Search Results (4,904)

The process of urbanization has intensified the urban heat environment, with the degradation of thermal conditions closely linked to the morphological characteristics of different functional zones. This study delineated urban functional areas using a multivariate dataset and investigated the seasonal and threshold effects of landscape and architectural features on land surface temperature (LST) through boosted regression tree (BRT) modeling and Spearman correlation analysis. The key findings are as follows: (1) LST exhibits significant seasonal variation, with the strongest urban heat island effect occurring in summer, particularly within industry, business, and public service zones; residence zones experience the greatest temperature fluctuations, with a seasonal difference of 24.71 °C between spring and summer and a peak temperature of 50.18 °C in summer. (2) Fractional vegetation cover (FVC) consistently demonstrates the most pronounced cooling effect across all zones and seasons. Landscape indicators generally dominate the regulation of LST, with their relative contribution exceeding 45% in green land zones. (3) Population density (PD) exerts a significant, seasonally dependent dual effect on LST, where strategic population distribution can effectively mitigate extreme heat events. (4) Mean building height (MBH) plays a vital role in temperature regulation, showing a marked cooling influence particularly in residence and business zones. Both the perimeter-to-area ratio (LSI) and frontal area index (FAI) exhibit distinct seasonal variations in their impacts on LST. (5) This study establishes specific indicator thresholds to optimize thermal comfort across five functional zones; for instance, FVC should exceed 13% in spring and 31.6% in summer in residence zones to enhance comfort, while maintaining MBH above 24 m further aids temperature regulation. These findings offer a scientific foundation for mitigating urban heat waves and advancing sustainable urban development. Full article

Background/Objective: Exertional rhabdomyolysis (ER) is primarily driven by mechanical stress on muscles during strenuous or unaccustomed exercise, often exacerbated by environmental factors like heat and dehydration. While the general cellular pathway involving energy depletion and calcium overload is understood in horse ER models, the underlying mechanisms specific to the ER are not universally known within humans. This study aimed to evaluate whether patients with ER exhibited transcriptional signatures that were significantly different from those of healthy individuals. Methods: This study utilized RNA sequencing on skeletal muscle samples from 19 human patients with ER history, collected at a minimum of six months after the most recent ER event, and eight healthy controls to investigate the transcriptomic landscape of ER. To identify any alterations in biological processes between the case and control groups, functional pathway analyses were conducted. Results: Functional pathway enrichment analyses of differentially expressed genes revealed strong suppression of mitochondrial function. This suppression included the “aerobic electron transport chain” and “oxidative phosphorylation” pathways, indicating impaired energy production. Conversely, there was an upregulation of genes associated with adhesion and extracellular matrix-related pathways, indicating active restoration of muscle function in ER cases. Conclusions: The study demonstrated that muscle tissue exhibited signs of suppressed mitochondrial function and increased extracellular matrix development. Both of these facilitate muscle recovery within several months after an ER episode. Full article

The rapid urbanization process has accelerated the degradation of ecosystem services (ESs) in peri-urban rural areas of the Yangtze River Delta (YRD), leading to increasing landscape ecological risks (LERs). Establishing a scientifically grounded landscape ecological risk assessment (LERA) system and corresponding control strategies is therefore imperative. Using rural areas of Jiangning District, Nanjing as a case study, this research proposes an optimized dual-dimensional coupling assessment framework that integrates ecosystem service value (ESV) and ecological risk probability. The spatiotemporal evolution of LER in 2000, 2010, and 2020 and its key driving factors were further studied by using spatial autocorrelation analysis and geodetector methods. The results show the following: (1) From 2000 to 2020, cultivated land remained dominant, but its proportion decreased by 10.87%, while construction land increased by 26.52%, with minimal changes in other land use types. (2) The total ESV increased by CNY 1.67 × 10⁹, with regulating services accounting for over 82%, among which water bodies contributed the most. (3) LER showed an overall increasing trend, with medium- to highest-risk areas expanding by 55.37%, lowest-risk areas increasing by 10.10%, and lower-risk areas decreasing by 65.48%. (4) Key driving factors include landscape vulnerability, vegetation coverage, and ecological land connectivity, with the influence of distance to road becoming increasingly significant. This study reveals the spatiotemporal evolution characteristics of LER in typical peri-urban villages. Based on the LERA results, combined with terrain features and ecological pressure intensity, the study area was divided into three ecological management zones: ecological conservation, ecological restoration, and ecological enhancement. Corresponding zoning strategies were proposed to guide rural ecological governance and support regional sustainable development. Full article

Finite-time thermodynamics (FTT) describes the study of thermodynamic processes that take place in finite time. Due to the finite-time requirement, in general the system cannot move from equilibrium state to equilibrium state. As a consequence, excess entropy is generated, available work is reduced, and/or the maximally achievable efficiency is not achieved; minimizing these negative side-effects constitutes an optimal control problem. Particularly challenging are processes and cycles that involve phase transitions of the working fluid material or the target material of a synthesis process, especially since most materials reside on a highly complex energy landscape exhibiting alternative metastable phases or glassy states. In this perspective, we discuss the issues and challenges involved in dealing with such materials when performing thermodynamic processes that include phase transitions in finite time. We focus on thermodynamic cycles with one back-and-forth transition and the generation of new materials via a phase transition; other systems discussed concern the computation of free energy differences and the general applicability of FTT to systems outside the realm of chemistry and physics that exhibit cost function landscapes with phase transition-like dynamics. Full article

The age of entrepreneurship calls for the evolving of learning and development (L&D) models to meet the dynamic demands of innovation, sustainability, and technology innovation. This study examines the trends and issues of L&D models for entrepreneurs, more so focusing on how these models influence business success in a rapidly changing global landscape. The research employs bibliometric analysis, VOSviewer cluster analysis, and co-citation analysis to explore the literature from 1994 to 2024. Data collected from the Web of Science Core Collection database reflect significant trends in entrepreneurial L&D, with particular emphasis on the use of digital tools, sustainability processes, and governance systems. Findings emphasize the imperative role of L&D in fostering entrepreneurship, more so in areas such as digital transformation and the adoption of new technologies. The study also identifies central regions propelling this field, such as UK and USA. Future studies will be centered on the role of digital technologies, innovation, and green business models within entrepreneurial L&D frameworks. This study provides useful insight into the future of L&D within the entrepreneurial domain, guiding academia and companies alike in the planning of effective learning strategies to foster innovation and sustainable business growth. Full article

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a major global health challenge characterized by complex adipose–liver interactions mediated by adipokines and hepatokines. Despite rapid field evolution, a comprehensive understanding of research trends and translational advances remains fragmented. This study systematically maps the scientific landscape through bibliometric analysis, identifying emerging domains and future clinical translation directions. Methods: A comprehensive bibliometric analysis of 1002 publications from 2004 to 2025 was performed using thematic mapping, temporal trend evaluation, and network analysis. Analysis included geographical and institutional distributions, thematic cluster identification, and research paradigm evolution assessment, focusing specifically on adipokine–hepatokine signaling mechanisms and clinical implications. Results: The United States and China are at the forefront of research output, whereas European institutions significantly contribute to mechanistic discoveries. The thematic map analysis reveals the motor/basic themes residing at the heart of the field, such as insulin resistance, fatty liver, metabolic syndrome, steatosis, fetuin-A, and other related factors that drive innovation. Basic clusters include metabolic foundations (obesity, adipose tissue, FGF21) and adipokine-centered subjects (adiponectin, leptin, NASH). New themes focus on inflammation, oxidative stress, gut microbiota, lipid metabolism, and hepatic stellate cells. Niche areas show targeted fronts such as exercise therapies, pediatric/novel adipokines (chemerin, vaspin, omentin-1), and advanced molecular processes that focus on AMPK and endoplasmic-reticulum stress. Temporal analysis shows a shift from single liver studies to whole models that include the gut microbiota, mitochondrial dysfunction, and interactions between other metabolic systems. The network analysis identifies nine major clusters: cardiovascular–metabolic links, adipokine–inflammatory pathways, hepatokine control, and new therapeutic domains such as microbiome interventions and cellular stress responses. Conclusions: In summary, this study delineates current trends and emerging areas within the field and elucidates connections between mechanistic research and clinical translation to provide guidance for future research and development in this rapidly evolving area. Full article

The Mediterranean region, identified by scientists as a ‘climate hot spot’, is experiencing warmer and drier conditions, along with an increase in the intensity and frequency of extreme weather events. One such extreme phenomena is droughts. The recent wildfires in this region are a concerning consequence of this phenomenon, causing severe environmental damage and transforming natural landscapes. However, droughts involve a two-way interaction: On the one hand, climate change and various human activities, such as urbanization and deforestation, influence the development and severity of droughts. On the other hand, droughts have a significant impact on various sectors, including ecology, agriculture, and the local economy. This study investigates drought dynamics in four Mediterranean countries, Greece, France, Italy, and Spain, each of which has experienced severe wildfire events in recent years. Using satellite-based Earth observation data, we monitored drought conditions across these regions over a five-year period that includes the dates of major wildfires. To support this analysis, we derived and assessed key indices: the Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI), and Normalized Difference Drought Index (NDDI). High-resolution satellite imagery processed within the Google Earth Engine (GEE) platform enabled the spatial and temporal analysis of these indicators. Our findings reveal that, in all four study areas, peak drought conditions, as reflected in elevated NDDI values, were observed in the months leading up to wildfire outbreaks. This pattern underscores the potential of satellite-derived indices for identifying regional drought patterns and providing early signals of heightened fire risk. The application of GEE offered significant advantages, as it allows efficient handling of long-term and large-scale datasets and facilitates comprehensive spatial analysis. Our methodological framework contributes to a deeper understanding of regional drought variability and its links to extreme events; thus, it could be a valuable tool for supporting the development of adaptive management strategies. Ultimately, such approaches are vital for enhancing resilience, guiding water resource planning, and implementing early warning systems in fire-prone Mediterranean landscapes. Full article

In the context of algorithm selection, the careful design of benchmark functions and problem instances plays a pivotal role in evaluating the performance of optimization methods. Traditional benchmark functions have been criticized for their limited resemblance to real-world problems and insufficient coverage of the problem space. Exploratory landscape analysis (ELA) offers a systematic framework for characterizing objective functions, based on quantitative landscape features. This study proposes a method for generating benchmark functions tailored to single-objective continuous optimization problems with boundary constraints using predefined ELA feature vectors to guide their construction. The process begins with the creation of random decision variables and corresponding objective values, which are iteratively adjusted using the covariance matrix adaptation evolution strategy (CMA-ES) to ensure alignment with a target ELA feature vector within a specified tolerance. Once the feature criteria are met, the resulting topological map point is used to train a neural network to produce a surrogate function that retains the desired landscape characteristics. To validate the proposed approach, functions from the well-known Black Box Optimization Benchmark (BBOB) suite are replicated, and novel functions are generated with unique ELA feature combinations not found in the original suite. The experiment results demonstrate that the synthesized landscapes closely resemble their BBOB counterparts and preserve the consistency of the algorithm rankings, thereby supporting the effectiveness of the proposed approach. Full article

Small towns in mountainous regions face significant challenges in formulating effective landscape zoning strategies due to pronounced landscape fragmentation, which is driven by both the dominance of large-scale forest resources and the lack of coordination between administrative planning departments. To tackle this problem, this study focused on Yuqian, a quintessential small mountainous town in Hangzhou, Zhejiang Province. The town’s layout was divided into a grid network measuring 70 m × 70 m. A two-step cluster process was employed using ArcGIS and SPSS software to analyze five landscape variables: altitude, slope, land use, heritage density, and visual visibility. Further, eCognition software’s semi-automated segmentation technique, complemented by manual adjustments, helped delineate landscape character types and areas. The overlay analysis integrated these areas with administrative village units, identifying four landscape character types across 35 character areas, which were recategorized into four planning and management zones: urban comprehensive service areas, agricultural and cultural tourism development areas, industrial development growth areas, and mountain forest ecological conservation areas. This result optimizes the current zoning types. These zones closely match governmental sustainable development zoning requirements. Based on these findings, we propose integrated landscape management and conservation strategies, including the cautious expansion of urban areas, leveraging agricultural and cultural tourism, ensuring industrial activities do not impact the natural and village environment adversely, and prioritizing ecological conservation in sensitive areas. This approach integrates spatial and administrative dimensions to enhance landscape connectivity and resource sustainability, providing key guidance for small town development in mountainous regions with unique environmental and cultural contexts. Full article

An analysis of Albanian Muslims in Italy provides a compelling case study of communities perceived as marginal. Studies of Muslims in Italy tend to focus on the majority and chronologically older groups within the country’s Islamic landscape, particularly those from Asia and Africa. In addition to providing a better understanding of Islam in Italy, a study of the identity and community-building issues of the Albanian community of origin offers many insights into that community’s complexity. Albanians in Italy have a very specific historical and religious heritage; so, analyzing their roots and community-building processes helps us to better understand the development of Islam on the margins of large national organizations and majority groups. This article presents the results of the first national study of Albanian Muslims in Italy. Online interviews and field observations were conducted in 2024 within the Union of Muslim Albanians in Italy (Unione degli Albanesi Musulmani in Italia—UAMI), using the ethnographic method. The Association has fewer members compared with national level organizations. It was founded in 2009 to address specific issues related to the management of Muslim Albanian religious identity. The Association has sought to address the fragmentation of religion and Albanian nationalism, a consequence of a long period of state atheism, and to counter the literalist and radical tendencies in the interpretation of religion that have emerged in Albania since the collapse of the communist regime. In addition to these challenges, the Association has also tackled issues related to the Islamic religion in its local and global dimensions. The analysis of these challenges and the ways to deal with them offers a new framework in the Italian Islamic panorama, despite its marginality. The results of this research point to the emergence of new forms of rooting and belonging characterized by spirituality over orthopraxis. These forms adopt a religious approach open to diversity and pluralism. Full article

RNA-seq analysis of the highly differentiated human retinal pigment epithelial (RPE) cell-line ARPE-19, cultured on transwells for ≥4 months, yielded 44,909 genes showing 83.35% alignment with the human reference genome. These included mRNA transcripts of RPE-specific genes and those involved in retinopathies. Monolayers were fed photoreceptor outer segments (POS), designed to be synchronously internalised, mimicking homeostatic RPE activity. Cells were subsequently fixed at 4, 6, 24 and 48 h when POS were previously shown to maximally co-localise with Rab5, Rab7, LAMP/lysosomes and LC3b/autophagic compartments. A comprehensive analysis of differentially expressed genes involved in proteolysis revealed a pattern of gene orchestration consistent with POS breakdown in the autophagy-lysosomal pathway. At 4 h, these included elevated upstream signalling events promoting early stages of cargo transport and endosome maturation compared to RPE without POS exposure. This transcriptional landscape altered from 6 h, transitioning to promoting cargo degradation in autolysosomes by 24–48 h. Longitudinal scrutiny of mRNA transcripts revealed nuanced differences even within linked gene networks. POS exposure also initiated transcriptional upregulation in ubiquitin proteasome and chaperone-mediated systems within 4–6 h, providing evidence of cross-talk with other proteolytic processes. These findings show detailed evidence of transcriptome-level responses to cargo trafficking and processing in RPE cells. Full article

Obsidian was a key toolstone for the development of maritime lifeways in the western archipelago of southernmost South America. This area is a fragmented landscape where the major north–south movement of people along the Pacific was only possible by navigation because it is constrained by major biogeographic barriers. Two obsidian sources have been recorded, each one located on the extremes of the archipelago, and each has played a key role in the canoe-adapted societies that used them. As indicated by repeated inductively coupled plasma mass spectrometry analyses, obsidian from Chaitén Volcano to the north was distributed between 38°26′ S and 45°20′ S, and obsidian from Seno Otway to the south was distributed between 50° and 55° S, although it mainly occurred in sites close to the Strait of Magellan and within constrained time periods. This study explores the distribution of these two types of obsidians, their chronology, their frequencies in the archaeological record, the main artifact classes that are represented, and the technological processes in which they were involved. This examination indicates common aspects in the selection of high-quality toolstones for highly mobile maritime groups and discusses the different historical trajectories of two obsidians that appear decoupled across the Holocene. Full article

The interleukin-20 (IL-20) cytokine subfamily, a subset of the IL-10 superfamily, includes IL-19, IL-20, IL-22, IL-24, and IL-26. Recently, their involvement in cancer biology has gained attention, particularly due to their impact on the tumor microenvironment (TME). Notably, IL-20 subfamily cytokines can exert both pro-tumorigenic and anti-tumorigenic effects, depending on the context. For example, IL-22 promotes tumor growth by enhancing cancer cell proliferation and protecting against apoptosis, whereas IL-24 demonstrates anti-tumor activity by inducing cancer cell death and inhibiting metastasis. Additionally, these cytokines influence macrophage polarization—an essential factor in the immune landscape of tumors—thereby modulating the inflammatory environment and immune evasion strategies. Understanding the dual role of IL-20 subfamily cytokines within the TME and their interactions with cancer cell hallmarks presents a promising avenue for therapeutic development. Interleukin-20 receptor antagonists are being researched for their role in cancer therapy, since they potentially inhibit tumor growth and progression. This review explores the relationship between IL-20 cytokines and key cancer-related processes, including growth and proliferative advantages, angiogenesis, invasion, metastasis, and TME support. Further research is necessary to unravel the specific mechanisms underlying their contributions to tumor progression and to determine their potential for targeted therapeutic strategies. Full article

Mining activities in a quarry significantly interfere with the landscape, weaken its ecological functions, disrupt the continuity of habitats and change its natural character. The aim of this study is to present a robust, transparent, and participatory methodological framework centered on the Reclamation Quality Index, which enables a comprehensive and repeatable assessment of reclamation quality. At a time when the restoration of functional, ecologically stable and long-term sustainable landscapes is increasingly important, there is a need for reliable tools to assess the quality of restoration. This article presents an original methodology for the evaluation of quarry reclamation, which combines scientific precision with practical applicability. The proposed Reclamation Quality Index is built on multidisciplinary foundations and uses the Delphi methodology, through which expert knowledge and weighted preferences enter the evaluation process. A tool designed in this way makes it possible to quantify the quality of land restoration, identify the benefits of individual interventions, support effective planning, and strengthen the strategic management of post-mining transformation. At the same time, the Reclamation Quality Index creates space for the application of the principles of ecological stability and integration of the landscape as a living, dynamic system in the process of restoration. With its structure and philosophy, the methodology represents a prospective approach to the evaluation and planning of the post-extraction landscape. Its application goes beyond academia, as it can serve as a support for environmental policymaking, landscape planning, and assessing the quality of restoration in practice. Full article

This paper presents the Green Watershed Index (GWI) methodology, focusing on the 17 sustainability indicators selected in the Razey watershed, NW Iran. Field surveys and data collection have provided the possibility of field inspection and measurement of the present condition of the watershed and the indicators taken. Based on the degree of compliance with the required process, each indicator was scored from 0 to 10 and classified into three categories: unsustainable, semi-sustainable, and sustainable. Using the Entropy method to assign weight to each indicator and formulating a proportional mathematical relationship, the GWI score for each sub-watershed was derived. Spatial changes regarding the selected indicators and, consequently, the GWI were detected in the study area. Development of water infrastructure, particularly in the upstream sub-watersheds, plays a great role in increasing the GWI score. The highest weight is related to environmental productivity (0.26), and the five indicators of water footprint, knowledge management and information quality system, landscape attractiveness, waste recycling, and corruption control have approximately zero weight due to their monotonous spatial distribution throughout sub-watersheds. Only sub-watershed R1 has the highest score (5.13), indicating a semi-sustainable condition. The rest of the sub-watersheds have unsustainable conditions (score below 5). Concerning the GWI, the watershed is facing a critical situation, necessitating the implementation of management and conservation strategies that align with the sustainability level of each sub-watershed. Full article