Search Results (182)

Background: Rapid Eye Movement (REM) sleep behavior disorder (RBD) is a parasomnia resulting from degeneration of pontine and medullary circuits responsible for muscle atonia during REM sleep, leading to dream-enactment behaviors and vocalizations. It is strongly linked to α-synucleinopathies, particularly Parkinson’s disease. Current biomarkers such as neurophysiological measures and imaging support diagnosis and monitoring, but remain invasive or costly. Aim: This study aims to evaluate vocal and speech alterations as exploratory, non-validated candidate biomarkers of REM sleep behavior disorder. Methods: A systematic review was conducted according to PRISMA 2020 guidelines. PubMed, IEEE Digital Library Web of Science, Embase and the Cochrane Library were systematically searched for studies published from database inception to November 2025, as preregistered on the Open Science Framework. Studies were selected through a multi-step screening process and underwent qualitative quality assessment. Results: Twelve studies met inclusion criteria. Individuals with RBD exhibited abnormal nocturnal vocalizations and early lexical, syntactic, and narrative disruptions despite preserved perceptual speech. Quantitative analyses identified consistent deficits in prosody, phonation stability, timing, and articulation, with significant group differences and diagnostic accuracy up to 96% sensitivity. Multilingual cohorts demonstrated progression over time, while digital phenotyping detected emerging Parkinsonian signs with AUC > 0.70. Conclusions: Speech and vocal abnormalities in iRBD reflect early neurodegenerative changes and show promising but still exploratory diagnostic and prognostic potential. Integrating vocal markers with established biomarkers may enhance early detection; however, further research is required to validate a reliable and reproducible vocal signature of prodromal synucleinopathies. Full article

Background/Objectives: Cystic fibrosis (CF) is a genetic condition with an increasing life expectancy in recent years. As a result, addressing psychosocial aspects in this population has become an increasingly important concern. This mixed-methods systematic review aimed to update the current knowledge on the psychosocial aspects of living with CF in adults. Methods: Following PRISMA guidelines, a literature search was conducted in November 2024 across several databases, including Scopus, ScienceDirect, Academic Search Complete, MEDLINE, Supplemental Index, Complementary Index, APA PsycInfo, Business Source Complete, SciELO, and the Directory of Open Access Journals via EBSCO. Results: Of the 701 articles retrieved, 24 were analyzed, including a total of 2023 participants (mean age: 31.2 years; 57.2% female). Quantitative findings identified optimistic coping as the most frequent strategy associated with improved survival. High social support and gratitude emerged as key factors for treatment adherence and quality of life, while depression remained the primary mental health concern. Qualitatively, the findings highlighted concerns with adult life transitions and financial stressors. Participants described experiences of social stigma and embarrassment linked to chronic symptoms, often leading to selective disclosure to avoid discrimination. Conclusions: This review confirms that psychosocial factors are central to the adult CF experience, shifting the focus beyond biological survival and highlighting areas that require clinical intervention. As life expectancy increases, clinical care must evolve to incorporate interventions that address these factors to improve mental health and overall quality of life (QoL), ensuring that patients are supported through the unique challenges of extended adulthood. Full article

The noctuid moth Dioszeghyana schmidtii (Dioszeghy, 1935) is a geographically restricted and poorly known species associated with xerothermic oak ecosystems of Central, Eastern, and Southeastern Europe and Asia Minor. Despite its inclusion in European conservation frameworks, information on its distribution, biology, and ecological requirements remains fragmented, regionally uneven, and scattered across the faunistic literature in multiple languages. This review synthesizes published records, taxonomic sources, ecological observations, and curated occurrence data to provide an updated and critically assessed overview of the species’ biology, habitat associations, and biogeographic pattern. Distributional information was compiled exclusively from the literature and vetted public databases, with mapped occurrences representing confirmed regional presence rather than fine-scale occupancy. The species exhibits a patchy but ecologically coherent distribution closely linked to open, thermophilous Quercus woodlands, particularly those dominated by Q. cerris and related oak species. Major threats include habitat loss, forest densification, fragmentation, and phenological mismatches associated with climate change. By identifying persistent knowledge gaps and sources of uncertainty, this review highlights priorities for future research, monitoring, and habitat-based conservation of D. schmidtii and similar early-spring, oak-associated Lepidoptera. Full article

Background: Stenotrophomonas maltophilia is an increasingly important multidrug-resistant opportunistic pathogen frequently isolated from clinical, environmental, and plant-associated niches. Despite its medical relevance, the global population structure, species-complex boundaries, and genomic determinants of antimicrobial resistance (AMR) and ecological adaptation remain poorly resolved, partly due to inconsistent annotations and fragmented genomic datasets. Methods: Approximately 2400 genome assemblies annotated as Stenotrophomonas maltophilia were available in the NCBI Assembly database at the time of query. After pre-download filtering to exclude metagenome-assembled genomes and atypical lineages, 1750 isolate genomes were retrieved and subjected to stringent quality control (completeness ≥ 90%, contamination ≤ 5%, ≤500 contigs, N50 ≥ 10 kb, and ≤1% ambiguous bases), yielding a final curated dataset of 1518 high-quality genomes used for downstream analyses. Genomes were assessed using CheckM, annotated with Prokka, and compared using average nucleotide identity (ANI), pan-genome analysis, core-genome phylogenomics, and functional annotation. AMR genes, mobile genetic elements (MGEs), and metadata (source, host, and geographic origin) were integrated to assess lineage-specific genomic features and ecological distributions. Results: ANI-based clustering resolved the S. maltophilia complex into multiple distinct genomospecies and revealed extensive misidentification of publicly deposited genomes. The pan-genome was highly open, reflecting strong genomic plasticity driven by accessory gene acquisition. Core-genome phylogeny resolved well-supported clades associated with clinical, environmental, and plant-related niches. Resistome profiling showed widespread intrinsic MDR determinants, with certain lineages enriched for efflux pumps, β-lactamases, and trimethoprim–sulfamethoxazole resistance markers. MGE analysis identified lineage-specific integrative conjugative elements, prophages, and transposases that correlated with source and geographic distribution. Conclusions: This large-scale analysis provides the most comprehensive genomic overview of the S. maltophilia complex to date. Our findings clarify species boundaries, highlight substantial taxonomic misannotation in public databases, and reveal lineage-specific AMR and mobilome patterns linked to ecological and clinical origins. The curated dataset and evolutionary insights generated here establish a foundation for global genomic surveillance, epidemiological tracking, and future studies on the evolution of antimicrobial resistance in S. maltophilia. Full article

Background/Objectives: Malocclusion is one of the most prevalent oral health concerns in paediatric dentistry, with anterior open bite (AOB) and posterior crossbite (PCB) being among the most common forms. Non-nutritive sucking habits (NNSHs), including digit-sucking habits (DSHs) and pacifier-sucking habits (PSHs), have been linked to malocclusion development. While both habits are known to impact dental and skeletal development, their comparative effects remain unclear. This systematic review and meta-analysis aims to determine the difference in the development and prevalence of anterior open bite and posterior crossbite between patients with digit-sucking and pacifier-sucking habits. Materials and Methods: An exhaustive review of the literature was conducted on the 25 November 2024 across three databases, namely EBSCOhost (including PubMed-Medline), Web of Science and Scopus. The following PICO question was constructed for the systematic review: “In children and teenagers, is there a difference in the development and prevalence of malocclusions (Anterior Open bite & Posterior Crossbite) between patients with a history of digit sucking habits and patients with a history of pacifier sucking habits?”A meta-analysis was also performed with the selected studies, and the software used to carry out the meta-analysis was R 4.3.1 (R Core Team (2023)). Results: From the initial search, 102 articles were found and a further 11 articles were obtained from manual findings. 12 articles were included in the final systematic review and meta-analysis. The meta-analysis indicated that the risk of AOB and PCB was increased by both DSH and PSH. Conclusions: Both DSH and PSH significantly increased the risk of AOB and PCB. PSH posed a significantly higher risk than DSH for PCB development (OR = 2.66, p < 0.001), while no significant difference in AOB prevalence was observed between DSH and PSH (OR = 1.77, p = 0.150). Full article

Background: Emerging evidence suggests that lipedema may share hormonal, inflammatory, and genetic mechanisms with gynecologic diseases, particularly endometriosis. However, the extent and nature of these interrelationships remain poorly characterized, supporting the need for this scoping review. Objectives: To map and synthesize the available evidence on the clinical, pathophysiological, and epidemiological interrelationships between lipedema in women, endometriosis, and other gynecologic diseases. Methods: Searches were conducted in international and regional health databases, including MEDLINE (PubMed), CINAHL, Scopus, Embase, Web of Science, the Cochrane Library, LILACS/VHL, APA PsycInfo, SciELO, Epistemonikos, and La Referencia, as well as grey literature sources and relevant institutional websites. There were no language restrictions. The search period began in 1940, the year in which lipedema was first described by Allen and Hines. Study selection followed a two-stage process conducted independently by two reviewers, consisting of title and abstract screening followed by full-text review. Data extraction was performed using a pre-developed and peer-reviewed instrument covering participants, concept, context, study methods, and main findings. The review protocol was registered in the Open Science Framework. Results: Twenty-five studies from ten countries were included. Synthesized evidence supports the characterization of lipedema as a systemic condition with metabolic and hormonal dimensions. Key findings include symptom onset linked to reproductive milestones, a high frequency of gynecologic and endocrine comorbidities, and molecular features overlapping with steroid-dependent pathologies. These patterns reflect a recent shift from a predominantly lymphovascular paradigm toward a more integrated endocrinometabolic framework. Conclusions: The findings indicate that lipedema clusters with hormone-sensitive gynecologic and endocrine features across reproductive life stages. Full article

Background/Objectives: Most research linking diet and mental health outcomes is from high-income countries, limiting insight into how these relationships manifest in culturally diverse, vulnerable contexts, such as the Caribbean. This scoping review aims to map existing research on the relationship between aspects of diet and mental health within Caribbean populations, to identify evidence gaps and guide future research. Methods: Eleven databases were searched for studies published between 2000 and 2024 in 33 Caribbean countries which assessed the relationship between diet and mental health outcomes. Duplicate screening and extraction were conducted using Redcap software, and a narrative synthesis and evidence gap map were created. The original protocol was registered with Open Science Framework. Results: Forty-four records were included, nine of which focused on eating disorders (examined separately). Most were cross-sectional studies of the general population, with few experimental and qualitative studies. Surveys were the most frequently applied data collection tool, often without mention of local adaptation or validation. Most records examined food security and depression as their ‘diet’ and ‘mental health’ variables, respectively. Frequently explored relationships included autism and seafood intake and fruit and vegetable intake, while depression and food security was the most widely examined relationship across studies. Conclusions: Caribbean research on diet–mental health relationships is growing though it is limited in scope, design, and cultural validity. Strengthening this evidence base requires studies whose primary aim is in nutritional psychiatry, using culturally relevant tools, and an expansion of study designs that incorporate Caribbean food systems and sociocultural contexts surrounding diet and mental health. Full article

The concept of sustainability in the supermarket sector has emerged as a strategic priority, as companies are required to reduce their environmental footprint and enhance their social and economic performance. The aim of this literature review is to identify, document, and analyze the key performance indicators (KPIs) applied in the sector, with emphasis on environmental, social, and economic dimensions, and to investigate the extent to which technical energy interventions are linked to business and consumer benefits. The methodology was inspired by the general logic of organized search and selection procedures, and for this reason, elements of the PRISMA framework were used, with a search conducted across multiple international scientific databases and selection criteria ensuring the validity and relevance of the sources. The analysis classified the indicators into the following three categories: environmental (e.g., CO₂ emissions, energy consumption), social (e.g., customer satisfaction, corporate image), and economic (e.g., ESG score, return on investment). The study revealed substantial progress made by supermarket chains globally in adopting energy-efficiency technologies, such as LED lighting and renewable energy with proven benefits in reducing consumption and consequently, improving environmental performance. However, a lack of holistic integration between technical interventions and social-economic indicators was identified, limiting the use of KPIs as a strategic tool for guiding specific sustainability strategies. This research concludes that there is a need to develop unified, sector-specific measurement frameworks that integrate environmental, social, and economic parameters, as well as empirical research that quantitatively connects energy strategies with business and consumer performance through comparable indicators in the context of supermarket operations, thereby opening ground for further exploration of the field. Full article

Background: Intestinal angioedema is an important drug-induced adverse effect that is often misdiagnosed due to vague and nonspecific symptoms. This study aimed to identify drugs with potential to cause intestinal angioedema by performing a disproportionality analysis, supplemented with literature review. Methods: Using OpenVigil, we extracted relevant individual case safety reports from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database. Drugs with signal of disproportionate reporting (SDR) of intestinal angioedema were identified. A literature review was performed using PubMed and Embase databases to identify potential suspect drugs. Results: During 2004–2024, 303 cases of intestinal angioedema were reported to FAERS. Fourteen suspect medications showed SDR; of these, seven drugs were also reported in the literature to have caused intestinal angioedema, including angiotensin-converting enzyme inhibitors, losartan, and acetylsalicyclic acid. A literature search identified 89 relevant articles, providing details of 121 cases. Some drugs linked to intestinal angioedema in the literature did not show SDR. Conclusions: Disproportionality analysis as well as a literature review showed that most patients were middle-aged females on antihypertensive therapy. The results will assist health professionals in determining the temporal association of acute abdomen with the suspected drug, potentially avoiding unnecessary interventions and their attendant complications. Full article

This paper presents a PRISMA-guided systematic literature review (2015–2025) of 20 empirical studies on digital transformation in retail banking, examining how artificial intelligence (AI) strengthens cybersecurity, enables FinTech collaboration through interoperable APIs and open-banking infrastructures, and embeds data-driven decision-making across core functions. We searched major databases, applied predefined eligibility criteria, appraised study quality, and coded outcomes related to digital adoption, operational resilience, and customer experience. The synthesis indicates that AI-enabled controls and API-mediated partnerships are consistently associated with higher digital-maturity indicators, conditional on robust model-risk governance and prudent third-party/outsourcing management. Benefits span improved customer experience, efficiency, and inclusion; however, legacy systems, regulatory fragmentation, cyber threats, and organizational resistance remain binding constraints. We propose a unified framework linking technology choices, regulatory design, and organizational outcomes, and distill actionable guidance for policymakers (e.g., interoperable standards, proportional AI governance, sector-wide cyber resilience) and bank managers (sequencing AI use cases, risk controls, and partnership models). Future research should assess emerging technologies—including quantum-safe security and central bank digital currencies (CBDCs)—and their implications for digital-banking stability and trust. Full article

In the highly volatile realm of global security, the necessity for leading-edge and effectual border resilience tactics has never been more imperative. This PRISMA 2020 guided systematic literature review (SLR) examines the intersection of artificial intelligence (AI), open-source intelligence (OSINT), and social media intelligence (SOCMINT) for enhancing border protection. Our systematic investigation across major databases (IEEE Xplore, Scopus, SpringerLink, MDPI, ACM) and grey literature sources yielded 3932 initial records and, after screening and eligibility assessment, 73 studies and reports from acknowledged organizations, contributing to the evidence synthesis. Three research questions (RQ1–RQ3) were addressed concerning the following: (a) the effectiveness and application of AI in OSINT/SOCMINT for border protection, its (b) data, technical, and operational limitations, and its (c) ethical, legal, and societal implications (GELSI). Evidence matrices summarize the findings, while narrative syntheses underline and thematically group the extracted insights. Results indicate that AI techniques—fluctuating from machine learning (ML) and natural language processing (NLP) to computer vision and emerging large language models (LLMs)—produce quantifiable improvements in forecasting irregular migration, detecting human trafficking, and supporting multimodal intelligence fusion. However, limitations include misinformation, data bias, adversarial vulnerabilities, governance deficits, and sandbox-to-production gaps. Ethical and societal concerns highlight risks of surveillance overreach, discrimination, and insufficient oversight, among others. To our knowledge, this is the first SLR at this intersection. We conclude that, AI-assisted OSINT/SOCMINT presents transformative potential for border protection requiring, nonetheless, balanced governance, robust validation, and future research on LLM/agentic AI, human–AI teaming, and oversight mechanisms. Full article

Background/Objectives: Baihe Dihuang Tang (BDT), a classical herbal formula from Zhang Zhongjing’s Han Dynasty work Jin Gui Yao Lue, is widely used to treat depressive disorder by nourishing Yin, clearing heat, and tonifying the heart and lungs. However, its pharmacological mechanisms remain unclear. This study aims to explore BDT’s antidepressant effects via MAOA-regulated serotonin (5-HT) metabolism and synaptic plasticity, supported by experimental validation, while using network pharmacology to predict MAOA-targeting active components. Methods: Active components and targets of BDT were screened using TCMSP, TCMID, and other databases, and then a component-target-pathway network was constructed. A chronic restraint stress (CRS)-induced depressive mouse model was established. Behavioral tests, including open field test (OFT), elevated plus maze (EPM), forced swimming test (FST) and tail suspension test (TST), were conducted to evaluate antidepressant effects. ELISA, qRT-PCR, and Western blot were employed to assess hippocampal 5-HT metabolism (MAOA, 5-HT/5-HIAA ratio) neurotrophic signaling (BDNF, TrkB) and synaptic plasticity-related proteins (PSD-95, SYN1). Results: BDT significantly reduced FST/TST immobility time and improved anxiety-like behaviors in OFT/EPM. BDT treatment downregulated MAOA expression, elevated hippocampal 5-HT/5-HIAA ratio, activated BDNF/TrkB pathway, and upregulated PSD-95/SYN1. Network pharmacology confirmed MAOA’s central role, identifying MAOA/serotonergic synapse modulation as BDT’s main mechanism and pinpointing Ferulic acid, Caffeate, Stigmasterol, (−)-nopinene, Eugenol, and cis-Anethol as MAOA-targeting bioactive components. Conclusions: BDT ameliorates depressive-like behaviors. This effect is mechanistically linked to suppression of MAOA-mediated 5-HT catabolism—a key validated target. This suppression elevates hippocampal 5-HT bioavailability, thereby activating BDNF/TrkB signaling and promoting synaptic plasticity. Network pharmacology confirmed MAOA as a primary target and identified specific modulatory bioactive components. Full article

Background/Objectives: Loneliness and social isolation are common among older adults and linked to adverse health outcomes. Videoconferencing can support social connections, but the role of aging-in-place organizations (AIPOs), such as senior centers and Area Agencies on Aging, in facilitating adoption is poorly understood. This review examined how AIPOs use relational videoconferencing to promote social engagement among older adults. Methods: We applied a hybrid methodology combining a scoping review with latent topic modeling to contextualize and analyze the evidence base. Exploratory searches revealed limited literature specifically addressing AIPO involvement; therefore, we first conducted latent topic modeling of the broader literature on social videoconferencing among older adults to establish a thematic foundation for the subsequent PRISMA-guided scoping review. Thematic analysis of this broader corpus, identified through 2021 database searches, applied Latent Dirichlet Allocation (LDA) to a collection of peer-reviewed articles. Subsequent refinement of this corpus by removing non-primary research and non-AIPO records produced the narrower PRISMA subset used for the scoping review. The scoping review followed JBI guidelines and was based on database searches (EBSCOhost: MEDLINE, AgeLine, SocINDEX, Health Source: Nursing/Academic Edition, and Family & Society Studies Worldwide; ProQuest Social Science Premium Collection; and PubMed, including MEDLINE, PMC, and in-process content) for peer-reviewed studies published between 2011 and 2025. Inclusion criteria required primary research involving adults aged 65 years or older, use of videoconferencing technology for social engagement, and reference to AIPOs or analogous community-based aging services. The protocol was post-registered with the Open Science Framework. Results: The LDA analysis of 101 peer-reviewed articles identified six latent themes describing the broader research landscape: problem of isolation, character of socialization, physical health, technology as intervention, technology as social medium, and supportive environments. This thematic framework informed the scoping review, which screened 1908 records and retained 25 publications (representing 24 unique studies) explicitly referencing AIPO involvement in relational videoconferencing. Only one study predated COVID-19. Mapping these studies to the LDA-derived themes revealed the least consistent coverage to be in supportive environments and physical health, particularly among AIPOs other than senior or community centers. Conclusions: Relational videoconferencing has potential to sustain and expand older adults’ social connections, but evidence mapped through the scoping review shows that documentation of how AIPOs support adoption is sparse. The hybrid approach advances understanding of videoconferencing in aging contexts and identifies priorities for documenting, comparing, and refining AIPO practices to inform future interventions and policy. Full article

Open Government Data (OGD) portals have the potential to be powerful tools for advancing progress toward the United Nations (UN) Sustainable Development Goals (SDGs). In this paper, we examine the extent to which U.S. municipal open data portals support SDG 11 (Sustainable Cities and Communities) and a more complete set of sustainable city indicators, which we call SDG 11+. We focus on the 19 U.S. cities ranked in the 2024 Sustainable Cities Index. Amazingly, none of the cities had data that directly addressed SDG 11 indicators, showing a pressing need to link U.S. OGD portals with the SDGs. In terms of SDG 11 target areas, data were most available for transportation (31% of datasets) and green and public spaces (25% of datasets), though these databases often lacked demographic and equity details. Cities ranking highly on sustainability (New York, San Francisco, and Washington, D.C.) had far more such datasets available than low-ranked cities (Atlanta, Tampa, and Pittsburgh). We propose an expanded list of urban sustainability indicators (some within other SDGs) and recommend that cities emphasize coordination with the SDGs, usability, breadth of content, links with policy, timely updating, and greater disaggregation of data when managing OGD portals. Full article

Background: Management of patients in closed-door intensive care units (ICUs) is often associated with limited family visits and a highly technological environment, which can lead to patient deconditioning through altered circadian rhythms and depersonalization, contributing to psychological distress in addition to physiological distress. In recent years, there has been a shift in trends in the management of ICU patients with an emphasis on more social and psychological support, with the option of an open-door ICU. Objective: This study aims to evaluate the role of humanized care through social and psychological support in improving patients’ outcomes through the concept of open-door ICUs. Methods: This systematic review was conducted under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. Six databases were searched (LILACS, SciELO, PubMed, Scopus, ScienceDirect, and Dialnet) using a strategy based on MeSH and DeCS terms. Studies published between 2018 and 2025, in English, Spanish, and Portuguese, were included. Fifty studies were selected and analyzed using open, axial, and selective coding techniques. The review protocol was registered in PROSPERO (CRD420251080952). Results: Three main categories emerged: (1) Patient and Family Perceptions of ICU Care; (2) flexible visitation and technological mediation; and (3) humanization-centered care. These factors were linked to improved emotional well-being, reduced anxiety, enhanced communication, and stronger trust between families and healthcare professionals. Conclusions: Based on the results of our systematic review, we emphasize the importance of adopting humanized care practices in open-door ICUs. In particular, strategies like flexible visitation, emotional and spiritual support, respectful communication, and family involvement contribute to compassionate, patient-centered care. We recommend institutional policies that need to be designed that support humanization for patients and families. Full article