Search Results (614)

3-Monochloropropanediol esters (3-MCPDEs) and glycidyl esters (GEs) are food processing contaminants that raise significant food safety concerns due to their established potential for carcinogenicity. This study aimed to determine the occurrence of 3-MCPDEs and GEs in common Malaysian food items and to evaluate the associated health risks through dietary exposure assessment. A total of 251 samples, consisting of retail products and cooked/prepared meals, were analysed using GC-MS. The food consumption data were obtained from published national food surveys. Risk was characterised using health-based guidance values (HBGVs) and margin of exposure (MOE), lifetime cancer risk (LCR), and disability-adjusted life year (DALY) estimates. 3-MCPDE was detected in 94.8% of samples (range: ND to 7.77 mg/kg), while GE was found in 83.3% of samples (range: ND to 9.41 mg/kg). The highest levels were consistently observed in refined vegetable fats and oil products, specifically shortening (3-MCPDE: 3.53 [IQR 2.76–5.16] mg/kg; GE: 4.78 [IQR 3.52–6.14] mg/kg) and margarine (3-MCPDE: 2.50 [IQR 1.11–3.59] mg/kg; GE: 3.60 [IQR 1.18–5.26] mg/kg). Exposure assessment identified fried rice as the largest contributor to total daily intake (3-MCPDE: 3.16 μg/kg BW/day; GE: 1.36 μg/kg BW/day). Total exposure to 3-MCPDE exceeded the provisional maximum tolerable daily intake (PMTDI) established by JECFA by 39.5%, indicating a potential health concern. Low MOE estimates (<10,000) for 3-MCPDE and GE were determined for several food categories, including snacks, kuih-muih, and fried cooked dishes. Chronic GE exposure was estimated to cause up to 6.9 (for mean consumers) and 24.9 (for high consumers) cancer cases per year, with total the DALYs quantified at 124.2 years lost per 100,000 of the population. These data represent a worst-case scenario; however, risks could be minimised through continued surveillance, mitigation strategies by relevant authorities regarding food processing, and informed dietary choices. Full article

Background/Objectives: Poorly soluble aluminium (Al) compounds have successfully been used for decades as adjuvants in vaccines, enabling an effective immune response. Yet the safety of Al exposure from vaccines is consistently questioned, especially regarding infants. Since toxicokinetic data of aluminium after vaccination in humans are not available, model-informed predictions are needed for risk assessment. Methods: Using a physiologically-based toxicokinetic model, we predicted the Al exposure from i.m. injections of Al-adjuvanted vaccines for full-term neonates to 50-year-old adults following the recommended vaccination schedule in Germany 2025 in addition to the continuous oral background Al exposure from dietary intake. Results: During the first two years of life, moderate (max. 2-to-3-fold) but transient increases of Al concentrations in plasma and in the relevant target organs liver and bone due to vaccinations were predicted. Increase in brain Al content was 4%. Most importantly, in all tissues, maximum Al levels did not exceed normal levels observed in infants soon after birth or known from adults. In children and adults, the rise in Al concentrations in plasma and tissues due to single vaccinations was marginal. The calculated contribution of vaccinations to the Al body burden at age 50 was negligible. Conclusions: From a toxicokinetic perspective, the additional Al exposure in full-term infants, children and adults from vaccinations with Al-adjuvanted vaccines according to the current recommended schedules is considered safe. The model has proven a valuable tool for predictions of Al exposure from vaccinations. Full article

Background: In reverse shoulder arthroplasty (RSA), preservation of the subscapularis (SSC) has gained attention because of its biomechanical and functional significance. However, when SSC preservation is attempted using the conventional deltopectoral (DP) approach, glenoid visualization and instrument access may be limited. The purpose of this Technical Note is to describe a modified deltopectoral exposure technique, hereafter referred to as the Margin-Shifted, Yawing, Subscapularis-Sparing, and Transitioned Lateralized Deltopectoral (MYST–LDP) approach, and to assess its feasibility in primary RSA. Methods: The MYST–LDP approach incorporates a laterally shifted incision apex, a proximally oriented curved arc (“yawing”) toward the acromion, complete preservation of the subscapularis, and a distally transitioned limb aligned with the anterior humeral axis. We describe the surgical technique and our initial experience in three consecutive primary RSA cases performed using an inlay implant system to minimize humeral lateralization and allow focused assessment of exposure geometry. Results: In all cases, the SSC was preserved without conversion to a standard DP exposure. Adequate glenoid visualization was achieved using three retractors without excessive soft-tissue tension, allowing controlled glenoid preparation and component implantation without additional exposure or conversion. No approach-related intraoperative complications were observed. Conclusions: The MYST–LDP approach is a feasible modification of the deltopectoral exposure that preserves both SSC and the deltoid while facilitating glenoid visualization and instrument alignment. This technique represents an ergonomic and tissue-preserving option within the familiar DP framework for surgeons performing SSC-preserving RSA. Further comparative and quantitative studies are warranted to determine its clinical value. Full article

This study provides a comprehensive evaluation of the effects of environmental stressors and physical exertion on human nociceptive processing across multiple ecologically relevant conditions. Using a repeated-measures design, participants (N = 45) completed up to five controlled laboratory (thermoclimatic chamber) sessions (baseline, simulated altitude at 4200 m asl, heat at +42 °C, cold at −10 °C, and exertion). Participants were tested by using electrical stimuli. Linear mixed-effects models with participant-level random intercepts, alongside estimated marginal means and bootstrap derived effect sizes, enabled robust characterization of within-subject differences. Thermal stress emerged as the strongest modulator of nociception. Heat exposure significantly elevated sensory and pain thresholds compared with all other conditions, whereas tolerance thresholds peaked during cold exposure, yielding the largest observed effects. Altitude consistently produced the lowest thresholds across all modalities. These contrasts were confirmed statistically in the mixed-effects models, and effect-size analyses indicated substantial within-subject differences between the thermal extremes. By integrating three distinct nociceptive modalities and extreme environment simulations, this work offers novel and informative insights into how environmental stressors shape pain processing. The discovery of opposing thermal effects on sensory/pain versus tolerance thresholds—within the same cohort and design—reveals modality-specific patterns not previously documented and suggests that hypoxia may further modulate these responses. Full article

The behavior of Reinforced Concrete (RC) rectangular, slender columns is examined in this study upon exposure to heat-damage effects and fully confined by Carbon Fiber Reinforced Polymer (CFRP) wraps, where a new interaction diagram is proposed. The Nonlinear Finite Element Analysis (NLFEA) method is adopted to comprehensively understand the behavior of the RC columns, where a validation process takes place, followed by a wide parametric study. The studied parameters include the effect of different temperatures (23 °C (room temperature), 200 °C, 400 °C, 600 °C, and 800 °C) and nine eccentricity-to-height ratios where biaxial moments exist (0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, and 0.8). It has been found that the deformation, toughness, and the axial column’s strength are significantly improved by providing one layer of CFRP sheets for heat-damaged RC columns, while the stiffness behavior is only marginally affected. In addition, increasing the temperature reduces the energy absorption capacity and the ultimate strength of the columns while these are reduced by increasing the loading eccentricity value. However, columns experience a sudden and brittle failure when subjected to combined bending and axial loadings that might be accompanied by steel yielding or buckling of the column’s cross-section. Finally, the interaction diagram between the load and bending actions was constructed by addressing the results of the simulated columns. Full article

This paper developed a probabilistic framework for system level reliability and risk assessment that coupled hydraulic loading with structural response and explicitly modelled cascading interactions and statistical dependence between components. The contribution is a system-level reliability and risk modelling methodology that integrates dynamic cascading interactions, non-stationary design-life reliability accumulation, and system-level optimisation within a unified Monte Carlo architecture. Dynamic Monte Carlo simulation was used to evaluate individual, joint, conditional, and system-scale probabilities of failure across varying flood magnitudes and design lives. Model verification confirmed that discretisation and sampling errors were small relative to parameter-driven variability. Results showed that long-term system reliability arose from the combined influence of flood frequency, exposure duration, and the strength of interaction between interdependent structures. Frequent loading accelerates the accumulation of failure probability through repeated events, whereas rare events contribute more slowly but dominate extreme outcomes, indicating that cumulative reliability cannot be inferred by the linear extrapolation of annual probabilities. In an examined diversion–levee–basin configuration, strong structural coupling amplified vulnerability by contracting joint stability margins and increasing conditional failure probabilities. The system-level optimisation of structural parameters over the examined design life reduced cumulative system failure probability from 0.305 to 0.153, whereas single-component optimisation redistributed risk within the system without reducing total system risk. The framework advances beyond static risk analysis by integrating time-dependent reliability, cascading dependencies, and design-life optimisation for system-scale mitigation. Full article

This study aimed to estimate dietary exposure to aflatoxins (AFs) and characterize its associated risks through the consumption of dried fruits and chocolates among the adult population of Yerevan, the capital city of Armenia. Asflatoxin B1 (AFB1) and total AFs were determined using HPLC in 10 composite samples of widely consumed dried fruits and chocolates, prepared by pooling 100 individual sub-samples into 5 dried fruits and 5 chocolate composites. Individual consumption data were obtained via food frequency questionnaires and were stratified by consumer groups and percentiles. Exposure scenarios (lower-, middle-, upper-bound and detected mean) were applied, and risk was assessed using the margin of exposure (MOE) approach with a BMDL₁₀ of 0.4 μg/kg bw/day. The study findings revealed that dried fruits had higher contamination levels (detected mean content of 10 μg/kg AFB1, 15 μg/kg total AFs) compared to chocolates (detected mean content of 0.5 μg/kg AFB1, and 0.9 μg/kg total AFs), resulting in lower MOE values despite smaller consumption quantities. Detectable AFs in dried fruits from open (street) markets exceeded the EU maximum limits, while Armenia currently lacks national regulatory limits for these products. MOEs were below 10,000 for most consumption groups, indicating a potential public health concern. This research emphasizes the urgent need for continuous monitoring and the establishment of harmonized national regulatory limits for AFs in dried fruits. Full article

Candida parapsilosis is a major cause of healthcare-associated infections due to its persistence on abiotic surfaces and efficient transmission via healthcare workers’ hands. This study evaluated the antifungal efficacy and safety of clinically relevant antiseptics against 60 C. parapsilosis clinical isolates using a surface carrier test designed to simulate contamination and disinfection events on hospital surfaces. Antifungal activity was assessed by logarithmic reduction (log₁₀) assays on surface carriers and by minimum inhibitory concentration (MIC) testing. Potential synergistic interactions between antiseptics and selected phytochemicals were investigated using checkerboard assays, and toxicity was evaluated in vivo using Caenorhabditis elegans. Surface carrier assays showed that 70% ethanol and 0.5% alcoholic chlorhexidine (CHG) achieved the highest fungicidal activity, with reductions of up to 5 log₁₀ after 1 min exposure at 25 °C. Polyhexamethylene guanidine hydrochloride (PHMGH) displayed consistently low MIC values (0.4–0.9 ppm) and intermediate surface activity. CHG combined with eugenol or menthol produced strong synergistic interactions, reducing CHG MICs from up to 6250 ppm to as low as 20 ppm (>300-fold). Toxicity assays revealed a narrow safety margin for CHG, whereas PHMGH showed a more gradual concentration-dependent toxicity profile. These findings highlight clinically relevant differences in antiseptic performance and identify combination strategies that may reduce CHG exposure while maintaining antifungal efficacy. Full article

Against the backdrop of accelerating climate change, extreme weather events have increasingly caused yield losses in agricultural crops. Meanwhile, they undermine the stability of production systems, posing an increasingly severe threat to agriculture. This study draws on the “diversity–stability” hypothesis to construct a country-level measure of agricultural production resilience in China (ARES). Using output time series for multiple agricultural products, we capture the co-movements of shocks and system resilience through output stability and volatility. By combining ARES with climate exposure measures, we assemble a panel dataset covering 1343 counties over the period 2000–2023 and employ a dynamic panel threshold model to jointly account for persistence in ARES and state-dependent nonlinearities in climate impacts. The results reveal significant path dependence in ARES and pronounced threshold effects across climate dimensions. In the full sample, extreme high-temperature days become significantly detrimental after crossing the threshold, whereas extreme low-temperature days become significantly beneficial in the high-exposure regime. Extreme rainfall days and extreme drought days generally exhibit positive effects that weaken markedly beyond their respective thresholds, indicating diminishing marginal gains in ARES under severe exposure. The comprehensive climate physical risk index significantly suppresses ARES when it is below the threshold value; however, after surpassing the threshold, its marginal effect becomes significantly weaker. Heterogeneity analyses across hilly, plain, and mountainous areas, as well as nationally designated key counties for poverty alleviation and development, further show that threshold locations and regime-specific effects differ substantially by terrain and development conditions. These findings highlight the need for “threshold-based” climate adaptation governance, emphasizing targeted investments and risk-financing instruments to prevent ARES collapse under tail-risk regimes. Full article

High-content cemented soils are critical for modern geotechnical technologies (e.g., pre-bored precast piles), yet their long-term durability remains underexplored. This study investigates the 28- to 365-day mechanical and microstructural evolution of high-content cemented silty clay under freshwater and seawater curing via UCS, SEM, MIP, and XRD. Under freshwater, cement content directly dictated strength, with the 8:2 mix reaching 24.31 MPa at 365 days. However, marginal efficiency analysis confirmed diminishing returns for excessive binder, establishing the 7:3 ratio as the optimal baseline. Seawater exposure induced a biphasic response: a 4.6% early strength gain at 28 days, followed by severe degradation (a 23.5% drop at 365 days). Concurrently, the failure mode shifted to macroscopic “pseudo-ductility,” with peak strain increasing from 2.37% to 3.04%. Crucially, a micro–macro inconsistency emerged: although seawater physically refined the pore structure (micropore proportion doubled to 30.2% at 90 days) via expansive salts filling mesopores, macroscopic strength declined. XRD confirmed this degradation coincides with severe long-term alkaline buffer (Ca(OH)₂) depletion. Consequently, lifecycle durability assessments for high-binder marine systems must not rely solely on physical metrics like porosity, but adopt a coupled multi-factor framework prioritizing chemical stability. Full article

Objectives: The impact of renal ischemia during partial nephrectomy (PN) on postoperative renal function remains controversial. On-clamp PN provides improved surgical exposure and haemostasis but induces warm ischemia, which may impair renal function. Off-clamp PN avoids ischemia-related injury and may better preserve renal function, although concerns persist regarding blood loss and oncological safety. We systematically compared perioperative and functional outcomes, as well as surgical margin status between on-clamp and off-clamp PN. Methods: We performed a systematic search of PubMed, Embase, Cochrane, Web of Science, and Scopus to identify randomized controlled trials (RCTs) and observational studies comparing on-clamp versus off-clamp PN with no publication time limitations. Outcomes included estimated glomerular filtration rate (eGFR), percentage eGFR change, estimated blood loss (EBL), transfusion rates, positive surgical margins (PSMs), operative time, and complications. Results: Thirty-nine studies (four RCTs) including 10,154 patients were analysed. Off-clamp PN was associated with a smaller decline in eGFR (mean difference [MD] −4 mL/min/1.73 m², 95% CI −5.7 to −2.8) and lower percentage eGFR loss (MD −1.7%, 95% CI −2.8 to −0.7). On-clamp PN was associated with lower EBL (MD −48 mL, 95% CI −72 to −25). Transfusion rates favored on-clamp PN but were not statistically significant (OR 0.7, 95% CI 0.5–1.0). On-clamp PN was associated with a higher risk of PSM (OR 1.3, 95% CI 1.0–1.7) and postoperative complications (OR 1.3, 95% CI 1.1–1.6). Between-study heterogeneity and predominance of observational data were key limitations. Conclusions: Off-clamp PN provides superior renal functional preservation and lower risks of PSMs and complications, at the cost of increased blood loss. These findings support individualized surgical decision-making based on patient and tumor characteristics. What does the study add?: This study provides an extensive and detailed comparison of off-clamp versus on-clamp partial nephrectomy, encompassing more than 10,000 patients from 39 studies. By integrating the available evidence up to late 2024, it delivers comprehensive estimates of the renal functional benefits associated with ischemia-free surgery. Our findings delineate the trade-offs between renal preservation, blood loss, and surgical margin status, thereby informing individualised decision-making in nephron-sparing surgery and refining current understanding of when ischemia avoidance is most clinically advantageous. Patient summary: Our study suggests that performing partial nephrectomy without temporarily clamping the kidney blood vessels may better preserve kidney function and reduce cancer-related surgical risks, but can lead to increased blood loss during surgery. These findings indicate that the choice of surgical technique should be individualised, taking into account tumour features and patient-specific factors. Full article

Background: Cervical cancer remains a leading cause of cancer-related deaths among women in Nigeria. In 2023, the Government of Nigeria, with support from Gavi and partners, introduced the single-dose human papillomavirus (HPV) vaccine through a phased, school-based campaign. The first phase was launched in October 2023 across 16 states, followed by a second phase in May 2024 that expanded coverage to the remaining states and the Federal Capital Territory. This study evaluates the additional impact of a behavioral insights–informed digital intervention, comprising a social media campaign amplified by trained pharmacists serving as local influencers, implemented in 2025 to increase acceptance and uptake of HPV vaccination during routine immunization. Methods: A pre-test/post-test quasi-experimental design with a control group was implemented in three Nigerian states in 2025 to assess the additional impact of a behavioral insights–informed social media campaign designed to strengthen social approval for HPV vaccination, increase awareness of vaccination locations, and reinforce caregivers’ recognition of their adolescent daughters’ desire to be vaccinated. Messages were amplified by trained pharmacists who served as local influencers. Caregivers of adolescent girls aged 9–17 years were recruited online through targeted Facebook and Instagram advertisements during Nigeria’s transition from school-based HPV vaccination campaigns to routine immunization. Caregivers in treatment areas were exposed to geofenced social media advertisements on Facebook and Instagram and pharmacist counseling, while those in control areas were not. Logistic regression models using a difference-in-difference approach estimated the campaign’s effect on HPV vaccination, controlling for caregiver and adolescent characteristics. Additional statistical models assessed the campaign’s impact on caregivers’ motivation and ability—key drivers of behavior according to the Fogg Behavior Model. Results: HPV vaccination increased at a significantly higher rate in the treatment compared to the control area. The adjusted odds of an adolescent girl being vaccinated were 1.48 times higher in the treatment area at follow-up (95% CI: 1.14–1.92). Adjusted marginal effects indicated that exposure to the campaign increased the probability of vaccination by 8.9 percentage points relative to the control group. The rate at which caregivers’ motivation (aOR = 1.31, 95% CI: 1.00–1.70) and ability (knowing where to get vaccinated: aOR = 1.38, 95% CI: 1.07–1.79; ease of vaccination: aOR = 1.59, 95% CI: 1.22–2.06) increased was also higher in the treatment area. There was no relative increase in intervention versus control groups in factual knowledge regarding HPV vaccination. Conclusions: A behavioral insights–informed social media campaign in which pharmacists served as influencers was associated with higher HPV vaccine uptake during routine immunization. The higher rate of vaccination observed in intervention areas was associated with higher rates of caregiver motivation and ability but not with higher rates of caregiver knowledge. These findings are consistent with the potential of behavioral insights–informed digital campaigns to complement routine immunization efforts and improve vaccine uptake in low- and middle-income countries. Full article

Direct air capture (DAC) of CO₂ via temperature-swing adsorption (TSA) can support sustainable carbon dioxide removal, but only if sorbents regenerate with low energy demand and maintain performance under humid ambient air. In this paper, we evaluate three commercial molecular sieves (JLPM3, 13X, and 4A) in packed-bed tests using humid ambient air. We compared 40 g samples as received with 200 g samples conditioned for 12 days at 100 °C to emulate prolonged exposure to regeneration temperature (the cumulative effect of many heating/desorption cycles); all cycle-stabilized uptake values are reported from the conditioned materials. JLPM3 delivered the highest stabilized CO₂ uptake (0.24 ± 0.01 mmol·g⁻¹), consistent with a combined physisorption/chemisorption mechanism. Its higher total porosity (26.190%) and smaller mesopores (7.569 nm width) promoted rapid mass transfer and site accessibility, while slightly greater micropore area (710.285 m²·g⁻¹) and volume (0.267 cm³·g⁻¹) than 13X supported its marginally higher capacity. Evidence of partial structural degradation under mechanical and thermal stress indicates that minimizing strain during cycling will be important for scale-up and for reducing sorbent replacement. Conditioning at 100 °C activated additional chemisorption sites across all sieves but reduced physisorption capacity. Importantly, a ~100 °C desorption step fully regenerated physisorbed CO₂ while purging moisture from zeolite pores, indicating that low-temperature TSA (compatible with low-grade or waste heat) can replace harsher 300 °C regeneration and lower energy demand. CO₂–H₂O competition experiments confirmed substantial site occupancy by water vapor, which limits capture under humid conditions and motivates water management strategies. Overall, maximizing DAC performance requires tailoring pore structure and operating conditions while preserving sorbent integrity; JLPM3 emerges as a promising candidate for more energy- and resource-efficient DAC. Full article

Health emergencies linked to epidemic outbreaks in vulnerable contexts require rapid and effective architectural responses. Natural ventilation represents a key strategy for infection control and indoor comfort, yet traditional airflow calculation methods require climatic and construction data, which are often unavailable or incomplete. In emergency situations, this results in the inapplicability of such methods and creates a critical information gap. This study proposes a simplified equation to estimate airflow rate (Q) in single-sided and cross-ventilation configurations, based on openable surface area and a reference Effective Window Air Speed (EWAS). Two infectious disease treatment centers were modeled and simulated using EnergyPlus (E+) under five climatic scenarios—two real and three hypothetical—characterized by low, medium, and high wind exposure. Simulation results were compared with existing formulas and with the proposed simplified equation. Although the simplified model introduces a margin of error compared with dynamic simulations, it provides meaningful estimates, with mean deviations typically in the 20–35% range, lower in single-sided conditions and higher for cross-ventilation under medium-to-high wind exposure. The study demonstrates that an ultra-simplified approach can serve as a support tool for the design of temporary healthcare facilities in resource-limited contexts, where rapidity and data accessibility are essential. Full article

This research investigates novel polymeric composite materials made from recycled polyolefin and waste plant biomass (poplar seeds and vegetable peels), which have potential applications in the relatively unexplored field of electrical insulation. For composites made from poplar seeds with low density polyethylene matrix, the structure appears more uniform, even with increased biomass content, in contrast to those utilizing high density polyethylene matrix, which displays notable heterogeneous areas where the polymer appears separated from the fibrous network at higher biomass levels. Concerning the composites of vegetable peels with high density polyethylene matrix, the fragments of vegetable peels are clearly recognizable, and their bond to the polymer matrix appears weaker. When incorporating vegetable peels into the polypropylene matrix, it results in a better distribution of the vegetable peel fragments within the polymer matrix, as well as enhanced structural homogeneity. Overall, the incorporation of biomass reduces the Shore hardness measurement for every polymer matrix. Regarding tear resistance, the inclusion of biomass reduces the values only for low density polyethylene with poplar seeds. For both high density polyethylene and polypropylene, regardless of the biomass type, the property seems to enhance marginally with the addition of biomass. The primary advantage of utilizing these composites is that their water absorption rate is at least twice as low as that of transformer board, while still offering a similar capacity for absorbing transformer oil. All composite types exceeded the minimum required threshold of 70 °C for service exposure, and adhered to insulation class A, similar to cellulose-based insulations. The addition of cellulose to polyolefin composites appears to slightly improve their breakdown strength. The conductivity for this type of composite is at least three times lower than that of cellulose insulation materials, rendering them beneficial for applications in electrical engineering as potential substitutes for cellulose-based materials in multiple electrical insulation uses, e.g., for insulating low voltage electrical machines, as well as serving as a substitute for pressboard in transformers. Additionally, their thermoplastic properties offer enhanced processing versatility, opening up new opportunities for electrical engineering technology, especially with regard to electrical insulation recyclability in the context of a circular economy. Full article