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20 pages, 38867 KB  
Article
“Sweet” or “Decompositional”? The Bernardine Pseudo-Plainchant in the 1761 Series Concentuum Divae Annae Sacra from the Dominican Nunnery in Święta Anna near Częstochowa (Poland)
by Michał Jędrzejski
Arts 2026, 15(7), 155; https://doi.org/10.3390/arts15070155 - 3 Jul 2026
Viewed by 139
Abstract
This article is devoted to the 18th-century Bernardine repertoire of pseudo-plainchant, that is, Latin liturgical monophony, which differs significantly from the style of Gregorian and Neo-Gregorian chant. The research employs methods of codicological (from Latin, codex = book) analysis of the source, as [...] Read more.
This article is devoted to the 18th-century Bernardine repertoire of pseudo-plainchant, that is, Latin liturgical monophony, which differs significantly from the style of Gregorian and Neo-Gregorian chant. The research employs methods of codicological (from Latin, codex = book) analysis of the source, as well as analysis of the repertoire, melody, text and musical notation. Melodies are also transcribed and compared with selected manuscripts from the Library of the Bernardine Province in Kraków. The research reveales that the pseudo-plainchant collection comprises 14 ordinarium missae (the Ordinary of the Mass, i.e., the fixed or invariable parts of the Mass), one Gloria and 15 Patrem (Credo, the Creed). The repertoire dedicated to St Anne, local patron saint, shares tonal language, elements of rhythm and metre, key signatures, chromatic signs, melodic sequences, the repeated use of the same musical material, alternatim technique (vocal and instrumental parts performed alternately), contrasts in performance, register and style, melodies based on Polish church songs, and geographical titles. The term “sweet” (suaves) appearing on the title page may indicate the aesthetic stance of the Bernardines from Święta Anna and their positive attitude towards the repertoire in question, although 20th-century musicological literature has attributed decompositional elements to it. In this way, the manuscript under study may serve as a basis for updating our understanding of the pseudo-plainchant repertoire as such. Full article
(This article belongs to the Section Musical Arts and Theatre)
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18 pages, 2059 KB  
Article
Constanza de Castilla’s Marian Doctrines in a Dominican Setting: Her ‘Officium Incarnacionis Domini Nostri Ihesus Christi’
by Lesley Karen Twomey
Religions 2026, 17(6), 671; https://doi.org/10.3390/rel17060671 - 4 Jun 2026
Viewed by 306
Abstract
The Dominican Constanza de Castilla’s exceptional liturgical book, her Libro de devociones y oficios [Book of Devotions and Offices], served devotional and practical purposes in the convent of Santo Domingo el Real in Madrid. The article begins by examining Dominican nuns’ participation in [...] Read more.
The Dominican Constanza de Castilla’s exceptional liturgical book, her Libro de devociones y oficios [Book of Devotions and Offices], served devotional and practical purposes in the convent of Santo Domingo el Real in Madrid. The article begins by examining Dominican nuns’ participation in Corpus Christi processions. It then examines Constanza’s liturgy for the Mass of the Incarnation (25 March). A study of liturgical calendars and offices both prior to and contemporary to Constanza reveals that there are no Castilian offices given the title ‘Incarnation of Our Lord’. Comparison of the contents of the office with the same liturgies reveals none with the exact same antiphons or readings. However, Constanza’s choice of the name ‘office of the Incarnation’ is matched to a similar wording in the account book of Franciscan nuns. They also give the name day of the Incarnation to the feast they celebrate on 25 March. The article also summarizes the theological theme of kenosis, Christ’s self-abasement, apparent elsewhere in the Book of Devotions and Offices and which is touched upon in the office of the Incarnation. Finally, it examines the links between Thomas Aquinas’s thinking on the Virgin Birth and where that is echoed by Constanza. This article concludes that, for this short office, Constanza’s Mass shows no signs of having been copied from existing offices, always with the proviso that what remains of fourteenth and fifteenth century liturgies provides an imperfect picture. Full article
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17 pages, 1127 KB  
Article
Measles in the Post-COVID Era: Incidence Trends, Vaccination Coverage, Demographic and Subnational Distribution in Saudi Arabia, 2015–2024
by Lama Alzamil
Vaccines 2026, 14(5), 445; https://doi.org/10.3390/vaccines14050445 - 16 May 2026
Viewed by 480
Abstract
Background/Objectives: The COVID-19 pandemic disrupted routine immunisation globally. Saudi Arabia presents a unique epidemiological context for measles, combining high vaccination coverage with mass pilgrimages and a large expatriate workforce. This study examined measles incidence trends, vaccination coverage, and demographic and geographic burden distribution [...] Read more.
Background/Objectives: The COVID-19 pandemic disrupted routine immunisation globally. Saudi Arabia presents a unique epidemiological context for measles, combining high vaccination coverage with mass pilgrimages and a large expatriate workforce. This study examined measles incidence trends, vaccination coverage, and demographic and geographic burden distribution in Saudi Arabia (2015–2024), with comparative analysis against GCC countries, the Eastern Mediterranean Region (EMR), and global data. Methods: Annual incidence and vaccination coverage data were obtained from the WHO Global Health Observatory and WHO/UNICEF WUENIC; monthly, regional, age- and nationality-stratified data from the Saudi Ministry of Health Annual Statistical Book (2015–2024). Incidence was expressed per 1,000,000 population across three epochs: pre-COVID-19 (2015–2019), pandemic disruption (2020–2021), and post-COVID-19 rebound (2022–2024). Descriptive analyses included period means, percentage changes, rate ratios, and rate differences. Results: Pre-COVID-19 incidence (mean 19.7/1,000,000) remained below EMR and global averages. The pandemic produced near-complete suppression (−96.6% to 1.1/1,000,000 in 2020), exceeding global (−82.2%) and EMR (−61.2%) declines. A marked rebound occurred in 2023 (67.8/1,000,000), surpassing the pre-pandemic peak despite MCV1/MCV2 coverage above 96%. Non-Saudi nationals bore disproportionate burden in 2021 (20.7 vs. 1.1/1,000,000) and 2023 (70.4 vs. 64.8/1,000,000). Children under 15 accounted for 71.6–90.6% of annual cases, with the 5–<15-year group’s contribution rising from 12.7% (pre-COVID mean) to 27.7% in 2024. Geographic burden shifted annually with no consistently dominant region. Conclusions: Saudi Arabia’s post-pandemic rebound despite high national coverage implicates sub-population susceptibility gaps among non-national residents and school-age children, alongside importation risks from mass pilgrimage. Targeted strategies addressing demographic and geographic heterogeneity are essential to meet WHO 2030 elimination targets. Full article
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10 pages, 1946 KB  
Article
Open Book on the Water Slide: A Case Series of APC2 Pelvic Ring Injuries from High-Energy Aquatic Accidents
by Adeeb Algaith, Kapil Soni, Attila Mácsai, Lilla Sándor, Ákos Csonka, Endre Varga and Petra Hartmann
J. Clin. Med. 2026, 15(5), 1729; https://doi.org/10.3390/jcm15051729 - 25 Feb 2026
Viewed by 522
Abstract
Background and Objectives: Pelvic ring injuries with symphyseal disruption are classically associated with high-energy mechanisms such as motor vehicle collisions. Recently, waterslides have emerged as an underrecognized but distinct source of severe pelvic trauma. Waterslide-related pelvic trauma represents a distinct biomechanical entity [...] Read more.
Background and Objectives: Pelvic ring injuries with symphyseal disruption are classically associated with high-energy mechanisms such as motor vehicle collisions. Recently, waterslides have emerged as an underrecognized but distinct source of severe pelvic trauma. Waterslide-related pelvic trauma represents a distinct biomechanical entity characterized by a supine or semi-supine body position at splashdown, extreme forced hip abduction, asymmetric lower-limb positioning, and abrupt hydrodynamic deceleration. The high descent velocity, abrupt hydrodynamic deceleration, and forced hip abduction at water entry may combine to generate open-book-type pelvic injuries. Evidence guiding diagnosis and surgical management in this setting remains scarce. Materials and Methods: We retrospectively analyzed a consecutive series of adult patients sustaining waterslide-related anterior–posterior compression type II (APC2) pelvic ring injuries. Demographic data and the body mass index (BMI), fracture classification, surgical strategy, complications, and functional outcomes were reviewed. Only patients with complete imaging, operative records, and follow-up were included. Results: Four patients (38–72 years) met the inclusion criteria. All sustained rotationally unstable open-book pelvic injuries and were classified as APC2; three were AO/OTA 61B2.3 and one 61B3.3. All patients were overweight or obese (BMI 27.2–31.2). Pelvic binders provided an effective acute reduction in symphyseal diastasis; however, in one bilateral injury, CT imaging obtained with the binder in situ masked posterior ligamentous instability. Definitive surgical fixation was performed in all cases. Early mechanical failure occurred in two patients treated with short anterior symphyseal plate constructs. In the bilateral injury, isolated anterior fixation failed repeatedly until posterior sacroiliac stabilization was added. No deep infections or thromboembolic events occurred. Although two patients required short observational ICU stays, none were admitted for hemodynamic instability or pelvic bleeding. Conclusions: At 12-month follow-up, three patients achieved pain-free ambulation without assistive devices, while one patient required intermittent use of a single crutch; all patients regained independence in daily activities. Waterslide accidents represent a high-energy injury mechanism capable of producing severe APC2 pelvic disruptions, particularly in patients with an elevated BMI. Awareness of this mechanism and meticulous assessment of posterior stability are essential to avoid under-treatment and mechanical failure. Full article
(This article belongs to the Special Issue Orthopedic Trauma: Diagnosis, Treatment and Rehabilitation)
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28 pages, 870 KB  
Review
Defining Elite Zones: A Scoping Review of Body Physique and Body Fat in Elite Athletes
by Ximena Martinez-Mireles, Erik Ramírez, José Omar Lagunes-Carrasco, Ricardo López-García, Silvia García, Cristina Bouzas, Rogelio Salas-García and Josep A. Tur
J. Funct. Morphol. Kinesiol. 2026, 11(1), 13; https://doi.org/10.3390/jfmk11010013 - 29 Dec 2025
Viewed by 3156
Abstract
Background: Body physique refers to body size, structure, and composition. PS is used to describe the profile of athletes in different sports. Aims: To determine body physique and body fat percentage in elite athletes using the Hattori chart and to identify the elite [...] Read more.
Background: Body physique refers to body size, structure, and composition. PS is used to describe the profile of athletes in different sports. Aims: To determine body physique and body fat percentage in elite athletes using the Hattori chart and to identify the elite zone. Methods: Scoping review. The search was performed in PubMed, Google Scholar, Ovid Books, CAB eBooks, Clarivate InCites, MyiLibrary, Web of Science, Taylor & Francis Online, Core Collection, and Scopus. The search strategy was “body physique” OR “anthropometric” OR “body composition” AND “elite athlete” OR “athlete” OR “elite”. Results: Using indirect methods, elite athletes showed intermediate solid body physique (male) and lean intermediate body physique (female), and 13.6% ± 3.6% (male) and 22.3% ± 2.8 (female) body fat. Using doubly indirect methods, elite athletes showed lean intermediate body physique (male), and intermediate body physique (female), and a percentage of body fat of 13.7% ± 5.2% (male) and of 21.7% ± 4.3% (female) of body fat. Conclusions: Hattori’s chart facilitates the visualization of changes in body mass index, fat-free mass index, fat mass index, and percentage of body fat, helping personalize training, monitor composition changes, and guide nutrition programs to optimize performance and health. Full article
(This article belongs to the Special Issue Body Composition Assessment: Methods, Validity, and Applications)
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14 pages, 289 KB  
Article
Goedesics Completeness and Cauchy Hypersurfaces of Ricci Solitons on Pseudo-Riemannian Hypersurfaces at the Fictitious Singularity: Schwarzschild-Soliton Geometries and Generalized-Schwarzschild-Soliton Ones
by Orchidea Maria Lecian
Axioms 2025, 14(12), 896; https://doi.org/10.3390/axioms14120896 - 2 Dec 2025
Cited by 1 | Viewed by 407
Abstract
The methodology is developed here to write Ricci solitons on the newly found structure of the pseudo-spherical cylinder. The methodology is specified for Schwarzschild solitons and for Generalized-Schwarzschild solitons. Accordingly, a new classification is written for the Schwarzschild solitons and for the Generalized-Schwarzschild [...] Read more.
The methodology is developed here to write Ricci solitons on the newly found structure of the pseudo-spherical cylinder. The methodology is specified for Schwarzschild solitons and for Generalized-Schwarzschild solitons. Accordingly, a new classification is written for the Schwarzschild solitons and for the Generalized-Schwarzschild solitons. The rotational field is spelled out. The potential for a tangent vector field is used. The conditions are recalled to discriminate which submanifold of a Ricci manifold is a soliton or is an almost-Ricci soliton. It is my aim to prove that a concurrent vector field is uniquely determined after the 4-velocity vector of a Schwarzschild soliton. As a result, the analytically specified manifold, which is a spacelike submanifold of the Schwarzschild spacetime that admits Ricci solitons. The rotational killing fields are tangent to the event horizon. The conditions that are needed to match the new aspects are spelled out analytically. As a result, the two manifolds described in the work of Bardeen et al. about the requested mass of a stationary, axisymmetric solution of the Einstein Field Equations of the spacetime, which contains a blackhole surrounded with matter from the new results obtained after correcting the work of Hawking 1972 about would-be point ’beyond the conjugate point’ on the analytic continuation of the would-be geodesics: they are proven here to become the tangent manifold (which is expressed from the tangent bundle in General-Relativistic notation). The prescription here is based on one of the books of Landau et al., that the matter is not put into the metric tensor, not even in the ultra-Relativistic limit. This way, the pseudo-spherical cylinder is one implemented from the Minkowskian description and whose asymptotical limit is proven. The new methodology allows one to describe the outer region of the blackhole as one according to which the (union of the trapped) regions is one with null support. For the purpose of the present investigation, the definition of concurrent vector fields in General-Relativity is newly developed. As a further new result, the paradigm is implemented for the shrinking case, which admits as subcase the Schwarzschild manifolds and the Generalized-Schwarzschild manifolds. The Penrose 1965 Theorem is discussed for the framework outlined here; in particular, the presence of trapped hypersurfaces is discarded. The no-hair theorem can now be discussed. Full article
(This article belongs to the Special Issue Mathematical Physics in General Relativity Theory)
18 pages, 6233 KB  
Article
The Role of Adsorption in Agarose Gel Cleaning of Artworks on Paper
by Teresa T. Duncan, Michelle R. Sullivan, Amy Elizabeth Hughes, Kathryn M. Morales, Edwin P. Chan and Barbara H. Berrie
Gels 2025, 11(12), 965; https://doi.org/10.3390/gels11120965 - 29 Nov 2025
Cited by 2 | Viewed by 1762
Abstract
We present an exploration of an overlooked process in gel cleaning that promotes efficient cleaning of discoloration and stains from artworks on paper: adsorption. Agarose, in both solid and gelled forms, is an efficient adsorbent of crystal violet, which is used here as [...] Read more.
We present an exploration of an overlooked process in gel cleaning that promotes efficient cleaning of discoloration and stains from artworks on paper: adsorption. Agarose, in both solid and gelled forms, is an efficient adsorbent of crystal violet, which is used here as a marker to assess the capability of a system to immobilize solutes. Incorporating additional adsorbents, either 1% by mass microcellulose or silica gel, into the gel before casting greatly improves the efficiency of removing and retaining dye from water. This addition induces a slight (2×) increase in the elastic modulus but results in no impactful change in the handling properties for conservation practice. We show that the addition of silica gel increases the efficacy of removing water-soluble degradation products from a sheet of historic book paper. A case study of a water-damaged eighteenth-century print, with element maps collected using mapping µX-ray fluorescence analysis before and after gel cleaning, demonstrates that microcellulose-containing gels can be used to remove water-soluble salts from the print. This work provides a new methodology for tailoring gels to target specific conservation treatment outcomes. Specifically, efficient adsorption of solubilized material increases the efficacy of the gel cleaning and minimizes redeposition. Full article
(This article belongs to the Special Issue Gel Materials for Heritage Conservation)
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24 pages, 8977 KB  
Article
The Bodily and Multi-Sensory Experiences of Cistercian Nuns: The Collective Liturgy and Ceremonies of the Holy Week in Lichtenthal
by Davide Tramarin
Religions 2025, 16(11), 1380; https://doi.org/10.3390/rel16111380 - 29 Oct 2025
Viewed by 1505
Abstract
Holy Week, the most significant period of the Christian liturgical year, was marked by solemn and complex rituals enacted within the sacred spaces of medieval religious communities. In the case of Cistercian female monasteries, scholarly attention has largely centered on Easter dramatic representations [...] Read more.
Holy Week, the most significant period of the Christian liturgical year, was marked by solemn and complex rituals enacted within the sacred spaces of medieval religious communities. In the case of Cistercian female monasteries, scholarly attention has largely centered on Easter dramatic representations such as the Depositio or the Visitatio Sepulchri, while the official liturgy—Hours, Masses, processions, and the official rituals of the Easter Triduum—has remained comparatively understudied. This article addresses that gap by examining the Holy Week liturgy as performed by the Cistercian nuns of Lichtenthal (Baden-Baden, Germany), on the basis of an exceptional and understudied source: the original Ecclesiastica Officia (mid-13th century, Karlsruhe, Badisches Generallandesarchiv, 65/323). Containing comprehensive normative prescriptions for the Easter liturgy adapted for the Lichtenthal community, this manuscript enables a detailed reconstruction of the nuns’ primary collective experiences during these days. The study brings together evidence from architecture, works of art, and liturgical books, while integrating insights from sensory studies, in order to underscore the bodily and multi-sensory dimensions of the rituals. In doing so, it highlights the implications of the nuns’ active participation in Holy Week ceremonies and contributes to a deeper understanding of medieval female religious ritual experience, challenging conventional notions of enclosure and liturgical practice. Full article
(This article belongs to the Special Issue Studies on Medieval Liturgy and Ritual)
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16 pages, 729 KB  
Article
Towards Credible and Comparable Accounting of Environmental Attributes: Applicability and Limitation on Non-Proportional Allocation as Mass Balance Model
by Taichi Suzuki, Jun Nakatani and Ichiro Daigo
Sustainability 2025, 17(21), 9446; https://doi.org/10.3390/su17219446 - 24 Oct 2025
Cited by 2 | Viewed by 1182
Abstract
There is a growing demand for industrial materials that claim environmental attributes based on life cycle thinking. To track and manage such environmental attributes, Chain of custody (CoC) models are growingly applied. Among CoC models, the mass balance model–credit method (MB-CR) and book [...] Read more.
There is a growing demand for industrial materials that claim environmental attributes based on life cycle thinking. To track and manage such environmental attributes, Chain of custody (CoC) models are growingly applied. Among CoC models, the mass balance model–credit method (MB-CR) and book and claim (B&C) model implement non-proportional allocation of environmental attributes. Though there is a case that applying these models could avoid additional environmental burdens that would otherwise occur, the eligibility of applying non-proportional allocation requires careful consideration. This study aims to clarify the requirement and limitation for applying MB-CR and B&C models and to justify the cases of applying those models. A key requirement is environmental rationality, defined as the ability to contribute to avoiding additional environmental burdens, particularly during transition phases where the target environmental attribute is not abundant. A key limitation is technical feasibility, which constrains allocation within what is physically achievable for industrial materials. This study contributes to establishing a scientifically grounded and systematically structured methodology for non-proportional allocation of environmental attributes. Applying MB-CR and B&C models under the requirement and limitation ensures that the non-proportional allocation aligns with the avoidance of environmental burden while maintaining credibility, transparency, and feasibility in environmental claims of industrial materials. Full article
(This article belongs to the Special Issue Advancing Towards Smart and Sustainable Supply Chain Management)
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14 pages, 266 KB  
Article
Substack, the New “Home” for Cultural Journalism
by María Yanet Acosta Meneses and Gloria Gómez-Escalonilla
Journal. Media 2025, 6(3), 128; https://doi.org/10.3390/journalmedia6030128 - 18 Aug 2025
Viewed by 7629
Abstract
The crisis in the media industry has led some journalists to explore professional alternatives on platforms like Patreon, Ghost, Medium, and Substack—best known for their newsletter services and member-based paid subscriptions. These platforms operate independently of social media, allowing writers to build and [...] Read more.
The crisis in the media industry has led some journalists to explore professional alternatives on platforms like Patreon, Ghost, Medium, and Substack—best known for their newsletter services and member-based paid subscriptions. These platforms operate independently of social media, allowing writers to build and maintain their own communities. This article explores a contemporary model of online literary mediation through a qualitative case study that combines cultural studies approaches with in-depth interviews. Focusing on a platform called Substack, the research analyzes how cultural content—particularly book recommendations and cultural commentary—is produced by journalists and writers. Despite the increasing presence of such content in mass media, this phenomenon remains underexplored in the academic literature. This study addresses that gap by examining the practices of cultural journalists in Spain on Substack. Full article
10 pages, 950 KB  
Article
Modern Analytical Chemistry Meets Heritage Books: Analysis of Volatile Organic Compounds (VOCs) from Two Books Preserved at the Biblioteca Capitolare of Busto Arsizio
by Chiara Chiodini, Pierangela Rovellini, Matteo Chiodini, Luca Giacomelli, Daniela Baglio and the 5B IISS Torno Working Group
Molecules 2025, 30(11), 2447; https://doi.org/10.3390/molecules30112447 - 3 Jun 2025
Cited by 2 | Viewed by 1645
Abstract
The development of sensitive, non-invasive methods is essential for the preservation and study of heritage books, allowing insights into their historical production processes and conservation needs. Volatile organic compound (VOC) analysis provides a valuable, non-destructive approach to assess paper composition and degradation in [...] Read more.
The development of sensitive, non-invasive methods is essential for the preservation and study of heritage books, allowing insights into their historical production processes and conservation needs. Volatile organic compound (VOC) analysis provides a valuable, non-destructive approach to assess paper composition and degradation in historical volumes. In this study, we analyzed VOC emissions from two books preserved at the Biblioteca Capitolare of Busto Arsizio, Italy: a 16th-century Latin grammar book and a 19th-century mathematics handbook for measurement conversions. Using headspace solid-phase microextraction (HS-SPME) and gas chromatography–mass spectrometry (GC-MS), VOCs were sampled after 24 h of storage at room temperature. The results revealed distinct degradation markers: Straight-chain aldehydes, indicative of lipid oxidation, were more prevalent in the 16th-century book, reflecting the higher quality and durability of its rag-based paper. In contrast, elevated furfural levels in the 19th-century book suggest accelerated cellulose hydrolysis typical of wood pulp paper. Additionally, the presence of menthol and anethole in both volumes points to the use of bacteriostatic agents for preservation. These findings not only highlight differences in material composition but also underscore the importance of tailored conservation approaches for historical documents from different eras. Full article
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13 pages, 785 KB  
Article
Developing a Risk Stratification Tool to Predict Patients with Gestational Diabetes Mellitus at Risk of Insulin Treatment: A Cohort Study
by Xi Yang, Hannah L. Nathan, Ebruba E. Oyekan, Tim I. M. Korevaar, Doaa Ahmed, Katherine Pacifico, Aisha Hameed, Manju Chandiramani, Anita Banerjee and Caroline Ovadia
J. Pers. Med. 2025, 15(6), 223; https://doi.org/10.3390/jpm15060223 - 30 May 2025
Cited by 1 | Viewed by 2407
Abstract
Objectives: We aimed to develop and validate a simple, easy-to-use risk stratification tool to use in the diagnosis of gestational diabetes mellitus (GDM) to triage those more likely to require insulin treatment. Methods: Using an audit of patients with GDM in 2019, [...] Read more.
Objectives: We aimed to develop and validate a simple, easy-to-use risk stratification tool to use in the diagnosis of gestational diabetes mellitus (GDM) to triage those more likely to require insulin treatment. Methods: Using an audit of patients with GDM in 2019, multivariable logistic regression was used to select variables and develop a prediction model for insulin requirement. A stratification tool was developed by dichotomising these selected variables; its performance was assessed with an internal cohort from 2021 and externally from patients managed at a separate hospital. Results: Patients with a higher fasting blood glucose concentration (OR 2.41, 95% CI 1.84–3.15) and higher booking body mass index (OR 1.48, 95% CI 1.07–2.03) were more likely to require insulin therapy whilst a later gestational-weeks-at-diagnosis value gave a lower risk of insulin therapy (OR 0.71, 95% CI 0.62–0.81 per week). The low-risk group for insulin requirement was defined thus: fasting blood glucose < 5.6 mmol/L, booking BMI < 30 kg/m2, and gestational weeks at diagnosis ≥ 24 weeks. This classification had a negative predictive value (NPV) of 94% for insulin requirement, with a sensitivity of 84% and specificity of 56% in the development cohort. Similarly, in the internal and external validation cohorts, the NPVs were 93 and 90%, with sensitivity values of 77 and 78%, respectively. Conclusions: This study developed a pragmatic tool with three criteria for stratifying the GDM group not requiring insulin treatment, with successful validation for clinical use. Full article
(This article belongs to the Section Methodology, Drug and Device Discovery)
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23 pages, 1137 KB  
Review
Exploring Future Pandemic Preparedness Through the Development of Preventive Vaccine Platforms and the Key Roles of International Organizations in a Global Health Crisis
by Jihee Jeon and Eunyoung Kim
Vaccines 2025, 13(1), 56; https://doi.org/10.3390/vaccines13010056 - 10 Jan 2025
Cited by 11 | Viewed by 8479
Abstract
Background: The emergence of more than 40 new infectious diseases since the 1980s has emerged as a serious global health concern, many of which are zoonotic. In response, many international organizations, including the US Centers for Disease Control and Prevention (CDC), the World [...] Read more.
Background: The emergence of more than 40 new infectious diseases since the 1980s has emerged as a serious global health concern, many of which are zoonotic. In response, many international organizations, including the US Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO), and the European Center for Disease Prevention and Control (ECDC), have developed strategies to combat these health threats. The need for rapid vaccine development has been highlighted by Coronavirus disease 2019 (COVID-19), and mRNA technology has shown promise as a platform. While the acceleration of vaccine development has been successful, concerns have been raised about the technical limits, safety, supply, and distribution of vaccines. Objective: This study analyzes the status of vaccine platform development in global pandemics and explores ways to respond to future pandemic crises through an overview of the roles of international organizations and their support programs. It examines the key roles and partnerships of international organizations such as the World Health Organization (WHO), vaccine research and development expertise of the Coalition for Epidemic Preparedness Innovations (CEPI), control of the vaccine supply chain and distribution by the Global Alliance for Vaccines and Immunization (GAVI), and technology transfer capabilities of the International Vaccine Institute (IVI) in supporting the development, production, and supply of vaccine platform technologies for pandemic priority diseases announced by WHO and CEPI and analyzes their vaccine support programs and policies to identify effective ways to rapidly respond to future pandemics caused by emerging infectious diseases. Methods: This study focused on vaccine platform technology and the key roles of international organizations in the pandemic crisis. Literature data on vaccine platform development was collected, compared, and analyzed through national and international literature data search sites, referring to articles, journals, research reports, publications, books, guidelines, clinical trial data, and related reports. In addition, the websites of international vaccine support organizations, such as WHO, CEPI, GAVI, and IVI, were used to examine vaccine support projects, initiatives, and collaborations through literature reviews and case study methods. Results: The COVID-19 pandemic brought focus on the necessity for developing innovative vaccine platforms. Despite initial concerns, the swift integration of cutting-edge development technologies, mass production capabilities, and global collaboration have made messenger RNA (mRNA) vaccines a game-changing technology. As a result of the successful application of novel vaccine platforms, it is important to address the remaining challenges, including technical limits, safety concerns, and equitable global distribution. To achieve this, it is essential to review the regulatory, policy, and support initiatives that have been implemented in response to the COVID-19 pandemic, with particular emphasis on the key stages of vaccine development, production, and distribution, to prepare for future pandemics. An analysis of the status of vaccine development for priority pandemic diseases implies the need for balanced vaccine platform development. Also, international organizations such as WHO, CEPI, GAVI, and IVI play key roles in pandemic preparedness and the development and distribution of preventive vaccines. These organizations collaborated to improve accessibility to vaccines, strengthen the global response to infectious diseases, and address global health issues. The COVID-19 pandemic response demonstrates how the synergistic collaboration of WHO’s standardized guidelines, CEPI’s vaccine research and development expertise, GAVI’s control of the vaccine supply chain and distribution, and IVI’s technology transfer capabilities can be united to create a successful process for vaccine development and distribution. Conclusions: In preparation for future pandemics, a balanced vaccine platform development is essential. It should include a balanced investment in both novel technologies such as mRNA and viral vector-based vaccines and traditional platforms. The goal is to develop vaccine platform technologies that can be applied to emerging infectious diseases efficiently and increase manufacturing and distribution capabilities for future pandemics. Moreover, international vaccine support organizations should play key roles in setting the direction of global networking and preparing for international vaccine support programs to address the limitations of previous pandemic responses. As a result, by transforming future pandemic threats from unpredictable crises to surmountable challenges, it is expected to strengthen global health systems and reduce the social and economic burden of emerging infectious diseases in the long term. Full article
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20 pages, 2011 KB  
Article
Potential Changes in Distribution of Major Conifers and Their Seed Mass across Siberia by the Mid-Twenty-First Century in a Warming Climate
by Elena I. Parfenova, Elena V. Bazhina, Sergei R. Kuzmin, Nina A. Kuzmina, Galina V. Kuznetsova, Vera A. Senashova, Georgy I. Antonov, Susan G. Conard and Nadezhda M. Tchebakova
Forests 2024, 15(10), 1691; https://doi.org/10.3390/f15101691 - 25 Sep 2024
Cited by 2 | Viewed by 2498
Abstract
Research highlights: At the turn of the 21st century, there were more forest territories found disturbed by both natural processes (climate change, wildfires, insect outbreaks, permafrost thawing, etc.) and anthropogenic interferences (air pollution, clearcuts, etc.). Seed collecting, then growing seedlings in forest [...] Read more.
Research highlights: At the turn of the 21st century, there were more forest territories found disturbed by both natural processes (climate change, wildfires, insect outbreaks, permafrost thawing, etc.) and anthropogenic interferences (air pollution, clearcuts, etc.). Seed collecting, then growing seedlings in forest nurseries, and then planting seedlings over lost forest areas are the forestry measures needed to restore the forest after disturbances. Goals were to construct bioclimatic models of ranges and seed mass of major Siberian conifers (Siberian pine (Pinus sibirica Du Tour), Siberian fir (Abies sibirica Ledeb.), Siberian spruce (Picea obovata Ledeb.), Siberian larches (Larix sibirica Ledeb., L. gmelini (Rupr) Rupr, and L. cajanderi Mayr.) and Pinus sylvestris L.) and predict their potential change in a warming climate by the mid-century. Methods: Multi-year seed mass data were derived from the literature, seed station data, and were collected in the field. Climate data (January and July data and annual precipitation) were derived from published Russian reference books and websites on climate. Bioclimatic indices (growing degree-days > 5 C, negative degree-days < 0 C, and annual moisture index) were calculated from January and July temperatures and annual precipitation for both contemporary and the 2050s (2040–2060) climates using the general circulation model INM-CM5-0 and two climate change scenarios, ssp126 and ssp585, from CMIP6. Our bioclimatic range models (envelope and MaxEnt models) and regression seed mass models for major conifers were built based on these bioclimatic indices. Additionally, their ranges were limited by the permafrost border, which divided the forest area into the permafrost-free zone, where five conifers are able to grow, and the permafrost zone, where only one conifer, Dahurian larch, is able to survive. Results: Under warmed climates, the ranges of all Siberian conifers would expand 1.5-fold due to the decrease in the permafrost zone, except Dahurian larch, which would lose 5–20% of its coverage due to permafrost retreat. Conifers shifting northward would be slower than predicted only by warmed climates because permafrost would thaw slower than climates would warm. Scots pine may expand by up to 60%, covering dryer lands in the south. Future climates were found to favor seed mass increase for major Siberian conifers and for heavier seed to shift northward. Our major conifers differ by the type of seed dispersal mode: zoochoric, animal (Siberian pine) and anemochoric, and wind-dispersed (other five trees). The seed masses of the five anemochoric conifers varied within the range of 1.5–15 g of 1000 seeds, which is about 40–50-fold less than that of zoochoric Siberian pine. Site climate explained about 28–65% of the seed mass variation for the five anemochoric trees and only 11% for Siberian pine (zoochoric tree). This finding needs additional research to explain the reasons. Conclusions: Warmed climates would favor the expansion of the ranges of major Siberian conifers and their seed mass to be heavier, which would support the high-quality seed production for forest well-being and its restoration in Siberia. Full article
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Article
Research and Analysis of Woodblock Printing Ink from the Qing Dynasty Used in the Shuyede Press of Shandong
by Jing Li, Qianqian Dong, Shuxuan Shi and Yuhu Li
Coatings 2024, 14(8), 920; https://doi.org/10.3390/coatings14080920 - 23 Jul 2024
Viewed by 2532
Abstract
Archival writing material is an important carrier to record and reflect archival content, and its material and durability are closely related to the life of archives. The “Shuyede” press in Shandong Province, which originated in the reign of Kangxi (1662 AD–1722 AD) in [...] Read more.
Archival writing material is an important carrier to record and reflect archival content, and its material and durability are closely related to the life of archives. The “Shuyede” press in Shandong Province, which originated in the reign of Kangxi (1662 AD–1722 AD) in the Qing dynasty, printed many important archives and ancient books of the Qing dynasty (1644 AD–1911 AD). In order to explore the material composition of woodblock printing ink from the Shuyede press, modern analytical and detection techniques such as scanning electron microscopy–energy-dispersive spectrometry (SEM-EDS), Fourier-transform infrared spectroscopy (FTIR), gas chromatography–mass spectrometry (GC/MS), and pyrolysis gas chromatography–mass spectrometry (Py-GC/MS) were applied for the analysis and identification of the ink on woodblock plates from the Shuyede press. The results showed that two kinds of printing ink—pine soot ink and oil soot ink—used were in these woodblocks from the Shuyede press in the Qing dynasty in the collection of Shandong Museum, and the binding material in the ink was animal glue, indicating that both pine and oil soot inks were used as printing ink in the Qing dynasty. Full article
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