Search Results (8,112)

International tourism has helped numerous economies and regions over the years in achieving the objective of long-term sustainable economic growth. The “Association of Southeast Asian Nations (ASEAN)” is the rising hub for international tourism due to its rich history, rich vibrant culture, pleasant weather conditions, and beautiful landscape. However, research evidence about the tourism-growth relationship in the context of ASEAN economies is indeed very scarce. Accordingly, this research paper focuses on the members of the ASEAN region to examine the true influence that international tourism has on economic growth. Relevant econometric technique such as the “Fixed Effects (FEF)” is chosen for analysis based on the Hausman test, “Feasible Generalized Least Squares (FGLS)” is used for robustness, and “Two Stages Least Squares (2SLS)” is employed for tackling the likely endogeneity issue. The results show that international tourism has contributed positively to the economic growth of the ASEAN economies. Similarly, openness to global trade and education have also helped the ASEAN economies in securing long run sustainable economic growth. Lastly, the inflation rate has decelerated the pace of economic growth, while government expenditures have accelerated the pace of economic growth among ASEAN members. Our empirical findings are robust to alternative model specifications and alternative econometric estimations. Therefore, we expect our empirical findings to help the policymakers of the ASEAN economies in developing suitable policy responses regarding the growth performance of their economies through the channel of international tourism. Full article

The Internet of Things (IoT) revolutionizes connectivity, enabling innovative applications across healthcare, industry, and smart cities but also introducing significant cybersecurity challenges due to its expanded attack surface. Intrusion Detection Systems (IDSs) play a pivotal role in addressing these challenges, offering tailored solutions to detect and mitigate threats in dynamic and resource-constrained IoT environments. Through a rigorous analysis, this study classifies IDS research based on methodologies, performance metrics, and application domains, providing a comprehensive synthesis of the field. Key findings reveal a paradigm shift towards integrating artificial intelligence (AI) and hybrid approaches, surpassing the limitations of traditional, static methods. These advancements highlight the potential for IDSs to enhance scalability, adaptability, and detection accuracy. However, unresolved challenges, such as resource efficiency and real-world applicability, underline the need for further research. By contextualizing these findings within the broader landscape of IoT security, this work emphasizes the critical importance of developing IDS solutions that ensure the reliability, privacy, and security of interconnected systems, contributing to the sustainable evolution of IoT ecosystems. Full article

This study explores the potential of Digital Earth Africa (DE Africa) coastlines products for assessing the Coastal Vulnerability Index (CVI) along the Casablanca coastline, Morocco. The analysis integrates remotely sensed shoreline data with elevation, slope, and geomorphological information from ASTER GDEM and geological maps within a GIS environment. Shoreline change metrics, including Shoreline Change Envelope (SCE), Net Shoreline Movement (NSM), Linear Regression Rate (LRR), and End Point Rate (EPR), were used to evaluate erosion trends from 2000 to 2023. Results show that sandy beach areas, particularly those below 12 m elevation, are highly exposed to erosion (up to 1.5 m/yr) and vulnerable to coastal hazards. Approximately 44% and 23% of the study area were classified as having very high and high vulnerability, respectively. The results indicate that remotely sensed data and GIS techniques are valuable and cost-effective tools for multi-scale geo-hazard coastal assessment studies. The study demonstrates that DE Africa products, combined with local landscape data, provide a valuable tool for coastal vulnerability assessment and monitoring in Africa. Full article

The study of tropical landscape dynamics is of critical importance, particularly within protected areas, for evaluating ecosystem functioning and the effectiveness of natural conservation efforts. This study aims to identify landscape dynamics within the Dong Nai Biosphere Reserve (including Cat Tien National Park and the Ma Da Forest) using remote sensing (Landsat and others) and geographic information system methods. The analysis is based on changes in the Enhanced Vegetation Index (EVI), land cover transformations, landscape metrics (Class area, Percentage of Landscape and others), and natural landscape fragmentation, as well as a spatio-temporal assessment of anthropogenic impacts on the area. The results revealed structural changes in the landscapes of the Dong Nai Biosphere Reserve between 2000 and 2024. According to Sen’s slope estimates, a generally EVI growth was observed in both the core and buffer zones of the reserve. This trend was evident in forested areas as well as in regions of the buffer zone that were previously occupied by highly productive agricultural land. An analysis of Environmental Systems Research Institute (ESRI) Land Cover and Land Cover Climate Change Initiative (CCI) data confirms the relative stability of land cover in the core zone, while anthropogenic pressure has increased due to the expansion of agricultural lands, mosaic landscapes, and urban development. The calculation of landscape metrics revealed the growing isolation of natural forests and the dominance of artificial plantations, forming transitional zones between natural and anthropogenically modified landscapes. The human disturbance index, calculated for the years 2000 and 2024, shows only a slight change in the average value across the territory. However, the coefficient of variation increased significantly by 2024, indicating a localized rise in anthropogenic pressure within the buffer zone, while a reduction was observed in the core zone. The practical significance of the results obtained lies in the possibility of their use for the management of the Dongnai biosphere Reserve based on a differentiated approach: for the core and the buffer zone. There should be a ban on agriculture and development in the core zone, and restrictions on urbanized areas in the buffer zone. Full article

Genomic studies have provided key insights into the molecular pathogenesis of differentiated thyroid carcinoma (DTC), including the role of genes involved in the homologous recombination (HR) related to DNA repair and genomic stability. This research aimed to investigate the genetic landscape of HR genes in thyroid pathology, associated with recurrence risk and clinical prognosis. The study involved six individuals with thyroid conditions, including two patients diagnosed with papillary thyroid carcinoma (PTC) and four individuals with benign thyroid disease. The research material consisted of tumor samples collected during surgical procedures. Protein interactions were analyzed using the STRING database (string-db.org). Homologous recombination genes were sequenced using the HRR Panel vr1.0 on the MiSeq™ Sequencing System. Bioinformatics analysis revealed a relationship between BRAF mutations and HR gene defects in PTC. Mutations in BRCA1, BRCA2, and FANCA genes, typically associated with thyroid tumors, were identified in the tissue of papillary thyroid cancer (PTC). A statistically significant correlation was found between the FANCA gene mutation (rs7195066) and the recurrent course of the PTC. The preliminary findings suggest a potential role for non-pathogenic BARD1 mutations in follicular adenoma. No significant association was found between genes involved in homologous recombination repair and the incidence of papillary thyroid carcinoma, suggesting that these genes may not play a major role in the development of this type of thyroid cancer. Full article

Triple-negative breast cancer (TNBC) has historically been challenging to treat due to limited therapeutic options. Since 2018, the treatment landscape has evolved substantially with the approval of precision therapies, including immune checkpoint inhibitors, poly (ADP-ribose) polymerase inhibitors, and antibody–drug conjugates. Despite these advancements, the therapeutic benefit remains limited due to various clinical challenges, largely driven by TNBC heterogeneity and an incomplete understanding of drug–tumor crosstalk mechanisms—both contributing to a restricted pool of eligible patients and variable treatment responses. Concurrently, emerging drugs tested in recent pivotal TNBC trials have demonstrated variable outcomes. Additionally, the associated economic burden has become a pressing global concern, as several approved drugs provide insufficient clinical benefit in relation to high expenditures, often driven by drug pricing. The situation is particularly critical in low- and middle-income countries, where TNBC is highly prevalent, yet access to even chemotherapeutic treatment remains limited. These factors collectively hinder real-world patient outcomes. This review provides a comprehensive analysis of TNBC management, integrating clinical advancements with economic perspectives and raising awareness of underdiscussed topics. The overview presented herein highlights the necessity for a global, interdisciplinary approach and patient centered care in TNBC drug development. Full article

Maize, one of the world’s three major food crops, plays a vital role in global food security. Analyzing the spatiotemporal patterns of maize cultivation in Hunan Province and their influencing factors contributes to enhancing planting quality and efficiency, optimizing production patterns, and supporting provincial food security initiatives. Utilizing maize cultivation data from Hunan Province (2001–2023), this study employed the standard deviation ellipse, center of gravity shift model, and principal component analysis to examine production patterns and their drivers. Key findings include the following: (1) The maize planting area exhibited an overall increasing trend from 2001 to 2023, with a spatial convergence from the northwest towards the east. Cultivation hot spots were identified in Shaoyang, Loudi, and Changde. Maize cultivation was predominantly concentrated in areas with gentle slopes (0–3°) and gradually shifted eastward towards similar terrain. (2) The provincial maize production center of gravity followed a “Z”-shaped trajectory, moving eastward and southward with Loudi City as its core. While the spatial distribution pattern shifted from “northwest–southeast” to “west–east”, the core concentration area maintained its “northwest–southeast” orientation. Concurrently, the fragmentation of cultivated land within the maize planting landscape increased. (3) Maize planting hot spots expanded from the northwest towards the central and eastern regions, extending southward. Cold spot areas shifted from the central region towards the northeast. By the study’s end, the central region had emerged as the core maize planting area. (4) Agricultural production conditions and policy factors were identified as the main drivers of spatiotemporal changes in maize acreage within Hunan Province. Full article

Accurate land use/land cover (LULC) maps generated through cloud computing can support large-scale land management. Leveraging the rich resources of Google Earth Engine (GEE) is essential for developing historical maps that facilitate the analysis of regional LULC dynamics. We implemented the best-performing scheme on GEE to produce 30 m LULC maps for the Shandong Peninsula urban agglomeration (SPUA) and to detect LULC changes, while closely observing the spatio-temporal trends of landscape patterns during 2004–2024 using the Shannon Diversity Index, Patch Density, and other metrics. The results indicate that (a) Gradient Tree Boost (GTB) marginally outperformed Random Forest (RF) under identical feature combinations, with overall accuracies consistently exceeding 90.30%; (b) integrating topographic features, remote sensing indices, spectral bands, land surface temperature, and nighttime light data into the GTB classifier yielded the highest accuracy (OA = 93.68%, Kappa = 0.92); (c) over the 20-year period, cultivated land experienced the most substantial reduction (11,128.09 km²), accompanied by impressive growth in built-up land (9677.21 km²); and (d) landscape patterns in central and eastern SPUA changed most noticeably, with diversity, fragmentation, and complexity increasing, and connectivity decreasing. These results underscore the strong potential of GEE for LULC mapping at the urban agglomeration scale, providing a robust basis for long-term dynamic process analysis. Full article

The fashion industry, despite its global economic importance, is a major contributor to environmental degradation and social inequality. In response, sustainable fashion has emerged as a growing movement advocating ethical, ecological, and socially responsible practices. This study presents a comprehensive bibliometric analysis of 1134 peer-reviewed journal articles on sustainable fashion indexed in Scopus from 1986 to 2025. Results show an exponential rise in research output after 2015, with interdisciplinary contributions from social sciences, business, environmental science, and engineering. By applying performance analysis and science mapping techniques, the study identifies five major research themes: “Consumer Behavior,” “Design Ethics,” “Circular Economy,” “Innovation,” and “Digital Media.” The geographic distribution reveals strong outputs from both developed and emerging economies. This study provides an integrative overview of the intellectual landscape of sustainable fashion and serves as a roadmap for researchers, policymakers, and practitioners who are interested in the development of sustainable fashion. Full article

Gully erosion, driven by the interplay of natural processes and human activities, results in severe soil degradation and landscape alteration, yet approaches for accurately quantifying erosion triggered by extreme precipitation using multi-source high-resolution remote sensing remain limited. This study first extracted digital surface models (DSM) for the years 2014 and 2024 using Ziyuan-3 and GaoFen-7 satellite stereo imagery, respectively. Subsequently, the DSM was calibrated using high-resolution unmanned aerial vehicle photogrammetry data to enhance elevation accuracy. Based on the corrected DSMs, gully erosion depths from 2014 to 2024 were quantified. Erosion patches were identified through a deep learning framework applied to GaoFen-1 and GaoFen-2 imagery. The analysis further explored the influences of natural processes and anthropogenic activities on elevation changes within the gully erosion watershed. Topographic monitoring in the Sandu River watershed revealed a net elevation loss of 2.6 m over 2014–2024, with erosion depths up to 8 m in some sub-watersheds. Elevation changes are primarily driven by extreme precipitation-induced erosion alongside human activities, resulting in substantial spatial variability in surface lowering across the watershed. This approach provides a refined assessment of the spatial and temporal evolution of gully erosion, offering valuable insights for soil conservation and sustainable land management strategies in the Loess Plateau region. Full article

Urbanization, characterized by rapid construction land expansion, has transformed natural landscapes and significantly altered river networks in emerging metropolitan areas. Understanding the historical and current conditions of river networks is crucial for policy-making in sustainable urban development planning. Based on the topographic maps and remote sensing images, this study employs a multi-metric framework to investigate river network variations in the Suzhou-Wuxi-Changzhou metropolitan area, a rapidly urbanized plain with high-density river networks in the Yangtze River Delta, China. The results indicate a significant decline in the quantity of rivers, with the average river density in built-up areas falling from 2.70 km·km⁻² in the 1960s to 1.95 km·km⁻² in the 2010s, along with notable variations in the river network’s structure, complexity and its storage and regulation capacity. Moreover, shifts in the structural characteristics of river networks reveal that urbanization has a weaker impact on main streams but plays a dominant role in altering tributaries. The analysis demonstrates the extensive burial and modification of rivers across the metropolitan plains. These findings underscore the essence of incorporating river network protection and restoration into sustainable urban planning, providing insights for water resource management and resilient city development in rapidly urbanizing regions. Full article

Autism spectrum disorder (ASD) is a heritable neurodevelopmental condition with a complex genetic architecture. Dissecting the interplay between inherited variants and high-impact de novo variants is critical for understanding its etiology. We conducted a family-based study involving 42 families with ASD (139 individuals). Using a targeted next-generation sequencing (NGS) panel of 236 genes, we identified and characterized rare inherited and de novo variants in affected probands, parents, and unaffected siblings. Our analysis revealed a complex genetic landscape marked by diverse inheritance patterns. De novo variants were predominantly observed in individuals with atypical autism, while biparental (homozygous) inheritance was more common in Asperger syndrome. Maternally inherited variants showed significant enrichment in intronic regions, pointing to a potential regulatory role. We also detected variants in several high-confidence ASD risk genes, including SHANK3, MYT1L, MCPH1, NIPBL, and TSC2, converging on pathways central to synaptic function and neurogenesis. Across the cohort, five variants of uncertain significance (VUS) were identified, comprising two inherited variants in ABCC8 and additional variants in CUL23, TSC2, and MCPH1. Our findings underscore the profound genetic heterogeneity of ASD and suggest that distinct genetic mechanisms and inheritance patterns may contribute to different clinical presentations within the spectrum. This highlights the power of family-based genomic analyses in elucidating the complex interplay of inherited and de novo variants that underlies ASD. Full article

With the rapid development of urbanization and tourism in China, increasing attention has been paid to the protection and utilization of historical and cultural heritage, while tourists’ demands for travel experiences have gradually shifted towards in-depth cultural perception. This paper selects Beijing Fayuan Temple Historic and Cultural District as the research case, and adopts methods such as the LDA (Latent Dirichlet Allocation) topic model, collection and analysis of online text data, and field research to explore the current situation of pedestrian space in Fayuan Temple District and its optimization strategies from the perspective of tourists’ perception. The study found that the dimensions of tourists’ perception of the pedestrian space in Fayuan Temple District mainly include six aspects: historical buildings and relics, tour modes and transportation, natural landscapes and environment, historical figures and culture, residents’ life and activities, and tourists’ experiences and visits. By integrating online text data, questionnaire surveys, and on-site behavioral observations, the study constructed a “physical environment-cultural experience-behavioral network” three-dimensional IPA (Importance–Possession Analysis) evaluation model, and analyzed and evaluated the high-frequency perception elements in tourists’ spontaneous evaluations. Based on the current situation evaluation of the pedestrian space in Fayuan Temple District, this paper puts forward optimization strategies for the perception of pedestrian space from the aspects of block space, transportation usage, landscape ecology, digital technology, and cultural symbol translation. It aims to promote the high-quality development of historical blocks by improving and optimizing the pedestrian space, and achieve the dual goals of cultural inheritance and utilization of tourism resources. Full article

Accurate prediction of photovoltaic performance hinges on resolving the electron density in the P-region and the hole density in the N-region. Motivated by this need, we present a comprehensive assessment of a meshless global radial basis function (RBF) collocation strategy for the steady current continuity equation, covering a one-dimensional two-region P–N junction and a two-dimensional single-region problem. The study employs Gaussian (GA) and generalized multiquadric (GMQ) bases, systematically varying shape parameter and node density, and presents a detailed performance analysis of the meshless method. Results map the accuracy–stability–computation-time landscape: GA achieves faster convergence but over a narrower stability window, whereas GMQ exhibits greater robustness to shape-parameter variation. We identify stability plateaus that preserve accuracy without severe ill-conditioning and quantify the runtime growth inherent to dense global collocation. A utopia-point multi-objective optimization balances error and computation time to yield practical node-count guidance; for the two-dimensional case with equal weighting, an optimum of 19 intervals per side emerges, largely insensitive to the RBF choice. Collectively, the results establish global RBF collocation as a meshless, accurate, and systematically optimizable alternative to conventional mesh-based solvers for high-fidelity carrier-density prediction in P-N junctions, thereby enabling more reliable performance analysis and design of photovoltaic devices. Full article

Rural landscapes are changing rapidly, yet many assessments remain descriptive and weakly connected to planning instruments. This study connects rural landscape analysis with planning and management by examining post-earthquake transformations in Topaktaş (Tuşba, Van), a village redesigned and relocated after the 2011 events. Using ArcGIS 10.8 and the Analytic Hierarchy Process (AHP), we integrate DEM, slope, aspect, CORINE land cover Plus, surface-water presence/seasonality, and proximity to hazards (active and surface-rupture faults) and infrastructure (Karasu Stream, highways, village roads). A risk overlay is treated as a hard constraint. We produce suitability maps for settlement, agriculture, recreation, and industry; derive a composite optimum land-use surface; and translate outputs into decision rules (e.g., a 0–100 m fault no-build setback, riparian buffers, and slope thresholds) with an outline for implementation and monitoring. Key findings show legacy footprints at lower elevations, while new footprints cluster near the upper elevation band (DEM range 1642–1735 m). Most of the area exhibits 0–3% slopes, supporting low-impact access where hazards are manageable; however, several newly designated settlement tracts conflict with risk and water-service conditions. Although limited to a single case and available data resolutions, the workflow is transferable: it moves beyond mapping to actionable planning instruments—zoning overlays, buffers, thresholds, and phased management—supporting sustainable, culturally informed post-earthquake reconstruction. Full article