Search Results (306)

Biodegradable nanocomposite materials possessing self-healing behavior are emerging as an attractive option of being used in advanced mechatronic systems. The current study is focused on a thorough examination of the micromechanical properties of graphene–reinforced polylactic acid (PLA)/polycaprolactone (PCL) composite samples, followed by estimation of their self-healing behavior upon heating. Polymer blend–based nanocomposite materials were prepared using the green and reliable in terms of good nanofiller dispersion melt extrusion method. 3D printed nanocomposite specimens with impeccable flatness were subjected to fine microscratch testing by applying a constant force experimental mode. The surface resistance of the three-component polymer materials against the lateral movement of the stylus fulfilling the scratch and the impact of the dual-phase PLA/PCL ratio on the nanocomposite mechanical performance were estimated by calculation of the coefficient of friction (COF = F_x/F_z). COF values in the range of 0.8–1.4 indicated excellent nanocomposite resilience against scratch. Creating a heterogeneous polymer system that combines phase-separated soft and hard domains with close melt and glass transition temperatures, respectively, may facilitate the physical flow of macromolecular chains into voids or free volume areas. This aspect can be critical in the achievement of thermally–induced self-healing properties of the composite material. Scanning electron microscopy (SEM) imaging of the microscratches, made before and after Joule heating of the polymer samples, revealed a significant degree of surface recovery and a sensible reduction in the width of the adjusted scratch grooves. Full article

Antimicrobial resistance is a significant problem that has been studied in recent years. Viral diseases have generated high levels of morbidity and mortality, and recently, the world population faced a highly contagious viral disease (SARS-CoV-2), which caused millions of deaths without an effective drug capable of controlling the infectious process. As a result, various therapeutic alternatives to antimicrobials have emerged that target microorganisms, support the immune system, and reduce inflammation. Lactoferrin is a ultifunctional glycoprotein of the mammalian innate immune system that has shown various benefits, notably its antimicrobial and, primarily, its antiviral effects. No resistance or toxicity to this protein has been reported, which is why it is called a “miracle protein”. This is the first review to focus on the antiviral effects of lactoferrin in clinical trials. In addition, in vitro and in vivo studies evaluating lactoferrin against various viral etiologies are also discussed. Full article

We investigate a random field of mutually dependent random variables (“spins”), indexed by a finite one-dimensional lattice, called in physical sciences the one-dimensional Ising model, in which the random variables can take only ±1 values (see the text for a precise definition). One of the couplings, termed a “bond,” that describes the mutual influence of two adjacent random variables is altered—it does not equal the others, thereby introducing a single “defect” bond. This defect bond represents a localised perturbation within an otherwise uniform system. Utilising the recurrence relations of Chebyshev polynomials and the bijective map between the number of spins and the polynomial index, we present a new method for calculations and systematically explore, using it, the system’s properties across different chain lengths and boundary conditions. As an application, we derive analytical expressions for the dependence of the average values of the random variables on their position within the chain, which we refer to as the “local magnetisation profile”. From the findings related to the system with a defect bond, we present a novel result for this profile under free (Dirichlet) boundary conditions and re-derive the corresponding result for antiperiodic boundary conditions. Full article

Meat products face microbial safety challenges, while growing consumer demand for “clean label” options discourages the use of synthetic preservatives. Although Nisin and cultured dextrose (CD) are known natural antimicrobials, their combined application in meat systems has not been fully assessed. Herein, we systematically evaluated the antibacterial activity of CD in combination with Nisin against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) using a uniform design. While regression modeling of the in vitro data indicated a potent synergistic interaction at lower concentrations, the optimal practical combination for meat preservation was identified as 0.02% Nisin and 0.5% CD. This combination was applied to braised chicken breast stored at 0–4 °C, with microbial counts, pH, color, and sensory quality monitored over 28 days. The results indicated that this Nisin-CD combination significantly suppressed the growth of total viable bacteria, S. aureus, and E. coli, stabilized pH, minimized color variation, and maintained sensory acceptability. Therefore, the 0.02% Nisin and 0.5% CD combination is recommended as an effective clean-label strategy to extend the shelf life of meat products by enhancing microbial safety and quality without synthetic preservatives. Full article

The study presents the thermal evaluation of soft knitted textile systems with removable gel cooling panels. Two prototype configurations with different geometries and gel panel sizes were investigated using infrared thermography under controlled laboratory conditions. The results show a moderated and gradual cooling response during contact. The strongest surface cooling occurred shortly after contact, followed by a gradual increase in the surface temperature of the textile system due to heat transfer from the skin-temperature simulator. While the temperature of the skin-temperature simulator stabilised rapidly, the textile surface maintained a perceptible cooling effect over a longer period. Surface temperatures remained within ranges associated with comfort and safety under the applied experimental conditions. The findings indicate that system geometry and gel panel size influence heat exchange, while the knitted textile structure contributes to the observed cooling behaviour of the complete system. The results support the potential of knitted textile systems with removable gel cooling panels for gentle, localised cooling applications in controlled, non-clinical settings. Full article

The study proposes a sensor-based experimental protocol for quantifying dynamic facial temperature changes during face mask use by means of infrared thermography (IRT). Eight face masks, including filtering respirators, surgical masks, and one textile mask, were evaluated on three participants under controlled indoor conditions. Thermographic data were acquired at four defined measurement stages: prior to mask application, immediately after donning, after 15 min of continuous wear, and immediately after removal. The measurements reveal a reproducible temporal temperature pattern across participants and mask types, consisting of an initial cooling phase, subsequent heat accumulation during wear, and a pronounced temperature increase following removal. Thermal variations were observed both in mask-covered and uncovered facial regions. The inner canthus exhibited high sensitivity to these changes, supporting its use as a stable reference area. The study demonstrates the suitability of IRT for protocol-driven, non-contact assessment of dynamic facial thermal response during mask use. Full article

Lateral Organ Boundaries Domain (LBD) proteins are plant-specific transcription factors characterized by a typical N-terminal LOB domain and are critical for plant growth, development, and stress response. Currently, LBD genes have been investigated in various plant species, but they have yet to be identified in Neolamarckia cadamba, known as a ‘miracle tree’ for its fast growth and acknowledged for its potential medicinal value in tropical and subtropical areas of Asia. In this study, a total of 65 NcLBD members were identified in N. cadamba by whole-genome bioinformatics analysis. Phylogenetic analysis revealed their classification into two clades with seven distinct groups, and their uneven distribution across 18 chromosomes, along with 6 tandem repeats and 58 segmental duplications. Furthermore, enrichment analysis of transcription factor binding motifs within NcLBD promoters identified the MYB-related and WRKY families exhibited the most significant enrichment in the NcLBD promoter. Protein interaction network analysis revealed potential interactions among NcLBD proteins, as well as their interactions with various transcription factors. RNA-seq and qRT-PCR analyses of NcLBDs transcript levels showed distinct expression patterns both across various tissues and under different hormone and abiotic stress conditions. Specifically, NcLBD3, NcLBD37, and NcLBD47 were highly expressed in vascular cells and induced by abiotic stress, including cold, drought, and salt, suggesting their significant role in the processes. In summary, our genome-wide analysis comprehensively identified and characterized LBD gene family in N. cadamba, laying a solid foundation for further elucidating the biological functions of NcLBD genes. Full article

Recent text-to-image AI systems have revived the long-standing fantasy of the image that appears to generate itself. Building on Chesher and Albarrán-Torres’s concept of ‘autolography’, this article situates contemporary AI-generated imagery within a longer lineage of self-generating images that extends from religious acheiropoieta (‘not made by hand’) through photography to computational image-making. Through the lens of Practice-as-Research (PaR), it positions digital photogrammetry as a knowledge ground in which the fantasy of the self-generating image continues to perform the faith structures of earlier visual cultures. Drawing on photogrammetric experiments originating within Lisbon’s Church of São Domingos in 2018, this article examines unexpected artifacts—ghosts, smears, and fragmentations—that emerge from movement, and reveal the body of the researcher in the centre. It argues that such digital ‘miracle’ images function as contingent, embodied events, and renders visible the labour, presence, and gestures typically erased by automated systems. It playfully proposes the ‘cheiropoieton’ (‘made by hand’) as an embodied counter-ethics to autolography, insisting on friction, care, and accountability in contemporary image-making. Full article

This article reinterprets the doctrine of iʿjāz al-Qurʾān (the inimitability of the Qurʾān) by shifting the question from what makes the Qurʾān miraculous to how it is miraculous. It argues that the Qurʾān’s primary miracle lies not merely in its content, i.e., its eloquence or correspondence with scientific truth, but in its method: the transformation of the very frameworks through which knowledge, reason, and revelation were understood. Using Muḥammad ʿĀbid al-Jābirī’s tripartite epistemology of bayān (expressive reasoning), burhān (demonstrative reasoning), and ʿirfān (reflective reasoning) together with Gadamer’s “fusion of horizons,” the article argues that the Qurʾān can be read as fusing and transcending these three systems, uniting Arabic eloquence, Greek rationalism, and Persian–gnostic spirituality into a single, holistic discourse. Through close analysis of key passages, such as Abraham’s dialectical reasoning in Sūrat al-Anbiyāʾ and the metaphysics of light in Āyat al-Nūr, the article shows how the Qurʾān integrates poetic language, rational argument, and mystical depth to create an epistemic design that addresses intellect, emotion, and spirit simultaneously. This synthesis allows the Qurʾān to be interpreted, within classical and later exegetical traditions, not only as a linguistic or theological miracle but as a paradigmatic reconfiguration of cognition: one that these traditions understood as teaching readers how to think, reflect, and awaken. Full article

The growing accumulation of plastic and electronic waste highlights the urgent need for sustainable and biodegradable polymers. However, developing intrinsically conductive biodegradable polymers remains challenging, particularly for packaging and sensing applications. Poly(lactic acid) (PLA) is intrinsically non-conductive, and enhancing its functionality without compromising structural integrity is a key research goal. In this study, PLA-based filaments were developed using melt extrusion, incorporating cellulose nanocrystals (CNCs), graphene nanoplatelets (GNPs), and carbon nanotubes (CNTs), individually and in hybrid combinations with total filler contents between 1 and 5 wt%. The inclusion of CNC enhanced the dispersion of GNP and CNT, promoting the formation of interconnected conductive networks within the PLA matrix, allowing the percolation threshold to be reached at a lower fillers concentration. Hybrid formulations showed a balance melt strength and processability suitable for fused deposition modelling (FDM) 3D printing and prototypes successfully made. This study also provides the first systematic evaluation of temperature-dependent thermal conductivity of PLA-based composites at multiple temperatures (25, 5, and −20 °C), relevant to typical food and medical supply chains conditions. Full article

Chronic lymphocytic leukemia (CLL) has systemic effects that extend beyond malignant lymphocytes, potentially altering the structure and function of circulating red blood cells (RBCs). In this study, atomic force microscopy (AFM) was combined with complementary calorimetric analysis to investigate the membrane ultrastructure, nanomechanical characteristics, and thermodynamic behavior of RBCs from untreated CLL patients and those receiving targeted therapies (Obinutuzumab/Venetoclax or Ibrutinib). RBCs from untreated patients exhibited pronounced reduction in membrane roughness, increased stiffness and adhesion forces, and altered thermal unfolding of cytoskeletal and membrane proteins, indicative of impaired structural flexibility and stability. Treatment with Obinutuzumab/Venetoclax partially restored surface topography, but stiffness and adhesion forces remained elevated, suggesting persistent cytoskeletal rigidity. The obscured spectrin and Band 2–4 thermal transitions and the elevated total enthalpy change revealed by differential scanning calorimetry indicated a modified conformation or binding state of membrane proteins. In contrast, Ibrutinib therapy produced near-normal nanomechanical and thermal characteristics, reflecting a more comprehensive restoration of RBC integrity. These findings demonstrate that CLL and its therapies distinctly influence erythrocyte morphology and mechanics, underscoring the systemic impact of the disease. The strong correspondence between AFM and calorimetric data highlights the potential of integrated biophysical approaches to detect subtle RBC alterations and to serve as complementary indicators for therapeutic monitoring. Full article

This article examines the theory of miracles formulated by the distinguished Shī’ī-Mu’tazilī theologian, al-Sharīf al-Murtaḍā (965–1044 CE), specifically to contextualize his controversial doctrine of Qurʾānic iʿjāz, known as ṣarfah. The study reconstructs al-Murtaḍā’s general theory of miracles by analyzing his primary works and comparing his positions with standard Muʿtazilī theology. The investigation focused on how his metaphysical and moral frameworks interact to define the nature of miracles. I argue that al-Murtaḍā articulated a “minimal theory of miracles,” wherein miracles function as restricted, localized, and audience-relative “breaches of norms” (khawāriq al-ʿādāt) rather than violations of universal laws. In his view, miracles are morally necessary but temporally restricted acts of God, designed solely to authenticate a prophet to their immediate community. Al-Murtaḍā’s theory shifts the evidential burden of prophetic proof—including the Qur’ān—from continuing intrinsic supernatural qualities to discrete historical testimony. Finally, this study suggests that al-Murtaḍā appears to offer a rationally coherent alternative notion of miracles, that may well succeed from some of the most pressing contemporary intellectual challenges. Full article

For millennia, theologians and philosophers debated whether extraterrestrial intelligent life (ETI) exists in the universe. Some theologians concluded God enjoys creating so much he would not stop at one planet. Others argue God limits his miracles to those needed to achieve his purposes, which require only one planet with intelligent life. Thanks to exponential advances in observational astrophysics, scientists now are weighing in on the “are we alone in the cosmos” debate. Though far from resolving all the debate’s components, they now are able to provide definitive answers or steps towards definitive answers to several of the theological/philosophical issues. These answers arise from the following research endeavors: (1) search for ETI (SETI) efforts, results, and determined odds; (2) interplanetary panspermia; (3) ETI planetary habitability requirements; (4) ETI stellar habitability requirements; (5) ETI galactic habitability requirements; (6) “hard steps” in the evolution of life from non-life; (7); “hard steps” in ETI evolution from simple life; (8) interstellar space travel and exploration limitations; (9) nature of UAPs lacking natural or human-made explanations; and (10) nature of non-physical reality. The resultant answers increasingly are creating arenas of common agreement plus opening up avenues of dialog among theologians and scientists. This dialog on ‘are we alone in the cosmos’ is shedding additional light on humanity’s role and purposes in the cosmos. Full article

The intellectual legacy of the Baṣrān Muʿtazila has had a profound and lasting impact on the development of discussions on Qurʾānic inimitability. Numerous writings have been composed by Baṣrān Muʿtazila on the topic; among them is Iʿjāz al-Qurʾān by Abū Rashīd al-Naysābūrī, an unpublished manuscript preserved in the King Saud University Library under the number 7752. This paper focuses on the development of al-Naysābūrī’s understanding of Qurʾānic inimitability in the context of this manuscript, especially analysing his reception of early Muʿtazilī (specifically Bahshamī) thoughts on Qurʾānic inimitability. Moreover, it pays particular attention to al-Naysābūrī’s engagement with the critiques directed against the Bahshamī theory of Qurʾānic inimitability. This paper adopts a source-criticism approach to studying the manuscript and evaluating the historical development of its contents. It argues that the theoretical foundation underlying the theory of miraculous eloquence developed by ʿAbd al-Jabbār drew al-Naysābūrī’s attention towards a deep engagement with hypothetical dialogues inspired by the refutations of questions concerning Qurʾānic inimitability posed by the freethinkers’ movement. This engagement prompted al-Naysābūrī to adopt and assess numerous hypothetical frameworks and conditional views, including the ṣarfa theory, in his defence of Qurʾānic inimitability. This approach of addressing the freethinker critiques aligns greatly with the dynamic and responsive nature of Baṣrān Muʿtazila’s thoughts against freethinkers’ movement. Full article

This paper explores the function of miracles in classical and modern Islamic theology, focusing particularly on Fethullah Gülen’s interpretation and its relevance to contemporary discussions on revelation, rationality, and science. Traditionally, miracles are viewed as divine signs confirming prophethood by surpassing natural laws and serving as challenges to disbelievers. While classical scholars upheld their evidentiary role, modern thinkers—under the influence of positivism and rationalism—have sought to reinterpret or dismiss their validity, particularly sensory or physical miracles. In this context, Gülen presents a distinctive perspective that reframes miracles not merely as supernatural phenomena, but as signs pointing to both spiritual truths and technological inspiration. Drawing from the insights of Said Nursi, Gülen highlights how prophetic miracles have anticipated and guided scientific advancements, thereby integrating material progress with spiritual wisdom. Gülen’s holistic understanding of human nature and prophetic guidance, rooted in the concept of human beings as the most refined creation (ahsani taqwīm), positions prophets as leaders of both spiritual and intellectual advancement. This dual role challenges the perceived conflict between revelation and reason, asserting that rationality reaches its full potential only when informed by prophetic insight. The paper also situates Gülen’s thought within broader modern theological discourses, particularly in response to critiques that Islam is incompatible with science. Gülen affirms the necessity of revelation not as a hindrance to rational inquiry but as its essential guide, likening prophets to expert physicians who administer the elixir of revelation to protect and elevate the human mind. By analysing Gülen’s approach to miracles and prophetic intellect (fatānah), this paper argues that his theology offers a balanced framework for reconciling religion and science, and contributes a meaningful response to contemporary debates surrounding the rationality of faith and the enduring relevance of prophethood. Full article