Search Results (1,295)

Obesity and overweight conditions, frequently accompanied by hypercholesterolemia, are major risk factors for cardiovascular disease. Lifestyle interventions remain the cornerstone of non-pharmacological treatment; however, their effectiveness in improving lipid profiles is limited. Intermittent hypoxic training (IHT) has recently emerged as a potential strategy to enhance metabolic outcomes. This study aimed to evaluate the effects of a 4-week intensive IHT program combined with a calorie-restricted diet on lipid profile and body composition in men with overweight or obesity and secondary hypercholesterolemia. Twenty physically inactive men (35.3 ± 5.4 years) were randomly assigned to either a hypoxic group (H, n = 10) or a normoxic control group (C, n = 10). Both groups followed the same training protocol and diet, differing only in environmental training conditions. Body composition, resting metabolic rate, and blood lipid parameters (total cholesterol, TC; high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; non-high-density lipoprotein cholesterol, non-HDL-C; Triglycerides, TG) were assessed before and after the intervention. Compared with the C group, participants in the H group achieved significantly greater reductions in body mass (−5.4% vs. −2.6%, p < 0.05) and fat mass (−14.7% vs. −7%, p < 0.01). IHT also induced marked decreases in TC (−22.6%, p < 0.001), LDL-C (−25.8%, p < 0.001), non-HDL-C (−26.5%, p < 0.001), and TG (−31.4%, p < 0.01), along with a significant improvement in the atherogenic index of plasma (AIP, −24.4%, p < 0.05). In contrast, the C group showed only non-significant downward trends. No significant changes in HDL-C were observed in either group. These findings suggest that IHT combined with dietary restriction produces more favorable changes in lipid profile and body composition than normoxic training. IHT may therefore represent a promising adjunct to conventional lifestyle-based interventions in the management of obesity-related hypercholesterolemia. Full article

Background: Obesity and insomnia are prevalent public health issues with shared behavioral and physiological pathways. However, their interplay remains understudied in occupational cohorts. Obesity and insomnia are prevalent public health issues with shared behavioral and physiological pathways. However, their interplay remains understudied in occupational cohorts. This study aimed to evaluate the associations of sociodemographic factors, lifestyle habits, and insomnia severity with multiple obesity indices in a large population of Spanish workers. Methods: We conducted a cross-sectional analysis of 84,898 workers (2021–2024). Data were obtained from annual occupational health assessments conducted across multiple Spanish regions between 2020 and 2024. Insomnia severity was assessed using the Insomnia Severity Index (ISI), dietary quality using the 14-item Mediterranean Diet Adherence Screener (MEDAS-14), and physical activity using the International Physical Activity Questionnaire—Short Form (IPAQ-SF). Adiposity was measured using Body Mass Index (BMI), waist-to-height ratio (WtHR), the Clínica Universidad de Navarra–Body Adiposity Estimator (CUN-BAE), and the Metabolic Score for Visceral Fat (METS-VF). Multivariable logistic regression models were used to examine associations adjusted for age, sex, education, and occupational social class. Results: Higher ISI scores were significantly and independently associated with elevated adiposity across all indices, with the strongest association observed for METS-VF (odds ratio = 1.19, 95% CI 1.14–1.25, p < 0.001). Women showed higher mean CUN-BAE and METS-VF values than men (CUN-BAE: 37.4 ± 6.2 vs. 25.6 ± 6.4; p < 0.001; METS-VF: 5.7 ± 0.7 vs. 6.4 ± 0.6; p < 0.001), despite lower BMI (25.3 ± 4.8 vs. 26.8 ± 4.3; p < 0.001). Lower physical activity (OR = 5.70; 95% CI 4.91–6.50), poor adherence to the Mediterranean diet (OR = 3.29; 95% CI 2.88–3.70), smoking (OR = 1.29; 95% CI 1.22–1.36), and lower occupational class (Class III: OR = 1.77; 95% CI 1.56–1.97) were also significantly associated with higher obesity markers. Associations were more pronounced among women and participants with severe insomnia symptoms. Conclusions: Insomnia severity, sociodemographic disadvantage, and unhealthy behaviors (low physical activity, poor diet, smoking) were all independent correlates of general and visceral adiposity. The findings underscore the need for comprehensive workplace health programs that integrate sleep quality assessment, dietary improvement, and physical activity promotion to prevent obesity and its metabolic consequences. Full article

Vocational training can lead to higher employment rates and improved incomes, particularly for young women in low-resource settings like Kampala’s slums. Despite these benefits, further research is needed to understand the full impact and mechanisms of vocational training on youth in low-resource environments. In 2022, a focus group project, part of a larger study, involved 60 women aged 18 to 24, recruited from three Youth Support Centers operated by the Uganda Youth Development Link (UYDEL) in Kampala. Six focus groups (about 10 women in each group) were held to explore urban stress and how vocational training might mitigate social and environmental stressors and improve mental health. Data analysis conducted using NVivo software identified five key themes: economic benefits, skill development, building confidence and self-esteem, improved social and behavioral well-being, and enhanced lifestyle and quality of life. This formative research underscores that vocational training benefits young women, highlighting outcomes such as job acquisition, financial empowerment, and skill development. Additionally, self-esteem and confidence development emphasize the training’s role in fostering mental health and agency and addressing gender inequality. These findings underscore the value of vocational training in enhancing the mental health and overall well-being of young women and suggest areas for future research for how to best optimize and scale these programs in low-resource settings. Full article

Background/objectives: Overweight and obesity in adolescents is a significant public health concern, yet limited interventions exist in Australia to promote healthy behavior change in families and young people. This retrospective, real-world evaluation aimed to describe the impact of an 8-week e-Health program (Think, Eat And Move, [TEAM]) on anthropometric, behavioral and wellbeing outcomes in adolescents. Methods: Eligible TEAM program participants were aged 13–17 years, resided in Central or Eastern Sydney, Australia, had overweight/obesity, were at risk of or had a chronic health condition and/or required healthy lifestyle support. Retrospective program data were used to assess the impact of TEAM on weight, height and BMI z-score, dietary intake, physical activity and wellbeing indices. Results: Of 567 registered participants, 313 completed the TEAM program and were included in the analysis (median age 14.4 years, 56.2% female). The median (interquartile range) BMI z-score reduced from 1.8 (1.4–2.2) pre-program to 1.6 (1.1–2.1) post-program (p < 0.001, n = 262). Significant improvements in health behaviors following the program were observed, including increased consumption of fruit, vegetables and water; reduced consumption of confectionery and take-away foods; increased days of physical activity; and reduced sedentary time. Significant positive changes were also observed in knowledge and wellbeing measures. Conclusions: Adolescents completing the TEAM program demonstrated clinically important changes in anthropometry and improved nutrition and physical activity behaviors. E-Health modalities for promoting behavior change should be considered in public health strategies for adolescents. Full article

Managing blood glucose levels and adhering to exercise is challenging for older adults with obesity and type 2 diabetes mellitus (T2DM). Digital voice assistants (DVAs) utilising conversation-based interactions and natural language may overcome barriers to accessing home-based lifestyle programs, but end-user perspectives are essential for implementation. This analysis investigated end-user perspectives on implementation outcomes of a DVA-delivered lifestyle program nested within a randomised controlled trial of 50 older adults (aged 50–75 years) with obesity and T2DM (DVA n = 25; control n = 25). Following trial completion, 10 DVA participants (mean ± SD age 67 ± 4 years) completed semi-structured interviews guided by the Practical Planning for Implementations and Scale-up guide and Proctor’s implementation outcome taxonomy. Over half (60%) were willing to pay for the DVA-delivered program, indicating perceived value. DVA audiovisual and conversation-based modalities enhanced engagement and acceptability. Most end-users found the DVA program feasible as a modality for delivering lifestyle programs, but suggested greater personalisation to bolster sustainability. Overall, the intervention was identified as acceptable and appropriate, suggesting digitally delivered programs may be feasible and sustainable for long-term use. Findings should be interpreted cautiously, given the small sample size and short intervention period. Nevertheless, end-users’ suggestions could inform the implementation of digital health interventions into healthcare systems. Full article

Background: Perceived stress occurs when environmental demands are appraised as exceeding an individual’s coping resources, triggering emotional dysregulation and physiological hyperactivation with adverse mental and physical outcomes. University students are particularly vulnerable to psychological distress due to academic pressure, social transitions, and lifestyle changes. Despite increasing attention to mental health in higher education, data on perceived stress among Italian university students remain limited. This study aimed to assess stress profiles using the Italian Perceived Stress Scale—Revised (IPSS-R) and to explore associations with sociodemographic and academic variables. Methods: A multicenter cross-sectional study was conducted among 2.103 undergraduate and master’s students enrolled in Italian universities. Participants completed the 15-item IPSS-R, which measures three dimensions: general stress, coping, and academic stress. Sociodemographic and academic data were collected via a structured questionnaire. Non-parametric tests and Principal Component Analysis were employed to identify group differences and multivariate patterns. Results: Two principal components were retained through the principal component analysis, overall perceived stress (40.9% of the variance) and coping-related responses (13.7% of the variance). The mean total IPSS-R score was 30.6 (SD = 7.08, p < 0.001), reflecting moderate-to-high levels of perceived stress. Academic demands emerged as the predominant stressors. Higher stress levels were reported by female students, younger individuals, first-year undergraduates, and those enrolled in health sciences and STEM programs. Conversely, older students, postgraduate students, and those studying in Southern Italy demonstrated stronger coping abilities and lower academic stress. Students attending private universities reported elevated academic pressure, potentially due to heightened family and financial expectations. Conclusions: Italian university students experience substantial perceived stress, primarily driven by academic workload, performance expectations, and institutional pressure. Early identification using instruments such as the IPSS-R may enable targeted interventions to promote mental health and academic achievement in student support services, during triage, in wellness checks, and in psychoeducation. Full article

Background and Aims: In recent decades, lifestyle patterns have undergone significant transformations, particularly in low- and middle-income countries (LMICs). These changes have contributed to a dual nutritional crisis characterized by the coexistence of undernutrition and overweight/obesity, commonly referred to as the Double Burden of Malnutrition (DBM). Compounding this issue is the persistent prevalence of parasitic infections, due to poor personal hygiene and sanitation practices which further exacerbate nutritional imbalances, creating what is now recognized as the Triple Burden of Malnutrition (TBM). This review aims to explore the evolving lifestyle factors that have contributed to the emergence of the DBM and to examine its intersection with parasitic infections. The focus is particularly on South Asian low- and middle-income countries, where these overlapping burdens present a significant public health challenge. By highlighting the interconnectedness of malnutrition, obesity, and parasitic diseases, this study seeks to provide a comprehensive understanding of the current nutritional landscape in South Asian LMICs and to inform future health interventions and policies. Methods: This study was conducted using published and unpublished secondary data that are available on websites and other printed materials. One of the main requirements is date, with 2013 being regarded as the initiative’s landmark. Another crucial factor is the availability of the entire article. For this study, only research publications published in English were taken into consideration. Zotero was used for compilation. The majority of the analysis was performed using percentages and ratios. A thorough evaluation of all the studies’ methodology, design, execution, and reporting was performed in order to spot any systematic flaws in this study. Results: Only 45 of the 105 full-text papers that were screened met the requirements for inclusion. Of these studies, 15 satisfied the inclusion and exclusion requirements. The results show that China, with a comparatively higher income level status, has more prevalence of overweight and obesity among children (11.5%) and women (34.6%) than India (2.1% of OWOB among children and 20.6% among women). Nepal stands behind China and India with 1.2% of OWOB among children and between them with 22.2% OWOB among women. Interestingly, among the three South Asian nations, India has the highest stunting, wasting, and underweight among children (38.4%, 21%, and 35.7%, respectively) followed by Nepal (35.8%, 9.7%, and 27%) and China (8.1%, 2%, and 2.5%). This study finds no significant difference in the prevalence of intestinal parasitic infections among OWOB and underweight populations. This review finds that the DBM along with parasitic infections has resulted in a Triple Burden of Malnutrition, which is currently a major public health issue in low- and middle-income countries in South Asia. Discussion: The various types of malnutrition were once thought of and treated as distinct public health problems, but the new understanding is that undernutrition and overnutrition are linked, and that in order for policy solutions to be successful, double-duty measures that simultaneously address multiple dimensions must be put in place. When the DBM is combined with parasite illnesses, it becomes the Triple Burden of Malnutrition, which is the primary cause of the financial burden in LMICs. China has the worst obesity problem, yet it also has more obesity-related laws and intervention programs than India and Nepal combined. All three nations, however, have failed to stop or deal with the dramatic increase in OWOB over the last 20 years. For effective implementation and results, genetic and psychological factors must also be taken into account when developing policies and programs to tackle the obesity epidemic, undernutrition, and parasite diseases. Conclusions: The prevalence of the DBM has been rising globally, with South Asia seeing a faster rate of increase. A growing DBM is favorably correlated with national economic development. In South Asian LMICs, the DBM combined with parasite diseases has resulted in a Triple Burden of Malnutrition, a debilitating illness. Full article

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly attracting growing concern around the world. While there has been progress in the development of pharmacologic treatments, lifestyle and dietary interventions remain as the first-line approach for management. This scoping review aimed to identify dietary strategies for managing MASLD and to highlight current research gaps and challenges. Methods: A systematic search of PubMed and Science Direct was conducted up to 10 July 2025, for relevant studies on dietary modifications and MASLD. Data extracted included types of interventions, outcomes related to liver health, and research limitations. Results: Dietary interventions were shown to consistently improve hepatic and metabolic outcomes. In a randomized controlled trial of 12 weeks (n = 259), a Mediterranean diet reduced hepatic steatosis by 39% and improved insulin sensitivity. A calorie-restricted lifestyle program in adults with MASLD (n = 196) reduced liver fat by 25% over 52 weeks. Resistant starch supplementation (n = 200) lowered intrahepatic triglyceride content by 8% through gut microbiome modulation. A pilot RCT of medically tailored meals in cirrhosis (n = 40) reduced ascites symptoms and improved quality of life. Finally, prebiotic supplementation in MASLD (n = 200) lowered systemic inflammation and increased immune-regulating microbes. In contrast, Western dietary patterns and ultra-processed foods were consistently linked to lipotoxicity and inflammation. Conclusions: Dietary interventions remain critical for the management of chronic liver disease and continue to play a vital role even as pharmacotherapy options emerge. Further research should explore precision nutrition and microbiome-based therapies while also addressing the methodological limitations like the underutilization of causal inference frameworks. Finally, it is also important to consider culturally tailored interventions to account for barriers in access and equity in underserved populations. Full article

This research aims to describe existing evidence on the availability of culturally adapted lifestyle, nutrition, and physical activity programs among Native Hawaiian, CHamoru, and Filipino populations who are affected by obesity at rates higher than the general US population, contributing to poorer health outcomes. Addressing this disparity requires programs that are culturally adapted and grounded for these specific populations. A comprehensive description of the availability of lifestyle interventions for Native Hawaiians, Pacific Islanders, and Filipinos is missing in the literature. A systematic literature review was performed in July 2025 to gather articles that included lifestyle (nutrition and/or physical activity) interventions addressing obesity and/or related chronic diseases and that utilized one or more cultural adaptations for Native Hawaiian, CHamoru, and/or Filipino populations. Data were extracted, and methodological quality, social ecological model (SEM) level, and risk for bias was assessed. Twenty-nine articles met inclusion criteria. Interventions addressed pre-diabetes (n = 7), hypertension (n = 7), and/or obesity (n = 5) and included combined nutrition and physical activity (n = 16). Sixteen articles included interventions culturally adapted for Filipino populations only, 7 for Native Hawaiians only, 6 for both Native Hawaiians and Filipinos, and 2 included CHamorus. The most common combination of approaches were interventions that incorporated individual, interpersonal, and community SEM levels (n = 17). Intervention components were reflective of culturally relevant physical activities (n = 16) and nutrition (n = 11). Based on this research, there is a need for additional research to include CHamoru communities and interventions to be tested in geographic locations where these populations have migrated. Full article

Objectives: The present study analyzes the effects of a high-intensity interval training (HIIT) program based on the Tabata method on physiological and psychological variables in contemporary dancers (n = 10) and sedentary individuals (n = 8), who performed a 10-week protocol, with sessions of self-loading exercises structured in intervals of 20 s of effort and 10 s of rest three times a week. Methods: Parameters of body composition, muscle strength, aerobic and anaerobic capacity, heart rate variability, as well as perceptions of health, anxiety, stress, sleep quality, and levels of physical activity and sedentary lifestyle were evaluated. Results: The results showed that no significant changes occurred in most body composition variables, except for visceral fat, where group differences were observed (F = 5.66, p = 0.030, η²ₚ = 0.261). In the indicators of strength and power, the dancers improved the height and relative power of the jump (F = 5.996, p = 0.026, η²ₚ = 0.273), while the sedentary ones increased the strength of the handgrip (p = 0.023). In terms of functional performance, both groups significantly increased anaerobic endurance (F = 10.374, p = 0.005, η²ₚ = 0.393), although no changes were recorded in maximal oxygen consumption or heart rate variability (p > 0.05). On a psychological level, improvements in healthy lifestyle habits and a decrease in the trait anxiety variable were evidenced in dancers (p = 0.023), while in sedentary participants no relevant effects were found. Conclusions: In conclusion, the Tabata protocol may represent an efficient and complementary strategy to enhance strength, anaerobic power, and psychological well-being, particularly among dancers. The observed improvements suggest potential benefits related to movement quality, injury prevention, and general physical conditioning. Full article

Participation in cancer prevention programs is suboptimal. Socioeconomic backgrounds play a role in cancer awareness and prevention programs. We conducted a narrative review, summarizing the evidence on the integration of cancer prevention extended to non-occupational risk factors at the workplace. Cancer prevention programs include screenings (colonoscopy, mammography, Pap-test), vaccinations (anti-HPV, anti-HBV), and interventions focused on lifestyle changes. Such strategies may face several barriers related to individual or environmental factors. The workplace is potentially an ideal setting for implementing extended cancer prevention strategies because (i) occupational health surveillance (OHS) targets adults, including hard-to-reach subgroups; (ii) it is structured, with health records and exams for risk assessment; (iii) it offers a key chance to promote cancer awareness and prevention through direct worker–physician interaction. Such an innovative approach requires a coordinated effort to build professional networks and manage high-risk workers. Its successful implementation depends on financial support and the active involvement of physicians, employers, and workers. Occupational-based cancer prevention represents a novel and promising strategy, though its feasibility and cost-effectiveness need to be assessed through large-scale studies. Full article

Background/Objectives: The number of overweight and obese people has significantly increased in the world, and this phenomenon is referred to as globesity. Globally increasing obesity has become one of the major problems to be dealt with for countries, given obesity-related health problems, including nutrition-related noncommunicable diseases and some types of cancer, and the economic and social costs of obesity. Therefore, countries try to combat obesity through diverse strategies related to nutrition, physical activity, and education. In this regard, identifying the factors behind obesity is critical to making progress in the fight against obesity. Methods: This study explores the interplay amongst ICT (information and communication technologies) indicators, including Internet and mobile phone usage, unemployment, and adult obesity in the BRICS states from 1995 to 2022, using recently developed cointegration techniques and causality tests. Results: The outcomes of causality tests uncover an interaction between Internet and mobile phone usage, unemployment, and adult obesity. In addition, the cointegration coefficients reveal that Internet and mobile phone usage positively impact adult obesity, while unemployment has a negative effect on adult obesity. Conclusions: Our outcomes uncover that improper use of the Internet and mobile phones foster adult obesity, but proper utilization of the Internet and mobile phones can be effective instruments in combatting adult obesity through increasing the awareness of healthy lifestyles and online weight loss programs. Full article

Objective: This study aimed to evaluate the impact of an exclusively vegetarian diet, combined with physical activity and lifestyle interventions, on metabolic parameters in patients with metabolic syndrome, with a focus on preventing premature aging and improving overall health status. Materials and Methods: A total of 150 participants (82 females, 68 males; aged 36–80 years, with a mean age of 61.45 years) diagnosed with metabolic syndrome were enrolled. Participants followed an exclusively vegetarian diet (≈2100 kcal/day; 65% carbohydrates, 23% lipids, 15% proteins, 52.4 g dietary fiber, and 0 mg cholesterol) along with a structured lifestyle program that included physical activity (2.5 h/day, intensity 2–6 METs), psychological counseling, smoking cessation support, weight and blood pressure management, hydrotherapy, massage, phytotherapy, and stress-reduction sessions. Baseline and post-intervention assessments were performed to measure total cholesterol, LDL, HDL, triglycerides, glycemia, BMI, and blood pressure. Results: After 10 days of intervention, significant improvements were observed across all measured parameters: total cholesterol decreased by 41.21 mg/dL (−19.54%), triglycerides decreased by 72.86 mg/dL (−34.9%), LDL cholesterol decreased by 26.24 mg/dL (−19.71%), fasting glycemia decreased by 30.4 mg/dL (−21.61%), BMI decreased by 3%, systolic blood pressure decreased by 10.82 mmHg, and diastolic blood pressure decreased by 6.44 mmHg. Conclusions: Our findings demonstrate that a structured lifestyle intervention, centered on a vegetarian diet and physical activity, has a significant beneficial effect on metabolic health. This approach improves cardiovascular risk factors, glycemic control, and body composition, and may play a preventive role against premature aging. Full article

Residing in public housing is associated with adverse health outcomes, partly due to higher prevalence of unhealthy lifestyle behaviors linked to lower socioeconomic status. Health promotion and disease prevention interventions can mitigate these disparities but are often underutilized due to accessibility barriers and low health literacy. Delivering interventions directly within public housing areas may enhance reach and effectiveness. However, synthesized knowledge of such interventions remains limited. This scoping review aimed to identify and summarize available evidence on health-promoting and disease-preventive interventions in these settings. The review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRIMA-ScR) guidelines. A systematic search was performed in PubMed, CINAHL, Embase, and Scopus. Articles were screened using predefined criteria. Intervention details, key findings, and digital components were extracted and categorized. 31 articles were included, covering eight intervention categories: (1) Health promoter programs, (2) Nutrition programs, (3) Health screenings, (4) Health promotion messages, (5) Physical activity programs, (6) Mental health programs, (7) Oral health programs, and (8) Other health interventions. Five articles incorporated digital components. This review highlights the value of resident involvement, demonstrated by positive outcomes in interventions with strong community engagement. Despite promising effects, digital health components were underutilized, representing a missed opportunity for scalable, cost-effective interventions. Full article

Background: The human gastrointestinal tract harbors a complex microbiota that plays a vital role in metabolic health. Dysbiosis of the gut microbiome has been linked to metabolic syndrome (MetS), a growing health concern characterized by obesity, hypertension, and dyslipidemia, all of which are strongly associated with insulin resistance and low-grade inflammation. This study aimed to analyze changes in gut microbiome composition and metabolic parameters in individuals with MetS following a 3-month shared medical appointment program driven by a patient-centered agenda with an emphasis on lifestyle pillars of diet, activity, sleep, and stress management. Methods: Thirty-six individuals with MetS were recruited. Of these, 14 completed a structured metabolic health program with facilitated group appointments, including personalized dietary adjustments, increased physical activity, stress management, and clinical monitoring, while 22 served as an untreated group. Fecal samples were collected for full-length 16S rRNA sequencing. Clinical and biochemical parameters, including body weight, blood pressure, HbA1c, triglycerides, and liver enzymes, were assessed. Microbiome data were analyzed for alpha and beta diversity and differential abundance. Correlations between microbial genera and clinical parameters were evaluated using Spearman correlation. Results: Post-intervention, significant improvements were observed in body weight (p = 0.0061), HbA1c (p = 0.033), triglycerides (p = 0.047), AST (p = 0.016), and systolic blood pressure (p = 0.020). Alpha and beta diversity of the gut microbiome showed no significant changes. However, differential abundance analysis revealed increased levels of butyrate-producing and anti-inflammatory genera including Duncaniella, Megasphaera, Pseudoruminococcus, and Oliverpabstia. Conclusions: A 3-month lifestyle intervention in individuals with MetS was associated with marked improvements in metabolic health and beneficial shifts in gut microbiota composition. These findings suggest that even small lifestyle modifications may be a potential therapeutic target for metabolic syndrome management, highlighting the need for personalized approaches in future research. Full article