB  
Article
Multi-Fidelity Surrogate-Assisted Aerodynamic Optimization of Aircraft Wings
by Eleftherios Nikolaou, Spyridon Kilimtzidis and Vassilis Kostopoulos
Aerospace 2025, 12(4), 359; https://doi.org/10.3390/aerospace12040359 - 20 Apr 2025
Viewed by 816
Abstract
This paper presents a multi-fidelity optimization procedure for aircraft wing design, implemented in the early stages of the aircraft design process. Since wing shape is a key factor that influences aerodynamic performance, having an accurate estimate of its efficiency at the conceptual design [...] Read more.
This paper presents a multi-fidelity optimization procedure for aircraft wing design, implemented in the early stages of the aircraft design process. Since wing shape is a key factor that influences aerodynamic performance, having an accurate estimate of its efficiency at the conceptual design phase is highly beneficial for aircraft designers. This study introduces a comprehensive optimization framework for designing the wing of a Class I fixed-wing mini-UAV with electric propulsion, focusing on maximizing aerodynamic efficiency and operational performance. Utilizing Class-Shape Transformation (CST) in combination with Surrogate-Based Optimization (SBO) techniques, the research first optimizes the airfoil shape to identify the most suitable airfoil for the UAV wing. Subsequently, SBO techniques are applied to generate wing geometries with varying characteristics, including aspect ratio (AR), taper ratio (λ), quarter-chord sweep angle (Λ0.25), and tip twist angle (ε). These geometries are then evaluated using both low- and high-fidelity aerodynamic simulations. The integration of SBO techniques enables an efficient exploration of the design space while minimizing the computational costs associated with iterative simulations. Specifically, the proposed SBO framework enhances the wing’s aerodynamic characteristics by optimizing the lift-to-drag ratio and reducing drag. Full article
(This article belongs to the Section Aeronautics)
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15 pages, 5041 KiB  
Article
A Copper-Molybdenum Etchant with Wide Process Window, Long Bath Life and High Stability for Thin Film Transistor Liquid Crystal Display Applications
by Bing Zhang, Yafen Yang and David Wei Zhang
Materials 2025, 18(8), 1795; https://doi.org/10.3390/ma18081795 - 14 Apr 2025
Viewed by 632
Abstract
Conventional etchants for multi-metal/alloy stacked structures often suffer from nonuniform etching, residual layers, or undercutting, failing to meet high-generation production standards. This study presents a stable copper-molybdenum (Cu-Mo) etchant with extended bath life for thin film transistor liquid crystal display (TFT-LCD) applications, achieved [...] Read more.
Conventional etchants for multi-metal/alloy stacked structures often suffer from nonuniform etching, residual layers, or undercutting, failing to meet high-generation production standards. This study presents a stable copper-molybdenum (Cu-Mo) etchant with extended bath life for thin film transistor liquid crystal display (TFT-LCD) applications, achieved through compositional optimization. Systematic investigations have been conducted on the effects of etching time, copper ion (Cu2+) loading (bath life) and storage time on the etch performance, alongside evaluations of sudden-eruption point and material compatibility. Results demonstrate that over-etching beyond the “detected endpoint” by 10% to 90% maintains critical dimension (CD) bias and taper angle of MoNiTi(MTD)/Cu/MTD three-layer and Cu/MTD two-layer within process specifications, as well as the difference between the CD bias of the three-layer and two-layer structures at the same over-etch time. The optimized formulation exhibits a 20% broader process window and 20% longer bath life compared to the process-of-record (POR) etchant. Shelf stability exceeds 15 days with minimal performance degradation, while maintaining compatibility with industrial equipment materials. These advancements address key challenges in high-precision etching for advanced TFT-LCD manufacturing, providing a scalable solution for next-generation display production. Full article
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17 pages, 17326 KiB  
Article
Enhanced Adaptive Sine Multi-Taper Power Spectral Density Estimation for System Performance Evaluation in Low-Frequency Gravitational Wave Detection
by Caiyun Liu, Yang Li, Changkang Fu, Hongming Zhang, Qiang Wang, Dong He and Yongmei Huang
Appl. Sci. 2025, 15(7), 3919; https://doi.org/10.3390/app15073919 - 3 Apr 2025
Viewed by 457
Abstract
The power spectral density estimation algorithms, logarithmic frequency axis for power spectral density (LPSD), and the LISA-LPSD algorithm are widely utilized in the implementation of system evaluations for space-based gravitational-wave-detection projects, particularly in the low-frequency band ranging from 0.1 mHz to 1 Hz. [...] Read more.
The power spectral density estimation algorithms, logarithmic frequency axis for power spectral density (LPSD), and the LISA-LPSD algorithm are widely utilized in the implementation of system evaluations for space-based gravitational-wave-detection projects, particularly in the low-frequency band ranging from 0.1 mHz to 1 Hz. However, existing adaptive sine multi-taper algorithms suffer from low resolution and high computational complexity in obtaining the optimal cone number across the entire frequency domain, which has hindered its application in this field. These algorithms often face challenges related to inadequate resolution when dealing with low-frequency signals, as well as the issue of high computational demands. In response to these challenges, this paper introduces an advanced adaptive sine multi-taper algorithm designed to optimize the determination of the cone number. By balancing the relationship between bias and variance, this approach facilitates gradient processing of the cone number specifically tailored for low-frequency signals. Comparative evaluations against the LPSD algorithm, the original adaptive sine multi-taper algorithm, and the LISA-LPSD algorithm reveal that the proposed method demonstrates superior spectral resolution and reduced algorithmic complexity. This improvement offers a more effective solution for the system evaluation of low-frequency gravitational-wave-detection projects. Full article
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21 pages, 23686 KiB  
Article
Improved Thin-Kerf Processing in Cf/SiC Composite by Waterjet-Guided Nanosecond Laser Decreases Oxidation and Thermal Effect
by Jiayu Wang, Guangyi Zhang, Qiaoli Wang, Youmin Rong, Chaochao Zhao, Chunguang Chen, Binying Bao, Wenwu Zhang and Liyuan Sheng
Materials 2025, 18(7), 1560; https://doi.org/10.3390/ma18071560 - 29 Mar 2025
Cited by 2 | Viewed by 587
Abstract
As a hard and brittle material, the processing of Cf/SiC ceramic matrix composites (CMCs) faces significant challenges, especially in the processing of small-sized shapes. To address this challenge, laser processing with gas-assisted nanosecond laser (GNL) and waterjet-guided nanosecond laser (WNL) modes [...] Read more.
As a hard and brittle material, the processing of Cf/SiC ceramic matrix composites (CMCs) faces significant challenges, especially in the processing of small-sized shapes. To address this challenge, laser processing with gas-assisted nanosecond laser (GNL) and waterjet-guided nanosecond laser (WNL) modes were applied to fabricate thin kerfs in the Cf/SiC composite. The surface morphology, microstructure, and chemical composition of the processed Cf/SiC composite were investigated comparatively. The results revealed that the coupling of helium in the GNL mode laser processing could make full use of the laser energy, but resulted in spattering in the kerf margin and a recast layer in the kerf surface, accompanied by obvious oxidation, while the coupling of the waterjet in the WNL mode laser processing decreased the oxidation significantly and removed the remelting debris, which produced a clear and flat kerf surface. Due to the taper caused by laser energy dissipation, the single-path laser processing in the Cf/SiC composite had a limited depth. The maximum depth of the kerf prepared by single-path laser processing with the GNL mode was about 328 μm, while that with the WNL mode was about 302 μm. The multi-path laser processing with the GNL and WNL modes could fabricate a through kerf in the Cf/SiC composite, but the coupling medium obviously influenced the surface morphology and microstructure of the underlying region. The kerf surface prepared by the GNL mode had a varied surface morphology, which transited from the top layer, covered with oxide particles and some cracks, to the bottom layer, featured with micro-grooves and small oxides. The kerf surface prepared by the WNL mode had a consistently smooth and clean morphology featured with broken carbon fiber and residual SiC matrix. The slow laser energy dissipation and open environment in the GNL mode resulted in a bigger HAZ and relatively serious oxidation, which caused local phase transformation and microstructure degradation. The isolation condition and rapid cooling in the WNL mode decreased the HAZ and restrained the oxidation, almost keeping the original microstructure. The thicknesses of the HAZ in the GNL- and WNL-processed Cf/SiC composite were about 200 μm and 100 μm, respectively. The WNL-processed Cf/SiC composite had a lower oxidation and thermal damage surface, which is instructive for the processing of the Cf/SiC composite. Full article
(This article belongs to the Special Issue Recent Advances in Precision Manufacturing Technology)
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25 pages, 4969 KiB  
Article
A Design Guide to Tapered Conformable Pressure Tanks for Liquid Hydrogen Storage
by Joren Malfroy, Johan Steelant and Dirk Vandepitte
Aerospace 2025, 12(3), 190; https://doi.org/10.3390/aerospace12030190 - 27 Feb 2025
Cited by 2 | Viewed by 1241
Abstract
Liquid hydrogen has the potential to significantly reduce in-flight carbon emissions in the aviation industry. Among the most promising aircraft configurations for future hydrogen-powered aviation are the blended wing body and the pure flying wing configurations. However, their tapered and flattened airframe designs [...] Read more.
Liquid hydrogen has the potential to significantly reduce in-flight carbon emissions in the aviation industry. Among the most promising aircraft configurations for future hydrogen-powered aviation are the blended wing body and the pure flying wing configurations. However, their tapered and flattened airframe designs pose a challenge in accommodating liquid hydrogen storage tanks. This paper presents a design guide to tapered conformable pressure tanks for liquid hydrogen storage. The proposed tank configurations feature a multi-bubble layout and are subject to low internal differential pressure. The objective is to provide tank designers with simple geometric rules and practical guidelines to simplify the design process of tapered multi-bubble pressure tanks. Various tank configurations are discussed, starting with a simple tapered two-bubble tank and advancing to more complex tapered configurations with a multi-segment and multi-bubble layout. A comprehensive design methodology is established, providing tank designers with a step-by-step design procedure and highlighting the practical guidelines in each step of the design process. Full article
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22 pages, 4474 KiB  
Article
Advancing Stem Volume Estimation Using Multi-Platform LiDAR and Taper Model Integration for Precision Forestry
by Yongkyu Lee and Jungsoo Lee
Remote Sens. 2025, 17(5), 785; https://doi.org/10.3390/rs17050785 - 24 Feb 2025
Cited by 1 | Viewed by 1005
Abstract
Stem volume is a critical factor in managing and evaluating forest resources. At present, stem volume is commonly estimated indirectly by constructing a taper model that utilizes sampling, diameter at breast height (DBH), and tree height. However, these estimates are constrained by errors [...] Read more.
Stem volume is a critical factor in managing and evaluating forest resources. At present, stem volume is commonly estimated indirectly by constructing a taper model that utilizes sampling, diameter at breast height (DBH), and tree height. However, these estimates are constrained by errors arising from spatial and stand environment variations as well as uncertainties in height measurements. To address these issues, this study aimed to accurately estimate stem volume using light detection and ranging (LiDAR) technology, a key tool in modern precision forestry. LiDAR data were used to build comprehensive three-dimensional models of forests with multi-platform LiDAR systems. This approach allowed for precise measurements of tree heights and stem diameters at various heights, effectively mitigating the limitations of earlier measurement methods. Based on these data, a Kozak taper curve was developed at the individual tree level using LiDAR-derived tree height and diameter estimates. Integrating this curve with LiDAR data enabled a hybrid approach to estimating stem volume, facilitating the calculation of diameters at points not directly identifiable from LiDAR data alone. The proposed method was implemented and evaluated for two economically significant tree species in Korea: Pinus koraiensis and Larix kaempferi. The RMSE comparison between the taper curve-based approach and the hybrid volume estimation method showed that, for Pinus koraiensis, the RMSE was 0.11 m3 using the taper curve-based approach and 0.07 m3 for the hybrid method, while for Larix kaempferi, the RMSE was 0.13 m3 and 0.05 m3, respectively. The estimation error of the hybrid method was approximately half that of the taper curve-based approach. Consequently, the hybrid volume estimation method, which integrates LiDAR and the taper model, overcomes the limitations of conventional taper curve-based approaches and contributes to improving the accuracy of forest resource monitoring. Full article
(This article belongs to the Special Issue Remote Sensing-Assisted Forest Inventory Planning)
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14 pages, 1797 KiB  
Article
Study on the Reasonability of Single-Objective Optimization in Miniscrew Design
by Yu-Ching Li, Jiun-Ren Hwang and Chin-Ping Fung
Materials 2025, 18(5), 973; https://doi.org/10.3390/ma18050973 - 21 Feb 2025
Viewed by 517
Abstract
Miniscrews are used in orthodontic treatment and can be applied immediately after implantation, making their initial stability crucial. However, clinical reports show that the success rate is not 100%, and many researchers have tried to identify the factors influencing success and optimize designs. [...] Read more.
Miniscrews are used in orthodontic treatment and can be applied immediately after implantation, making their initial stability crucial. However, clinical reports show that the success rate is not 100%, and many researchers have tried to identify the factors influencing success and optimize designs. A review of the literature reveals that studies on the same geometric parameter of miniscrews using different indicators and different brand samples have led to conflicting results. This study will use consistent miniscrew conditions to verify whether the design differences in the literature are reasonable. This study employs the Taguchi method and ANOVA for optimization analysis. The four control factors comprise thread pitch, thread depth, tip taper angle, and self-tapping notch. Using an L9(34) orthogonal array, the experimental models are reduced to nine. The primary stability indicators for the miniscrew include bending strength, pull-out strength, insertion torque, and self-tapping performance. The results of the single-objective experiments in this study align with the findings from the other literature. However, when analyzed collectively, they do not yield the same optimal solution. Under equal weighting, the combined multi-objective optimal solution is A2B2C1D1. This study exhibits minimal experimental error, ensuring high analytical reliability. The findings confirm that the optimal design does not converge across four single-objective analyses, as different stability indicators yield contradictory trends in design parameters. Given that these four indicators already demonstrate notable discrepancies, the influence of additional stability factors would be even more pronounced. Therefore, a multi-objective optimization approach is essential for the rational design of miniscrews. Full article
(This article belongs to the Section Biomaterials)
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29 pages, 34281 KiB  
Article
Bio-Inspired Thin-Walled Straight and Tapered Tubes with Variable Designs Subjected to Multiple Impact Angles for Building Constructions
by Quanjin Ma, Nor Hazwani Mohd Yusof, Santosh Kumar Sahu, Yiheng Song, Nabilah Afiqah Mohd Radzuan, Bo Sun, Ahmad Yunus Nasution, Alagesan Praveen Kumar and Mohd Ruzaimi Mat Rejab
Buildings 2025, 15(4), 620; https://doi.org/10.3390/buildings15040620 - 17 Feb 2025
Cited by 2 | Viewed by 850
Abstract
Thin-walled structures are extensively utilized in construction because of their lightweight nature and excellent energy absorption efficiency, especially under dynamic loads. Improving the energy-absorbing performance of thin-walled structures by inspiring natural multi-cell designs is a sufficient approach. This paper investigates the energy-absorbing characteristics [...] Read more.
Thin-walled structures are extensively utilized in construction because of their lightweight nature and excellent energy absorption efficiency, especially under dynamic loads. Improving the energy-absorbing performance of thin-walled structures by inspiring natural multi-cell designs is a sufficient approach. This paper investigates the energy-absorbing characteristics of variable novel cross-section designs of thin-walled structures subjected to oblique impact loading. Straight and tapered types with seven cross-sectional designs of novel thin-walled structures were studied. The nonlinear ABAQUS/Explicit software 6.13 version was implemented to analyze the crashworthiness behaviors for the proposed variable cross-section designs under different loading angles. The crushing behaviors of the proposed thin-walled structures were examined for various wall thicknesses of 0.5 mm, 1.5 mm, and 2.5 mm and impact loading angles of 0°, 15°, 30°, and 45°. It was determined that the energy-absorbing characteristics of novel thin-walled structures can be efficiently controlled by varying two geometries and seven cross-section designs. A multi-criteria decision-making method (MCDM) using a complex proportional assessment method (COPRAS) was performed to select the optimum thin-walled structures with cross-section designs. It was shown that a tapered square thin-walled structure with 2.5 mm thickness had the best crashworthiness performances with energy absorption (EA) of 11.01 kJ and specific energy absorption (SEA) of 20.32 kJ/kg under a 30° impact angle. Moreover, the results indicated that the EA of the thin-walled structure decreased with the increase in the impact loading angle. In addition, with the increase in the impact loading angle, the peak crushing force (PCF) decreased and reflected the reduction in energy absorbed at a larger angle. The MCDM method in conjunction with the COPRAS method is proposed, it provides valuable insights for safer and more resilient building construction. Full article
(This article belongs to the Special Issue Bionic Materials and Structures in Civil Engineering)
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22 pages, 5917 KiB  
Article
Development of a Widely Accessible, Advanced Large-Scale Microfluidic Airway-on-Chip
by Brady Rae, Gwenda F. Vasse, Jalal Mosayebi, Maarten van den Berge, Simon D. Pouwels and Irene H. Heijink
Bioengineering 2025, 12(2), 182; https://doi.org/10.3390/bioengineering12020182 - 13 Feb 2025
Cited by 2 | Viewed by 1497
Abstract
On-chip microfluidics are advanced in vitro models that simulate lung tissue’s native 3D environment more closely than static 2D models to investigate the complex lung architecture and multifactorial processes that lead to pulmonary disease. Current microfluidic systems can be restrictive in the quantities [...] Read more.
On-chip microfluidics are advanced in vitro models that simulate lung tissue’s native 3D environment more closely than static 2D models to investigate the complex lung architecture and multifactorial processes that lead to pulmonary disease. Current microfluidic systems can be restrictive in the quantities of biological sample that can be retrieved from a single micro-channel, such as RNA, protein, and supernatant. Here, we describe a newly developed large-scale airway-on-chip model that employs a surface area for a cell culture wider than that in currently available systems. This enables the collection of samples comparable in volume to traditional cell culture systems, making the device applicable to any workflow utilizing these static systems (RNA isolation, ELISA, etc.). With our construction method, this larger culture area allows for easier handling, the potential for a wide range of exposures, as well as the collection of low-quantity samples (e.g., volatiles or mitochondrial RNA). The model consists of two large polydimethylsiloxane (PDMS) cell culture chambers under an independent flow of medium or air, separated by a semi-permeable polyethylene (PET) cell culture membrane (23 μm thick, 0.4 μm pore size). Each chamber carries a 5 × 18 mm, 90 mm2 (92 mm2 with tapered chamber inlets) surface area that can contain up to 1–2 × 104 adherent structural lung cells and can be utilized for close contact co-culture studies of different lung cell types, including airway epithelial cells, fibroblasts, smooth muscle cells, and endothelial cells. The parallel bi-chambered design of the chip allows for epithelial cells to be cultured at the air–liquid interface (ALI) and differentiation into a dense, multi-layered, pseudostratified epithelium under biological flow rates. This millifluidic airway-on-chip advances the field by providing a readily reproducible, easily adjustable, and cost-effective large-scale fluidic 3D airway cell culture platform. Full article
(This article belongs to the Special Issue Microfluidics and Sensor Technologies in Biomedical Engineering)
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31 pages, 1809 KiB  
Systematic Review
The Management of IgG4-Related Disease in Children: A Systematic Review
by Evdoxia Sapountzi, Eleni P. Kotanidou, Vasiliki-Rengina Tsinopoulou, Lampros Fotis, Liana Fidani and Assimina Galli-Tsinopoulou
Children 2025, 12(2), 213; https://doi.org/10.3390/children12020213 - 11 Feb 2025
Cited by 1 | Viewed by 1780
Abstract
Background/Objectives: IgG4-related disease (IgG4-RD) is a multi-organ disease with greatly varying therapeutic approaches and a lack of specific treatment algorithms. This systematic review aimed to determine the therapeutic approaches for pediatric IgG4-RD in real-word practice. Methods: We searched PubMed and Google [...] Read more.
Background/Objectives: IgG4-related disease (IgG4-RD) is a multi-organ disease with greatly varying therapeutic approaches and a lack of specific treatment algorithms. This systematic review aimed to determine the therapeutic approaches for pediatric IgG4-RD in real-word practice. Methods: We searched PubMed and Google Scholar for articles on pediatric IgG4-RD cases published in English from 2012 to August 2024, focusing on treatments and outcomes. Study type, treatment(s), dose/regimen, age and sex, organ(s) involved, and treatment outcomes were manually extracted from each study. Results: Of the 219 studies identified, we analyzed 81 studies, including 114 pediatric IgG4-RD cases. Fifty-seven percent of patients suffered from multi-organ disease and required several treatment schemes. Around 75% received steroids, alone or in combination, regardless of the organ affected. The treatment outcomes were positive in most cases, although relapses occurred in approximately 30% of patients, usually upon steroid tapering. Other common therapeutic approaches included immunosuppressants, often used as steroid-sparing agents, with azathioprine and mycophenolate mofetil being the most common; surgery for localized disease; and biologics, mainly rituximab, used in more severe/refractory cases. Uncommon but effective therapies included adalimumab and ruxolitinib. Drug combinations seemed to be more efficacious than monotherapies across studies. Patients > 10 years old more frequently received aggressive approaches (surgery and rituximab) and more often experienced relapses. Relapse rates were higher among females. Conclusions: This review highlights the use of systemic steroids as an effective first-line treatment for pediatric IgG4-RD, but also underscores the use of non-steroid-based alternatives in combination with steroids or other immunosuppressants for the effective management of IgG4-RD. Full article
(This article belongs to the Special Issue Advances in Research on Childhood Immune and Allergic Diseases)
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19 pages, 2276 KiB  
Article
A Broadband Mode Converter Antenna for Terahertz Communications
by Biswash Paudel, Xue Jun Li and Boon-Chong Seet
Electronics 2025, 14(3), 551; https://doi.org/10.3390/electronics14030551 - 29 Jan 2025
Viewed by 937
Abstract
The rise of artificial intelligence (AI) necessitates ultra-fast computing, with on-chip terahertz (THz) communication emerging as a key enabler. It offers high bandwidth, low power consumption, dense interconnects, support for multi-core architectures, and 3D circuit integration. However, transitioning between different waveguides remains a [...] Read more.
The rise of artificial intelligence (AI) necessitates ultra-fast computing, with on-chip terahertz (THz) communication emerging as a key enabler. It offers high bandwidth, low power consumption, dense interconnects, support for multi-core architectures, and 3D circuit integration. However, transitioning between different waveguides remains a major challenge in THz systems. In this paper, we propose a THz band mode converter that converts from a rectangular waveguide (RWG) (WR-0.43) in TE10 mode to a substrate-integrated waveguide (SIW) in TE20 mode. The converter comprises a tapered waveguide, a widened waveguide, a zigzag antenna, and an aperture coupling slot. The zigzag antenna effectively captures the electromagnetic (EM) energy from the RWG, which is then coupled to the aperture slot. This coupling generates a quasi-slotline mode for the electric field (E-field) along the longitudinal side of the aperture, exhibiting odd symmetry akin to the SIW’s TE20 mode. Consequently, the TE20 mode is excited in the symmetrical plane of the SIW and propagates transversely. Our work details the mode transition principle through simulations of the EM field distribution and model optimization. A back-to-back RWG TE10-to-TE10 mode converter is designed, demonstrating an insertion loss of approximately 5 dB over the wide frequency range band of 2.15–2.36 THz, showing a return loss of 10 dB. An on-chip antenna is proposed which is fed by a single higher-order mode of the SIW, achieving a maximum gain of 4.49 dB. Furthermore, a balun based on the proposed converter is designed, confirming the presence of the TE20 mode in the SIW. The proposed mode converter demonstrates its feasibility for integration into a THz-band high-speed circuit due to its efficient mode conversion and compact planar design. Full article
(This article belongs to the Special Issue Broadband Antennas and Antenna Arrays)
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32 pages, 8559 KiB  
Article
MultiProduct Optimization of Cedrelinga cateniformis (Ducke) Ducke in Different Plantation Systems in the Peruvian Amazon
by Juan Rodrigo Baselly-Villanueva, Andrés Fernández-Sandoval, Evelin Judith Salazar-Hinostroza, Gloria Patricia Cárdenas-Rengifo, Ronald Puerta, Tony Steven Chuquizuta Trigoso, Yennifer Lisbeth Rufasto-Peralta, Geomar Vallejos-Torres, Gianmarco Goycochea Casas, Carlos Alberto Araújo Junior, Gerónimo Quiñónez-Barraza, Pedro Álvarez-Álvarez and Helio Garcia Leite
Forests 2025, 16(1), 164; https://doi.org/10.3390/f16010164 - 16 Jan 2025
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Abstract
This study addressed multi-product optimization in Cedrelinga cateniformis plantations in the Peruvian Amazon, aiming to maximize volumetric yields of logs and sawn lumber. Data from seven plantations of different ages and types, established on degraded land, were analyzed by using ten stem profile [...] Read more.
This study addressed multi-product optimization in Cedrelinga cateniformis plantations in the Peruvian Amazon, aiming to maximize volumetric yields of logs and sawn lumber. Data from seven plantations of different ages and types, established on degraded land, were analyzed by using ten stem profile models to predict taper and optimize wood use. In addition, the structure of each plantation was evaluated using diameter distributions and height–diameter ratios; log and sawn timber production was optimized using SigmaE 2.0 software. The Garay model proved most effective, providing high predictive accuracy (adjusted R2 values up to 0.963) and biological realism. Marked differences in volumetric yield were observed between plantations: older and more widely spaced plantations produced higher timber volumes. Logs of optimal length (1.83–3.05 m) and larger dimension wood (e.g., 25.40 × 5.08 cm) were identified as key contributors to maximizing volumetric yields. The highest yields were observed in mature plantations, in which the total log volume reached 508.1 m3ha−1 and the sawn lumber volume 333.6 m3ha−1. The findings demonstrate the power of data-driven decision-making in the timber industry. By combining precise modeling and optimization techniques, we developed a framework that enables sawmill operators to maximize log and lumber yields. The insights gained from this research can be used to improve operational efficiency and reduce waste, ultimately leading to increased profitability. These practices promote support for smallholders and the forestry industry while contributing to the long-term development of the Peruvian Amazon. Full article
(This article belongs to the Special Issue Advances in Technology and Solutions for Wood Processing)
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