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Keywords = lubricating film structure

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26 pages, 16090 KB  
Article
A LBM-LES Coupled-Based Simulation and Parameter Optimization for Improving Oil-Stirring Lubrication Efficiency in High-Speed Transmission Systems
by Yunfeng Tan, Qihan Li, Qiliang Ma, Runyuan Zheng and Lin Li
Appl. Sci. 2026, 16(14), 6998; https://doi.org/10.3390/app16146998 - 13 Jul 2026
Viewed by 124
Abstract
The lubrication performance of high-speed transmission systems directly affects mechanical power consumption and operational reliability. During high-speed oil-stirring lubrication, strong gas–liquid interfacial shear, liquid-film deformation, droplet splashing, and oil-mist transport generate an unsteady multiphase turbulent flow field. Conventional continuum-based numerical methods often face [...] Read more.
The lubrication performance of high-speed transmission systems directly affects mechanical power consumption and operational reliability. During high-speed oil-stirring lubrication, strong gas–liquid interfacial shear, liquid-film deformation, droplet splashing, and oil-mist transport generate an unsteady multiphase turbulent flow field. Conventional continuum-based numerical methods often face difficulties in resolving interface breakup and transient turbulent dissipation under high-speed rotational excitation. To address this problem, this study develops a coupled Lattice Boltzmann–Large Eddy Simulation (LBM–LES) method for oil–air two-phase flow in a high-speed oil-stirring lubrication system. The D3Q27 discrete velocity model, cumulant collision operator, WALE subgrid-scale model, free-surface tracking, and local grid refinement are integrated to analyze free-surface deformation, oil-mist evolution, and power-loss characteristics. Taking a notched toothless oil-stirring disk as the reference configuration, the effects of oil immersion depth and disk topology on gas–liquid phase distribution, oil-mist coverage, power consumption, and vortex-induced energy dissipation are investigated. The results indicate that oil immersion depth has a nonlinear influence on lubrication performance and power loss. Among the investigated cases, an immersion depth of 20 mm provides a favorable balance between upper-region oil-mist coverage and lower-region oil-pool stability. At this depth, the notched disk exhibits directional oil delivery and relatively low power consumption, whereas the double-rhombus structure expands the oil-mist coverage but increases the average power consumption to approximately 175 W. These findings provide numerical support for balancing oil-mist coverage, mechanical power consumption, and disk topology design in high-speed transmission lubrication systems. Full article
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23 pages, 16197 KB  
Article
An Improved Mesh Stiffness Model for Cracked Spur Gears Considering Tooth Surface Contact Characteristics
by Shihua Zhou, Xuan Li, Chenhui Zhou, Tengyuan Xu, Ye Zhang and Zhaohui Ren
Machines 2026, 14(7), 759; https://doi.org/10.3390/machines14070759 - 6 Jul 2026
Viewed by 244
Abstract
Tooth crack, as a typical fault, directly affects the meshing characteristics of gears, which causes abnormal vibration and noise during the gear meshing process, with some even threatening the operational safety of the mechanical device. Meanwhile, the mapping relation between the tooth crack [...] Read more.
Tooth crack, as a typical fault, directly affects the meshing characteristics of gears, which causes abnormal vibration and noise during the gear meshing process, with some even threatening the operational safety of the mechanical device. Meanwhile, the mapping relation between the tooth crack and the actual meshing characteristics is still unclear under the tooth surface morphology and lubrication properties. Aiming at this issue, an integrated time-varying meshing stiffness (I-TVMS) model with cracks is proposed under the complex and variable working conditions. Based on the potential energy method, the analytical expressions with cracks are derived and calculated, and, then, the variation laws of I-TVMS under different crack parameters, tooth surface morphology, and structural and excitation parameters are investigated. Combined with the healthy tooth, the crack increases the contact load on the tooth surface, and reduces the oil film thickness, which decreases the I-TVMS of the cracked tooth. The greater the crack depth and torque is, the smaller the oil film thickness, and the weaker the I-TVMS fluctuation will be. The influence of the crack angle depends on the crack type and meshing region. The tooth-root crack is more sensitive in the single-tooth region, whereas the tooth surface crack shows a larger change only in the double-tooth mean value. When the crack location transitions from the tooth root to the tooth top, the stiffness attenuation gradually weakens. Full article
(This article belongs to the Section Machine Design and Theory)
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17 pages, 14220 KB  
Article
Experimental and Theoretical Studies on Enhanced Lubricity of Hyperbranched Polyamide-Amine for Water-Based Drilling Fluids
by Wei Wang, Rongsheng Lin, Lin Xu, Zhujun Zhang, Lei Wang, Siqi Yang, Wuwei Feng, Peng Xu and Meilan Huang
Polymers 2026, 18(13), 1560; https://doi.org/10.3390/polym18131560 - 23 Jun 2026
Viewed by 280
Abstract
High friction and drag are among the challenging subjects for constructing water-based drilling fluids available in horizontal drilling. Lubricants play a major role in mitigating friction of water-based drilling fluids, and thus, developing new lubricants is necessary for efficient horizontal drilling. In this [...] Read more.
High friction and drag are among the challenging subjects for constructing water-based drilling fluids available in horizontal drilling. Lubricants play a major role in mitigating friction of water-based drilling fluids, and thus, developing new lubricants is necessary for efficient horizontal drilling. In this work, a generation 1.5 (1.5G) hyperbranched polyamide-amine P(EDA-MA-OA), which serves as a candidate for a traditional lubricant with linear conformation, was newly synthesized via a divergent approach. A set of physicochemical characterizations was carried out on P(EDA-MA-OA) to confirm its effective synthesis. The results indicated that P(EDA-MA-OA) has a nanoparticulate morphology with a size of approximately 100 nm. Its molecular structure shows strong thermal stability, with initial thermal decomposition occurring at 146 °C. The water-based drilling fluid formulated with P(EDA-MA-OA) as the lubricant exhibits effective comprehensive properties and, in particular, the lubrication coefficient was 0.067, comparable to that of the oil-based drilling fluid, indicating enhanced lubricity by the incorporation of the hyperbranched polymer. The results of molecular simulations show that P(EDA-MA-OA) possesses a unique “basket-like” architecture, with C18 long chains enveloping the central active segments, namely the carbonyl (-C=O) and amide (-CO(NH2)) groups. When interacting with montmorillonite (MMT) particulates, the active groups can interact with MMT, allowing the eight C18 branched terminal chains to form a “molecular brush” with a normal orientation toward the MMT interface, which can serve as a hydrophobic lubricating film to improve lubricity. A lubrication model was finally proposed to rationalize the enhanced lubricity from the hyperbranched polymers in the water-based drilling fluid. Full article
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24 pages, 4479 KB  
Article
Inclination-Driven Thin-Film Dynamics: Geometry-Induced Regime Ordering in the (Bo, Pe, Da) Space
by Helena Cristina Vasconcelos, Reşit Özmenteş and Maria Meirelles
Physics 2026, 8(2), 47; https://doi.org/10.3390/physics8020047 - 1 Jun 2026
Viewed by 386
Abstract
We develop a leading-order continuum framework for thin-film hydrodynamics on inclined solid substrates, integrating capillarity, intermolecular forces, gravitational symmetry breaking, confined transport, and stochastic wetting into a single formulation. Starting from lubrication theory with capillary curvature and disjoining-pressure interactions, we obtain a lubrication-scale [...] Read more.
We develop a leading-order continuum framework for thin-film hydrodynamics on inclined solid substrates, integrating capillarity, intermolecular forces, gravitational symmetry breaking, confined transport, and stochastic wetting into a single formulation. Starting from lubrication theory with capillary curvature and disjoining-pressure interactions, we obtain a lubrication-scale thin-film equation that incorporates inclination-driven advection, nanoscale stabilization, and humidity-controlled source–sink fluxes. A dimensionless analysis shows that, within the long-wave lubrication approximation, inclination induces a coordinated leading-order coupling among the Bond (Bo), Péclet (Pe), and Damköhler (Da) numbers. This coupling defines a characteristic inclination-angle-dependent scaling trajectory Γ(θ) in the (Bo, Pe, Da) space: material parameters set the system’s position along this curve, while the geometric constraint organizes the ordering of hydrodynamic, transport, and confinement regimes. We further derive leading-order crossover criteria associated with transport transitions (Pe ≃ 1) and reactive-confinement loss (Da ≃ 1), providing explicit regime boundaries that can be evaluated for representative parameter ranges. A representative parameterization of an ultrathin atmospheric electrolyte film is then used to make these crossovers explicit, yielding illustrative inclination thresholds that depend on the chosen parameter set. Coupling the deterministic structure to a minimal stochastic closure captures intermittent wet–dry dynamics under environmental forcing. In this closure, inclination selectively accelerates the drying pathway through the drainage time (and thus drying rate λdry), while rewetting remains primarily humidity-controlled, to leading order, providing a scaling-based description of wet-state persistence and time-of-wetness versus θ. The resulting framework provides a continuum-scale physical description of confined films under geometric asymmetry, relevant to wetting, interfacial drainage, confined transport, and thin-film systems in which symmetry breaking and coupled interfacial–transport processes coexist. Full article
(This article belongs to the Section Classical Physics)
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23 pages, 23479 KB  
Article
Investigation of Generator Rotor Dynamic Characteristics Under Unbalanced Electromagnetic Forces
by Jiashun Dai, Hong Lu, Yukuo Guo, Hao Xue, Jiangnuo Mei and Qiong Wang
Sensors 2026, 26(11), 3392; https://doi.org/10.3390/s26113392 - 27 May 2026
Viewed by 362
Abstract
With the increasing complexity of operating conditions and the trend toward structural compactness in generators, the unbalanced electromagnetic force induced by air-gap eccentricity has become a critical factor affecting rotor dynamic behavior and operational reliability. To address the strong coupling and modeling challenges [...] Read more.
With the increasing complexity of operating conditions and the trend toward structural compactness in generators, the unbalanced electromagnetic force induced by air-gap eccentricity has become a critical factor affecting rotor dynamic behavior and operational reliability. To address the strong coupling and modeling challenges among the electromagnetic field, mechanical force field, and lubrication flow field under eccentric conditions, this study proposes a multi-physics coupled modeling approach that integrates electromagnetic, structural, and fluid dynamic interactions. Based on the spatial pose characteristics of the rotor under eccentric conditions, a three-dimensional mathematical model of the air-gap length is established, and an analytical expression for the lubricating oil film thickness distribution is derived. This framework enables the coupled solution of unbalanced electromagnetic force, hydrodynamic oil film supporting force, and rotor dynamic response. A 60 kW-rated diesel generator was selected as the research object for both numerical simulations and experimental investigations. The numerical results indicate that when the load power increases from 0 kW to 60 kW, the displacement amplitude of the rotor in the y-direction increases by approximately 155%, demonstrating a significant enhancement of transverse vibration intensity under increasing unbalanced electromagnetic excitation. Comparison between experimental and numerical results shows good agreement in both variation trends and amplitude levels, with a maximum relative error of 4.07%, thereby validating the accuracy and reliability of the proposed electromagnetic–structural–fluid coupled model for predicting rotor dynamic response in generators. Full article
(This article belongs to the Section Physical Sensors)
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16 pages, 1799 KB  
Article
Interfacial Energy Tuning for Shear-Resilient Boundary Films in Organic Friction Modifier Systems
by Raudah Nordin, Nur Aisya Affrina Mohamed Ariffin, Jiahe Poy, Jo-Han Ng, King Jye Wong and William Woei Fong Chong
Lubricants 2026, 14(6), 216; https://doi.org/10.3390/lubricants14060216 - 25 May 2026
Viewed by 271
Abstract
Lubricant additive optimisation, such as using an Organic Friction Modifier (OFM), often relies on empirical methods because the role of interfacial energetics in boundary lubrication remains uncertain. This study explores how interfacial energy interactions affect the tribological performance of glycerol monooleate (GMO)–polyalphaolefin-4 (PAO4) [...] Read more.
Lubricant additive optimisation, such as using an Organic Friction Modifier (OFM), often relies on empirical methods because the role of interfacial energetics in boundary lubrication remains uncertain. This study explores how interfacial energy interactions affect the tribological performance of glycerol monooleate (GMO)–polyalphaolefin-4 (PAO4) blends using ball-on-disk friction and wear tests. The 7 wt% GMO blend showed the best results, with friction reduced by about 4 times and the wear scar diameter by nearly 6 times compared to neat PAO4. Film-thickness estimates indicate that all tests operated within the boundary-to-mixed lubrication regime, suggesting that friction reduction is associated with interfacial interactions rather than hydrodynamic film formation. The Owens–Wendt–Kaelble surface energy analysis reveals that increasing GMO concentration shifts the lubricant’s dispersive–polar balance, with the 7 wt% formulation exhibiting dispersive–polar characteristics closer to those of the steel substrate. Low friction persisted as sliding velocity increased, and rupture-threshold analysis is consistent with improved tribological response under increasing load and sliding conditions. These findings suggest that the favourable tribological response observed for the investigated formulations may be associated with balanced interfacial energetic characteristics, particularly between dispersive and polar interactions. The observed friction and wear behaviour under increasing sliding conditions is interpreted in terms of friction and wear responses under boundary-dominated conditions, rather than through direct structural characterisation of boundary films. These trends are interpreted in relation to changes in dispersive and polar interactions at the interface. The results provide an interpretive framework for designing OFM systems that may be relevant to high-shear environments, including applications such as hydrogen internal combustion engines. Full article
(This article belongs to the Special Issue Wear-Resistant Coatings and Film Materials, 2nd Edition)
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21 pages, 8850 KB  
Article
Integrated Multi-Physics Design of a GGG40 Agricultural Trailer Wheel Hub: Concurrent Topology Optimisation and CFD-Based Lubrication Enhancement
by Onur Gök
Lubricants 2026, 14(5), 207; https://doi.org/10.3390/lubricants14050207 - 19 May 2026
Viewed by 422
Abstract
Wheel hubs in heavy-duty agricultural trailers operate under demanding conditions comprising rough terrain, impact loads, and highly variable load spectra. Current design practice relies predominantly on experience-based sizing rather than systematic multi-physics analysis. This study presents an integrated design methodology combining finite element [...] Read more.
Wheel hubs in heavy-duty agricultural trailers operate under demanding conditions comprising rough terrain, impact loads, and highly variable load spectra. Current design practice relies predominantly on experience-based sizing rather than systematic multi-physics analysis. This study presents an integrated design methodology combining finite element analysis (FEA), density-based topology optimisation, and computational fluid dynamics (CFD) to concurrently improve the structural and tribological performance of a GGG40 spheroidal graphite cast iron agricultural trailer wheel hub. A reference commercial hub geometry was modelled and analysed under multiple load conditions with a safety factor of 5. Critical stress regions were identified, and the free design volume was optimised while preserving all functional surfaces. The optimised design achieved 35% mass reduction (14.9 to 9.6 kg), 30% lower maximum von Mises stress (235 to 165 MPa), and up to 40% stress reduction in the bearing seat region. Oil-circulation channels integrated into the bearing housing raised mean lubrication flow velocity by 28% and eliminated stagnation zones, yielding a more homogeneous oil-film distribution and directly benefiting bearing tribological performance. The proposed framework provides a manufacturable engineering methodology that concurrently addresses structural integrity and lubrication performance in agricultural wheel hub design. Full article
(This article belongs to the Special Issue Machine Design and Tribology)
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25 pages, 11424 KB  
Article
Friction and Wear Behavior of Graphite Inlay Lubrication Structures for Localized Rings with Spherical Friction Pairs
by Xiang Xu, Xingyu Ma, Chang Sun, Haihua Wu, Xinze Zhao, Biao Liu and Meiyun Zhao
Lubricants 2026, 14(5), 200; https://doi.org/10.3390/lubricants14050200 - 13 May 2026
Viewed by 358
Abstract
Conventional solid-inlay lubrication research has focused on the overall inlay layout and generalized lubrication effects; localized inlay lubrication enables precise release of the lubricant and rapid formation of a uniform and dense lubricant film. The aim of this study is to use a [...] Read more.
Conventional solid-inlay lubrication research has focused on the overall inlay layout and generalized lubrication effects; localized inlay lubrication enables precise release of the lubricant and rapid formation of a uniform and dense lubricant film. The aim of this study is to use a combination of simulations and experimentation to establish a localized spherical friction pair containing a filled-hole structure, so that optimal lubrication can be predicted accurately. We designed seven different kinds of localized annular band inlay axial tiles, with ratios of 10, 12, 15, 18, 20, 22, and 25; carried out a transient mechanical analysis through finite element software, comparing the equivalent stress and friction coefficient of the inlay tiles with different ratios; and conducted friction wear tests through a self-developed spherical wear test bench. The friction surfaces of the tested specimens were analyzed for sliding friction coefficients and wear, as well as by SEM surface and EDS analyses. The results show that the best mechanical properties and the smallest theoretical friction coefficients are obtained when the relative ratio of the ring diameter to inlay hole diameter is 25. This study provides a theoretical basis for the design of spherical solid-inlay lubrication structures in the region of the split-belt ring design. Full article
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17 pages, 2123 KB  
Article
Sustainable Polyurea Greases Based on Epoxidized Soybean Oil: Influence of Ureido Structure on Performance
by Yifan Chen, Xiaoling Yao, Hongjiang Yu and Gaobo Lou
Molecules 2026, 31(9), 1484; https://doi.org/10.3390/molecules31091484 - 29 Apr 2026
Cited by 1 | Viewed by 594
Abstract
In this study, sustainable polyurea greases were prepared using epoxidized soybean oil (ESO) as bio-based base oil, with octadecylamine (ODA) reacted with three diisocyanates: 4,4′-diphenylmethane diisocyanate (MDI), 1,6-hexamethylene diisocyanate (HDI), and toluene diisocyanate (TDI). The diisocyanate structure dominated the thickener microstructure: MDI-ODA formed [...] Read more.
In this study, sustainable polyurea greases were prepared using epoxidized soybean oil (ESO) as bio-based base oil, with octadecylamine (ODA) reacted with three diisocyanates: 4,4′-diphenylmethane diisocyanate (MDI), 1,6-hexamethylene diisocyanate (HDI), and toluene diisocyanate (TDI). The diisocyanate structure dominated the thickener microstructure: MDI-ODA formed a compact short-rod fibrillar network with strong hydrogen bonding and π–π stacking, endowing the grease with the highest consistency (256), dropping point (262 °C), lowest oil separation (2.7%), and optimal thermal stability (T5% = 278 °C). HDI-ODA showed a lamellar structure with moderate performance, while TDI-ODA presented a loose porous network. Rheological tests confirmed MDI-ODA/ESO possessed the highest yield stress and structural recovery (79.5%). Tribological tests showed MDI-ODA/ESO delivered the lowest friction coefficient and wear scar diameter. Compared with non-epoxidized soybean oil (SO), ESO significantly enhanced grease performance. This improvement is attributed to the ring-opening reaction between the N–H of the ureido group and the epoxy groups of ESO, which improves thickener–oil compatibility. In addition, the polar epoxy groups promote the formation of stable lubricating films. This work verifies that diisocyanate structure and base oil epoxidation are critical for high-performance sustainable polyurea greases. Full article
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21 pages, 4435 KB  
Article
Hydro-Mechanical Coupling Behavior of Cemented Silty Sand in Zones with Fluctuating Water Levels: An Empirical Damage Model
by Junbo Bi, Jingjing Wang, Weichao Sun and Shuaiwei Wang
Appl. Sci. 2026, 16(8), 3614; https://doi.org/10.3390/app16083614 - 8 Apr 2026
Viewed by 377
Abstract
Land subsidence in the Yellow River Floodplain, approaching 60 mm/year, is severely exacerbated by annual groundwater oscillations of 3 to 8 m. Conventional hydro-mechanical models, which primarily rely on effective stress principles, often struggle to fully capture the moisture-induced structural degradation of calcareous [...] Read more.
Land subsidence in the Yellow River Floodplain, approaching 60 mm/year, is severely exacerbated by annual groundwater oscillations of 3 to 8 m. Conventional hydro-mechanical models, which primarily rely on effective stress principles, often struggle to fully capture the moisture-induced structural degradation of calcareous cemented soils under such hydraulic disturbances. To address this theoretical gap, we conducted a multifactor orthogonal triaxial experiment to quantitatively decouple the macroscopic factors governing the hydro-mechanical degradation. The results reveal that moisture content acts as the absolute dominant driver, accounting for 81.65% of the variance in macroscopic shear strength variance and completely overwhelming the mechanical advantages provided by initial compaction. A generalized dual-path water-sensitive damage model was explicitly derived, mathematically uncovering a fundamental asynchronous degradation mechanism. Cohesion exhibits an inward-concave, brittle fracture trajectory, which is macroscopically inferred to be associated with the water-induced softening of calcareous bonds (phase-transition parameter 0.81, maximum allocation 75.1%). Conversely, the internal friction angle demonstrates an outward-convex, hysteretic decline (parameter 1.59), maintaining structural interlocking until severe water-film lubrication occurs. By decoupling highly state-dependent initial strength parameters from invariant degradation operators, the modified Mohr–Coulomb model achieved exceptional forward blind-prediction accuracy. Validations across distinct initial skeletal structures constrained relative prediction errors strictly between −19.3% and +13.7% without any subjective parameter recalibration. The quantified extreme vulnerability theoretically proves that minor water infiltration can instantly eradicate over 75% of cohesive strength, necessitating a paradigm shift from shallow mechanical compaction to stringent waterproofing in regional engineering practices. Full article
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27 pages, 9320 KB  
Article
A Study of the Groove Geometry Effects on the Performance of Water-Lubricated Rubber Journal Bearings
by Ahmad Golzar Shahri, Asghar Dashti Rahmatabadi, Mahdi Zare Mehrjardi and Mehrdad Rabani
Appl. Sci. 2026, 16(7), 3603; https://doi.org/10.3390/app16073603 - 7 Apr 2026
Viewed by 587
Abstract
This study aims to investigate the static performance of water-lubricated rubber bearings (WLRBs) with axial grooves. To achieve this objective, an analytical approach is employed that combines a modified Reynolds equation, accounting for surface groove effects and rubber deformation, with a Winkler model [...] Read more.
This study aims to investigate the static performance of water-lubricated rubber bearings (WLRBs) with axial grooves. To achieve this objective, an analytical approach is employed that combines a modified Reynolds equation, accounting for surface groove effects and rubber deformation, with a Winkler model and finite element analysis of pressure distribution. By developing a fluid–structure interaction model that incorporates rubber liner deformation, this research reveals the interaction between WLRB geometry and steady-state performance parameters. The investigation evaluates the influence of geometric characteristics, including groove shape, number, and size, on the performance of elastomeric liner WLRBs, while assessing optimal groove depths under various conditions. The study analyzes five distinct groove geometries, including semi-cylindrical, rectangular prism, and three pyramidal types with different apex positions, in a six-groove bearing configuration, presenting their qualitative effects on the behavior of the examined bearings. The key findings indicate that increasing groove size or quantity reduces maximum pressure and load-carrying capacity while elevating friction coefficients. As groove count rises, supporting surfaces diminish, causing pressure distribution to intensify and minimum film thickness to decrease under a specified external load. A notable result reveals that when groove depth exceeds film thickness, performance becomes geometry-independent; however, shallower grooves exhibit significant geometric effects. Additionally, the study identifies groove ends as critical functional zones where film thickness reduction substantially enhances pressure distribution and static performance. Comparative analysis shows that longitudinal grooves with triangular cross sections outperform semi-circular and rectangular variants, with the backward triangular configuration demonstrating superior characteristics due to optimal end-film properties. In conclusion, this research provides a detailed understanding of how groove geometry influences the static performance of WLRBs, highlighting the importance of groove design, particularly at the groove ends, in optimizing bearing functionality. The findings offer valuable insights for the design and selection of groove configurations in water-lubricated rubber bearing applications. Full article
(This article belongs to the Special Issue Advanced Surface Engineering for Tribological Applications)
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16 pages, 3614 KB  
Article
Corneal Toxicity of Mirvetuximab Soravtansine: Multimodal Imaging Features and Implications for Ophthalmologic Management
by Francesco De Dominicis, Andrea Giudiceandrea, Martina Cocuzza, Simone Bruzio, Romina Fasciani, Luigi Mosca, Chiara Giudiceandrea, Matteo Salgarello, Epifanio Giudiceandrea, Filippo Amore, Stanislao Rizzo, Maria Vittoria Carbone, Vanda Salutari, Anna Fagotti and Tommaso Salgarello
Diagnostics 2026, 16(7), 1107; https://doi.org/10.3390/diagnostics16071107 - 7 Apr 2026
Viewed by 812
Abstract
Background: Mirvetuximab soravtansine (MIRV) improves outcomes in FRα-positive, platinum-resistant ovarian cancer; however ocular adverse events (OAEs), particularly corneal epithelial toxicity, are frequent and warrant structured ophthalmologic monitoring. Methods: In this retrospective observational study, 31 consecutive patients receiving MIRV for FRα-positive gynecologic malignancies underwent [...] Read more.
Background: Mirvetuximab soravtansine (MIRV) improves outcomes in FRα-positive, platinum-resistant ovarian cancer; however ocular adverse events (OAEs), particularly corneal epithelial toxicity, are frequent and warrant structured ophthalmologic monitoring. Methods: In this retrospective observational study, 31 consecutive patients receiving MIRV for FRα-positive gynecologic malignancies underwent standardized ophthalmic assessments at baseline and prior to each treatment cycle (every 21 days). The protocol included best corrected visual acuity (BCVA), slit-lamp biomicroscopy, anterior-segment optical coherence tomography (AS-OCT), corneal topography, and tear film analysis. OAEs were graded according to the Common Terminology Criteria for Adverse Events (CTCAE) v5.0, based on symptom severity and functional impairment. Results: OAEs occurred in all patients (31/31, 100%), predominantly grade 1–2. Corneal epithelial toxicity was documented in 28/31 patients (90.3%), while no grade ≥ 3 events were observed. Symptoms typically developed 7–14 days after the second infusion. AS-OCT and corneal topography consistently revealed epithelial microcysts and surface irregularities, which were usually detected during scheduled pre-cycle ophthalmologic evaluations. Tear-film instability (break-up time ≤ 5 s) developed in 19/31 patients (61.3%), generally within 10 days after the second infusion, and improved in all but 2 patients (6.5%) following prophylactic lubrication. Transient refractive changes occurred in 28/31 patients (90.3%) and were associated with a temporary BCVA reduction (mean nadir ~20/32 Snellen), followed by recovery during follow-up. Conclusions: MIRV-related ocular alterations are frequent but reversible and clinically manageable. Multimodal imaging combined with functional and refractive assessment provides sensitive markers of corneal epithelial toxicity and supports integrated ophthalmologic monitoring to preserve visual function and maintain oncologic treatment continuity. Full article
(This article belongs to the Section Medical Imaging and Theranostics)
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32 pages, 2069 KB  
Review
Advances in the Use of Ionic Liquids as Smart Lubricants and Additives for Tribological Applications
by Jan Blahut, Michal Michalec, Vít Šimara, Petr Svoboda, Oldřich Zmeškal and Patrik Sokola
Materials 2026, 19(6), 1183; https://doi.org/10.3390/ma19061183 - 17 Mar 2026
Viewed by 1543
Abstract
Ionic liquids have emerged as a promising class of lubricants and lubricant additives due to their unique physicochemical properties, including negligible vapor pressure, high thermal stability, tunable molecular structure, and strong surface affinity. This review summarizes recent advances in the application of ionic [...] Read more.
Ionic liquids have emerged as a promising class of lubricants and lubricant additives due to their unique physicochemical properties, including negligible vapor pressure, high thermal stability, tunable molecular structure, and strong surface affinity. This review summarizes recent advances in the application of ionic liquids in tribology, with emphasis on molecular design, lubrication mechanisms, rheological behavior, material compatibility, and industrial applicability. The role of cation–anion combinations in governing adsorption, boundary film formation, and tribochemical reactivity is critically discussed. Particular attention is given to ionic liquids used as neat lubricants and as additives in conventional mineral and synthetic oils, where synergistic interactions and concentration-dependent effects are evaluated. The formation of protective tribofilms, confinement-induced structuring, and rheological characteristics under high pressure are analyzed as key contributors to friction and wear reduction. Challenges related to corrosion, miscibility, viscosity control, cost, and large-scale synthesis are examined in the context of practical implementation. Finally, future research directions are outlined, including data-driven molecular design, computational screening, and sustainable synthesis strategies. Although ionic liquids offer significant advantages under boundary and extreme operating conditions, their broader industrial deployment requires systematic optimization balancing performance, compatibility, environmental safety, and economic feasibility. Full article
(This article belongs to the Special Issue Synthesis, Characterization and Applications of Ionic Liquids (ILs))
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19 pages, 3644 KB  
Article
Correlations Between Sensory Evaluations and Instrumental Measurements in Milk Chocolate with Varying Emulsifier Levels and Particle Sizes
by Burcu Sasmaz and Gurbuz Gunes
Foods 2026, 15(5), 938; https://doi.org/10.3390/foods15050938 - 7 Mar 2026
Cited by 1 | Viewed by 837
Abstract
This study was conducted to investigate and identify correlations among sensory and comprehensive consumer test results with rheological, textural, and tribological properties of milk chocolate in response to varying levels of particle size and emulsifier. To simulate realistic oral conditions, artificial saliva was [...] Read more.
This study was conducted to investigate and identify correlations among sensory and comprehensive consumer test results with rheological, textural, and tribological properties of milk chocolate in response to varying levels of particle size and emulsifier. To simulate realistic oral conditions, artificial saliva was incorporated into instrumental analyses. Rheological analysis revealed that increasing particle size and emulsifier concentration significantly reduced plastic viscosity, while emulsifier concentration alone increased yield stress due to structural reorganization within the fat phase. Tribological measurements demonstrated that larger particles increased friction in boundary and mixed lubrication regimes, whereas emulsifiers reduced friction in these regimes by enhancing fluid film formation. Under elastohydrodynamic conditions and with artificial saliva, friction was more influenced by the interaction between particle size and emulsifier level. Textural analysis showed that both parameters significantly influenced hardness, with saliva further softening the samples, especially those with higher emulsifier levels. Sensory evaluations indicated that emulsifiers enhanced flavor release and mouthfeel attributes, while smaller particles contributed to smoother texture and more balanced flavor perception. Consumer acceptance tests confirmed that samples with smaller particles and higher emulsifier levels received the highest scores in overall liking, taste, and texture. Instrumental parameters strongly correlated with key sensory attributes, with yield stress showing the highest positive associations with creaminess, smoothness, fat/milk flavor, and liking, while higher viscosity and friction were negatively linked to flavor release and mouthfeel. Instrumental hardness negatively correlated with cacao intensity and astringency, while saliva-induced softening was positively associated with sweetness and liking, highlighting the role of dynamic oral softening. Full article
(This article belongs to the Section Food Physics and (Bio)Chemistry)
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16 pages, 6126 KB  
Article
Modulating Casein-Stabilized Emulsions Through the Incorporation of Different Emulsifiers: Impacts on Microstructure and Oral Tribology
by Shujun Ji, Ping Liu, Mengya Sun, Mengmeng Xu, Xiaojie Zhang, Qiongyu Wang, Zhihua Pang and Xinqi Liu
Foods 2026, 15(5), 846; https://doi.org/10.3390/foods15050846 - 3 Mar 2026
Viewed by 626
Abstract
This study investigated the combined effects of oil concentration, emulsifier type, and saliva on the lubrication behavior of casein-based oil-in-water emulsions to support the design of milk-based foods with optimized mouthfeel. Emulsions stabilized with Tween 20, whey protein isolate (WPI), or sucrose ester [...] Read more.
This study investigated the combined effects of oil concentration, emulsifier type, and saliva on the lubrication behavior of casein-based oil-in-water emulsions to support the design of milk-based foods with optimized mouthfeel. Emulsions stabilized with Tween 20, whey protein isolate (WPI), or sucrose ester were prepared at oil concentrations ranging from 0.01% to 3%, and their viscosity, microstructure, tribological properties, and ζ-potential were systematically characterized, with human saliva incorporated to simulate oral conditions. Oil concentration did not significantly alter viscosity, although droplet aggregation increased with higher oil levels. Lubrication performance was governed primarily by emulsifier type: Tween 20 generated an oil film at approximately 0.2% oil, WPI exhibited progressively enhanced lubricity with increasing oil concentration, and sucrose ester produced consistently poor lubrication due to its rigid interfacial layers. Saliva addition improved lubrication across all systems and reduced oil precipitation by promoting the formation of smaller, more stable structures. These findings demonstrate that emulsifier selection is central to modulating oil–protein–saliva interactions, with WPI at moderate oil levels yielding favorable lubrication with controlled oil release, thereby providing a mechanistic basis for developing healthier, palatable milk-based foods. Full article
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