Search Results (69)

Lutetium-177-PSMA-617 (Lu-PSMA) radioligand therapy (RLT) is established in metastatic castration-resistant prostate cancer (mCRPC), with regulatory approvals based on the VISION and TheraP trials. Subsequent trials have extended the evidence to taxane-naive mCRPC (PSMAfore) and demonstrated that combining Lu-PSMA with enzalutamide yields a significant overall survival benefit over enzalutamide alone (ENZA-p). However, higher and more homogeneous PSMA expression in treatment-naive disease, combined with lower tumor burden and preserved bone marrow reserve, provides a biological rationale for deploying RLT earlier in the disease course. In metastatic hormone-sensitive prostate cancer (mHSPC), the Phase III PSMAddition trial reported improved radiographic progression-free survival when Lu-PSMA was added to standard androgen deprivation therapy (ADT) plus androgen receptor pathway inhibitor (ARPI), and the Phase II UpFrontPSMA trial demonstrated enhanced biochemical responses with Lu-PSMA induction before docetaxel. In oligometastatic and oligorecurrent disease, the BULLSEYE and LUNAR trials have shown progression-free survival benefits, raising the possibility of deferring androgen deprivation therapy and its associated morbidity. Meanwhile, next-generation radionuclides, including actinium-225 (WARMTH) and the dual beta-Auger emitter terbium-161 (VIOLET), are entering clinical development to address the radiobiological limitations of Lutetium-177. This review synthesizes the evidence for PSMA-targeted radioligand therapy across the prostate cancer disease continuum and discusses patient selection, treatment sequencing, and the access and cost-effectiveness considerations that will shape adoption in earlier disease settings. Full article

The belief that the moon disturbs sleep is widespread, but the factors associated with it remain poorly understood. I therefore examined how frequently poor sleep is attributed to moon phases, whether this varied across the lunar cycle, and which personal and environmental factors were associated with “moon blaming”. Data were derived from an ongoing online survey. At the time of analysis, 1815 participants had completed a 16-item questionnaire assessing sleep quality, sleep duration, sleep timing on workdays and free days, alarm clock use, environmental and personal sleep-disturbing factors, residential setting, age, gender, attention to lunar phases, and whether the moon was perceived as a cause of poor sleep. The primary outcome was endorsement of the moon as a sleep-disturbing factor. Logistic regression with stepwise Akaike information criterion selection was used to identify the strongest predictors of attributing the moon for poor sleep. Questionnaire timing was also examined across the lunar cycle. Among environmental factors, the moon was the most frequently endorsed cause of poor sleep (36%), followed by outdoor temperature (31%), indoor noise (26%), and bad weather (22%). Rumination was the most commonly reported personal factor (73%), but it did not predict moon attribution. Instead, the strongest correlates were weather-related sleep complaints, tracking lunar phases, age, and gender, with endorsement increasing with age and being more common among women. Moon-related complaints also peaked during the week after the full moon. These findings suggest that perceived lunar effects on sleep are shaped, at least in part, by attributional and expectation-related processes. Full article

The Moon is at the centre of many popular beliefs, including the notion that the number of parturitions increases during Full Moon days, a belief widely held among breeders to anticipate calving periods. However, this association has been rarely explored in dairy cattle farming. This retrospective study was conducted to evaluate the association between the lunar cycles and calving distribution, with particular focus on a potential increase during full-moon nights. Data from 383,926 calvings of Montbéliard breed, recorded between March 2022 and January 2025, mostly in Franche-Comté (98.2%), France, were analyzed using a Generalized Linear Model (GLM). Results revealed a significant association between the lunar cycle and calving distribution. Model-adjusted means were significantly higher than the overall mean during the New Moon and the Last Quarter phases (+2.6%, p < 0.05), and significantly lower during the Full Moon phase (−3.1%, p < 0.01). At the synodic day level, days 21 and 29 presented the highest model-adjusted means (+23.2% and +23.4% above the overall mean, respectively; p < 0.001), while days 4 and 15 presented the lowest (−35.2% and −31.1%, respectively; p < 0.001). Across all seasons, a consistent trend toward increased calving frequency was observed during the New Moon phase, reaching statistical significance only in Spring (+5.7%, p < 0.05). These findings may offer potential implications for veterinarians and breeders, particularly when considering approaches to ensure adequate colostrum intake, which may contribute to improving management of parturition periods. Full article

NASA intends to return humans to the Moon, where partial gravity will put them at risk of musculoskeletal deconditioning. Resveratrol (RSV) is a promising nutritional countermeasure that may protect muscle health during disuse; however, its efficacy and mechanism in simulated lunar gravity are unknown. Forty adult male Wistar rats underwent 14 days of normal loading or partial weight-bearing at 20% of normal loading (PWB20). Unloaded animals received daily RSV supplementation with or without an ERα antagonist to test whether ERα was required to mediate RSV benefits. Muscle function was longitudinally assessed, and a Western blot was used to quantify key signaling proteins in the soleus muscle. PWB20 led to a significant reduction in grip strength (−14.2%) associated with marked changes in electrophysiological muscle properties. RSV-supplemented animals performed better throughout the study, but not when Erα was inhibited. RSV supplementation resulted in a greater ERα phosphorylation ratio compared to PWB20 alone (3.5 vs. 1.91). These results suggest that RSV can mitigate muscle deconditioning in a lunar gravity analog and that ERα signaling is required. Full article

The Chengdu–Chongqing Twin-City Economic Circle (CC-TCEC), located in the Sichuan Basin, frequently experiences persistent winter PM_2.5 pollution due to basin-constrained ventilation and strong meteorology–emission coupling. Using daily PM_2.5 observations from 113 monitoring stations with a strict two-year training and one-year testing split, we develop hybrid spatiotemporal forecasting models that couple a graph neural network (GCN/GAT) for inter-station spatial dependence learning with a temporal backbone (LSTM/Transformer) for evolving concentration dynamics. We adopt a rolling one-day-ahead forecasting scheme using a 7-day look-back window. Across 12-month, 6-month, and 3-month evaluation windows, the meteorology-augmented Multi-GAT-Transformer shows a slight but consistent advantage over the other tested variants, suggesting potential benefits of attention-based spatial weighting and long-range temporal self-attention under nonstationary basin pollution regimes. Spatiotemporal mappings derived from the best-performing configuration suggest that elevated winter PM_2.5 is mainly associated with low-lying areas such as the Chengdu Plain, industry clusters, and dense urban cores, with peaks that also coincide with the New Year and the pre-Lunar New Year period, suggesting a possible contribution from elevated traffic and production activity. These impacts are amplified by winter stagnation (low winds, high humidity, limited precipitation). From a policy perspective, the results support sustainability-oriented winter haze management by enabling early episode warning and hotspot prioritization. Full article

Exploring the lunar complex and extreme terrain presents formidable challenges for conventional lunar rovers. To address these limitations, this study proposes a novel hexapod jumping hybrid robot that incorporates a “figure-of-eight” (butterfly-shaped) six-branched wheel-legged mechanism and a jumping system that stores elastic energy via deformation of its elastic body. Inspired by the multimodal locomotion of grasshoppers, the robot dynamically switches between two operational modes: high-efficiency wheeled locomotion on relatively flat surfaces and agile jumping to traverse steep slopes and surmount large obstacles. A bio-inspired gait, inspired by the crawling patterns of a hexapod insect, is implemented using a Central Pattern Generator (CPG)-based controller to produce coordinated, rhythmic limb movements. Dynamic simulations of the jumping mechanism were conducted to optimize the critical parameters of the elastic structure and its associated control strategy. Experiments on a physical prototype were conducted to validate the robot’s wheeled mobility and jumping performance. The results demonstrate that the robot exhibits excellent adaptability to rugged terrains and obstacle-dense environments. The integration of multimodal locomotion and adaptive gait control significantly enhances the robot’s operational robustness and survivability in the harsh lunar environment, opening new possibilities for future lunar exploration missions. Full article

The lack of high-precision imaging data for lunar volcanic regions currently hinders the detailed characterization of lava tube systems and their associated fine-scale geomorphology. To address this information deficit, this study establishes the Jingpo Lake Volcanic Field (JLVF) in Northeast China as a primary terrestrial analog for the lunar Marius Hills complex. We systematically characterize the basaltic morphometric continuum, tracing the geological evolution from proximal scoria cones through medial lava tube skylights to distal lava plateaus. Focusing on the subsurface transport system, we identify a linear chain of discontinuous skylights that structurally mirrors the “proto-rille” stage of lunar sinuous rilles. Quantitative morphometry reveals that these terrestrial vents reproduce the geometric duality of lunar pits, ranging from stable “deep shafts” to degraded “funnel pits,” effectively validating the mechanical diversity of the lunar inventory. Critically, the “U-to-V” cross-sectional transition observed in JLVF collapse trenches serves as diagnostic ground-truth evidence, confirming that lunar rilles originate from the catastrophic roof failure of subsurface tubes rather than purely thermal erosion. Regarding the lava plateau, our field investigation resolves sub-meter micro-textures—including laminar pahoehoe ropes and inflation fissures—that are typically obscured by the resolution limits of current lunar orbiters. These findings suggest that the seemingly “smooth” lunar maria likely host complex, rugged micro-terrains. Therefore, comparing lunar volcanic regions with simulated volcanic fields from Earth is crucial. Analyzing potential volcanic products from angles undetectable by some lunar satellites can offer vital insights for future lunar exploration. Full article

Background: Irisin, a recently discovered muscle-originating hormone, has been found to act as a biomarker of several ailments, while no guideline clearly indicates its testing so far in any particular population category or pathological condition. Objective: We analyzed blood (circulating) irisin in relation to the potential correlations with the evaluation of glucose and bone profile. Methods: This was a prospective, pilot, exploratory study (between December 2024 and August 2025). The enrolled patients were menopausal women aged ≥50. Exclusion criteria: Endocrine tumors, thyroid dysfunction, malignancies, or chronic kidney disease. Baseline (fasting) testing was followed by 75 g oral glucose tolerance test (OGTT). Enzyme-linked immunosorbent assay (ELISA)-based irisin assay (MyBioSource) was performed. The subjects underwent central Dual-Energy X-Ray Absorptiometry (DXA), which provided lumbar, femoral neck and total hip bone mineral density (BMD)/T-score (GE Lunar Prodigy), and lumbar DXA-based trabecular bone score (TBS iNsight). Results: We enrolled 89 females [mean age of 62.84 ± 9.33 years, average years since menopause (YSM) of 15.94 ± 9.23]. Irisin (102.69 ± 98.14 ng/mL) did not correlate with age, YSM, but with body mass index (r = 0.36, p < 0.001). Bone formation marker osteocalcin (r = −0.25, p = 0.018) was negatively associated with irisin, amidst multiple other mineral metabolism assays (including PTH and 25-hydroxyvitamin D). Irisin positively correlated with insulin (r = 0.385, p = 0.0008), HbA1c (r = 0.243, p = 0.022), and HOMA-IR (r = 0.313, p = 0.007). Additional endocrine assays pointed a statistically significant association between irisin and TSH, respectively, ACTH (r = 0.267, p = 0.01, and r = 0.309, p = 0.041, respectively). No correlation irisin-BMD/T-score/TBS was confirmed. Conclusions: Irisin correlates with markers of glucose status (insulin, HOMA-IR, and HbA1c), as well as body mass index and, to a lesser extent, bone metabolism markers. Interestingly, TSH and ACTH correlations open a new (hypothesis-generating) perspective in the endocrine frame of approaching this exerkine. To the best of our knowledge, no distinct study has so far addressed the TBS–irisin relationship or pinpointed the glucose effects on TBS, particularly in menopausal women. Full article

Background/Objectives: Midlife is associated with changes in body weight and fat distribution in women; however, it remains unclear whether these changes can be attributed to chronological aging, menopause, or associated lifestyle changes. The objective of this study was to compare the possible differences in body fat distribution parameters measured by regional Lunar osteodensitometry scans (DXA) between clinically healthy, BMI-matched pre- and postmenopausal women. Methods: A cross-sectional analysis of body composition parameters, such as total body, android, and gynoid fat percentage, was performed using DXA hip and lumbar scans in 171 women aged 45–55 years. Comparisons were made across 50 premenopausal (median age 47.9 (4.5) years) and 121 postmenopausal women (median age 51.7 (3.7) years), matched for median BMI (25.8 (6.7) vs. 25.6 (7.8) kg/m²). Associations between body fat outcomes and predictors were examined using multivariable linear regression. Results: No significant differences were observed between study groups in body composition parameters, including android fat percentage (%), gynoid fat%, total body fat%, or android/gynoid ratio. Unlike age, menopausal status, or years since menopause, BMI was the only significant predictor of body fat distribution. In the entire cohort, total body fat percentage showed a modest but significant positive correlation with age (ρ = 0.200, 95%CI [0.043, 0.345], p = 0.009), while the menopause onset age was positively correlated with BMI (ρ = 0.195, 95%CI [0.002, 0.369], p = 0.032). Among postmenopausal women within the first two years of menopause, the android/gynoid ratio showed a positive correlation with years of estrogen deprivation (ρ = 0.451, 95%CI [0.144, 0.707], p = 0.007). Conclusions: Age was correlated with higher total body fat %; neither age nor menopausal status was correlated with BMI. In early postmenopause, the android/gynoid ratio increased with years since menopause. The median age at menopause observed in our study was 48 years, which is lower than in other Caucasian studies. Full article

Background/Objectives: Serum calcium concentrations have been associated with bone mineral density (BMD), but results seem to depend on sex. Genetic variants in the Ryanodine Receptor1 (RYR1) gene have been previously associated with low BMD in postmenopausal women. Serum RYR1 concentration was found to be higher in osteopenia and osteoporosis groups. The function and biological relevance of RYR1 in bone remodeling remains unknown. This cross-sectional study explored the relationship between serum calcium concentrations, BMD, and genetic variants in RYR1 in a Mexican-mestizo population. Methods: Serum samples from 966 participants were obtained from the third measurement of the Health Workers Cohort Study (HWCS) 2017–2019, conducted by the Mexican Social Security Institute (IMSS). All participants included in this study were of Mexican Mestizo origin and had data on BMD. We measured ionized calcium and genotyped the genetic variants rs2288888 (g.38455542G>A) and rs11083462 (g.38469040C>T) of the RYR1 gene. BMD of the total hip, lumbar spine, and femoral neck was measured using a Lunar DPX NT DEXA device. Results: Our results show that elevated serum calcium concentrations in females are associated with lower BMD at the hip and femoral neck. In contrast, higher calcium concentrations in males were associated with greater total hip BMD. In our study, the variants rs2288888 and rs11083462 were associated with higher serum calcium concentrations (under-adjusted and unadjusted data) in males but not females. Conclusions: Serum calcium levels are associated with BMD, depending on sex. The RYR1 gene variants rs2288888 and rs11083462 may have a protective effect in men. Full article

Planetary mapping has progressively evolved due to the increasing availability of high-quality data and advancements in analytical techniques applied to both surface and subsurface features. In particular, the enhanced spatial resolution and broader coverage provided by cameras and spectrometers aboard orbiting spacecraft around planetary bodies, now enable the production of more detailed geostratigraphic maps. Which maps go beyond the traditional planetary approach, with mineralogical data contributing significantly to the development of more comprehensive final products. Proclus crater is a fresh crater, 28 km in diameter, located on the northwest rim of the Crisium basin, where crystalline plagioclase, as well as pyroxenes and olivine, have been detected. Here, preliminarily, the geomorphological map showed the different surface textures and lineaments of the crater, and a spectral unit map highlighted the different spectral units present in the area. The spectral unit map has been produced by using supervised classification, where the spectral endmembers were extracted by the mean of an automatic tool. The mineralogical interpretation retrieved from spectral endmembers supports the definition of six main spectral units and, moreover, indicates how two of them could be divided into subunits. Those subunits show the systematic variation in plagioclase, low-Ca and high-Ca pyroxene, and their relative abundances. Finally, the geostratigraphic maps associate compositional heterogeneity with different units of the crater, suggesting that this crater was originally characterized by lithologies rich in plagioclase, but mixed with variable low amounts of mafic phases. Since Proclus is a relatively small crater and the units better exposing the mineral’s original heterogeneity are principally distributed in the walls, the spectral units seem to suggest the presence of magma traps during the plagioclase floating during the lunar primary crust formation and constitute heterogeneous terrains within the Highland. Full article

This paper outlines the inception, conceptualization and primary morphological selection of a robotic system that employs raw lunar regolith for constructing protective berms and shelters on the Moon’s surface. The lunar regolith is considered the most readily available material for in situ resource utilization on the Moon. The lunar environment is characterized, and the operational task is defined, informing the development of high-level system requirements and a functional analysis through the glass-box method. The key morphological areas are identified, and candidate concepts are evaluated using the Analytic Hierarchy Process (AHP). The evaluation process employs a new approach to aggregating expert data through the ZM_II method to establish priorities of the design criteria, which eliminates the need for pairwise comparisons in data collection. Each criterion is associated with a specific and quantifiable metric, which is then used to evaluate the morphologies during the AHP. The selected morphologies are determined as: a vibrating hopper for intake (normalized decision value of 27.5% out of 5 candidate solutions), a roller system for container deployment and filling (26.2% out of 7), a magnetic RCU interface (22.6% out of 7), and a 4-DoF manipulator to place the RCUs in the environment (23.6% out of 5). The final morphology is selected by combining the decision values across the primary morphological areas into a unified decision metric. This is followed by the preliminary selection of the system’s surrounding architecture. The design conceptualization is performed within a real-life operational scenario, namely, to create a blast berm for the landing pad using the lunar regolith provided by an existing excavator. The next phase of the work will include the system’s detailed design, as well as investigations on the requirements for a variety of construction tasks on the lunar surface. Full article

Background and Clinical Significance: Spina bifida in the cervical region is closely associated with Chiari malformation, which is an amalgamation of terminology for separate conditions with similar pathophysiological mechanisms and progression from one another. Chiari malformations are associated with varying degrees of dilation of the foramen magnum or lack of fusion of the occipital bone with syringomyelia, herniation of the cerebellum, occipitocele and occipitomyelocele; Case Presentation: A previously healthy 23-year-old primigravida presented to our institution due to fetal demise in the third lunar month, established on routine outpatient maternal consultation. Point-of-care ultrasound revealed an amniotic sac measuring 3 cm in diameter and containing a single fetus, without cardiac function. Due to these, the patient was scheduled for pregnancy termination, during which the cervix was noted to be spontaneously dilated and abrasion accomplished complete evacuation of the amniotic sac, without its rupture. Upon sectioning of the amniotic sac, a fetus, measuring 2.5 cm in length, was noted, with a significant cuffing of the occipital and cervical paraspinal region. Histology revealed fetal structures with an adequate maturation index for its gestational age, but it presented with a pronounced meningoencephalomyelocele in the cervical and thoracic regions, characterized by the complete absence of vertebral arches and spinous processes from the atlanto-occipital to the sacral region; Conclusions: In the present case, not only is a significant and complex form of Chiari type III reported, but the condition is also associated with spina bifida aperta in all spinal regions, leading to meningoencephalomyelocele, incompatible with life. Full article

Travel policies during crises strongly reshape mobility patterns, raising the challenge of protecting public health while minimizing socio-economic disruption—an essential concern for sustainable development. Most evaluations quantify changes in travel volume, which hampers cross-city comparison and policy monitoring. This study proposes a distance-based sustainability metric—distance equivalence (DE)—that translates policy-induced mobility frictions into interpretable “added distance” within a gravity framework, enabling consistent measurement and monitoring of policy impacts. Using inter-city flows for 358 Chinese cities during the Stay-in-Place for Lunar New Year (SIP) guidance, we map DE, test spatial dependence (Moran’s I; LISA), and apply fuzzy-set Qualitative Comparative Analysis (fsQCA) to identify city-level configurations associated with high DE. DE exhibits significant spatial clustering, concentrating east of the Hu line, where dense urban networks amplify advisory checks. Three recurrent configurations—combining case counts, health-care capacity (hospital beds), and average inter-city distance—are linked to high DE. As a sustainability assessment tool, DE supports adaptive management, region-differentiated strategies, and ex-ante risk assessment for governments, public-health authorities, and transport agencies. The framework generalizes to short-term mobility interventions under crisis conditions, advancing the quantification of policy impacts on sustainable mobility and urban resilience. Full article

This study explores the cultural, productive, territorial, and organizational practices of cacao-producing families in Lebrija, Santander (Colombia), within the broader context of rural sustainability and peasant identity in Latin America. In response to recent national and international frameworks recognizing the rights of peasants, the research aims to document local knowledge systems and community-based strategies that sustain rural livelihoods. Through a qualitative ethnographic approach, including participatory workshops, semi-structured interviews, and social cartography, the study collected narratives, practices, and territorial dynamics over the course of one year. The results reveal that cacao production is not only an economic activity, but a deeply embedded cultural process that intertwines with memory, family ties, lunar cycles, and environmental stewardship. Participants described conflicts related to water access, deforestation, poultry farming, and the expansion of urban infrastructure. Despite these pressures, families demonstrated adaptive capacities through agrodiversity, traditional knowledge, and associative work. The study concludes that these cacao-based practices offer valuable insights into bottom-up strategies for resilience and territorial sustainability and calls for greater inclusion of peasant knowledge in rural development agendas. Full article