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155 Results Found

  • Article
  • Open Access
85 Citations
13,258 Views
16 Pages

30 October 2012

Adoption of personalized medicine in practice has been slow, in part due to the lack of evidence of clinical benefit provided by these technologies. Coverage by insurers is a critical step in achieving widespread adoption of personalized medicine. In...

  • Article
  • Open Access
1,264 Views
12 Pages

Background/Objectives: Allergic rhinitis (AR) significantly affects patients’ quality of life and poses a substantial burden on healthcare systems worldwide, with its prevalence rising among pediatric populations. This study aimed to investigat...

  • Article
  • Open Access
1 Citations
2,112 Views
18 Pages

23 November 2023

When large earthquakes occur over wide areas, in addition to damage to medical facilities, the disaster response capabilities of local governments are severely compromised. There is a very high possibility that the supply–demand balance of medi...

  • Article
  • Open Access
3 Citations
3,422 Views
15 Pages

7 December 2021

Globally, 20% to 40% of medical resources are wasted, which could be avoided through professional audit of health insurance claims. The professional audit can pinpoint excessive use of unnecessary medicines and medical examinations. Taiwan’s Na...

  • Review
  • Open Access
123 Citations
17,706 Views
9 Pages

The Role of Next-Generation Sequencing in Precision Medicine: A Review of Outcomes in Oncology

  • Margaret Morash,
  • Hannah Mitchell,
  • Himisha Beltran,
  • Olivier Elemento and
  • Jyotishman Pathak

17 September 2018

Precision medicine seeks to use genomic data to help provide the right treatment to the right patient at the right time. Next-generation sequencing technology allows for the rapid and accurate sequencing of many genes at once. This technology is beco...

  • Article
  • Open Access
7 Citations
7,715 Views
22 Pages

The scope and ambitions of biomedical institutions worldwide currently working toward the integration of personalized medicine (PM) require recognizing the potential profound impact on regulatory standards and on the economic functioning and financin...

  • Review
  • Open Access
15 Citations
6,483 Views
18 Pages

12 March 2020

About one-third of adult life is spent in the workplace. The use of psychoactive substances is a major preventable cause of morbidity and mortality. The consumption of psychoactive substances during or outside working hours greatly increases the freq...

  • Article
  • Open Access
8 Citations
5,800 Views
19 Pages

Prevalence of Polyherbacy in Ambulatory Visits to Traditional Chinese Medicine Clinics in Taiwan

  • Ming-Hwai Lin,
  • Hsiao-Ting Chang,
  • Chun-Yi Tu,
  • Tzeng-Ji Chen and
  • Shinn-Jang Hwang

Patients with a polyherbal prescription are more likely to receive duplicate medications and thus suffer from adverse drug reactions. We conducted a population-based retrospective study to examine the items of Chinese herbal medicine (CHM) per prescr...

  • Article
  • Open Access
8 Citations
4,424 Views
13 Pages

The Evaluation of Professional Divisions of Traditional Chinese Medicine in Taiwan through Patient Visit Records of 2012

  • Ta-Peng Wu,
  • Cheng-Hung Tsai,
  • Yu-Ting Su,
  • Chu-Chiao Wang,
  • Tzeng-Ji Chen,
  • Ching-Mao Chang and
  • Fang-Pey Chen

For decades, professional divisions have been represented as the main structural divisions in Western medicine throughout the world. In Taiwan, medical policymakers are also interested in designing professional divisions of traditional Chinese medici...

  • Article
  • Open Access
23 Citations
6,982 Views
10 Pages

15 October 2021

Traditional Korean medicine (TKM) is formally integrated into the Korean national health system and monitored through the systematic and computerized system, which could grasp the whole medical services utilization in Korea. This study analyzed TKM r...

  • Article
  • Open Access
10 Citations
5,414 Views
11 Pages

Doctor-Shopping Behaviors among Traditional Chinese Medicine Users in Taiwan

  • Ming-Hwai Lin,
  • Hsiao-Ting Chang,
  • Chun-Yi Tu,
  • Tzeng-Ji Chen and
  • Shinn-Jang Hwang

Doctor-shopping has caused an increase in medical expense, potential to receive duplicate medications, and suffer adverse drug reactions. We carried out a population-based retrospective study aimed at examining the user patterns of traditional Chines...

  • Article
  • Open Access
3,428 Views
18 Pages

Background/Objectives: Parkinson’s disease (PD) is a major neurodegenerative condition, mainly treated using dopamine-based therapies. However, the side effects and limitations of these therapies hinder their use. This study aimed to analyze th...

  • Article
  • Open Access
3 Citations
5,465 Views
16 Pages

Usage Patterns of Traditional Chinese Medicine for Patients with Bipolar Disorder: A Population-Based Study in Taiwan

  • Shu-Ping Chen,
  • Su-Tso Yang,
  • Kai-Chieh Hu,
  • Senthil Kumaran Satyanarayanan and
  • Kuan-Pin Su

18 February 2024

Background: Patients with bipolar disorder (BD) receive traditional Chinese medicine (TCM) for clinical needs unmet with psychotropic medications. However, the clinical characteristics of practices and outcomes of TCM in BD are not fully understood....

  • Article
  • Open Access
256 Views
20 Pages

18 November 2025

Background: National Health Insurance Herbal prescriptions (NHPs) are widely used; however, their multi-component composition complicates mechanistic interpretation and impedes the development of evidence-based approaches in traditional medicine and...

  • Article
  • Open Access
6 Citations
3,837 Views
17 Pages

The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea

  • Hyeonseok Noh,
  • Jeongju Jang,
  • Seungwon Kwon,
  • Seung-Yeon Cho,
  • Woo-Sang Jung,
  • Sang-Kwan Moon,
  • Jung-Mi Park,
  • Chang-Nam Ko,
  • Ho Kim and
  • Seong-Uk Park

28 July 2020

We aimed to investigate the association between Korean medicine (KM) treatment and the risk of Parkinson’s Disease (PD) in patients with inflammatory bowel disease (IBD) in South Korea. This study analyzed data from the National Health Insuranc...

  • Article
  • Open Access
9 Citations
6,142 Views
14 Pages

30 June 2022

Background and objectives: Traditional Chinese medicines (TCMs) are widely prescribed to relieve ischemic heart disease (IHD); however, no cohort studies have been conducted on the use of TCMs for patients with IHD. The aim of the study was to analyz...

  • Article
  • Open Access
11 Citations
7,941 Views
30 Pages

Essential Medicines in Universal Health Coverage: A Scoping Review of Public Health Law Interventions and How They Are Measured in Five Middle-Income Countries

  • Katrina Perehudoff,
  • Ivan Demchenko,
  • Nikita V. Alexandrov,
  • David Brutsaert,
  • Angela Ackon,
  • Carlos E. Durán,
  • Faris El-Dahiyat,
  • Firdaus Hafidz,
  • Rezwan Haque and
  • Rabia Hussain
  • + 3 authors

Very few studies exist of legal interventions (national laws) for essential medicines as part of universal health coverage in middle-income countries, or how the effect of these laws is measured. This study aims to critically assess whether laws rela...

  • Review
  • Open Access
18 Citations
17,031 Views
15 Pages

18 February 2022

For the last few decades, medical guidelines have recommended treating patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with graded exercise therapy (GET) and cognitive behavioural therapy (CBT). Moreover, doctors have questi...

  • Article
  • Open Access
11 Citations
3,081 Views
10 Pages

31 July 2022

As genetic testing becomes increasingly incorporated into clinical practice to aid in both the diagnosis and risk assessment of genetic diseases, patients benefit from genetic counseling to support their understanding of test results either before an...

  • Article
  • Open Access
5 Citations
3,152 Views
10 Pages

15 July 2022

Genetic testing is increasingly used in clinical practice to assist with the diagnosis of genetic diseases and/or provide information about disease risk, and genetic counseling supports patient understanding of test results before and/or after geneti...

  • Article
  • Open Access
5 Citations
12,727 Views
16 Pages

Over the past few decades, healthcare expenditures in the United States have increased due to a variety of different factors. Depending on their insurance plans, Americans have varying levels of health insurance coverage and may need to make co-payme...

  • Article
  • Open Access
10 Citations
2,953 Views
16 Pages

Objective: The affordability of rare disease drugs has become a social issue that cannot be ignored. This study aims to evaluate the current price and affordability of rare disease drugs in China, with evidence from Shandong province. Methods: Data o...

  • Article
  • Open Access
1 Citations
1,204 Views
16 Pages

Access to Orphan Medicinal Products in Bulgaria: An Analysis of the Positive Drug List and Individual Access Schemes

  • Rumen Stefanov,
  • Ralitsa Raycheva,
  • Kostadin Kostadinov,
  • Georgi Stefanov,
  • Iva Zdravkova-Aneva,
  • Elizabet Dzhambazova and
  • Georgi Iskrov

9 September 2025

Background/Objectives: Orphan medicinal products offer essential treatments for rare diseases, but patient access varies across European Union countries despite a common regulatory framework. In Bulgaria, access is primarily through inclusion in the...

  • Article
  • Open Access

Economic Impact of a Precision Nutrition Digital Therapeutic on Employer Health Costs: A Multi-Employer and Multi-Year Claims Analysis

  • Inti Pedroso,
  • Santosh Kumar Saravanan,
  • Shreyas Vivek Kumbhare,
  • Garima Sharma,
  • Daniel Eduardo Almonacid and
  • Ranjan Sinha

2 December 2025

Background: Obesity, gastrointestinal disorders, and mental health conditions are major drivers of employer healthcare expenditures, yet nutrition-focused interventions are infrequently reimbursed by health insurance. Precision nutrition, which integ...

  • Article
  • Open Access
1 Citations
3,997 Views
21 Pages

Many universal health care systems have increased the share of the price of medicines paid by the patient to reduce the cost pressure faced after the Great Recession. This paper assesses the impact of cost-sharing changes on the propensity to consume...

  • Article
  • Open Access
2,922 Views
10 Pages

Pandemic Financial Stress in Dental Medicine in Croatia

  • Edi Orlic,
  • Stjepan Spalj,
  • Natasa Ivancic Jokic,
  • Danko Bakarcic,
  • Odri Cicvaric and
  • Renata Grzic

27 December 2022

The aim of this cross-sectional research was to investigate how the COVID-19 pandemic affected the activity of dental medicine in the Republic of Croatia in 2020. It included 136 doctors of dental medicine who completed an online survey regarding the...

  • Article
  • Open Access
1,833 Views
11 Pages

This study is the first to examine factors in the utilization of physician services, dentist services, hospital care, and prescribed medications focusing exclusively on insured children in the United States. Data describing 48,660 insured children we...

  • Article
  • Open Access
7 Citations
7,841 Views
10 Pages

4 July 2022

Background: Owners often feel the cost of veterinary care is too high, as there remains a limited understanding of the cost of health care in human and veterinary medicine alike. Pet health insurance is often seen as a universal solution. However, es...

  • Article
  • Open Access
7 Citations
2,536 Views
13 Pages

Functional dyspepsia (FD) significantly reduces quality of life, and Korean medicine treatment, including herbal medicine, is frequently used in the clinical setting. We aimed to analyze the factors affecting Korean medicine health care (KMHC) use fo...

  • Article
  • Open Access
3 Citations
2,019 Views
14 Pages

Adaptation and Dissemination of Korean Medicine Clinical Practice Guidelines for Traffic Injuries

  • Kyeong-Tae Lim,
  • Hyun-Tae Kim,
  • Eui-Hyoung Hwang,
  • Man-Suk Hwang,
  • In Heo,
  • Sun-Young Park,
  • Jae-Heung Cho,
  • Koh-Woon Kim,
  • In-Hyuk Ha and
  • Me-riong Kim
  • + 4 authors

In South Korea, car insurance that includes medical coverage of traditional Korean medicine (TKM) has increased exponentially. Clinical practice guidelines (CPG) for traffic injuries were established in 2016. We aimed to revise and update de novo CPG...

  • Review
  • Open Access
4 Citations
3,392 Views
19 Pages

Importance and Reality of TDM for Antibiotics Not Covered by Insurance in Japan

  • Fumiya Ebihara,
  • Yukihiro Hamada,
  • Hideo Kato,
  • Takumi Maruyama and
  • Toshimi Kimura

Under the Japanese health insurance system, medicines undergoing therapeutic drug monitoring (TDM) can be billed for medical fees if they meet the specified requirements. In Japan, TDM of vancomycin, teicoplanin, aminoglycosides, and voriconazole, wh...

  • Article
  • Open Access
5 Citations
5,275 Views
10 Pages

Characteristics of Clinics without National Health Insurance Contracts: A Nationwide Survey in Taiwan

  • Pei-Jyun Lu,
  • Jui-Yao Liu,
  • Hsin Ma,
  • Tzeng-Ji Chen,
  • Li-Fang Chou and
  • Shinn-Jang Hwang

Based on the 1978 Alma-Ata Declaration, the key to achieving health for all is primary health care, and many countries have established various comprehensive health care systems. Because of the financial toll of a public health care system, governmen...

  • Article
  • Open Access
1 Citations
2,140 Views
9 Pages

Inappropriate antimicrobial use is a global problem, especially because the use of antimicrobials in excess of appropriate doses is associated with increased antimicrobial resistance. Duplicate prescriptions are an issue contributing to inappropriate...

  • Article
  • Open Access
3 Citations
2,282 Views
14 Pages

28 October 2022

(1) Insomnia is associated with poor quality of life and loss of productivity, and is a significant economic burden on society. Gamiguibi-tang (GGBT) is the most frequently prescribed herbal medicine for insomnia treatment. Hwangryunhaedok-tang (HHT)...

  • Review
  • Open Access
12 Citations
5,703 Views
21 Pages

The goal of the Patient Protection and Affordable Care Act (ACA) is to increase access to health insurance and decrease health care cost while improving health care quality. With more articles examining the relationship between one of the ACA provisi...

  • Opinion
  • Open Access
3 Citations
1,775 Views
9 Pages

The Right to Oncological Oblivion: A Legislative Response to Cancer Survivor Discrimination in Italy

  • Gianpiero D’Antonio,
  • Ginevra Bolino,
  • Letizia Sorace,
  • Gianpietro Volonnino,
  • Lavinia Pellegrini,
  • Nicola Di Fazio and
  • Paola Frati

21 August 2024

Despite the increasing efficacy of modern medicine in diagnosing and treating cancer, survivors often face discrimination in employment, economics, insurance, and society. Law no. 193/2023, also known as the “Oncological Oblivion Law”, ai...

  • Article
  • Open Access
32 Citations
4,695 Views
22 Pages

Objectives: With the increasing incidence of cancer, poor access to affordable anticancer medicines has been a serious public health problem in China. To help address this issue, we assessed the availability, price and affordability of pharmacotherap...

  • Feature Paper
  • Article
  • Open Access
38 Citations
8,766 Views
14 Pages

Clients’ Experience and Satisfaction of Utilizing Healthcare Services in a Community Based Health Insurance Program in Bangladesh

  • Abdur Razzaque Sarker,
  • Marufa Sultana,
  • Sayem Ahmed,
  • Rashidul Alam Mahumud,
  • Alec Morton and
  • Jahangir A.M. Khan

Background: Community-based health insurance is recognized as a promising tool for health system improvement for low-income people that improves the health status of enrolees and enhances productivity and labor supply. The experience and opinion of t...

  • Article
  • Open Access
12 Citations
4,801 Views
12 Pages

Unmet Healthcare Needs and Associated Factors in Rural and Suburban Vietnam: A Cross-Sectional Study

  • Ju Young Kim,
  • Dae In Kim,
  • Hwa Yeon Park,
  • Yuliya Pak,
  • Phap Ngoc Hoang Tran,
  • Truc Thanh Thai,
  • Mai Thi Thanh Thuy and
  • Do Van Dung

The purpose of this study was to examine the current utilization of healthcare services, exploring unmet healthcare needs and the associated factors among people living in rural Vietnam. This cross-sectional study was conducted with 233 participants...

  • Article
  • Open Access
4 Citations
6,491 Views
13 Pages

The Implementation Process for Pharmacogenomic Testing for Cancer-Targeted Therapies

  • Ann Chen Wu,
  • Kathleen M. Mazor,
  • Rachel Ceccarelli,
  • Stephanie Loomer and
  • Christine Y. Lu

1 October 2018

Recent advances in genomic medicine have led to the availability of genomic tests that have the potential to improve population health, yet the process for obtaining these tests and getting them reimbursed by insurers has not been described. The obje...

  • Article
  • Open Access
1 Citations
3,641 Views
13 Pages

26 June 2024

The current research, guided by the intersectionality theory and the Institute of Medicine’s healthcare access model, explored the determinants of preventive care utilization within the Asian American community. Analyzing data from the Asian Am...

  • Article
  • Open Access
6 Citations
3,975 Views
19 Pages

Affordability Assessment from a Static to Dynamic Concept: A Scenario-Based Assessment of Cardiovascular Medicines

  • Leila Zarei,
  • Iman Karimzadeh,
  • Najmeh Moradi,
  • Payam Peymani,
  • Sara Asadi and
  • Zaheer-Ud-Din Babar

The out-of-pocket payments for prescription medications can impose a financial burden on patients from low- and middle- incomes and who suffer from chronic diseases. The present study aims at evaluating the affordability of cardiovascular disease (CV...

  • Article
  • Open Access
4,772 Views
18 Pages

26 September 2017

Based on detailed shipping figures for Suriname’s main harbour in Paramaribo, we estimate the total shipments (in kilograms) of original and falsified medical products for 1996–2008 across five product categories. Using various time series techniques...

  • Review
  • Open Access
11 Citations
2,639 Views
14 Pages

Endoscopic Ultrasound-Guided Tissue Acquisition of Pancreaticobiliary Cancer Aiming for a Comprehensive Genome Profile

  • Susumu Hijioka,
  • Yoshikuni Nagashio,
  • Yuta Maruki,
  • Yuki Kawasaki,
  • Kotaro Takeshita,
  • Chigusa Morizane and
  • Takuji Okusaka

In recent years, cancer genomic medicine centered on comprehensive genome profile (CGP) analysis has become widely used in the field of pancreatic cancer. Endoscopic ultrasound-guided tissue acquisition (EUS-TA) has played an important role in pancre...

  • Article
  • Open Access
21 Citations
5,644 Views
10 Pages

Prescribing Patterns in Outpatient Clinics of Township Hospitals in China: A Comparative Study before and after the 2009 Health System Reform

  • Ding Ding,
  • Qingxia Pan,
  • Linghan Shan,
  • Chaojie Liu,
  • Lijun Gao,
  • Yanhua Hao,
  • Jian Song,
  • Ning Ning,
  • Yu Cui and
  • Ye Li
  • + 4 authors

Objective: China introduced a series of health reforms in 2009, including a national essential medicines policy and a medical insurance system for primary care institutions. This study aimed to determine the changing prescribing patterns associated w...

  • Article
  • Open Access
27 Citations
12,068 Views
22 Pages

The aim of our research was to collect comprehensive data about the public and physician awareness, acceptance and use of Personalized Medicine (PM), as well as their opinions on PM reimbursement and genetic privacy protection in the U.S. and Germany...

  • Article
  • Open Access
23 Citations
4,314 Views
13 Pages

Background: This study aims (1) to assess socioeconomic disparities in healthcare use and catastrophic health expenditure (CHE) among cancer patients in China, which is defined as the point at which annual household health payments exceeded 40% of no...

  • Review
  • Open Access
7 Citations
1,573 Views
17 Pages

Pharmaceutical Pricing and Reimbursement Policies in Algeria, Morocco, and Tunisia: Comparative Analysis

  • Hajer Dahmani,
  • Ines Fradi,
  • Leila Achour,
  • Mondher Toumi and
  • Maghreb Research Group

Objectives: In this paper, we outline and compare pharmaceutical pricing and reimbursement policies for in-patent prescription medicines in three Maghreb countries, Algeria, Morocco, and Tunisia, and explore possible improvements in their pricing and...

  • Article
  • Open Access
8 Citations
3,188 Views
10 Pages

This study aimed to determine and describe the prevalence of combination antibiotics dispensed in outpatients with health insurance in Syria. Data on all dispensed medicines between June 2018 and May 2019 for 81,314 adults were obtained, and medicine...

  • Article
  • Open Access
6 Citations
2,163 Views
11 Pages

16 August 2022

Given the increasing prevalence of tinnitus and expenditure related to its treatment, it is important to identify the efficacy of different treatment methods used for its diagnosis and treatment. To this end, this study analyzed the trends of medical...

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