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Search Results (974)

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11 pages, 5568 KB  
Article
A Multiple-Input Multiple-Output Transmission System Employing Orbital Angular Momentum Multiplexing for Wireless Backhaul Applications
by Afkar Mohamed Ismail, Yufei Zhao and Gaohua Ju
Network 2025, 5(3), 33; https://doi.org/10.3390/network5030033 - 25 Aug 2025
Abstract
This paper presents a long-range experimental demonstration of multi-mode multiple-input multiple-output (MIMO) transmission using orbital angular momentum (OAM) waves for Line-of-Sight (LoS) wireless backhaul applications. A 4 × 4 MIMO system employing distinct OAM modes is implemented and shown to support multiplexing data [...] Read more.
This paper presents a long-range experimental demonstration of multi-mode multiple-input multiple-output (MIMO) transmission using orbital angular momentum (OAM) waves for Line-of-Sight (LoS) wireless backhaul applications. A 4 × 4 MIMO system employing distinct OAM modes is implemented and shown to support multiplexing data transmission over a single frequency band without inter-channel interference. In contrast, a 2 × 2 plane wave MIMO configuration fails to achieve reliable demodulation due to mutual interference, underscoring the spatial limitations of conventional waveforms. The results confirm that OAM provides spatial orthogonality suitable for high-capacity, frequency-efficient wireless backhaul links. Experimental validation is conducted over an 100 m outdoor path, demonstrating the feasibility of OAM-based MIMO in practical wireless backhaul scenarios. Full article
(This article belongs to the Special Issue Advances in Wireless Communications and Networks)
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24 pages, 7981 KB  
Article
A Flexible and Compact UWB MIMO Antenna with Dual-Band-Notched Double U-Shaped Slot on Mylar® Polyester Film
by Vanvisa Chutchavong, Wanchalerm Chanwattanapong, Norakamon Wongsin, Paitoon Rakluea, Maleeya Tangjitjetsada, Chawalit Rakluea, Chatree Mahatthanajatuphat and Prayoot Akkaraekthalin
Electronics 2025, 14(17), 3363; https://doi.org/10.3390/electronics14173363 - 24 Aug 2025
Abstract
Ultra-wideband (UWB) technology is a crucial facilitator for high-data-rate wireless communication due to its extensive frequency spectrum and low power consumption. Simultaneously, multiple-input multiple-output (MIMO) systems have garnered considerable attention owing to their capability to enhance channel capacity and link dependability. This article [...] Read more.
Ultra-wideband (UWB) technology is a crucial facilitator for high-data-rate wireless communication due to its extensive frequency spectrum and low power consumption. Simultaneously, multiple-input multiple-output (MIMO) systems have garnered considerable attention owing to their capability to enhance channel capacity and link dependability. This article discusses the development of small, high-performance MIMO UWB antennas with mutual suppression capabilities to fully use the benefits of both technologies. Additionally, the suggested antenna features a straightforward design and dual-band-notched characteristics. The antenna structure includes two radiating elements measuring 85 × 45 mm2. These elements use a rectangular patch provided by a coplanar waveguide (CPW). Double U-shaped slots are incorporated into the rectangular patch to introduce dual-band-notched properties, which help mitigate interference from WiMAX and WLAN communication systems. The antenna is fabricated on a Mylar® polyester film substrate of 0.3 mm in thickness, with a dielectric constant of 3.2. According to the measurement results, the suggested antenna functions efficiently across the frequency spectrum of 2.29 to 20 GHz, with excellent impedance matching throughout the bandwidth. Furthermore, it provides dual-band-notched coverage at 3.08–3.8 GHz for WiMAX and 4.98–5.89 GHz for WLAN. The antenna exhibits impressive performance, including favorable radiation attributes, consistent gain, and little mutual coupling (less than −20 dB). Additionally, the envelope correlation coefficient (ECC) is extremely low (ECC < 0.01) across the working bandwidth, which indicates excellent UWB MIMO performance. This paper offers an appropriate design methodology for future flexible and compact UWB MIMO systems that can serve as interference-resilient antennas for next-generation wireless applications. Full article
(This article belongs to the Collection MIMO Antennas)
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26 pages, 1971 KB  
Article
Dynamic Allocation of C-V2X Communication Resources Based on Graph Attention Network and Deep Reinforcement Learning
by Zhijuan Li, Guohong Li, Zhuofei Wu, Wei Zhang and Alessandro Bazzi
Sensors 2025, 25(16), 5209; https://doi.org/10.3390/s25165209 - 21 Aug 2025
Viewed by 222
Abstract
Vehicle-to-vehicle (V2V) and vehicle-to-network (V2N) communications are two key components of intelligent transport systems (ITSs) that can share spectrum resources through in-band overlay. V2V communication primarily supports traffic safety, whereas V2N primarily focuses on infotainment and information exchange. Achieving reliable V2V transmission alongside [...] Read more.
Vehicle-to-vehicle (V2V) and vehicle-to-network (V2N) communications are two key components of intelligent transport systems (ITSs) that can share spectrum resources through in-band overlay. V2V communication primarily supports traffic safety, whereas V2N primarily focuses on infotainment and information exchange. Achieving reliable V2V transmission alongside high-rate V2N services in resource-constrained, dynamically changing traffic environments poses a significant challenge for resource allocation. To address this, we propose a novel reinforcement learning (RL) framework, termed Graph Attention Network (GAT)-Advantage Actor–Critic (GAT-A2C). In this framework, we construct a graph based on V2V links and their potential interference relationships. Each V2V link is represented as a node, and edges connect nodes that may interfere. The GAT captures key interference patterns among neighboring vehicles while accounting for real-time mobility and channel variations. The features generated by the GAT, combined with individual link characteristics, form the environment state, which is then processed by the RL agent to jointly optimize the resource blocks allocation and the transmission power for both V2V and V2N communications. Simulation results demonstrate that the proposed method substantially improves V2N rates and V2V communication success ratios under various vehicle densities. Furthermore, the approach exhibits strong scalability, making it a promising solution for future large-scale intelligent vehicular networks operating in dynamic traffic scenarios. Full article
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16 pages, 1586 KB  
Article
A Multi-Agent Deep Reinforcement Learning Anti-Jamming Spectrum-Access Method in LEO Satellites
by Wenting Cao, Feihuang Chu, Luliang Jia, Hongyu Zhou and Yunfan Zhang
Electronics 2025, 14(16), 3307; https://doi.org/10.3390/electronics14163307 - 20 Aug 2025
Viewed by 314
Abstract
Low-Earth-orbit (LEO) satellite networks face significant vulnerabilities to malicious jamming and co-channel interference, compounded by dynamic topologies, resource constraints, and complex electromagnetic environments. Traditional anti-jamming approaches lack adaptability, centralized intelligent methods incur high overhead, and distributed intelligent methods fail to achieve global optimization. [...] Read more.
Low-Earth-orbit (LEO) satellite networks face significant vulnerabilities to malicious jamming and co-channel interference, compounded by dynamic topologies, resource constraints, and complex electromagnetic environments. Traditional anti-jamming approaches lack adaptability, centralized intelligent methods incur high overhead, and distributed intelligent methods fail to achieve global optimization. To address these limitations, this paper proposed a value decomposition network (VDN)-based multi-agent deep reinforcement learning (DRL) anti-jamming spectrum access approach with a centralized training and distributed execution architecture. Following offline centralized ground-based training, the model was deployed distributedly on satellites for real-time spectrum-access decision-making. The simulation results demonstrate that the proposed method effectively balances training costs with anti-jamming performance. The method achieved near-optimal user satisfaction (approximately 97%) with minimal link overhead, confirming its effectiveness for resource-constrained LEO satellite networks. Full article
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17 pages, 1815 KB  
Review
Paternal Cocaine Exposure and Its Testicular Legacy: Epigenetic, Physiological, and Intergenerational Consequences
by Candela R. González and Betina González
Biology 2025, 14(8), 1072; https://doi.org/10.3390/biology14081072 - 18 Aug 2025
Viewed by 358
Abstract
Cocaine use remains a major public health concern, with rising global prevalence and a well-established profile of neurotoxicity and addictive potential. While the central nervous system has been the primary focus of cocaine research, emerging evidence indicates that cocaine also disrupts male reproductive [...] Read more.
Cocaine use remains a major public health concern, with rising global prevalence and a well-established profile of neurotoxicity and addictive potential. While the central nervous system has been the primary focus of cocaine research, emerging evidence indicates that cocaine also disrupts male reproductive physiology. In the testis, cocaine alters the endocrine microenvironment, induces cell-specific damage, and disrupts spermatogenesis. Cocaine also interferes with epigenetic programming in germ cells and mature sperm, potentially leading to heritable epimutations. Epidemiology data reveal that approximately two-thirds of regular cocaine users are males of reproductive age, and preclinical models have documented numerous behavioral and molecular alterations in their offspring, often linked to paternal cocaine exposure—such as increased drug resistance or vulnerability, altered anxiety-like behavior, impaired learning/memory, disrupted social behaviors, and shifts in neural circuitry and gene expression in reward-related brain regions. This review aims to integrate findings from studies that have independently examined testicular dysfunction, germline epigenetic reprogramming, and offspring outcomes, offering a unified perspective on their potential interconnections and highlighting future directions for research in the field of epigenetic inheritance. Full article
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18 pages, 1690 KB  
Article
Mode-Aware Radio Resource Allocation Algorithm in Hybrid Users Based Cognitive Radio Networks
by Sirui Luo and Ziwei Chen
Sensors 2025, 25(16), 5086; https://doi.org/10.3390/s25165086 - 15 Aug 2025
Viewed by 220
Abstract
In cognitive radio networks (CRNs), primary users (PUs) have the highest priority in channel resource allocation. Secondary users (SUs) can generally only utilize temporarily unused channels of PUs, share channels with PUs, or cooperate with PUs [...] Read more.
In cognitive radio networks (CRNs), primary users (PUs) have the highest priority in channel resource allocation. Secondary users (SUs) can generally only utilize temporarily unused channels of PUs, share channels with PUs, or cooperate with PUs to gain priority through the interweave, underlay, and overlay modes. Traditional optimization schemes for channel resource allocation often lead to structural wastage of channel resources, whereas approaches such as reinforcement learning—though effective—require high computational power and thus exhibit poor adaptability in industrial deployments. Moreover, existing works typically optimize a single performance metric with limited scenario scalability. To address these limitations, this paper proposes a CR network algorithm based on the hybrid users (HU) concept, which links the Interweave and Underlay modes through an adaptive threshold for mode switching. The algorithm employs the Hungarian method for SU channel allocation and applies a multi-level power adjustment strategy when PUs and SUs share the same channel to maximize channel resource utilization. Simulation results under various parameter settings show that the proposed algorithm improves the average signal to interference plus noise ratio (SINR) of SUs while ensuring PU service quality, significantly enhances network energy efficiency, and markedly improves Jain’s fairness among SUs in low-power scenarios. Full article
(This article belongs to the Special Issue Emerging Trends in Next-Generation mmWave Cognitive Radio Networks)
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22 pages, 4671 KB  
Article
Interference Signal Suppression Algorithm Based on CNN-LSTM Model
by Ningbo Xiao and Zuxun Song
Sensors 2025, 25(16), 5048; https://doi.org/10.3390/s25165048 - 14 Aug 2025
Viewed by 199
Abstract
Sensors and anti-interference technology have a complementary relationship. The anti-interference capability directly affects the measurement accuracy, reliability, and stability of sensors. In complex electromagnetic or natural environments, sensors are inevitably influenced by various interference sources. Effective anti-interference technology is the key to ensuring [...] Read more.
Sensors and anti-interference technology have a complementary relationship. The anti-interference capability directly affects the measurement accuracy, reliability, and stability of sensors. In complex electromagnetic or natural environments, sensors are inevitably influenced by various interference sources. Effective anti-interference technology is the key to ensuring the normal operation of sensors, and suppressing interference signals is one of the key links to improving communication quality. This paper proposes a CNN-LSTM-based interference signal suppression algorithm, aiming to enhance the anti-interference capability of wireless communication systems through deep learning technology. The algorithm utilizes CNN to extract the spatial features of the signal and LSTM to capture the temporal dynamic characteristics of the signal, outputting a predicted signal to effectively suppress interference signals. The performance of the experimental simulation algorithm under different interference scenarios was evaluated and compared with three models: LSTM, BO-LSTM, and CNN-GRU. The results demonstrated that this algorithm had a small error and a high degree of regression fitting. Finally, the effectiveness of the algorithm was verified by using the signal propagation model based on ITU-R P.1546 and the publicly available noise datasets collected from the actual environment. The research shows that this algorithm can significantly suppress the influence of interference signals and environmental noise on useful signals, providing a basis for promoting the evolution of sensors towards higher reliability and robustness. Full article
(This article belongs to the Special Issue Sensors Technologies for Measurements and Signal Processing)
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17 pages, 813 KB  
Review
Kidney Stone Disease: Epigenetic Dysregulation in Homocystinuria and Mitochondrial Sulfur Trans-Sulfuration Ablation Driven by COVID-19 Pathophysiology
by Anmol Babbarwal, Mahavir Singh, Utpal Sen, Mahima Tyagi and Suresh C. Tyagi
Biomolecules 2025, 15(8), 1163; https://doi.org/10.3390/biom15081163 - 14 Aug 2025
Viewed by 404
Abstract
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought to light unexpected complications beyond respiratory illness, including effects on kidney function and a potential link to kidney stone disease (KSD). This review proposes a novel [...] Read more.
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought to light unexpected complications beyond respiratory illness, including effects on kidney function and a potential link to kidney stone disease (KSD). This review proposes a novel framework connecting COVID-19-induced epigenetic reprogramming to disruptions in mitochondrial sulfur metabolism and the pathogenesis of kidney stones. We examine how SARS-CoV-2 interferes with host methylation processes, leading to elevated homocysteine (Hcy) levels and impairment of the trans-sulfuration pathway mechanisms particularly relevant in metabolic disorders such as homocystinuria. These epigenetic and metabolic alterations may promote specific kidney stone subtypes through disrupted sulfur and oxalate handling. Additionally, we explore the role of COVID-19-associated gut dysbiosis in increasing oxalate production and driving calcium oxalate stone formation. Together, these pathways may accelerate the transition from acute kidney injury (AKI) to chronic KSD, linking viral methylation interference, sulfur amino acid imbalance, mitochondrial dysfunction, and microbiota changes. Unlike earlier reviews that address these mechanisms separately, this work offers an integrated hypothesis to explain post-viral renal lithogenesis and highlights the potential of targeting sulfur metabolism and redox pathways as therapeutic strategies for KSD triggered or aggravated by viral infections such as COVID-19. Full article
(This article belongs to the Special Issue Acute Kidney Injury and Mitochondrial Involvement)
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16 pages, 4163 KB  
Article
Repeatability of Inertial Measurements of Spinal Posture in Daily Life
by Ryan Riddick, Mansour Abdullah Alshehri and Paul Hodges
Sensors 2025, 25(16), 5011; https://doi.org/10.3390/s25165011 - 13 Aug 2025
Viewed by 216
Abstract
Posture, physical activity, and sleep have been shown to be linked to many health issues but are difficult to assess in laboratories, especially in terms of long-term patterns. Worn on the body, inertial measurement units (IMUs) measure motion and have shown promise for [...] Read more.
Posture, physical activity, and sleep have been shown to be linked to many health issues but are difficult to assess in laboratories, especially in terms of long-term patterns. Worn on the body, inertial measurement units (IMUs) measure motion and have shown promise for longitudinal measurements of these phenomena, but the repeatability of their measurements in daily life has not been extensively characterized. This study assessed the repeatability of measures of spine posture and movement in a set of standardized tasks in the lab versus those performed at home using IMUs. We also evaluated issues that impact data quality for real-world measurements. The results showed moderate repeatability in the range of spinal motion assessed during the tasks (ICC = 0.67). In contrast, the absolute angles of the spine (such as the starting posture) were more variable and more difficult to estimate. The estimation of the reference posture was identified as a key factor. Five methods to estimate the reference posture were compared, and the use of a composite set of standardized tasks performed best (ICC = 0.72 ± 0.17). Additional studies and cross-validation with other sensors are needed to draw stronger conclusions about the optimal methodology. For measurements of daily life over 2 days, magnetic interference had a major impact on the data quality, affecting 43% of all data analyzed. Metrics were developed to assess data quality and strategies are proposed to improve repeatability in future work. Full article
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14 pages, 2652 KB  
Article
Optimized Multi-Antenna MRC for 16-QAM Transmission in a Photonics-Aided Millimeter-Wave System
by Rahim Uddin, Weiping Li and Jianjun Yu
Sensors 2025, 25(16), 5010; https://doi.org/10.3390/s25165010 - 13 Aug 2025
Viewed by 350
Abstract
This work presents an 80 Gbps photonics-aided millimeter-wave (mm Wave) wireless communication system employing 16-Quadrature Amplitude Modulation (16-QAM) and a 1 × 2 single-input multiple-output (SIMO) architecture with maximum ratio combining (MRC) to achieve robust 87.5 GHz transmission over 4.6 km. By utilizing [...] Read more.
This work presents an 80 Gbps photonics-aided millimeter-wave (mm Wave) wireless communication system employing 16-Quadrature Amplitude Modulation (16-QAM) and a 1 × 2 single-input multiple-output (SIMO) architecture with maximum ratio combining (MRC) to achieve robust 87.5 GHz transmission over 4.6 km. By utilizing polarization-diverse optical heterodyne generation and spatial diversity reception, the system enhances spectral efficiency while addressing the low signal-to-noise ratio (SNR) and channel distortions inherent in long-haul links. A blind equalization scheme combining the constant modulus algorithm (CMA) and decision-directed least mean squares (DD-LMS) filtering enables rapid convergence and suppresses residual inter-symbol interference, effectively mitigating polarization drift and phase noise. The experimental results demonstrate an SNR gain of approximately 3 dB and a significant bit error rate (BER) reduction with MRC compared to single-antenna reception, along with improved SNR performance in multi-antenna configurations. The synergy of photonic mm Wave generation, adaptive spatial diversity, and pilot-free digital signal processing (DSP) establishes a robust framework for high-capacity wireless fronthaul, overcoming atmospheric attenuation and dynamic impairments. This approach highlights the viability of 16-QAM in next-generation ultra-high-speed networks (6G/7G), balancing high data rates with resilient performance under channel degradation. Full article
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13 pages, 291 KB  
Article
Rest to Resist: How Recovery Shields Well-Being from Work–Family Strain
by Cátia Sousa and Laura Silva
Behav. Sci. 2025, 15(8), 1089; https://doi.org/10.3390/bs15081089 - 12 Aug 2025
Viewed by 352
Abstract
This study examines the mediating role of recovery experiences in the relationship between work–family conflict (WFC) and employee well-being. While WFC has been consistently linked to negative outcomes such as psychological distress and reduced life satisfaction, the mechanisms that may buffer its effects [...] Read more.
This study examines the mediating role of recovery experiences in the relationship between work–family conflict (WFC) and employee well-being. While WFC has been consistently linked to negative outcomes such as psychological distress and reduced life satisfaction, the mechanisms that may buffer its effects remain underexplored. Drawing on the Conservation of Resources Theory and the Effort-Recovery Model, we investigated whether four types of recovery experiences—psychological detachment, relaxation, mastery, and control—mediate the WFC–well-being relationship. A cross-sectional survey was conducted with 240 employees using validated self-report instruments. Data were analysed through correlation, regression, and mediation techniques, including bootstrapping procedures via PROCESS. The results confirmed a significant negative association between WFC and well-being. All four recovery experiences were positively related to well-being, with relaxation emerging as the strongest predictor. Mediation analyses showed that each of the recovery experiences partially mediated the relationship between WFC and well-being. These findings highlight the importance of recovery as a psychological buffer in the context of elevated work–family interference. Organizational practices that foster recovery—such as encouraging psychological detachment, offering flexible schedules, and promoting restorative activities—may contribute to sustaining employee mental health and resilience. Full article
(This article belongs to the Special Issue Workplace Health and Wellbeing)
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17 pages, 1738 KB  
Article
Evaluation of Optimal Visible Wavelengths for Free-Space Optical Communications
by Modar Dayoub and Hussein Taha
Telecom 2025, 6(3), 57; https://doi.org/10.3390/telecom6030057 - 4 Aug 2025
Viewed by 279
Abstract
Free-space optical (FSO) communications have emerged as a promising complement to conventional radio-frequency (RF) systems due to their high bandwidth, low interference, and license-free spectrum. Visible-light FSO communication, using laser diodes or LEDs, offers potential for short-range data links, but performance is highly [...] Read more.
Free-space optical (FSO) communications have emerged as a promising complement to conventional radio-frequency (RF) systems due to their high bandwidth, low interference, and license-free spectrum. Visible-light FSO communication, using laser diodes or LEDs, offers potential for short-range data links, but performance is highly wavelength-dependent under varying atmospheric conditions. This study presents an experimental evaluation of three visible laser diodes at 650 nm (red), 532 nm (green), and 405 nm (violet), focusing on their optical output power, quantum efficiency, and modulation behavior across a range of driving currents and frequencies. A custom laboratory testbed was developed using an Atmega328p microcontroller and a Visual Basic control interface, allowing precise control of current and modulation frequency. A silicon photovoltaic cell was employed as the optical receiver and energy harvester. The results demonstrate that the 650 nm red laser consistently delivers the highest quantum efficiency and optical output, with stable performance across electrical and modulation parameters. These findings support the selection of 650 nm as the most energy-efficient and versatile wavelength for short-range, cost-effective visible-light FSO communication. This work provides experimentally grounded insights to guide wavelength selection in the development of energy-efficient optical wireless systems. Full article
(This article belongs to the Special Issue Optical Communication and Networking)
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25 pages, 4032 KB  
Review
Insights to Resistive Pulse Sensing of Microparticle and Biological Cells on Microfluidic Chip
by Yiming Yao, Kai Zhao, Haoxin Jia, Zhengxing Wei, Yiyang Huo, Yi Zhang and Kaihuan Zhang
Biosensors 2025, 15(8), 496; https://doi.org/10.3390/bios15080496 - 1 Aug 2025
Viewed by 375
Abstract
Since the initial use of biological ion channels to detect single-stranded genomic base pair differences, label-free and highly sensitive resistive pulse sensing (RPS) with nanopores has made remarkable progress in single-molecule analysis. By monitoring transient ionic current disruptions caused by molecules translocating through [...] Read more.
Since the initial use of biological ion channels to detect single-stranded genomic base pair differences, label-free and highly sensitive resistive pulse sensing (RPS) with nanopores has made remarkable progress in single-molecule analysis. By monitoring transient ionic current disruptions caused by molecules translocating through a nanopore, this technology offers detailed insights into the structure, charge, and dynamics of the analytes. In this work, the RPS platforms based on biological, solid-state, and other sensing pores, detailing their latest research progress and applications, are reviewed. Their core capability is the high-precision characterization of tiny particles, ions, and nucleotides, which are widely used in biomedicine, clinical diagnosis, and environmental monitoring. However, current RPS methods involve bottlenecks, including limited sensitivity (weak signals from sub-nanometer targets with low SNR), complex sample interference (high false positives from ionic strength, etc.), and field consistency (solid-state channel drift, short-lived bio-pores failing POCT needs). To overcome this, bio-solid-state fusion channels, in-well reactors, deep learning models, and transfer learning provide various options. Evolving into an intelligent sensing ecosystem, RPS is expected to become a universal platform linking basic research, precision medicine, and on-site rapid detection. Full article
(This article belongs to the Special Issue Advanced Microfluidic Devices and Lab-on-Chip (Bio)sensors)
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68 pages, 2838 KB  
Review
Unravelling the Viral Hypothesis of Schizophrenia: A Comprehensive Review of Mechanisms and Evidence
by Mădălina Georgeta Sighencea and Simona Corina Trifu
Int. J. Mol. Sci. 2025, 26(15), 7429; https://doi.org/10.3390/ijms26157429 - 1 Aug 2025
Viewed by 882
Abstract
Schizophrenia is a challenging multifactorial neuropsychiatric disease that involves interactions between genetic susceptibility and environmental insults. Increasing evidence implicates viral infections as significant environmental contributors, particularly during sensitive neurodevelopmental periods. This review synthesises current findings on the viral hypothesis of schizophrenia, encompassing a [...] Read more.
Schizophrenia is a challenging multifactorial neuropsychiatric disease that involves interactions between genetic susceptibility and environmental insults. Increasing evidence implicates viral infections as significant environmental contributors, particularly during sensitive neurodevelopmental periods. This review synthesises current findings on the viral hypothesis of schizophrenia, encompassing a wide array of neurotropic viruses, including influenza viruses, herpesviruses (HSV-1 and 2, CMV, VZV, EBV, HHV-6 and 8), hepatitis B and C viruses, HIV, HERVs, HTLV, Zika virus, BoDV, coronaviruses (including SARS-CoV-2), and others. These pathogens can contribute to schizophrenia through mechanisms such as direct microinvasion, persistent central nervous system infection, immune-mediated neuroinflammation, molecular mimicry, and the disturbance of the blood–brain barrier. Prenatal exposure to viral infections can trigger maternal immune activation, resulting in cytokine-mediated alterations in the neurological development of the foetus that persist into adulthood. Genetic studies highlight the role of immune-related loci, including major histocompatibility complex polymorphisms, in modulating susceptibility to infection and neurodevelopmental outcomes. Clinical data also support the “mild encephalitis” hypothesis, suggesting that a subset of schizophrenia cases involve low-grade chronic neuroinflammation. Although antipsychotics have some immunomodulatory effects, adjunctive anti-inflammatory therapies show promise, particularly in treatment-resistant cases. Despite compelling associations, pathogen-specific links remain inconsistent, emphasising the need for longitudinal studies and integrative approaches such as viromics to unravel causal relationships. This review supports a “multi-hit” model in which viral infections interfere with hereditary and immunological susceptibilities, enhancing schizophrenia risk. Elucidating these virus–immune–brain interactions may facilitate the discovery of biomarkers, targeted prevention, and novel therapeutic strategies for schizophrenia. Full article
(This article belongs to the Special Issue Schizophrenia: From Molecular Mechanism to Therapy)
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14 pages, 2107 KB  
Article
Optimal Coherence Length Control in Interferometric Fiber Optic Hydrophones via PRBS Modulation: Theory and Experiment
by Wujie Wang, Qihao Hu, Lina Ma, Fan Shang, Hongze Leng and Junqiang Song
Sensors 2025, 25(15), 4711; https://doi.org/10.3390/s25154711 - 30 Jul 2025
Viewed by 326
Abstract
Interferometric fiber optic hydrophones (IFOHs) are highly sensitive for underwater acoustic detection but face challenges owing to the trade-off between laser monochromaticity and coherence length. In this study, we propose a pseudo-random binary sequence (PRBS) phase modulation method for laser coherence length control, [...] Read more.
Interferometric fiber optic hydrophones (IFOHs) are highly sensitive for underwater acoustic detection but face challenges owing to the trade-off between laser monochromaticity and coherence length. In this study, we propose a pseudo-random binary sequence (PRBS) phase modulation method for laser coherence length control, establishing the first theoretical model that quantitatively links PRBS parameter to coherence length, elucidating the mechanism underlying its suppression of parasitic interference noise. Furthermore, our research findings demonstrate that while reducing the laser coherence length effectively mitigates parasitic interference noise in IFOHs, this reduction also leads to elevated background noise caused by diminished interference visibility. Consequently, the modulation of coherence length requires a balanced optimization approach that not only suppresses parasitic noise but also minimizes visibility-introduced background noise, thereby determining the system-specific optimal coherence length. Through theoretical modeling and experimental validation, we determined that for IFOH systems with a 500 ns delay, the optimal coherence lengths for link fibers of 3.3 km and 10 km are 0.93 m and 0.78 m, respectively. At the optimal coherence length, the background noise level in the 3.3 km system reaches −84.5 dB (re: rad/√Hz @1 kHz), representing an additional noise suppression of 4.5 dB beyond the original suppression. This study provides a comprehensive theoretical and experimental solution to the long-standing contradiction between high laser monochromaticity, stability and appropriate coherence length, establishing a coherence modulation noise suppression framework for hydrophones, gyroscopes, distributed acoustic sensing (DAS), and other fields. Full article
(This article belongs to the Section Optical Sensors)
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