Search Results (159)

Background/Objectives: Children born small for gestational age (SGA) are at increased risk for impaired growth, metabolic disturbances, and neurodevelopmental difficulties. Although previous research has examined cognitive and behavioral outcomes in this population, findings remain inconsistent. Moreover, limited evidence is available regarding the potential effects of recombinant human growth hormone (rhGH) therapy on cognitive development. We aimed to assess cognitive performance, emotional–behavioral functioning, and neonatal predictors of neurocognitive outcomes in term SGA children compared with age- and sex-matched peers born appropriate for gestational age (AGA). We also explored potential differences in cognitive outcomes between rhGH-treated and untreated SGA children. Methods: A total of 18 term SGA children and 23 AGA controls underwent anthropometric measurements, biochemical evaluation, cognitive testing using the Wechsler Intelligence Scale for Children—Fourth Edition (WISC-IV), and behavioral assessment through the Child Behavior Checklist (CBCL). Birth weight, length, and head circumference were analyzed as potential predictors of cognitive performance. Results: SGA children demonstrated significantly lower Intelligence Quotient (IQ) scores than AGA peers, with marked weaknesses in Perceptual Reasoning index (PRI) and Processing Speed index (PSI), while Verbal Comprehension and Working Memory were preserved. They also exhibited higher internalizing behavioral symptoms, whereas externalizing behaviors did not differ between groups. Birth head circumference emerged as a strong predictor of PRI and a modest predictor of PSI. No associations were found between rhGH treatment parameters and cognitive outcomes. Larger longitudinal studies are needed to clarify how early growth restriction affects brain development and cognition and whether GH therapy influences these processes. Full article

Background and Objectives: Evidence on motor performance in children with autism spectrum disorder (ASD) is scarce and inconsistent. The association of motor impairments with autism severity and intelligence remains insufficiently studied. We aimed to examine motor performance parameters in children with ASD compared with typically developing (TD) peers. Materials and Methods: In this cross-sectional study, a convenience sample of 26 children with ASD, aged 4–10 years, was recruited from specialized centers in KSA, alongside 27 age- and sex-matched TD children. For the ASD group, severity (Childhood Autism Rating Scale, CARS-2) and intelligence quotient (Stanford–Binet Intelligence Scale, SB5) were extracted from medical records. CARS-2 score was utilized to categorize children with ASD into two groups (mild-to-moderate and severe groups). All study children were assessed for gross and fine motor skills using the Movement Assessment Battery for Children-2 (MABC-2), balance, muscle strength, endurance, and flexibility. Results: ASD groups recorded significantly lower scores in all MABC-2 component areas when compared to the TD group (p < 0.001). Aiming and catching percentile was significantly lower in the severe ASD group compared to the mild-to-moderate group (p = 0.05). Furthermore, children with ASD exhibited increased hypermobility, predominantly at the elbow joints, reduced grip strength, shorter distance in the modified 6 min walk test, and lower standing long-jump performance (p < 0.001) when compared to TD group; however, no significant difference was recorded between the ASD groups. Spearman correlation revealed that aiming and catching was negatively correlated with autism severity (CARS-2) (r = −0.38, p = 0.05) and positively with IQ (r = 0.51, p = 0.03). Aiming and catching was positively correlated with grip strength (r = 0.55, p = 0.003), endurance (r = 0.58, p = 0.002), and jump distance (r = 0.44, p = 0.03), while balance was positively correlated with grip strength (r = 0.44, p = 0.02). Conclusions: Children with ASD exhibit significant impairments in gross and fine motor performance compared with TD peers, accompanied by hypermobility, reduced strength, and diminished endurance. Notably, aiming and catching ability correlated with both IQ and autism severity as well as specific motor parameters, suggesting its potential as a clinical marker of motor–cognitive interaction in ASD. Full article

Underwater acoustic energy transmission (UAET) is critical for sustaining long-term operations of underwater platforms, but its efficiency is constrained by the limited aperture of underwater receivers—requiring acoustic energy to be concentrated within a pre-defined target angular domain. Existing array-weighting methods face inherent limitations: traditional window-based techniques optimize mainlobe–sidelobe trade-offs rather than target-specific energy concentration, while intelligent algorithms suffer from high computational cost, quasi-optimality, and poor reproducibility. To address these gaps, this study proposes an array beam energy aggregation optimization method based on Rayleigh quotient eigenvalues for UAET. First, a rigorous mathematical model of the acoustic energy concentration problem was established: by defining a target-domain energy operator matrix ${\mathrm{R}}_{\mathsf{\Theta }}$ with a Toeplitz–sinc structure (Hermitian positive definite), the energy-focusing problem was transformed into a tractable linear algebra problem. Second, the optimization objective of maximizing target-domain energy was formulated as a generalized Rayleigh quotient maximization problem, where the optimal amplitude weights correspond to the eigenvector of the maximum eigenvalue of ${\mathrm{R}}_{\mathsf{\Theta }}$—solved via Cholesky whitening and eigenvalue decomposition to ensure theoretical optimality and low computational complexity. Comprehensive validations were conducted via simulations and underwater physical experiments. Simulations on 1D uniform linear arrays and 2D 4-layer circular ring arrays showed that the proposed method outperformed traditional weighting methods and PSO in target angular energy concentration: for the 16-element linear array, its energy radiation efficiency in the 30° domain was 14% higher than classical methods (Blackman weighting). Underwater physical tests further confirmed its superiority: for the 4-layer circular ring array at 1 m, the acoustic energy efficiency in the 30° target domain reached 21.5% higher than Blackman weighting. Additionally, the method exhibited strong adaptivity (dynamic weight adjustment with target angular width) and scalability (performance improvement with array size), meeting UAET’s real-time and reliability requirements. This work provides a theoretically optimal and engineering-feasible solution for directional acoustic energy transfer in underwater environments, offering valuable insights for UAET system design. Full article

Background: Probiotic supplementation for very preterm infants is a common practice in many neonatal units. Assessing the effects of early postnatal exposure to probiotics on long-term neurodevelopment, growth, and atopy-related outcomes is important. Extremely preterm (EP: <28 weeks) infants enrolled in our previously reported randomized trial (SiMPro) comparing short-term effects of single (SS: B. breve M-16V) versus triple-strain (TS: B. breve M-16V, B. longum subsp. infantis-M63, B. longum subsp. longum-BB536) probiotic provided a unique opportunity to study this issue. Methods: This follow-up study assessed the five-year outcomes of SiMPro trial infants, including neurodevelopment (cognition (Full Scale Intelligence Quotient/ FSIQ using WPPSI-IV), behavior (Strengths and Difficulties Questionnaire), executive function (BRIEF–P)), growth (anthropometry) and blood pressure (BP). Atopy-related outcomes were evaluated at six to seven years using the ISAAC questionnaire. A linear mixed model was used for longitudinal outcomes. Impairment indicators were modeled using logistic regression and adjusted for Socio-Economic Indexes for Areas (SEIFA) centiles. Results: Follow-up rates (SS: 89.2% versus TS: 95%), neurodevelopmental outcomes [severe impairment (FSIQ < 70): SS: 7.4% versus TS: 4.3%; p = 0.68], growth, BMI, and BP were comparable between the SS and TS groups. The total difficulty score or BRIEF–P executive indices, disability rates (none: 66.7% versus 55.4%), and atopy-related outcomes were comparable between groups. Conclusions: Both TS and SS Bifidobacterium probiotic formulations were safe, with comparable neurodevelopmental, growth, and atopy-related outcomes at school age. Full article

In the face of advancing globalisation processes and intensified contacts between representatives of different cultures and religions, interreligious dialogue is becoming an important component of contemporary social coexistence. This article aims to establish a relationship between interpersonal skills, moral intelligence, and readiness to engage in interreligious dialogue among adult Poles. A total of 519 people aged 18 to 75 (M = 48.44; SD = 15.55) were surveyed. This study used the Readiness to Engage in Interreligious Dialogue Scale (TGDMVE), the Interpersonal Competence Questionnaire (ICQ-R) and the Moral Intelligence Quotient (MIQ). The results of the analyses indicated that, in terms of interpersonal competence, the strongest significant predictor of all five dimensions of readiness to engage in interreligious dialogue was active concern for others. In terms of moral intelligence, it was the ability to recognise spiritual needs. The results may have significant practical implications for the areas of intercultural education, the prevention of xenophobic attitudes, and the building of social capital based on dialogue, trust, and respect. Full article

The development of AI systems and benchmarks has been rapidly increasing, yet there has been a disproportionately small amount of examination into the domains used to evaluate these systems. Most benchmarks introduce bias by focusing on a particular type of domain or combine different domains without consideration of their relative complexity or similarity. We propose the Artificial Intelligence Quotient (AIQ) framework as a means for measuring the similarity and complexity of domains in order to remove these biases and assess the scope of intelligent capabilities evaluated by a benchmark composed of multiple domains. These measures are evaluated with several intuitive experiments using simple domains with known complexities and similarities. We construct test suites using the AIQ framework and evaluate them using known AI systems to validate that AIQ-based benchmarks capture an agent’s intelligence. Full article

Due to widespread industrial applications and increased discharges, concentrations of polyfluoroalkyl substances (PFAS) in potential drinking water sources have risen significantly, putting more people at risk of PFAS exposure. This study aimed to systematically clarify the occurrence characteristics (concentrations, detection frequencies, and temporal trends) of PFAS in global potential drinking water sources over the past decade, assess their oral exposure risks, and identify key PFAS species with high detection frequencies, high contamination levels, or high toxicity risks, thereby providing scientific support for the development of targeted control technologies and management strategies. This study systematically searched and reviewed the relevant literature published between 2014 and 2024 on PFAS levels in global potential drinking water sources, extracting data on PFAS concentrations, detection information, and sampling characteristics. Using the U.S. Environmental Protection Agency (EPA) Reference Dose (RfD) for oral exposure as the Acceptable Daily Intake (ADI), we evaluated the exposure risks of eight specific PFAS via the Risk Quotient for Specific Contaminants (RQ_RSC) model and analyzed the annual detection trends of the top thirty PFAS with the highest detection frequencies. Regarding total PFAS contamination, China, Brazil, Germany, South Africa, and the Danube River Basin exhibited particularly high levels, with China being the most severely contaminated. Risk assessment indicated that 45.6% of global potential drinking water sources were at high risk (RQ_RSC > 1), while 48.4% were at low risk (RQ_RSC < 0.2). Among the evaluated PFAS, PFOA, PFOS, PFDA, and GenX were associated with higher toxicity exposure risks. For the identified key concern PFAS, it is necessary to simplify detection techniques, promote targeted large-scale safe treatment technologies, and explore intelligent monitoring tools to reduce regulatory lag, thereby effectively monitoring, preventing, and controlling PFAS contamination. Full article

Dyslexia, a heterogeneous neurodevelopmental disorder, is characterized by persistent reading and spelling difficulties despite average intellectual potential. Although intellectual functioning in dyslexia is often described as average, emerging evidence suggests meaningful within-group variability. This study examined whether children and adolescents with dyslexia exhibited distinct intellectual profiles based on the Stanford-Binet Intelligence Scales, Fifth Edition (SB5). Data were obtained from a large, diagnostically verified sample of 3458 individuals aged 10–19 years assessed in psychological-pedagogical counseling centers across Poland. We used latent profile analysis (LPA) of all 10 SB5 subtests and compared models that specified 2–6 latent classes. The optimal solution identified two profiles: (a) a small subgroup (5%) with globally reduced intellectual functioning and a profound deficit in verbal working memory (>3 standard deviations below the norm) and (b) the predominant subgroup (95%) with broadly average intellectual functioning and relatively preserved reasoning abilities. Profile membership was associated with socioeconomic status; the low-functioning subgroup was associated with lower parental education and age, as younger participants were more likely to belong to this group. These findings highlight the dimensional nature of intellectual heterogeneity in dyslexia and underscore the diagnostic value of profile-based approaches over global intelligence quotient (IQ) scores. Full article

Breastfeeding based on the use of follow-on milk may contain traces of xenobiotic elements that could pose a risk to the health of the vulnerable population for which it is intended. Fluorine is a non-essential element that, at high concentrations, can produce adverse health effects such as dental fluorosis, decreased IQ (intelligence quotient), thyroid alterations, and kidney damage. Given the vulnerability of infants and the possible presence of fluoride in this type of product, the content of this anion was determined in a total of 46 samples of follow-on milk from different brands and types (starter, follow-on, and hydrolysate formulas) using a fluoride ion-selective electrode (EWI). The highest mean concentration of fluoride was recorded in the hydrolysate formulas (3.38 ± 2.78 mg/L). The dietary intake assessment indicated that some brands of hydrolyzed formulas could pose a health risk, providing up to 94.1% of the UL (upper level) with only one 90 mL serving in the 0–6-month age group. It is recommended that consumers be aware of the fluoride content in the water used to prepare bottles, as it can further increase total fluoride intake and therefore pose a risk to the health of infants. Full article

Acute stress impairs executive functions, and these higher-order cognitive processes are often positively associated with intelligence. Even though intelligence is generally stable over time, performance in an intelligence test can be influenced by a variety of factors, including psychological processes like motivation or attention. For instance, test anxiety has been shown to correlate with individual differences in intelligence test performance, and theoretical accounts exist for causality in both directions. However, the potential impact of acute stress before or during an intelligence test remains elusive. Here, in a research context, we investigated the effects of test anxiety and acute stress as well as their interaction on performance in the short version of the Intelligence Structure Test 2000 in its German version (I-S-T 2000 R). Forty male participants completed two sessions scheduled 28 days apart, with the order counterbalanced across participants. In both sessions, participants underwent either the socially evaluated cold-pressor test (SECPT) or a non-stressful control procedure, followed by administration of I-S-T 2000 R (parallelized versions on both days). The SECPT is a widely used laboratory paradigm that elicits a stress response through the combination of psychosocial and physical components. Trait test anxiety scores were obtained via the German Test Anxiety Inventory (TAI-G). Stress induction was successful as indicated by physiological and subjective markers, including salivary cortisol concentrations. We applied linear mixed models to investigate the effects of acute stress (elicited by our stress manipulation) and test anxiety on the intelligence quotient (IQ). The analysis revealed that neither factor had a significant effect, nor was there a significant interaction between them. Consistent with these findings, Bayesian analyses provided evidence supporting the absence of these effects. Notably, IQ scores increased significantly from the first to the second testing day. These results suggest that neither test anxiety nor stress is significantly impacting intelligence test performance. However, improvements due to repeated testing call for caution, both in scientific and clinical settings. Full article

Background: Physical activity, metacognitive awareness, and empathy are interconnected factors that play a significant role in the overall well-being of university students. Together, these elements contribute to the development of more self-aware, emotionally intelligent, and academically engaged students. The aim of this study is to explore the relationship between physical activity, empathy, and metacognition among physiotherapy students, as well as determining whether differences exist between undergraduate and graduate students. Methods: A cross-sectional study evaluated 468 physiotherapy students using the International Physical Activity Questionnaire—short version, the Metacognitive Awareness Inventory, and a shortened version of the Empathy Quotient supplemented with demographic questions. The respondents were students of undergraduate and graduate studies of physiotherapy, were male and female, and were between the ages of 18 and 25 years. Results: Higher levels of vigorous-intensity physical activity, walking, and total physical activity are significantly associated with increases in Declarative Knowledge (p = 0.000; p = 0.001; p = 0.000), Empathy Quotient (p = 0.029; p = 0.000; p = 0.006), and Cognitive Empathy (p = 0.002; p = 0.000; p = 0.001). Undergraduate students demonstrated higher levels of Declarative Knowledge (p = 0.000), whereas graduate students scored higher in Procedural Knowledge (p = 0.020), Planning (p = 0.000), Information Management Strategies (p = 0.000), and Evaluation (p = 0.005). Undergraduate students demonstrated higher overall empathy, cognitive empathy, and social skills (p = 0.000). Conclusions: This is the first study to examine this issue in the context of physiotherapy students. Our findings highlight the importance of creating integrated programs that promote physical activity, metacognitive awareness, and empathy concurrently among physiotherapy students. Enhancing metacognitive skills through targeted educational strategies helps students strengthen their critical thinking and self-regulation, enhance academic outcomes, and better prepare students for their professional role. Full article

The impact of mercury (Hg) on biological systems is well documented; however, the long-term effects of low-level exposure in children remain unclear, particularly with respect to oxidative stress and cognitive outcomes. This study evaluated Hg exposure and its associations with the gene expression and intelligence quotient (IQ) in two Afro-descendant child populations in Colombia. Hair total mercury (T-Hg) was quantified in 163 children under 7 years old, along with their sociodemographic data. Significant differences (p < 0.05) were found in fish consumption and mean hair T-Hg concentrations between children from Mahates (2.66 ± 0.30 meals/week; 0.32 ± 0.03 µg/g) and Zanjón (1.24 ± 0.09 meals/week; 0.24 ± 0.01 µg/g). The gene expression analysis revealed higher SOD1 expression in Mahates. The mean IQ scores were higher in Zanjón (74.7) than those in Mahates (71.7). Overall, Spearman’s correlation analysis showed no significant associations (p > 0.05) between T-Hg and the measured variables. The principal component analysis (PCA) revealed a clear separation between populations: Mahates, associated with a higher mercury burden and the upregulation of stress-response genes, and Zanjón, characterized by a better cognitive performance and lower mercury exposure. These findings suggest that despite the low overall exposure and non-significant bivariate correlations, the communities displayed distinct profiles, highlighting the value of integrated molecular–cognitive biomonitoring and motivate longitudinal studies addressing co-exposures and socioeconomic confounding. Full article

Objectives: Individuals with Autism Spectrum Disorder (ASD) exhibit difficulties in the social use of language, regardless of age, cognitive abilities, and symptom severity. The left Broca’s area and adjacent cortex are crucial for socio-pragmatic language, particularly in retrieving and integrating context-dependent words. Neuroimaging studies in ASD have shown hypoactivation of the Broca’s area and an aberrant pattern of functional connectivity between language-related regions, suggesting their potential involvement in socio-communicative deficits. Given the potential of tDCS to modulate brain activity, its application targeting Broca’s areas in addition to psychological intervention may represent a promising approach for enhancing socio-communicative skills in ASD. Thus, this study aims to investigate the effect of concomitant anodal tDCS and cognitive behavioral-oriented training (CBT) on pragmatic and communicative skills in young adults with ASD. Methods: A sample of 10 ASD individuals (18–25 years) underwent treatment with both active and sham tDCS targeting the left Broca’s area during concomitant CBT. Each condition was delivered for five consecutive days, and the order of the conditions was blindly randomized. Results: Active tDCS significantly improved global communicative and pragmatic abilities compared to sham. A negative correlation was observed between communicative skills improvement and Intelligence Quotient (IQ); no significant association was found between IQ and ASD symptoms’ severity. Conclusions: Multisession tDCS targeting the left Broca’s area, combined with CBT, may enhance social language in terms of both production and comprehension of non-literal meanings, supporting Broca’s area as a central neural hub for social language. Full article

Background: There is considerable evidence that breast feeding has a beneficial effect on the neurocognition of a child. However, most studies have confined their attention to the Intelligence Quotient (IQ), tending to ignore other aspects of neurodevelopment. Methodology: Here we present the relationship between breast feeding for at least 6 months with 373 neurocognitive outcomes measured from infancy through to late adolescence using data collected in the Avon Longitudinal Study of Parents and Children (ALSPAC). We first examined unadjusted regression associations with breast feeding at age 6 months. Where the unadjusted p-value was < 0.0001 (n = 152 outcomes), we adjusted for social and other factors. Results: This resulted in 42 outcomes with adjusted associations at p < 0.001. Specifically, these included associations with full-scale IQ at ages 8 and 15 years (adjusted mean differences [95% confidence interval (CI)] +4.11 [95% CI 2.83, 5.39] and +5.12 [95% CI 3.57, 6.67] IQ points, respectively, compared to not breastfeeding for 6 months). As well as the components of IQ, the other phenotypes that were strongly related to breast feeding for at least 6 months were measures of academic ability (reading, use of the English language and mathematics). In accordance with the literature, we show that children who are breast fed are more likely to be right-handed. The one association that has not been recorded before concerned aspects of pragmatic speech at 9 years where the children who had been breast fed were shown to perform more appropriately. Conclusions: We conclude that breast feeding for at least 6 months has beneficial effects on a number of neurocognitive outcomes that are likely to play a major part in the offspring’s future life course. We point out, however, the possibility that by using such stringent p-value criteria, other valid associations may have been ignored. Full article

Graphic design and image processes have a vital role in information technologies and safe, memorable learning activities, which can meet the need for modern and visual aids in the field of education. In this article, the concepts of comparison and competition have been presented using grades or numbers obtained for two different intelligence quotient (IQ) classes of students. The two classes are categorized as learners having textual (un-visualized) and visualized aids. We use the results and outcomes of the random sampling data of the two classes in the parameters of four different, competitive, two-compartmental mathematical models. One of the compartments is for students who only learn through textual learning, and the other one is for students who have access to visualized text resources. Four of the mathematical models were solved numerically, and their grades were obtained by different iterations using the data of the mean of different random sampling tests taken for thirty months; each sampling involved thirty students. The said data are also drawn by using a neural network approach, showing the fitting curves for all the data, the training data, the validation data, and the testing data with histogram, aggression, mean square error, and absolute error. The obtained dynamics are also compared with neural network dynamics. The results of the scenario pointed out that the best results (determined through high grades) were obtained among the students of visual aid learners, as compared to textual and conventional learners. The visualized resources, constructed within the mathematics syllabus domain, may help to upgrade multidimensional mathematical education and the learning activities of intermediate-level students. For this, the findings of the present study are helpful for education policymakers: there is a directive to focus on visual-based learning, utilizing data from various surveys, profile checks, and questionnaires. Furthermore, the techniques presented in this article will be beneficial for those seeking to build a better understanding of the various methods and ideas related to mathematics education. Full article