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12 pages, 2261 KiB  
Communication
Technological Challenges for a 60 m Long Prototype of Switched Reluctance Linear Electromagnetic Actuator
by Jakub Rygał, Roman Rygał and Stan Zurek
Actuators 2025, 14(8), 380; https://doi.org/10.3390/act14080380 - 1 Aug 2025
Viewed by 410
Abstract
In this research project a large linear electromagnetic actuator (LLEA) was designed and manufactured. The electromagnetic performance was published in previous works, but in this paper we focus on the technological challenges related to the manufacturing in particular. This LLEA was based on [...] Read more.
In this research project a large linear electromagnetic actuator (LLEA) was designed and manufactured. The electromagnetic performance was published in previous works, but in this paper we focus on the technological challenges related to the manufacturing in particular. This LLEA was based on the magnet-free switched-reluctance principle, having six effective energised stator “teeth” and four passive mover parts (4:6 ratio). Various aspects and challenges encountered during the manufacturing, transport, and assembly are discussed. Thermal expansion of steel contributed to the decision of the modular design, with each module having 1.3 m in length, with a 2 mm longitudinal dilatation gap. The initial prototype was tested with a 10.6 m length, with plans to extend the test track to 60 m, which was fully achievable due to the modular design and required 29 tons of electrical steel to be built. The stator laminations were cut by a bespoke progressive tool with stamping, and other parts by a CO2 laser. Mounting was based on welding (back of the stator) and clamping plates (through insulated bolts). The linear longitudinal force was on the order of 8 kN, with the main air gap of 7.5–10 mm on either side of the mover. The lateral forces could exceed 40 kN and were supported by appropriate construction steel members bolted to the concrete floor. The overall mechanical tolerances after installation remained below 0.5 mm. The technology used for constructing this prototype demonstrated the cost-effective way for a semi-industrial manufacturing scale. Full article
(This article belongs to the Section High Torque/Power Density Actuators)
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10 pages, 1320 KiB  
Article
Evaluation of the Effectiveness of Combined Treatment with Intravaginal Diazepam and Pelvic Floor Rehabilitation in Patients with Vulvodynia by Ultrasound Monitoring of Biometric Parameters of Pelvic Muscles: A Pilot Study
by Lucia Merlino, Enrico Ciminello, Agnese Immacolata Volpicelli, Stefano Tillier, Marianna Francesca Pasquali, Mattia Dominoni, Barbara Gardella, Roberto Senatori, Barbara Dionisi and Maria Grazia Piccioni
Diseases 2024, 12(8), 174; https://doi.org/10.3390/diseases12080174 - 1 Aug 2024
Cited by 2 | Viewed by 2065
Abstract
(1) Background: Vulvodynia is characterized by vulvar pain for at least three months and may have related variables, one of these being pelvic floor hypertonus. The purpose of this study was to compare the therapeutic effectiveness of two weekly sessions of pelvic floor [...] Read more.
(1) Background: Vulvodynia is characterized by vulvar pain for at least three months and may have related variables, one of these being pelvic floor hypertonus. The purpose of this study was to compare the therapeutic effectiveness of two weekly sessions of pelvic floor rehabilitation and 5 mg of vaginal diazepam daily vs. pelvic floor rehabilitation alone in individuals with vulvodynia. (2) Methods: A single-center, not-blind, randomized study enrolled 20 vulvodynic patients: A total of 10 were treated with dual therapy (intravaginal diazepam and pelvic floor rehabilitation), and 10 were treated with only pelvic floor rehabilitation. All of them underwent a pelvic floor ultrasound examination and VAS pain and Marinoff scale assessments before the beginning of therapy as well as three and six months later. (3) Results: The elevator plate angle ranged from 8.2 to 9.55 (p = 0.0005), hiatal area diameter ranged from 1.277 to 1.482 (p = 0.0002), levator symphysis distance ranged from 3.88 to 4.098 (p = 0.006), anorectal angle ranged from 121.9 to 125.49 (p = 0.006), Marinoff scale ranged from 2.3 to 1.4 (p = 0.009), and VAS scale ranged from 5.8 to 2.8 (p < 0.001). (4) Conclusions: This pilot study demonstrates that the suggested treatment improves the hypertonicity of the pelvic floor, as measured by ultrasound parameters, correlating with a reduction in symptomatology. Full article
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25 pages, 13990 KiB  
Article
Model Test and Numerical Simulation of Two Typical Close-Fitting Pile–Wall Integrated Structures in Deep Excavation
by Changjiang Wu, Wuqin Shen, Ying Xu and Guowei Wei
Buildings 2024, 14(8), 2347; https://doi.org/10.3390/buildings14082347 - 30 Jul 2024
Cited by 1 | Viewed by 1073
Abstract
Compared to conventional support methods, the close-fitting pile–wall integration technique features a minimized construction spacing between the retaining pile and the basement retaining wall. This approach leverages the pile stiffness to minimize the wall thickness and enhance underground space utilization. However, it currently [...] Read more.
Compared to conventional support methods, the close-fitting pile–wall integration technique features a minimized construction spacing between the retaining pile and the basement retaining wall. This approach leverages the pile stiffness to minimize the wall thickness and enhance underground space utilization. However, it currently lacks significant discussions and measured data about the interaction laws between the pile and the wall. The model test and finite element method (FEM) are employed to study the deformation and internal force interaction laws of two typical close-fitting pile–wall integrated structures, and a comparison with conventional design is conducted. Furthermore, this study separately investigates the impact of sensitivity factors, specifically the pile–wall stiffness ratio and floor plate stiffness, on both structures during the basement construction and serviceability stages. The test results can closely match the numerical simulation. The study results reveal that the wall impacts the bending moment of the pile to some extent. The internal force in the wall is significantly influenced by the lateral deformation of the pile and the floor plate. Compared to conventional designs, this structure significantly reduces the bending moment of the wall, particularly in the composite structure. Additionally, the analysis of sensitivity factors reveals their considerable influence on the pile–wall interaction. Full article
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24 pages, 8674 KiB  
Article
Composite Cold-Formed Steel Beams with Diagonal Rebars for Earthquake-Resistant Buildings
by James Samuel, Shalini Ramachandran Nair, Philip Saratha Joanna, Beulah Gnana Ananthi Gurupatham, Krishanu Roy and James Boon Piang Lim
Materials 2023, 16(8), 3002; https://doi.org/10.3390/ma16083002 - 10 Apr 2023
Cited by 13 | Viewed by 2401
Abstract
The construction industry is on the lookout for cost-effective structural members that are also environmentally friendly. Built-up cold-formed steel (CFS) sections with minimal thickness can be used to make beams at a lower cost. Plate buckling in CFS beams with thin webs can [...] Read more.
The construction industry is on the lookout for cost-effective structural members that are also environmentally friendly. Built-up cold-formed steel (CFS) sections with minimal thickness can be used to make beams at a lower cost. Plate buckling in CFS beams with thin webs can be avoided by using thick webs, adding stiffeners, or strengthening the web with diagonal rebars. When CFS beams are designed to carry heavy loads, their depth logically increases, resulting in an increase in building floor height. The experimental and numerical investigation of CFS composite beams reinforced with diagonal web rebars is presented in this paper. A total of twelve built-up CFS beams were used for testing, with the first six designed without web encasement and the remaining six designed with web encasement. The first six were constructed with diagonal rebars in the shear and flexure zones, while the other two with diagonal rebars in the shear zone, and the last two without diagonal rebars. The next set of six beams was constructed in the same manner, but with a concrete encasement of the web, and all the beams were then tested. Fly ash, a pozzolanic waste byproduct of thermal power plants, was used as a 40% replacement for cement in making the test specimens. CFS beam failure characteristics, load–deflection behavior, ductility, load–strain relationship, moment–curvature relationship, and lateral stiffness were all investigated. The results of the experimental tests and the nonlinear finite element analysis performed in ANSYS software were found to be in good agreement. It was discovered that CFS beams with fly ash concrete encased webs have twice the moment resisting capacity of plain CFS beams, resulting in a reduction in building floor height. The results also confirmed that the composite CFS beams have high ductility, making them a reliable choice for earthquake-resistant structures. Full article
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17 pages, 4679 KiB  
Article
Experimental Investigation and Numerical Simulation of Corrugated Steel Plate Shear Wall Considering the Gravity Load
by Fangfang Li, Junjie Gao, Yu Zhang, Yu Chen and Yang Lv
Buildings 2023, 13(2), 346; https://doi.org/10.3390/buildings13020346 - 26 Jan 2023
Cited by 2 | Viewed by 2095
Abstract
The corrugated steel plate shear wall (CSPSW) has high strength, ductility, and energy dissipation capacity and can be used as the lateral force-resisting system of multi-story and high-rise buildings. The vertical load transmitted by the upper floor and frame columns may inevitably act [...] Read more.
The corrugated steel plate shear wall (CSPSW) has high strength, ductility, and energy dissipation capacity and can be used as the lateral force-resisting system of multi-story and high-rise buildings. The vertical load transmitted by the upper floor and frame columns may inevitably act on the corrugated steel plate shear wall. However, the influence of the gravity load on the performance of the corrugated steel shear wall is not considered in most studies. To investigate the behavior of corrugated steel plate shear walls considering the actual gravity load, four scaled SPSWs under lateral and vertical loading were tested. The specimens’ failure mode, envelope curves, and hysteretic curves were analyzed. A numerical simulation model was established based on the validation of the experimental test on the SPSWs. The results showed that the hysteresis curves of the test were consistent with those of the simulation results. Finally, parametric analysis was conducted on the SPSWs with different types of infill plates, height-to-thickness ratio, and gravity loads. Full article
(This article belongs to the Section Building Structures)
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16 pages, 6376 KiB  
Article
Triboelectric Energy-Harvesting Floor Tile
by Panu Thainiramit, Subhawat Jayasvasti, Phonexai Yingyong, Songmoung Nandrakwang and Don Isarakorn
Materials 2022, 15(24), 8853; https://doi.org/10.3390/ma15248853 - 12 Dec 2022
Cited by 2 | Viewed by 4310
Abstract
The aim of this study was to investigate the real-world electrical parameters that strongly affected the performance of a triboelectric energy-harvesting floor tile design: triboelectric material thickness, cover plate displacement distance or gap width, and cover plate pressing frequency, so that real-world specifications [...] Read more.
The aim of this study was to investigate the real-world electrical parameters that strongly affected the performance of a triboelectric energy-harvesting floor tile design: triboelectric material thickness, cover plate displacement distance or gap width, and cover plate pressing frequency, so that real-world specifications of the harvesting floor tile can be accurately specified. The structure of the designed triboelectric energy harvester, with readily available polytetrafluoroethylene (PTFE) film and aluminum foil, was simple and hence easy to fabricate, and the material cost was low. A square wave was used to simulate the pressing frequency on the test bench’s cover plate. The results showed that the voltage and current were proportional to the gap width, and the thinner the triboelectric layer thickness, the higher the output voltage and current. A test bench with a 0.2 mm thick PTFE triboelectric layer generated the highest energy output. In a later experiment, a triboelectric energy-harvesting floor tile (TEHFT) prototype was constructed with 0.1 and 0.2 mm thick PTFE layers. We found that at 2 Hz stepping frequency and 0.1 mm PTFE thickness, the optimal load and cumulative energy of the TEHFT were 0.8 MΩ and 3.81 mJ, respectively, while with 0.2 mm PTFE thickness, these two parameters were 1.1 MΩ and 7.69 mJ, respectively. The TEHFT with 0.2 mm thick PTFE layer was able to illuminate a series of 100 to 150 LEDs, sufficient power to drive small electronics and sensor nodes. This discovery provides important data on the structure, material, and contact surface area of a TEHFT that can be adjusted to suit specific requirements of a special function triboelectric energy harvester. Full article
(This article belongs to the Special Issue Smart Materials and Devices for Energy Harvesting, Volume II)
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21 pages, 11741 KiB  
Article
Experimental Study of Frame-Supported Shear Wall Structure of High-Rise Buildings with Transfer Slab in Metro Depot
by Yishu Xia, Wuxiong Li, Weiya Liu, Yanhui Liu, Xin Xu and Chenyun Zhang
Buildings 2022, 12(11), 1940; https://doi.org/10.3390/buildings12111940 - 10 Nov 2022
Cited by 3 | Viewed by 6452
Abstract
Taking the frame-supported shear wall structure of a 102.1 m high metro depot as the test object, the structure has obvious vertical irregularity, and a quasi-static test was carried out on the structural model with the scale of 1/5. The damage development and [...] Read more.
Taking the frame-supported shear wall structure of a 102.1 m high metro depot as the test object, the structure has obvious vertical irregularity, and a quasi-static test was carried out on the structural model with the scale of 1/5. The damage development and strain of the structure were observed by applying displacement loads under different seismic actions, and the experimental phenomena and measured data were analyzed. The results show that the safety performance of the structure meets the seismic requirements of the MCE (Maximum considered earthquake) condition. Under the action of load, a reasonable damage mechanism is formed in which the components above the transfer story crack first and those below the transfer story crack later, which is in line with the design concept of “the performance objective of the bottom frame structure is higher than that of the upper shear wall structure”. The transfer plate is mainly subjected to shear deformation, the possible shear failure of the transfer plate should be avoided by reasonable design. Due to the large height difference between the first floor and the second floor, the structure may be adversely affected, so it is necessary to make the yielding floor appear in the bottom strengthening part above the transfer story. Under the SLE (Service level earthquake) and DBE (Design based earthquake) conditions, the bottom frame of the structure is mainly subjected to elastic deformation. Under the MCE (Maximum considered earthquake) condition, the bottom frame of the structure causes a lot of damage, increases energy consumption and decreases stiffness, which further proves that “the performance goal of the bottom frame structure is higher than that of the upper shear wall structure”. Full article
(This article belongs to the Collection Innovation of Materials and Technologies in Civil Construction)
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23 pages, 11238 KiB  
Article
Experimental and Numerical Study of an Innovative Infill Web-Strips Steel Plate Shear Wall with Rigid Beam-to-Column Connections
by Wahab Abdul Ghafar, Zhong Tao, Yan Tao, Yingcheng He, Lei Wu and Zhiqi Zhang
Buildings 2022, 12(10), 1560; https://doi.org/10.3390/buildings12101560 - 28 Sep 2022
Cited by 14 | Viewed by 5108
Abstract
Steel plate shear walls (SPSWs) offer good energy dissipation capability when subjected to seismic forces as a robust lateral load resisting structure. This research investigated the cyclic behaviors of innovative infill web-strips (IWS-SPSW) and conventional unstiffened steel plate shear (USPSW) experimentally and numerically. [...] Read more.
Steel plate shear walls (SPSWs) offer good energy dissipation capability when subjected to seismic forces as a robust lateral load resisting structure. This research investigated the cyclic behaviors of innovative infill web-strips (IWS-SPSW) and conventional unstiffened steel plate shear (USPSW) experimentally and numerically. As a result, two specimens of a 1:3 scale three-story single-bay IWS-SPSW and USPSW were fabricated and tested under cyclic lateral loading. Rigid moment-resistant connections were used for the steel plate shear wall beam-column connection. The steel shear walls with infill web strips showed high ductility and less shear load-bearing than the USPSW. The hysteresis results showed that the IWS-SPSW had high energy dissipation with no severe beam-columns damages. On the other hand, the USPSW displayed severe post-buckling, infill panel cracks, and first-floor column damages. Moreover, the IWS-SPSW shear strength did not fall in the test specimen beyond 2.5% average story drift, where the structure exhibited great seismic behavior. FE models were created and validated with experimental data. It has been proven that the infill web-strips can affect an SPSW system’s high performance and overall energy dissipation. From a parametric study, the material features of the infill web-strips, such as steel strength and thickness, can enhance the system’s impact even more. Full article
(This article belongs to the Special Issue Advances in the Behaviour of Steel Structures)
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22 pages, 3346 KiB  
Article
Roof Fractures of Near-Vertical and Extremely Thick Coal Seams in Horizontally Grouped Top-Coal Drawing Method Based on the Theory of a Thin Plate
by Guojun Zhang, Quansheng Li, Zhuhe Xu and Yong Zhang
Sustainability 2022, 14(16), 10285; https://doi.org/10.3390/su141610285 - 18 Aug 2022
Cited by 7 | Viewed by 2060
Abstract
During the mining process of the near-vertical seam, there will be movement and collapse of the “roof side” rock layer and the “overlying coal seam,” as well as the emergence of the “floor side” rock layer roof which is more complicated than the [...] Read more.
During the mining process of the near-vertical seam, there will be movement and collapse of the “roof side” rock layer and the “overlying coal seam,” as well as the emergence of the “floor side” rock layer roof which is more complicated than the inclined and gently inclined coal seams, which causes problems with slippage or overturning damage. With the increase of the inclination of the coal seam, the impact of the destruction of the immediate roof on the stope and roadway gradually becomes prominent, while the impact of the destruction of the basic roof on the stope and the roadway gradually weakens. The destruction of the immediate roof of the near-vertical coal seam will cause a large area of coal and rock mass to suddenly rush to the working face and the two lanes, resulting in rapid deformation of the roadway, overturning of equipment, overturning of personnel, and even severe rock pressure disaster accidents, all of which pose a serious threat to coal mine safety and production. It is necessary to carry out research on the mechanical response mechanism of the immediate roof of near-upright coal seams, to analyse the weighting process of steeply inclined thick coal seam sub-level mining. A four fixed support plate model and top three clamped edges simply supported plate model for roof stress distribution are established before the first weighting of the roof during the upper and lower level mining process. The bottom three clamped edges simply supported plate model and two adjacent edges clamped on the edge of a simply supported plate model are established for roof stress distribution before periodic weighting of the roof during the upper and lower level mining process. The Galerkin method is used to make an approximate solution of deflection equation under the effect of sheet normal stress, and then roof failure criterion is established based on the maximum tensile stress strength criterion and generalized Hooke law. This paper utilizes FLAC3D finite element numerical simulation software, considering the characteristics of steeply inclined thick coal seam sub-level mining. It undertakes orthogonal numerical simulation experiment in three levels with different depths, coal seam angles, lateral pressure coefficient, and orientation of maximum horizontal principal stress, and translates roof stress of corresponding 9 simulation experiment into steeply inclined roof normal stress. We conclude that the distribution law of normal stress along dip and dip direction of a roof under the circumstance of different advancing distances and different sub-levels. The caving pace of first weight and periodical weight were counted under the effect of the roof uniform normal stress. It can better predict the weighting situation of the working face and ensure the safe, efficient, and sustainable mining of coal mines. Full article
(This article belongs to the Topic Mining Safety and Sustainability)
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6 pages, 1620 KiB  
Case Report
Anatomical Changes in a Case with Asymmetrical Bilateral Maxillary Sinus Hypoplasia
by Adrian Cosmin Ilie, Adelina Maria Jianu, Mugurel Constantin Rusu and Alexandru Nicolae Mureșan
Medicina 2022, 58(5), 564; https://doi.org/10.3390/medicina58050564 - 20 Apr 2022
Cited by 4 | Viewed by 6108
Abstract
Background and Objectives: The maxillary sinus hypoplasia (MSH) is an occasional variation of the maxilla, occurring either unilaterally or bilaterally. Previous studies dealing with MSH have not detailed the consequent anatomical changes of the maxilla and adjacent fossae. Materials and Methods: [...] Read more.
Background and Objectives: The maxillary sinus hypoplasia (MSH) is an occasional variation of the maxilla, occurring either unilaterally or bilaterally. Previous studies dealing with MSH have not detailed the consequent anatomical changes of the maxilla and adjacent fossae. Materials and Methods: A 58-year-old female case was scanned in Cone Beam Computed Tomography and found to have asymmetrical bilateral MSH, who was then further evaluated anatomically. Results: The maxillary sinuses were hypoplastic and had mild mucosal thickenings. The orbital floors were curved. The uncinate process and the ethmoidal infundibulum were laterally displaced beneath the orbit floor. On each side, the lateral nasal wall protruded within the respective maxillary bone to reach above the vestibular cortical plate of the alveolar process. This expansion of the lateral nasal walls was limited to the premolar and first molar regions. The inferior turbinates were laterally curved. The perpendicular palatine plate was building a postero-lateral nasal wall in front of the pterygopalatine fossa. Conclusions: The classification systems of MSH should be detailed to indicate whether the normal uncinate process is medial or inferior to the orbit. The lateral expansion of the lateral nasal wall in MSH is limited to the anterior part of that wall. The laterally expanded nasal fossa could reach anterior to the pterygopalatine fossa in MSH. Seemingly, CBCT is a better tool than CT to evaluate the detailed anatomy of the modified anatomical structures in MSH; as such, it could be of help in a surgical approach. Full article
(This article belongs to the Topic Human Anatomy and Pathophysiology)
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15 pages, 1974 KiB  
Article
Standardized Biomechanical Investigation of Posture and Gait in Pisa Syndrome Disease
by Elisa Panero, Ugo Dimanico, Carlo Alberto Artusi and Laura Gastaldi
Symmetry 2021, 13(12), 2237; https://doi.org/10.3390/sym13122237 - 23 Nov 2021
Cited by 7 | Viewed by 2421
Abstract
Pisa syndrome is one of the possible postural deformities associated with Parkinson’s disease and it is clinically defined as a sustained lateral bending of the trunk. Some previous studies proposed clinical and biomechanical investigation to understand the pathophysiological mechanisms that occur, mainly focusing [...] Read more.
Pisa syndrome is one of the possible postural deformities associated with Parkinson’s disease and it is clinically defined as a sustained lateral bending of the trunk. Some previous studies proposed clinical and biomechanical investigation to understand the pathophysiological mechanisms that occur, mainly focusing on EMG patterns and clinics. The current research deals with the assessment of a standardized biomechanical analysis to investigate the Pisa syndrome postural effects. Eight patients participated in the experimental test. Both static posture and gait trials were performed. An optoelectronic system and two force plates were used for data acquisition, while a custom multi-segments kinematic model of the human spine was used to evaluate the 3D angles. All subjects showed an important flexion of the trunk superior segment with respect to the inferior one, with a strong variability among patients (range values between 4.3° and 41.0°). Kinematics, ground reaction forces and spatio-temporal parameters are influenced by the asymmetrical trunk posture. Moreover, different proprioception, compensation and abilities of correction were depicted among subjects. Considering the forces exchanged by the feet with the floor during standing, results highlighted a significant asymmetry (p-value = 0.02) between the omo and contralateral side in a normal static posture, with greater load distribution on the same side of lateral deviation. When asked to self-correct the posture, all patients demonstrated a reduction of asymmetry, but without stressing any statistical significance. All these aspects might be crucial for the definition of a PS patients’ classification and for the assessment of the efficacy of treatments and rehabilitation. Full article
(This article belongs to the Special Issue Motion, Gait Analysis and Asymmetry)
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17 pages, 5650 KiB  
Article
Intermittent Beginning to the Formation of Hydrogenous Ferromanganese Nodules in the Vast Field: Insights from Multi-Element Chemostratigraphy Using Microfocus X-ray Fluorescence
by Shiki Machida, Ryo Shimomura, Kentaro Nakamura, Tetsu Kogiso and Yasuhiro Kato
Minerals 2021, 11(11), 1246; https://doi.org/10.3390/min11111246 - 10 Nov 2021
Cited by 4 | Viewed by 2505
Abstract
Vast ferromanganese nodule fields have been found on the deep-sea floor of all oceans worldwide. They have received attention because they potentially provide high-grade metal resources to develop future high- and green-technology. However, how these vast nodule fields were formed and developed owing [...] Read more.
Vast ferromanganese nodule fields have been found on the deep-sea floor of all oceans worldwide. They have received attention because they potentially provide high-grade metal resources to develop future high- and green-technology. However, how these vast nodule fields were formed and developed owing to their widespread nature or tendency to be denser with an increasing number of nodules has not yet been established. In this study, the fine-scale inner structure of nodules of various sizes was analyzed on the basis of chemical mapping using microfocus X-ray fluorescence. We found that nodules distributed in the vast field around Minamitorishima (Marcus) Island have several types of innermost layers, which correspond to different chemostratigraphic layers of nodules that have been previously reported by us in this region. As nodules grow in order from the center to the outside, the different types in the innermost layer indicate a difference in the timing of the beginning of their growth. Moreover, because the differences in the chemical features of each layer reflect differences in the composition of the original deep-sea water, our results imply that the beginning of nodule formation occurred intermittently at each time of a water mass replacement due to new deep-sea currents flowing into this region. We recognized that the northern part of the study area was dominated by large nodules that started to grow in relatively earlier times, while the southern part tended to have many nodules that grew in relatively later times. Based on these observations, we hypothesize that the intermittent beginning of nodule formation is governed by the northward inflow of the deep-sea current that originated from the Lower Circumpolar Deep Water for an extended time to form the vast nodule field. Because patterns in the timing of nodule formation were different in the eastern and western regions, we thus further propose that the topographic framework, i.e., the arrangement of individual large seamounts and the cluster of small knolls and petit-spot volcanoes, strongly regulates the flow path of the deep-sea current, even if the position of the entire seamount changes owing to plate motion. The deep-sea current might supply some materials to be nuclei, resulting in the nodule formation at the beginning of the process. Full article
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20 pages, 1313 KiB  
Review
From Bipotent Neuromesodermal Progenitors to Neural-Mesodermal Interactions during Embryonic Development
by Nitza Kahane and Chaya Kalcheim
Int. J. Mol. Sci. 2021, 22(17), 9141; https://doi.org/10.3390/ijms22179141 - 24 Aug 2021
Cited by 9 | Viewed by 6865
Abstract
To ensure the formation of a properly patterned embryo, multiple processes must operate harmoniously at sequential phases of development. This is implemented by mutual interactions between cells and tissues that together regulate the segregation and specification of cells, their growth and morphogenesis. The [...] Read more.
To ensure the formation of a properly patterned embryo, multiple processes must operate harmoniously at sequential phases of development. This is implemented by mutual interactions between cells and tissues that together regulate the segregation and specification of cells, their growth and morphogenesis. The formation of the spinal cord and paraxial mesoderm derivatives exquisitely illustrate these processes. Following early gastrulation, while the vertebrate body elongates, a population of bipotent neuromesodermal progenitors resident in the posterior region of the embryo generate both neural and mesodermal lineages. At later stages, the somitic mesoderm regulates aspects of neural patterning and differentiation of both central and peripheral neural progenitors. Reciprocally, neural precursors influence the paraxial mesoderm to regulate somite-derived myogenesis and additional processes by distinct mechanisms. Central to this crosstalk is the activity of the axial notochord, which, via sonic hedgehog signaling, plays pivotal roles in neural, skeletal muscle and cartilage ontogeny. Here, we discuss the cellular and molecular basis underlying this complex developmental plan, with a focus on the logic of sonic hedgehog activities in the coordination of the neural-mesodermal axis. Full article
(This article belongs to the Special Issue Cell Fate Decisions in Neural Development)
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14 pages, 5848 KiB  
Article
Hysteretic Response of Tilt-Up Concrete Precast Walls with Embedded Steel Plate Connections
by Hyun-Do Yun, Hye-Ran Kim and Won-Chang Choi
Sustainability 2020, 12(19), 7907; https://doi.org/10.3390/su12197907 - 24 Sep 2020
Viewed by 7836
Abstract
Many connection systems are available that can transfer tension and shear loads from a precast concrete wall panel to a floor slab. However, due to the insufficient anchor depth in relatively thin precast concrete panels, it is difficult to attain adequate ductility and [...] Read more.
Many connection systems are available that can transfer tension and shear loads from a precast concrete wall panel to a floor slab. However, due to the insufficient anchor depth in relatively thin precast concrete panels, it is difficult to attain adequate ductility and stiffness to ensure structural integrity. Based on the authors’ previous research results, the supplementary reinforcement of embedded steel plates in precast concrete wall panels can enhance stiffness while maintaining allowable displacement and ductility. In this study, three full-size tilt-up precast concrete panels with embedded steel plates were fabricated. Lateral cyclic loads were applied to full support structures consisting of a precast concrete wall panel and a foundation. The test results were compared with the results predicted using existing code equations found in the American Concrete Institute 318-14 and the Prestressed Concrete Institute Handbooks. The test results confirm that the supplementary reinforcement of thin precast concrete wall panels can provide (i) the required strength based on current code equations, (ii) sufficient ductility, and (iii) the energy dissipation capacity to resist cyclic loading. Full article
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20 pages, 1698 KiB  
Review
Acquisition of the Midbrain Dopaminergic Neuronal Identity
by Simone Mesman and Marten P. Smidt
Int. J. Mol. Sci. 2020, 21(13), 4638; https://doi.org/10.3390/ijms21134638 - 30 Jun 2020
Cited by 33 | Viewed by 5751
Abstract
The mesodiencephalic dopaminergic (mdDA) group of neurons comprises molecularly distinct subgroups, of which the substantia nigra (SN) and ventral tegmental area (VTA) are the best known, due to the selective degeneration of the SN during Parkinson’s disease. However, although significant research has been [...] Read more.
The mesodiencephalic dopaminergic (mdDA) group of neurons comprises molecularly distinct subgroups, of which the substantia nigra (SN) and ventral tegmental area (VTA) are the best known, due to the selective degeneration of the SN during Parkinson’s disease. However, although significant research has been conducted on the molecular build-up of these subsets, much is still unknown about how these subsets develop and which factors are involved in this process. In this review, we aim to describe the life of an mdDA neuron, from specification in the floor plate to differentiation into the different subsets. All mdDA neurons are born in the mesodiencephalic floor plate under the influence of both SHH-signaling, important for floor plate patterning, and WNT-signaling, involved in establishing the progenitor pool and the start of the specification of mdDA neurons. Furthermore, transcription factors, like Ngn2, Ascl1, Lmx1a, and En1, and epigenetic factors, like Ezh2, are important in the correct specification of dopamine (DA) progenitors. Later during development, mdDA neurons are further subdivided into different molecular subsets by, amongst others, Otx2, involved in the specification of subsets in the VTA, and En1, Pitx3, Lmx1a, and WNT-signaling, involved in the specification of subsets in the SN. Interestingly, factors involved in early specification in the floor plate can serve a dual function and can also be involved in subset specification. Besides the mdDA group of neurons, other systems in the embryo contain different subsets, like the immune system. Interestingly, many factors involved in the development of mdDA neurons are similarly involved in immune system development and vice versa. This indicates that similar mechanisms are used in the development of these systems, and that knowledge about the development of the immune system may hold clues for the factors involved in the development of mdDA neurons, which may be used in culture protocols for cell replacement therapies. Full article
(This article belongs to the Special Issue Role of Gene Expression in the Physiology and Pathology of Neurons)
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