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Keywords = micro/nano robot

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17 pages, 377 KB  
Article
Fractional–Temporal Lorentz Graph Networks: Integrating Physical Memory into Dynamic Knowledge Reasoning
by Xinyuan Chen, Norshaharizan Puteh and Mohd Nizam Husen
Electronics 2026, 15(9), 1919; https://doi.org/10.3390/electronics15091919 - 1 May 2026
Abstract
Dynamic knowledge representation in curved manifolds conventionally relies on integer-order Markovian sequence encoders, intrinsically yielding exponential memory decay. This paradigm fails to model the anomalous diffusion and heavy-tailed historical dependencies inherent in complex evolutionary networks and dense physical environments. This manuscript proposes the [...] Read more.
Dynamic knowledge representation in curved manifolds conventionally relies on integer-order Markovian sequence encoders, intrinsically yielding exponential memory decay. This paradigm fails to model the anomalous diffusion and heavy-tailed historical dependencies inherent in complex evolutionary networks and dense physical environments. This manuscript proposes the Fractional–Temporal Lorentz Graph Convolutional Network (FTL-GCN), formalizing temporal evolution as a continuous fractional geometric flow explicitly defined on the tangent bundle of the Lorentz manifold. Analytical derivations demonstrate that the discrete Grünwald–Letnikov memory kernel establishes a non-exponential, power-law lower bound for historical state retention, preventing topological manifold collapse over extended temporal horizons. Empirical evaluations demonstrate that FTL-GCN achieves competitive forecasting accuracy against the latest 2025–2026 state-of-the-art discrete models within specific temporal windows, while uniquely mitigating predictive degradation by up to 52% in long-horizon dependency stress tests and maintaining sub-millisecond latency for physical control. The architecture is subsequently deployed within an in silico biophysical simulation for autonomous micro–nano robotic navigation in the Tumor Microenvironment (TME). By establishing a physical-mathematical structural analogy—mapping the empirical fractional viscoelasticity of the extracellular matrix to the cognitive network’s fractional derivative order—FTL-GCN sustains continuous-space navigation policies in dense anomalous environments where standard integer-order models experience mechanical slip. Full article
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12 pages, 12276 KB  
Article
An Integrated Photo-Magnetic Sensor Chip Using Giant Magnetoresistance (GMR) and Light-Dependent Resistor (LDR) Technologies Based on Microfabrication Compatibility
by Xuecheng Sun, Xiaolong Chen, Jiao Li, Chunming Ren, Tian Tian, Aiying Guo and Chong Lei
Micromachines 2026, 17(5), 511; https://doi.org/10.3390/mi17050511 - 22 Apr 2026
Viewed by 263
Abstract
Single-chip integration technology for multifunctional sensors has become an important development direction due to its low power consumption and versatile functionality. However, the fabrication compatibility between different sensing components remains a key challenge for high-performance integrated sensors, often leading to complex processes and [...] Read more.
Single-chip integration technology for multifunctional sensors has become an important development direction due to its low power consumption and versatile functionality. However, the fabrication compatibility between different sensing components remains a key challenge for high-performance integrated sensors, often leading to complex processes and increased costs. This work presents a microfabrication-compatible photo-magnetic integrated sensor chip based on micro–nano processing methods. The integrated sensor chip includes giant magnetoresistance (GMR) and a light-dependent resistor (LDR). The fabrication process was based on standard MEMS fabrication with compatibility and cost-effectiveness. The experimental results demonstrated that the chip can simultaneously realize both optical and magnetic detection with magnetic field sensitivity of 3.74 mV/Oe and photodetection sensitivity of 0.79 μA/(μW/cm2) at a 5 V bias. The integrated sensor features high-sensitivity magnetic performance and weak-light detection capability, with promising application in robotics and advanced manufacturing fields. Full article
(This article belongs to the Special Issue Micro/Nano Manufacturing of Electronic Devices)
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42 pages, 5443 KB  
Review
Pulley-Based Flapping Propulsion for Hoverable Micro Air Vehicles: A Critical Review, Comparative Metrics and Roadmap
by Sebastian Valencia, Jaime Enrique Orduy, Pedro Melo and Cristian Lozano
Drones 2026, 10(2), 143; https://doi.org/10.3390/drones10020143 - 18 Feb 2026
Viewed by 1278
Abstract
Flapping-wing micro air vehicles (FWMAVs) have gained increasing attention due to their manoeuvrability, low acoustic signature, and suitability for confined or cluttered environments. Despite considerable progress, existing reviews treat actuation mechanisms and mechanical transmissions in isolation, leaving a gap in the comparative assessment [...] Read more.
Flapping-wing micro air vehicles (FWMAVs) have gained increasing attention due to their manoeuvrability, low acoustic signature, and suitability for confined or cluttered environments. Despite considerable progress, existing reviews treat actuation mechanisms and mechanical transmissions in isolation, leaving a gap in the comparative assessment of pulley-based and alternative flapping systems. This study provides a comprehensive and quantitative synthesis of the literature on FWMAV mechanical architectures, with particular emphasis on pulley-driven transmissions used in platforms such as the Nano Hummingbird and the Robotic Hummingbird. A structured review methodology was applied, incorporating a systematic database search, extraction of performance parameters, and cross-platform comparison of flapping frequency, lift generation, power consumption, lift-to-weight ratio, and material choices. The analysis identifies consistent scaling trends across motor-driven, piezoelectric, and hybrid actuation families and highlights the efficiency and stroke-amplification advantages of pulley-based mechanisms for centimetre-scale hovering MAVs. The review also identifies unresolved challenges, including durability of transmission materials, standardisation of performance metrics, and the need for high-fidelity aerodynamic characterisation. Overall, this work offers an integrated framework for understanding the trade-offs among actuation and transmission strategies and provides a roadmap to guide future research and the practical development of next-generation FWMAVs. Full article
(This article belongs to the Section Drone Design and Development)
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35 pages, 37297 KB  
Article
Heterogeneous Acoustofluidic Distributions Induced by Different Radiation Surface Arrangements in Various Pseudo-Sierpiński-Carpet-Shaped Chambers
by Qiang Tang, Boyang Li, Chen Li, Junjie Wang, Huiyu Huang, Yulong Hu, Kan Zhu, Hao Chen, Xu Wang and Songfei Su
Micromachines 2026, 17(2), 259; https://doi.org/10.3390/mi17020259 - 16 Feb 2026
Viewed by 716
Abstract
In this research, an innovative scheme to generate heterogeneous acoustofluidic distributions in various pseudo-Sierpiński-carpet-shaped chambers with different filling fractions and cross-sectional configurations has been proposed and calculated for topographical manipulation of large-scale micro-particles. All of the structural components positioned in the pseudo-fractal chambers [...] Read more.
In this research, an innovative scheme to generate heterogeneous acoustofluidic distributions in various pseudo-Sierpiński-carpet-shaped chambers with different filling fractions and cross-sectional configurations has been proposed and calculated for topographical manipulation of large-scale micro-particles. All of the structural components positioned in the pseudo-fractal chambers are symmetrically distributed in space, and all ultrasonic radiation surfaces hold the unified settings of input frequency point, oscillation amplitude, and initial phase distribution along their respective normal directions. A large number of fascinating acoustofluidic patterns can be generated in the originally-static pseudo-Sierpiński-carpet-shaped chambers at different recursion levels without complicated vibration parameter modulation. The simulation results of acoustofluidic distributions and particle motion trajectories under different radiation surface arrangements further demonstrate the manipulation performance of these specially designed devices, and indicate that controllable spatial partitioning and intensity modulation of the acoustofluidic field can be achieved by adjusting the hierarchical order, cross-sectional configuration and combination mode of the radiation surfaces. Unlike the existing device construction method of miniaturized microfluidic systems, the artificial introduction of fractal elements like Sierpiński carpet/triangle, Koch snowflake, Mandelbrot set, Pythagoras tree, etc., can provide extraordinary perspectives and expand the application range of the acoustofluidic effect, which also makes ultrasonic micro/nano-scale manipulation technology more abundant and diversified. This exploratory research indicates the potential possibility of applying fractal structures as alternative component parts to purposefully customize acoustofluidic distributions for the further research of patterned manipulation of bio-organisms and navigation of micro-robot swarms in brand new ways that cannot be achieved through traditional methods. Full article
(This article belongs to the Special Issue Acoustic-Microfluidic Integration and Biological Applications)
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23 pages, 1443 KB  
Review
Miniaturization of Ocean Sensors Based on Optofluidic Technology: A Review
by Wennan Zhu, Kai Sun and Weicheng Cui
Sensors 2025, 25(21), 6591; https://doi.org/10.3390/s25216591 - 26 Oct 2025
Viewed by 1695
Abstract
The miniaturization of ocean parameter monitors is critical for environmental monitoring and oceanographic research. In recent years, rapid developments in data processing, artificial intelligence, micro-nano manufacturing and advanced materials have significantly improved sensing accuracy while reducing device size. The detection of key ocean [...] Read more.
The miniaturization of ocean parameter monitors is critical for environmental monitoring and oceanographic research. In recent years, rapid developments in data processing, artificial intelligence, micro-nano manufacturing and advanced materials have significantly improved sensing accuracy while reducing device size. The detection of key ocean parameters such as temperature, salinity, pressure, dissolved oxygen (DO), pH, nutrients, chlorophyll and so on is facilitated by these innovations. Among these emerging technologies, microfluidics and optofluidics have attracted large attention in the fields of biomedicine and environmental monitoring. These platforms have the advantages of high sensitivity, low power consumption and easy integration. Real-time and on-site monitoring can be achieved by them. Optofluidic technology shows great prospects for ocean sensing applications. Recent advances in optofluidic ocean sensors for the measurement of chemical parameters and their future potential are highlighted in this review. Ultimately, it presents the key role of optofluidic systems in realizing compact high-performance ocean parameter sensors. This plays an important role in paving the way for their integration into micro robots and the fourth generation of submersibles based on live fish. Full article
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23 pages, 13104 KB  
Article
A Hierarchical Distributed Control System Design for Lower Limb Rehabilitation Robot
by Aihui Wang, Jinkang Dong, Rui Teng, Ping Liu, Xuebin Yue and Xiang Zhang
Technologies 2025, 13(10), 462; https://doi.org/10.3390/technologies13100462 - 13 Oct 2025
Cited by 1 | Viewed by 1427
Abstract
With the acceleration of global aging and the rising incidence of stroke, the demand for lower limb rehabilitation has been steadily increasing. Traditional therapeutic methods can no longer meet the growing needs, which has led to the widespread application of robotic solutions to [...] Read more.
With the acceleration of global aging and the rising incidence of stroke, the demand for lower limb rehabilitation has been steadily increasing. Traditional therapeutic methods can no longer meet the growing needs, which has led to the widespread application of robotic solutions to address labor shortages. In this context, this paper presents a hierarchical and distributed control system based on ROS 2 and Micro-ROS. The distributed architecture decouples functional modules, improving system maintainability and supporting modular upgrades. The control system consists of a three-layer structure, including a high-level controller, Jetson Nano, for gait data processing and advanced command generation; a middle-layer controller, ESP32-S3, for sensor data fusion and inter-layer communication bridging; and a low-level controller, STM32F405, for field-oriented control to drive the motors along a predefined trajectory. Experimental validation in both early and late rehabilitation stages demonstrates the system’s ability to achieve accurate trajectory tracking. In the early rehabilitation stage, the maximum root mean square error of the joint motors is 1.143°; in the later rehabilitation stage, the maximum root mean square error of the joint motors is 1.833°, confirming the robustness of the control system. Additionally, the hierarchical and distributed architecture ensures maintainability and facilitates future upgrades. This paper provides a feasible control scheme for the next generation of lower limb rehabilitation robots. Full article
(This article belongs to the Special Issue AI Robotics Technologies and Their Applications)
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25 pages, 1098 KB  
Review
Review of Nano- and Micro- Indentation Tests for Rocks
by Qingqing He and Heinz Konietzky
Geosciences 2025, 15(10), 389; https://doi.org/10.3390/geosciences15100389 - 7 Oct 2025
Cited by 1 | Viewed by 2034
Abstract
Nano- and micro-indentation have become essential tools for quantifying the micromechanical behavior of rocks beyond traditional macroscopic tests. This review summarizes the historical evolution, experimental methodologies, and interpretation models (e.g., Oliver–Pharr, Doerner–Nix, energy-based methods, Hertz/ECM/Lawn), with a particular focus on rock-specific challenges such [...] Read more.
Nano- and micro-indentation have become essential tools for quantifying the micromechanical behavior of rocks beyond traditional macroscopic tests. This review summarizes the historical evolution, experimental methodologies, and interpretation models (e.g., Oliver–Pharr, Doerner–Nix, energy-based methods, Hertz/ECM/Lawn), with a particular focus on rock-specific challenges such as heterogeneity, anisotropy, and surface roughness. A structured literature survey (1980–August 2025) covers representative studies on shale, limestone, marble, sandstone, claystone, and granite. The transition from classical hardness measurements to advanced instrumented indentation has enabled more reliable determination of localized properties, including hardness, elastic modulus, fracture toughness, and creep. Special attention is given to the applicability and limitations of different interpretation models when applied to heterogeneous and anisotropic rocks. Current challenges include high sensitivity to surface conditions and difficulties in capturing the full complexity of natural rock behavior. Looking forward, promising directions involve intelligent systems that integrate AI-driven data analytics, robotic automation, and multiscale modeling (from molecular dynamics to continuum FEM) to enable predictive material design. This review aims to provide geoscientists and engineers with a comprehensive foundation for the effective application and further development of indentation-based testing in rock mechanics and geotechnical engineering. Full article
(This article belongs to the Section Geomechanics)
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26 pages, 8954 KB  
Article
A Two-Segment Continuum Robot with Piecewise Stiffness for Tracheal Intubation and Active Decoupling
by Jianhao Tang, Lingfeng Sang, Junjie Tian, Qiqi Pan, Yuan Han, Wenxian Li, Yu Tian and Hongbo Wang
Actuators 2025, 14(5), 228; https://doi.org/10.3390/act14050228 - 5 May 2025
Viewed by 1820
Abstract
This study presents a two-segment continuum robot with piecewise stiffness, designed to enhance the precision, adaptability, and safety of tracheal intubation procedures. The robot employs a continuum manipulator (CM) as its end-effector, featuring a proximal segment (PS) with an aluminum alloy interlocking joint, [...] Read more.
This study presents a two-segment continuum robot with piecewise stiffness, designed to enhance the precision, adaptability, and safety of tracheal intubation procedures. The robot employs a continuum manipulator (CM) as its end-effector, featuring a proximal segment (PS) with an aluminum alloy interlocking joint, which provides high axial stiffness for stable insertion, and a distal segment (DS) with a micro-nano resin-based notched structure, offering increased flexibility and compliance to navigate complex anatomical structures such as the epiglottis and vocal cords, thereby reducing airway trauma. To describe the motion behavior of the robot, a piecewise variable curvature kinematic model is developed, capturing the deformation characteristics of each segment under actuation. Furthermore, a piecewise stiffness analysis is conducted to determine the axial and bending stiffness of each segment, ensuring an appropriate balance between stability and flexibility. To enhance control precision, an active tendon-driven decoupling control strategy is introduced, effectively minimizing the interaction forces between flexible segments and improving end-effector maneuverability. The results demonstrate that the proposed design significantly improves the adaptability of the tracheal intubation robot, ensuring controlled insertion while reducing the risk of excessive force on the airway walls. This study provides theoretical and technical insights into the mechanical design and control strategies of continuum robots, contributing to the safety and efficiency of tracheal intubation. Full article
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40 pages, 16237 KB  
Review
A Comprehensive Review of Piezoelectric Ultrasonic Motors: Classifications, Characterization, Fabrication, Applications, and Future Challenges
by Sidra Naz and Tian-Bing Xu
Micromachines 2024, 15(9), 1170; https://doi.org/10.3390/mi15091170 - 21 Sep 2024
Cited by 31 | Viewed by 9842
Abstract
Piezoelectric ultrasonic motors (USMs) are actuators that use ultrasonic frequency piezoelectric vibration-generated waves to transform electrical energy into rotary or translating motion. USMs receive more attention because they offer distinct qualities over traditional magnet-coil-based motors, such as miniaturization, great accuracy, speed, non-magnetic nature, [...] Read more.
Piezoelectric ultrasonic motors (USMs) are actuators that use ultrasonic frequency piezoelectric vibration-generated waves to transform electrical energy into rotary or translating motion. USMs receive more attention because they offer distinct qualities over traditional magnet-coil-based motors, such as miniaturization, great accuracy, speed, non-magnetic nature, silent operation, straightforward construction, broad temperature operations, and adaptability. This review study focuses on the principle of USMs and their classifications, characterization, fabrication methods, applications, and future challenges. Firstly, the classifications of USMs, especially, standing-wave, traveling-wave, hybrid-mode, and multi-degree-of-freedom USMs, are summarized, and their respective functioning principles are explained. Secondly, finite element modeling analysis for design and performance predictions, conventional and nano/micro-fabrication methods, and various characterization methods are presented. Thirdly, their advantages, such as high accuracy, small size, and silent operation, and their benefits over conventional motors for the different specific applications are examined. Fourthly, the advantages and disadvantages of USMs are highlighted. In addition, their substantial contributions to a variety of technical fields like surgical robots and industrial, aerospace, and biomedical applications are introduced. Finally, their future prospects and challenges, as well as research directions in USM development, are outlined, with an emphasis on downsizing, increasing efficiency, and new materials. Full article
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26 pages, 4851 KB  
Article
Light-Fueled Self-Propulsion of Liquid Crystal Elastomer-Engined Automobiles in Zero-Energy Modes
by Zongsong Yuan, Yuntong Dai, Junxiu Liu and Kai Li
Mathematics 2024, 12(13), 2109; https://doi.org/10.3390/math12132109 - 4 Jul 2024
Cited by 1 | Viewed by 1632
Abstract
The defining attribute of self-excited motion is its capability to extract energy from a stable environment and regulate it autonomously, making it an extremely promising innovation for microdevices, autonomous robotics, sensor technologies, and energy generation. Based on the concept of an automobile, we [...] Read more.
The defining attribute of self-excited motion is its capability to extract energy from a stable environment and regulate it autonomously, making it an extremely promising innovation for microdevices, autonomous robotics, sensor technologies, and energy generation. Based on the concept of an automobile, we propose a light-fueled self-propulsion of liquid crystal elastomer-engined automobiles in zero-energy mode. This system utilizes a wheel comprising a liquid crystal elastomer (LCE) turntable as an engine, a wheel with conventional material and a linkage. The dynamic behavior of the self-propulsion automobile under steady illumination is analyzed by integrating a nonlinear theoretical model with an established photothermally responsive LCE model. We performed the analysis using the fourth-order Runge–Kutta method. The numerical findings demonstrate the presence of two separate motion patterns in the automobile system: a static pattern and a self-propulsion pattern. The correlation between the energy input and energy dissipation from damping is essential to sustain the repetitive motion of the system. This study delves deeper into the crucial requirements for initiating self-propulsion and examines the effect of critical system parameters on the motion of the system. The proposed system with zero-energy mode motions has the advantage of a simple structural design, easy control, low friction and stable kinematics, and it is very promising for many future uses, including energy harvesting, monitoring, soft robotics, medical devices, and micro- and nano-devices. Full article
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23 pages, 5029 KB  
Review
Magnetic Micro and Nano Sensors for Continuous Health Monitoring
by Tomasz Blachowicz, Ilda Kola, Andrea Ehrmann, Karoline Guenther and Guido Ehrmann
Micro 2024, 4(2), 206-228; https://doi.org/10.3390/micro4020015 - 6 Apr 2024
Cited by 15 | Viewed by 6060
Abstract
Magnetic micro and nano sensors can be used in a broad variety of applications, e.g., for navigation, automotives, smartphones and also for health monitoring. Based on physical effects such as the well-known magnetic induction, the Hall effect, tunnel magnetoresistance and giant magnetoresistance, they [...] Read more.
Magnetic micro and nano sensors can be used in a broad variety of applications, e.g., for navigation, automotives, smartphones and also for health monitoring. Based on physical effects such as the well-known magnetic induction, the Hall effect, tunnel magnetoresistance and giant magnetoresistance, they can be used to measure positions, flow, pressure and other physical properties. In biomedicine and healthcare, these miniaturized sensors can be either integrated into garments and other wearables, be directed through the body by passive capsules or active micro-robots or be implanted, which usually necessitates bio-functionalization and avoiding cell-toxic materials. This review describes the physical effects that can be applied in these sensors and discusses the most recent micro and nano sensors developed for healthcare applications. Full article
(This article belongs to the Section Microscale Physics)
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23 pages, 8858 KB  
Review
Recent Advances in Microrobots Powered by Multi-Physics Field for Biomedical and Environmental Applications
by Xiangyu Teng, Zezheng Qiao, Shuxuan Yu, Yujie Liu, Xinyu Lou, Huanbin Zhang, Zhixing Ge and Wenguang Yang
Micromachines 2024, 15(4), 492; https://doi.org/10.3390/mi15040492 - 2 Apr 2024
Cited by 3 | Viewed by 6151
Abstract
Microrobots powered by multi-physics fields are becoming a hotspot for micro–nano manufacturing. Due to the small size of microrobots, they can easily enter small spaces that are difficult for ordinary robots to reach and perform a variety of special tasks. This gives microrobots [...] Read more.
Microrobots powered by multi-physics fields are becoming a hotspot for micro–nano manufacturing. Due to the small size of microrobots, they can easily enter small spaces that are difficult for ordinary robots to reach and perform a variety of special tasks. This gives microrobots a broad application prospect in many fields. This paper describes the materials, structures, and driving principles of microrobots in detail and analyzes the advantages and limitations of their driving methods in depth. In addition, the paper discusses the detailed categorization of the action forms of microrobots and explores their diversified motion modes and their applicable scenarios. Finally, the article highlights the wide range of applications of microrobots in the fields of biomedicine and environmental protection, emphasizing their great potential for solving real-world problems and advancing scientific progress. Full article
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19 pages, 5941 KB  
Article
Self-Rotation of Electrothermally Responsive Liquid Crystal Elastomer-Based Turntable in Steady-State Circuits
by Zongsong Yuan, Junxiu Liu, Guqian Qian, Yuntong Dai and Kai Li
Polymers 2023, 15(23), 4598; https://doi.org/10.3390/polym15234598 - 1 Dec 2023
Cited by 4 | Viewed by 2042
Abstract
Self-excited motions, characterized by their ability to harness energy from a consistent environment and self-regulate, exhibit significant potential in micro-devices, autonomous robotics, sensor technology, and energy generation. This study introduces an innovative turntable system based on an electrothermally responsive liquid crystal elastomer (LCE). [...] Read more.
Self-excited motions, characterized by their ability to harness energy from a consistent environment and self-regulate, exhibit significant potential in micro-devices, autonomous robotics, sensor technology, and energy generation. This study introduces an innovative turntable system based on an electrothermally responsive liquid crystal elastomer (LCE). This system facilitates self-rotation within a steady-state circuit. Employing an electrothermal LCE model, we have modeled and numerically analyzed the nonlinear dynamics of an LCE-rope within steady-state circuits, utilizing the four-order Runge–Kutta method for calculations. The numerical results reveal the emergence of two distinct motion patterns in the turntable system under steady-state conditions: a self-rotation pattern and a static pattern. The self-rotation is initiated when the system’s absorbed energy surpasses the energy lost due to damping effects. Furthermore, this paper delves into the critical conditions necessary for initiating self-rotation and examines the influence of various key dimensionless parameters on the system’s rotation amplitude and frequency. These parameters include gravitational acceleration, the initial position of the mass ball, elastic stiffness of the LCE and spring, limiting temperature, heating zone angle, thermal shrinkage coefficient, and damping factor. Our computational findings establish that these parameters exert a modulatory impact on the rotation amplitude and period. This research enhances the understanding of self-excited motions and offers promising avenues for applications in energy harvesting, monitoring, soft robotics, medical devices, and micro- and nano-devices. Full article
(This article belongs to the Special Issue Polymeric Materials in Energy Conversion and Storage)
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25 pages, 11434 KB  
Article
Exceptionally Fast Temperature-Responsive, Mechanically Strong and Extensible Monolithic Non-Porous Hydrogels: Poly(N-isopropylacrylamide) Intercalated with Hydroxypropyl Methylcellulose
by Beata Strachota, Adam Strachota, Leana Vratović, Ewa Pavlova, Miroslav Šlouf, Samir Kamel and Věra Cimrová
Gels 2023, 9(12), 926; https://doi.org/10.3390/gels9120926 - 24 Nov 2023
Cited by 5 | Viewed by 4149
Abstract
Exceptionally fast temperature-responsive, mechanically strong, tough and extensible monolithic non-porous hydrogels were synthesized. They are based on divinyl-crosslinked poly(N-isopropyl-acrylamide) (PNIPAm) intercalated by hydroxypropyl methylcellulose (HPMC). HPMC was largely extracted after polymerization, thus yielding a ‘template-modified’ PNIPAm network intercalated with a modest residue of [...] Read more.
Exceptionally fast temperature-responsive, mechanically strong, tough and extensible monolithic non-porous hydrogels were synthesized. They are based on divinyl-crosslinked poly(N-isopropyl-acrylamide) (PNIPAm) intercalated by hydroxypropyl methylcellulose (HPMC). HPMC was largely extracted after polymerization, thus yielding a ‘template-modified’ PNIPAm network intercalated with a modest residue of HPMC. High contents of divinyl crosslinker and of HPMC caused a varying degree of micro-phase-separation in some products, but without detriment to mechanical or tensile properties. After extraction of non-fixed HPMC, the micro-phase-separated products combine superior mechanical properties with ultra-fast T-response (in 30 s). Their PNIPAm network was highly regular and extensible (intercalation effect), toughened by hydrogen bonds to HPMC, and interpenetrated by a network of nano-channels (left behind by extracted HPMC), which ensured the water transport rates needed for ultra-fast deswelling. Moreover, the T-response rate could be widely tuned by the degree of heterogeneity during synthesis. The fastest-responsive among our hydrogels could be of practical interest as soft actuators with very good mechanical properties (soft robotics), while the slower ones offer applications in drug delivery systems (as tested on the example of Theophylline), or in related biomedical engineering applications. Full article
(This article belongs to the Special Issue Advances in Cellulose-Based Hydrogels (2nd Edition))
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19 pages, 8009 KB  
Review
Medical Imaging Technology for Micro/Nanorobots
by Xuejia Liu, Yizhan Jing, Chengxin Xu, Xiaoxiao Wang, Xiaopeng Xie, Yanhe Zhu, Lizhou Dai, Haocheng Wang, Lin Wang and Shimin Yu
Nanomaterials 2023, 13(21), 2872; https://doi.org/10.3390/nano13212872 - 30 Oct 2023
Cited by 24 | Viewed by 8829
Abstract
Due to their enormous potential to be navigated through complex biological media or narrow capillaries, microrobots have demonstrated their potential in a variety of biomedical applications, such as assisted fertilization, targeted drug delivery, tissue repair, and regeneration. Numerous initial studies have been conducted [...] Read more.
Due to their enormous potential to be navigated through complex biological media or narrow capillaries, microrobots have demonstrated their potential in a variety of biomedical applications, such as assisted fertilization, targeted drug delivery, tissue repair, and regeneration. Numerous initial studies have been conducted to demonstrate the biomedical applications in test tubes and in vitro environments. Microrobots can reach human areas that are difficult to reach by existing medical devices through precise navigation. Medical imaging technology is essential for locating and tracking this small treatment machine for evaluation. This article discusses the progress of imaging in tracking the imaging of micro and nano robots in vivo and analyzes the current status of imaging technology for microrobots. The working principle and imaging parameters (temporal resolution, spatial resolution, and penetration depth) of each imaging technology are discussed in depth. Full article
(This article belongs to the Special Issue Advances in Micro-/Nanorobotics)
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