Search Results (2,810)

Heat shock transcription factors (HSFs) play a central role in mediating plant responses to abiotic stress. Anthocyanins, one of the most important secondary metabolites in plants, contribute to both stress tolerance and the enhancement in crop nutritional quality. However, the possible role of HSFs in regulating anthocyanin biosynthesis in sweet potato (Ipomoea batatas L.) remains unknown. This study conducted a genome-wide analysis of the sweet potato HSF gene family to explore their functions related to anthocyanin metabolism and salinity stress. Multiple stress-inducible promoter elements were identified within IbHSF22, including those induced by drought, salt, heat, ABA, and light. For functional characterization of this gene, a 35S-driven overexpression construct was prepared and then transformed into Nicotiana benthamiana. Overexpression of IbHSF22 led to a nearly two-fold increase in anthocyanin content, concurrently with the elevated expression of key structural genes such as NtCHS, NtF3H, NtDFR, and NtANS. Under salt stress, the transgenic plants also exhibited enhanced tolerance, which was associated with maintained antioxidant enzyme activity and concerted induction of stress-responsive genes, events that collectively resulted in decreased oxidative damage. Therefore, the present work identifies IbHSF22 as an integrator of anthocyanin biosynthesis and salt defense mechanisms. These findings provide a conceptual basis and candidate gene strategy for dual improvement in stress resilience and nutritional quality in sweet potato breeding. Full article

Systematic investigation into the structural integrity of adjustable ejectors, particularly concerning thermal–fluid–structural (TFS) coupling, is currently lacking. Utilizing the Workbench platform, this study performs unidirectional steady-state TFS coupling numerical simulation of the adjustable air ejector under off-design conditions to systematically analyze its internal flow characteristics and structural mechanical responses across various needle openings. The results show that thermal load is the dominant factor governing the ejector’s structural stress and deformation. The overall deformation is primarily characterized by axial elongation, with the maximum thermal deformation localized at the ejector’s exit section. The nozzle exit is identified as the primary structural weak point, exhibiting the highest local stress, which peaks at 196.8 MPa when the needle opening is minimized. Shock train structures extending from the nozzle’s divergent section into the mixing chamber, coupled with the axial displacement of the needle, significantly influence the ejector’s thermal deformation and thermal stress. Based on the thermally dominated stress mechanism identified, this study proposes a composite nozzle design utilizing a nickel-plated Invar alloy substrate. This material fully leverages Invar alloy’s low thermal expansion to mitigate thermal stress and deformation while the nickel plating ensures corrosion resistance, thereby significantly enhancing the nozzle’s mechanical properties and operational reliability in thermal environments. The findings of this analysis are applicable to off-design evaluations under unidirectional steady-state coupling conditions, providing a valuable reference for the structural design and strength optimization of similar ejectors operating in high-temperature, unsteady environments. Full article

Scholars and practitioners of international relations and security studies view technological capabilities in general, and digital ones in particular, as crucial to enhancing state power. Among other things, digital technologies sharpen intelligence, thus reducing the likelihood of strategic surprise by improving situational awareness and strengthening deterrence. Yet the empirical record of the early twenty-first century presents a paradox: states with highly advanced digital infrastructures remain vulnerable to unexpected strategic shocks, including intelligence failures. This article develops a conceptual framework, techno-digital vulnerability, that explains why digital superiority can paradoxically increase susceptibility to strategic surprise. Drawing on international relations theory, this article identifies four interrelated mechanisms: illusions of informational completeness; structural dependence on digital systems; hypervisibility of digitally open societies; and the systematic undervaluation of low-tech adversaries. The argument is illustrated through the case of Israel’s failure to foresee the Hamas attack of 7 October 2023. The article concludes by outlining the implications for digitally advanced democracies and for the study of strategic surprise in IR. Full article

Faced with the depletion of fossil resources and the need to promote a circular economy, lignocellulosic biomass represents a solution for energy transition and bioeconomy. However, wood sawdust, which contains bioactive compounds (secondary metabolites), is often burned in the open by many sawmills. This study aims to valorize Framiré wood sawdust by extracting its secondary metabolites through maceration and infusion, then converting the depleted residue into combustible briquettes. The yellowness index of the extracts ranged from 73.490 ± 0.021 (maceration) to 81.720 ± 0.014 (infusion). The total phenolic content varied from 0.097 ± 0.001 to 0.63 ± 0.049 gGAE/100 g dry matter for maceration and infusion, respectively. The extraction of bioactive compounds did not significantly affect the energy or mechanical properties of the fuels. Their higher heating value ranged from 26,153 ± 92 to 26,201 ± 90 kJ/kg for fuels with and without secondary metabolites, respectively. The Shock Resistance Index ranged from 139.33 ± 7.51% (without metabolites) to 153.00 ± 5.20% (with metabolites). A significant difference was observed in the specific consumption of the fuels, decreasing from 1.400 ± 0.100 to 0.861 ± 0.001 kg/L for fuels without and with secondary metabolites, respectively. These results open promising prospects, particularly for the use of Framiré extracts to develop flame-retardant products for wood and its derivatives. Full article

The crude oil futures market is highly susceptible to policy changes and international relations, which often trigger abrupt jumps in prices. The existing literature rarely considers jump volatility and the underlying impact mechanisms. This study proposes a hybrid forecasting model integrating a convolutional neural network (CNN) and self-attention (Transformer) for high-frequency financial data, based on the complex network characteristics between trading information and multi-market financialization indicators. Empirical results demonstrate that incorporating complex network indicators enhances model performance, with the CNN–Transformer model with a complex network achieving the highest predictive accuracy. Furthermore, we verify the model’s effectiveness and robustness in the WTI crude oil market via Diebold–Mariano tests and external event shock. Notably, this study also extends the analytical framework to jump intensity, thereby providing a more accurate and robust jump forecasting model for risk management and trading strategies in the crude oil futures market. Full article

In this article, we examine the dynamic interdependencies among components of Japan’s consumer price index (CPI) using a two-lag time-varying loading factor (TLTVLF) model. Whereas previous studies have typically decomposed CPI series into long-term trends, seasonal patterns, and cyclical fluctuations, such approaches mainly describe structural features without fully uncovering the latent mechanisms that drive price dynamics. The proposed TLTVFL modeling framework addresses this limitation by allowing both factor loadings and their lagged effects to evolve over time, thereby capturing gradual structural changes and the time-varying propagation of shocks across CPI categories. Using monthly data for ten major CPI categories from January 1970 to December 2024, we identify evolving common factors, category-specific sensitivities, and dynamic transmission patterns associated with major macroeconomic events. The findings reveal substantial temporal variation in inter-category linkages, offering fresh insights into sectoral contributions to inflationary pressures and providing policy-relevant implications for more effective monetary and fiscal interventions. Methodologically, this study extends the frontier of dynamic factor modeling, while empirically, it deepens the understanding of the mechanisms underlying price fluctuations over a long historical horizon. Full article

Ammonia is considered as a promising hydrogen carrier and a carbon-free fuel. Methods for improving ammonia combustion characteristics often involve its co-firing with more reactive fuels (natural gas, biofuels, etc.). Among the natural gas components, ethane is second most abundant. Therefore, the development of detailed chemical–kinetic mechanisms that accurately consider the interactions between ammonia and each component of natural gas is very important. Such mechanisms must be based on experimental data obtained under a wide range of conditions. In this work, NH₃/C₂H₆/O₂/Ar blends were studied in JSR (φ = 0.5–2.0, p = 1 atm, τ = 1 s, T = 800–1300 K) and in a shock tube (p = 7.3–8.6 atm, T = 1260–1590 K). Additionally, the structure of premixed flames was investigated (φ = 0.8–1.2, p = 1–5 atm). Eleven recently published detailed chemical–kinetic mechanisms were tested. The model Shrestha-2025 was updated to achieve better agreement with the entire set of experimental data. The effect of p and φ on intermediate species concentration was analyzed. Ammonia and ethane consumption pathways were also examined. Full article

The role of cardiac implantable electronic devices (CIEDs), including implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy (CRT) devices, in patients supported with left ventricular assist devices (LVADs) remains controversial. Although ICDs clearly reduce the risk of sudden cardiac death (SCD) and improve outcomes in advanced heart failure (HF), their benefit in patients with continuous-flow mechanical circulatory support is less certain. Initial small studies involving LVAD patients, particularly those with older pulsatile devices, suggested that ICDs confer a survival benefit during LVAD support. However, more recent evidence has been inconsistent. Some studies show modest protection against arrhythmic death, whereas others show no improvement in overall mortality. Similarly, CRT does not appear to offer significant additional hemodynamic benefits after LVAD implantation, and current evidence does not strongly support its routine continuation. Device-related complications—including lead failure, infection, electromagnetic interference, and inappropriate shocks—are major clinical concerns that can offset potential benefits. Accordingly, current guidelines recommend maintaining pre-existing ICD or CRT devices in LVAD patients but do not endorse the routine implantation of new devices after LVAD placement. The existing evidence highlights the need for a nuanced and individualized approach to CIED therapy in patients with LVAD. Future research should focus on randomized trials, registry-based analyses, and the exploration of novel technologies such as leadless pacing, subcutaneous ICDs, and advanced programming algorithms. Patient-centered outcomes, particularly quality of life and ethical considerations—such as ICD deactivation in end-of-life scenarios—must be considered in decision-making in this evolving field. Full article

Sepsis remains a leading cause of global mortality, and early management in the emergency department (ED) is a key determinant of clinical outcomes. Among the earliest physiological derangements in sepsis are abnormalities in coagulation, which represent not merely laboratory disturbances but fundamental reflections of dysregulated host response, endothelial injury, and evolving microvascular thrombosis. Sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC) form a dynamic continuum that frequently begins before shock is clinically apparent. Despite their prognostic value and pathophysiologic significance, these abnormalities are often underrecognized in the ED, where coagulation tests are still commonly interpreted through the narrow lens of bleeding risk rather than as markers of systemic thromboinflammation. This narrative review synthesizes current understanding of the mechanisms linking sepsis, endothelial dysfunction, and coagulation abnormalities; outlines the distinction between SIC and overt DIC; and highlights why early identification of coagulopathy in the ED is essential. We discuss practical bedside approaches, including recommended laboratory testing, pattern recognition, and application of validated scores such as the SIC and ISTH DIC criteria. System-level strategies, such as embedding coagulation testing into sepsis bundles, automating score calculation, and enhancing communication between the ED and ICU teams, are explored as avenues to improve early detection. Evidence suggests that ED recognition of SIC/DIC may refine risk stratification, guide triage decisions, and identify patients who may benefit from targeted anticoagulant strategies once stabilized. Ultimately, recognizing coagulation disorders in the ED reframes sepsis not solely as a hemodynamic crisis but as a complex, thromboinflammatory syndrome in which early intervention may alter trajectory and improve outcomes. Full article

Pseudomonas aeruginosa bloodstream infections (PABSIs) are a major clinical challenge due to their association with significant mortality and antimicrobial resistance mechanisms. The COVID-19 pandemic changed antimicrobial practices, intensive care management, and patient risk profiles, potentially influencing the epidemiology and outcomes of PABSIs. In the post-pandemic period, practices were expected to revert to normal. The objective of this scoping review was to identify and summarize reported mortality rates and risk factors for PABSIs in studies published between 2023 and 2025. Literature searches were conducted across PubMed, Web of Science, Embase, and Scopus. Screening was performed in accordance with PRISMA-ScR guidelines. Twenty-two eligible studies were included. Mortality rates varied across the study setting and populations; however, several consistent predictors were consistently identified, including carbapenem exposure, multidrug-resistant Pseudomonas aeruginosa, hematologic disease or malignancy, corticosteroid therapy, sepsis or septic shock, mechanical ventilation, and higher severity-of-illness scores. Few studies have linked molecular mechanisms to patient outcomes, highlighting important gaps in knowledge. Notably, only a small number of studies included the post-pandemic period but did not analyze the data separately. Despite limited available evidence, critically ill and immunocompromised patients remain at greatest risk of death from PABSIs. This review highlights the need for a broader comparative analysis in future. Full article

Against the backdrop of global warming, extreme heat events have become increasingly frequent and persistent across Chinese cities, posing severe threats to public health, industrial safety, and urban operations. Enhancing urban climate adaptation through the development of green infrastructure has therefore emerged as a critical governance priority. As a major national initiative promoting urban forest development and ecological civilization, the National Forest City Policy offers a potentially important pathway for mitigating extreme heat, yet its climate adaptation effects remain insufficiently examined through rigorous empirical evidence. This study takes the implementation of the National Forest City Policy as an exogenous policy shock to urban greening and employs panel data from Chinese 243 prefecture-level cities from 2000 to 2023 to conduct a difference-in-differences model, supplemented by an event-study approach, to identify the policy’s impact on annual extreme heat days. The empirical findings indicate that, after controlling for a series of socioeconomic characteristics, the National Forest City Policy significantly reduces the number of extreme heat days experienced by cities each year. Further mechanism analysis reveals that the National Forest City Policy’s mitigation effect is more pronounced in cities with higher Green Coverage Rate, Urban Climate Conditions, and Urban Green Space Quality. By evaluating the environmental impacts of the National Forest City Policy from a climate adaptation perspective, this study enriches the literature on urban forest development and extreme climate events, and provides empirical evidence and policy insights for enhancing urban climate resilience and optimizing greening strategies under China’s “dual-carbon” goals and a warming climate. Full article

A thermo-mechanical fracture modeling is proposed to address thermal failure issues, where the temperature field is calculated by a heat conduction model based on classical continuum mechanics (CCM), while the deformation field with discontinuities is calculated using the peridynamic (PD) model. The model is calculated using a CCM/PD alternating solution based on finite element discretization, which ensures the calculation accuracy and facilitates engineering applications. The original PD model defines damage solely based on the number of broken bonds in the vicinity of the material point, neglecting the distribution of these bonds. To address this limitation, a new definition of the PD damage accounting for both the number of broken bonds and their specific distribution is proposed. As a result, damage in various directions can be captured, enabling more realistic thermal fracture simulations based on a unified mesh discretization. The effectiveness of the proposed model is validated by comparing numerical examples with analytical solutions. Moreover, simulation results, including a thermal shock case with a transient temperature field, demonstrate the model’s ability to aid in understanding the initiation and propagation mechanisms of complex thermal fractures. Full article

With the advancement of the “dual carbon” goals, power transmission and transformation projects face complex challenges arising from the construction of new power systems. Traditional cost management models struggle to meet dynamic management demands, necessitating the establishment of analytical methods that systematically reflect the relationship between cost management levels and cost dynamics. This paper introduces system dynamics theory and methodology to construct a cost management model applicable to all phases of transmission and transformation projects. It aims to deeply analyze the relationship between project cost levels and expenses from the perspectives of system structure, feedback mechanisms, and dynamic behavior. Research indicates that pathways such as controlling cost deviations and optimizing resource allocation significantly impact total project costs. Specifically, enhancing design accuracy can effectively mitigate cost shocks caused by carbon price fluctuations, while timely implementation of cost control measures can significantly improve cost management levels. The system dynamics approach effectively reveals the dynamic interaction mechanism between cost management levels and costs in power transmission and transformation projects, providing theoretical foundations and methodological support for enhancing project cost control efficiency. Full article

Global warming and the increasing frequency of marine heatwaves (MHWs) threaten marine ecosystems and aquaculture. For the economically important spotted seabass (L. maculatus), the neuroendocrine basis of its stage-specific thermal responses has yet to be elucidated. This study examined the transcriptomic, physiological, and behavioral adaptations to chronic heat stress in late larval and late juvenile seabass over 14 days. After thermal acclimation, larvae demonstrated a marked behavioral shift, preferring warmer waters (26–34 °C). While heat stress upregulated key thermosensory genes (e.g., trpv1, trpv4) in the brain across both stages, it induced distinct expression profiles in the skin, suggesting a developmental transition from peripheral to central dominance in thermosensation. Brain transcriptomics revealed stage-specific pathway activation: juveniles engaged in neuroactive ligand-receptor interactions and MAPK signaling, whereas larvae showed enrichment in phosphatidylinositol signaling and protein processing. Both stages showed activation of the hypothalamic-pituitary-interrenal (HPI) axis (upregulation of crh, crhr1, crhr2, pomc) and heat shock response (hsp70, hsp90), accompanied by elevated serum cortisol. Notably, energy metabolism diverged significantly: larvae maintained appetite and developed hyperglycemia, while juveniles exhibited severe feeding suppression and hypoglycemia, which was correlated with differential regulation of appetite genes (npy, orexin, cck). Our results elucidate the distinct neuroendocrine mechanisms underlying thermal acclimation in L. maculatus and provide a scientific basis for developing climate-resilient aquaculture practices for this species. Full article

Psoriasis is a common inflammatory skin disease with chronic manifestation in which the role of neutrophil extracellular traps (NETs) and alarmins are increasingly recognized as contributors to systemic and cutaneous inflammation. However, the interaction between alarmins and NET-driven immune responses remains poorly defined. The main aim of this study is to define the role of target alarmins (i.e., IL-33 and TSLP) in NETs induction and its subsequent impact on oxidative stress and inflammation in the peripheral blood. In the present study, we recruited active psoriasis patients (n = 56) and control (n = 56) subjects. The frequency of circulating neutrophils, the levels of NET-associated markers (MPO (myeloperoxidase)–DNA complex, CitH3 (citrullinated histone H3), PAD4 (peptidyl arginine deiminase4), NADPH oxidase, and NE (neutrophil elastase)), and alarmin transcripts (IL (interleukin)-33, TSLP (thymic stromal lymphopoietin), S100A7, S100B, HSP (heat shock protein) 60/70 were quantified using flow cytometry, ELISA (Enzyme-linked immunosorbent assay), and qPCR (quantitative polymerase chain reaction), respectively, in each group. The NET formation potential of isolated neutrophils was assessed in the presence or absence of rhIL-33 and rhTSLP by immunocytofluorescence. The effect of rhIL-33- and rhTSLP-primed NETs in augmenting oxidative stress and inflammation was evaluated on peripheral blood mononuclear cells (PBMCs) by ELISA. Significantly higher circulating neutrophils (p < 0.001) and levels of NET-associated markers (i.e., MPO–DNA complex, CitH3, PAD4, NADPH oxidase, and NE) were observed in active psoriasis patients compared to controls. Lesional skin exhibited strong expression of MPO (p < 0.001) compared to normal skin. The alarmins, IL-33 and TSLP, were markedly upregulated in the blood and skin (p < 0.05). The rhIL-33 and rhTSLP treated neutrophils demonstrated enhanced NETosis in patients (p < 0.001). Increased expression of inflammatory cytokines and oxidative stress markers were reported in PBMCs when incubated with rhIL-33- and rhTSLP-primed NETs. Taken together, our investigation demonstrated the novel mechanism wherein the alarmins IL-33 and TSLP exacerbate NET formation that may drive enhanced inflammation and oxidative stress in psoriasis. Full article