Search Results (5,386)

Vertical land motion in urban areas is a critical manifestation of groundwater, directly affecting infrastructure stability and groundwater sustainability. While land subsidence caused by groundwater extraction has been widely investigated, the opposite process—surface uplift induced by groundwater recovery—remains poorly documented or understood, particularly regarding its hydrological mechanisms and potential hazards. Here, we integrate InSAR time-series analysis of Sentinel-1 imagery (2017–2025) with groundwater well records to quantify the spatial–temporal characteristics of uplift in Xi’an, China, and to evaluate its hydrogeological drivers. Results reveal a persistent surface uplift zone south of the ancient city in Xi’an, with rates up to 20 mm/yr. The uplift correlates closely with rising groundwater levels in the shallow confined aquifer, indicating a strong coupling between aquifer recharge and surface uplift. Calculated storage coefficients and hydraulic diffusivity values highlight marked spatial variations, constrained by some ground fissures that act as both mechanical discontinuities and hydrological barriers controlling pressure diffusion. Time-series analysis further identifies the eastward propagation of subsidence-to-uplift reversal in Yuhuazhai, an urban village with groundwater injection, which is used to quantify the diffusivity coefficients. Field investigations show that rapid groundwater rebound can lead to uplift-related hazards, such as basement seepage, underscoring that surface uplift must be considered alongside subsidence in urban water management. Full article

Background: Post-stroke neuropathic pain, particularly central post-stroke pain and facial pain syndromes, continues to be challenging to manage with conventional pharmacological approaches. While botulinum toxin A (BoNT-A) is well established for treating spasticity after stroke, its use in the management of central neuropathic pain remains less well established. Methods: This report presents two cases of patients with refractory neuropathic pain following ischemic cerebrovascular accidents who achieved significant pain relief through subcutaneous botulinum toxin administration, after failure of multiple conventional and intramuscular BoNT-A approaches. Results: Case 1 involves a 66-year-old patient with 18 years of post-stroke hemicorporeal pain who responded dramatically to subcutaneous BoNT-A injections after extensive prior treatment failures. Case 2 describes a 54-year-old with trigeminal-region and mandibular pain following ICA dissection who achieved complete pain resolution at facial sites with subcutaneous administration of BoNT-A. Conclusions: These cases demonstrate the potential efficacy of subcutaneous botulinum toxin for managing post-stroke neuropathic pain in selected patients and suggest a mechanism of action related to peripheral pain sensitization rather than motor denervation. Our findings support further investigation of subcutaneous administration techniques for pain management in specialized centers. Full article

The capacitance resistance model (CRM) is an analytical tool widely used to forecast reservoir performance in enhanced oil recovery (EOR) methods. By representing flow dynamics and the connectivity between injection and production wells through the parameter of interwell connectivity, CRM offers fast computational processing and minimal input data requirements. These advantages make CRM a practical alternative for rapid reservoir analysis, especially when full-scale numerical simulations are infeasible due to time and budget constraints. CRM, rooted in material balance and productivity equations, uses injection/production rates and bottom-hole pressure data to construct reservoir models through optimization techniques, which can then be combined with oil fractional flow models for predictive purposes. Initially designed for waterflooding operations, CRM has seen limited but promising applications in gas injection projects, where research remains incomplete. This study presents a new formulation of CRM tailored for immiscible gas injection, incorporating the pseudo-pressure concept coupled with a saturation profile. The pseudo-pressure concept is a mathematical transformation that linearizes gas flow equations by accounting for variations in gas compressibility and viscosity with pressure. The proposed CRM was evaluated using a PUNQ-S3 benchmark reservoir model in the CMG IMEX black oil simulator, involving two injectors and four producers. History- matching results for fluid production rates showed that the newly developed CRM achieved the lowest NRMSE, outperforming other CRM models across a wide range of reservoir properties. Sensitivity analyses were conducted to examine the effects of gas and oil PVT properties on the model’s performance. The newly developed CRM, incorporating the pseudo-pressure concept and saturation profiles, demonstrates superior performance in predicting fluid production rates, achieving an average NRMSE of 15.3% in a base case scenario, compared to other tested CRM models. Additionally, the sensitivity analysis on the effect of fluid properties shows that higher gas viscosity, lower gas formation volume factor, and increasing oil API gravity improve the CRM model’s performance, and under all tested conditions the newly developed CRM provides the most accurate production history match. This study not only establishes the new CRM as a robust and accurate predictive tool for immiscible gas injection but also provides a comprehensive discussion on reservoir parameter ranges and model limitations, advancing the applicability of CRM in EOR processes. Full article

This study presents a wavelet-based framework for mapping inter-well connectivity (IWC) between multiple injectors and producers to support waterflood optimization. The method applies Cross-Wavelet Transform Coherence (CrWTC) with a complex Morlet wavelet to injection and production rate data, enabling the time-localized and frequency-dependent identification of dynamic injector–producer communication. The novelty of this work lies in continuous coherence mapping, the use of the complex Morlet wavelet for improved sensitivity to nonstationary responses, continuous updating as new data become available, and benchmarking on both the Volve and COSTA datasets. Validation using reservoir simulation and field data showed strong qualitative agreement with expected connectivity behavior and demonstrated clearer tracking of connectivity evolution and waterfront movement than the Capacitance Resistance Method (CRM). The proposed approach improves the reliability and interpretability of IWC assessment and offers a practical tool for reservoir surveillance and waterflood management. Full article

Distributed fiber optic temperature sensing (DTS) monitoring technology is increasingly widely applied in oil reservoir water injection development. However, existing DTS interpretation methods for layered water injection processes have insufficiently considered the effects of multilayer injection and reservoir damage. To address this issue, this paper takes into account interlayer heterogeneity and reservoir damage and, based on the laws of conservation of mass and energy, comprehensively incorporates the effects of friction, the Joule–Thomson effect, thermal convection, and thermal expansion. By coupling wellbore pipe flow with formation seepage, a temperature profile prediction model for multilayer water absorption under steady-state water injection conditions is established. Comparative validation against classical models such as those by Babak and Nowak demonstrates that the proposed model achieves high computational accuracy. Using this model, the influence patterns of injection rate, tubing diameter, formation coefficient, and skin factor on wellbore temperature distribution are systematically analyzed: a higher injection rate leads to a smaller temperature rise in the injected water; a larger tubing diameter results in a greater temperature rise; the formation coefficient affects the temperature profile by regulating interlayer water absorption distribution, while reservoir damage (skin factor) has a relatively limited direct impact on the temperature profile. The model is applied to interpret DTS field data from Well A, and the water absorption rate of each sublayer is quantitatively obtained: the main water absorbing intervals are 1878.7–1897.5 m and 1919.5–1950.6 m, with water absorption accounting for 30.57% and 24.28% of the total injection rate, respectively, while the remaining intervals exhibit secondary water absorption. These interpretation results are in good agreement with earlier oxygen activation tests. This study provides a theoretical basis and analytical method for applying distributed fiber optic temperature measurement technology to monitor water absorption profiles in multilayer injection wells. Full article

Background: Neovascular age-related macular degeneration (nAMD) is a progressive chronic disease that represents a major cause of irreversible vision loss worldwide. In this study we aim to assess the short-term functional and anatomical outcomes of brolucizumab therapy in treatment-naïve patients with nAMD presenting with low baseline visual acuity in a single institution setting. Methods: This is a prospective non-randomized study that included 154 treatment-naïve eyes with low baseline visual acuity. We measured visual outcomes (BCVA, logMAR) and structural outcomes (CST, μm). We also stratified the study population into respective age subgroups to evaluate any possible trend between outcome changes and age differences. BCVA and CST were measured at baseline, at each consecutive month (month 1, 2 and 3) of the loading phase, as well as at the final timepoint (6 months). Intraocular pressure (IOP) before and after injection, as well as the incidence of serious adverse events, were monitored throughout the study. Results: Mean BCVA improved by 0.41 logMAR (+20 ETDRS letters) after the first injection, 0.65 logMAR (+32 letters) after the second, and reached a maximum improvement of 0.80 logMAR after the third injection. The most important BCVA improvement was seen in younger patients (<50 years), with mean BCVA decreasing from approximately 1.0 logMAR at baseline to around 0.3–0.4 logMAR at the final measurement. Mean CST declined by 45.5 μm after the first injection, 78.5 μm after the second, 117.8 μm after the third, and 143.6 μm at the final timepoint, indicating a pronounced anatomical response to intravitreal brolucizumab therapy. Conclusions: In conclusion, this study demonstrates that brolucizumab therapy provides significant short-term anatomical and functional improvements in treatment-naïve patients with nAMD and poor baseline visual acuity. Baseline visual acuity, treatment-naïve status, and patient age appear to be key determinants of visual gain. Full article

Retinopathy of Prematurity (ROP) affects preterm infants worldwide, involving abnormal development of retinal blood vessels associated with supplemental oxygen use in neonatal care. Although there have been strides in identifying at-risk infants, implementing early screening, updating disease criteria through the International Classification of Retinopathy of Prematurity (ICROP), and developing new therapies, ROP remains a leading cause of preventable blindness. As preterm birth survival rates rise, the incidence of ROP continues to increase and is projected to rise even in countries with abundant resources and well-established care programs. Improving ROP care requires global standardization of screening, diagnosis, and management to prevent missed diagnoses and minimize outcome variability. Intravitreal anti-vascular endothelial growth factor (VEGF) injections are changing the landscape of ROP management, but longitudinal research is needed to determine their long-term safety in preterm infants. Effective ROP management relies on teamwork across disciplines and open communication with parents. Given that parents are lifelong caregivers of a child who may be affected by ROP-related vision impairment, including them in the care team and encouraging psychosocial support is vital. Socioeconomic disparities and limited access to ROP-trained ophthalmologists exacerbate disease burden, underscoring the need for innovative solutions to improve access to care. This perspective emphasizes the importance of globally standardizing ROP prevention and care, noting that efforts are still incomplete, equitable access has not been realized, and the long-term role of anti-VEGF agents in ROP treatment remains unclear. Full article

Purpose: To evaluate the safety and feasibility of repeated subtenon administration of autologous platelet-rich plasma (PRP) in patients with degenerative retinal diseases and to explore preliminary, hypothesis-generating functional observations in retinitis pigmentosa (RP) and extensive macular atrophy with pseudodrusen-like appearance (EMAP). Methods: This prospective, open-label, uncontrolled pilot study included 13 patients (6 RP, 7 EMAP) who received three subtenon PRP injections (1.5 mL each) at baseline, Month 2, and Month 4, with follow-up through Month 6. The study was designed primarily to assess safety and feasibility and was not powered or intended to evaluate efficacy. The primary outcome was safety, including adverse events and intraocular pressure changes. Exploratory secondary outcomes included best-corrected visual acuity (BCVA, logMAR), visual field mean deviation (MD), and structural optical coherence tomography (OCT) parameters. Electrophysiological outcomes were analyzed descriptively due to incomplete paired data. Analyses were conducted within diagnostic groups, and no between-group comparisons were performed. Results: All 13 patients completed the study. No serious adverse events or permanent ocular morbidity were observed. Two transient and self-limited adverse events occurred (anterior uveitis and intraocular pressure elevation), both resolving without sequelae. In the overall cohort, BCVA remained stable without statistically significant change. In the RP subgroup, a small exploratory change in BCVA was observed (mean ΔlogMAR −0.09; nominal p = 0.048), corresponding to approximately 4–5 ETDRS letters; however, this finding was associated with wide confidence intervals and limited statistical power and should be interpreted cautiously. In the EMAP subgroup, functional stability was observed without evidence of consistent improvement. Visual field mean deviation and OCT findings were consistent with absence of short-term deterioration across available paired data. Electrophysiological outcomes showed no consistent directional change. Conclusions: Repeated subtenon PRP administration appeared feasible and well tolerated in this small, uncontrolled pilot cohort. Any observed functional changes are preliminary and hypothesis-generating only and do not establish efficacy. Larger, adequately powered controlled studies with standardized endpoints are required to determine the potential role of PRP in degenerative retinal diseases. Full article

In the current environmental and political scenario, hybrid vehicles play crucial roles in the transition to sustainable mobility. The role of internal combustion engines (ICEs) is also of utmost importance to comply with the even more stringent emissions regulations. To that end, also considering the need for increased power density in ICEs, turbocharging allows for improved performance and reduced emissions. Within this context, the present paper introduces the novelties of a patented turbo compound layout with supercharging capabilities, i.e., the Turbo Generator Electric Multistage Supercharger (TGEMS) system. The analysis also allowed for providing evidence of a “backpressure supercompensation effect” associated with rising exhaust backpressure in the ICE. TGEMS introduces a novel compressor group decoupled from the turbine. The analyses were carried out on a 2.0 L turbocharged gasoline direct injection engine. The “supercompensation” phenomenon was isolated using a stepwise procedure in which TGEMS was initially applied to the baseline engine to be exploited on a modified configuration featuring a downscaled turbine. The results were analyzed from the perspectives of specific fuel consumption reduction and total power output as well as operating flexibility increase. The results indicate that, in a context like TGEMS, the assumption that rising exhaust backpressure is always penalizing is no longer valid. Under higher backpressure conditions, TGEMS alone achieved −4.92% in specific fuel consumption at 5000 rpm, with +8.75% in maximum power output. Moreover, with the configuration with a downscaled turbine and the possibility to control the engine operating line, specific fuel consumption reductions of −7.93% at 5000 rpm and −6.83% at 3000 rpm were achieved. The maximum power output increment was +11.04%. These outcomes could open up to new downsizing perspectives and a new generation of “super-backpressured engines”. Full article

Erectile dysfunction (ED) is a common multifactorial condition with significant physical, psychological and relational consequences. While historically associated with aging, its rising prevalence among younger men underscores the need for updated diagnostic and therapeutic frameworks. This narrative review synthesizes contemporary evidence on the pathophysiology, diagnostic workup and management of ED, with emphasis on guideline-directed care and emerging treatment modalities. A comprehensive literature search was conducted, with evidence synthesized from key clinical guidelines, landmark trials and recent peer-reviewed studies. Lifestyle optimization remains the foundational step, followed by first-line pharmacotherapy with phosphodiesterase type 5 inhibitors (PDE5is), which demonstrate high efficacy and safety across diverse patient populations. For patients with inadequate PDE5is response, second-line options include alprostadil (intracavernosal, with approximately 70% success rates or intraurethral), vacuum erection devices and penile prosthesis surgery, with patient and partner satisfaction exceeding 95% for the latter when performed in experienced centers. Psychosexual therapy is an integral adjunct, particularly in psychogenic or mixed etiologies. Regenerative approaches such as low-intensity extracorporeal shockwave therapy (Li-SWT) and platelet-rich plasma (PRP) injections are under investigation; current evidence supports their use only in experimental settings due to limited long-term data. A multidisciplinary, individualized strategy—incorporating pharmacologic, surgical and psychosocial interventions—remains the cornerstone of modern ED management. This review critically distinguishes well-established evidence from ongoing clinical debates and translates findings into practical guidance for daily practice. Ongoing technological advances may further refine diagnostic accuracy and treatment personalization, but high-quality studies are needed to establish the role of regenerative and digital tools. Full article

In order to reveal the stress sensitivity characteristics of the Kuqa deep gas reservoir, this study investigates the problem from two complementary aspects. First, conventional variable confining pressure experiments and well-test interpretation are employed to clarify the basic stress sensitivity characteristics of the Kela 2 gas field under conditions of monotonically increasing effective stress. Second, considering that field operations such as gas injection and temperature rise may cause periodic pore-pressure fluctuations under nearly constant overburden pressure, this paper establishes a novel physical simulation method for multi-round charging and depletion recovery to investigate the additional reservoir responses under cyclic effective-stress evolution. The results show that (1) when the confining pressure increases from 5 MPa~40 MPa, the permeability of the core generally decreases, with a decrease of 5~85%. In contrast, the porosity decreased by only 2% to 12%. The number of cores with conventional air permeability greater than or equal to 1 mD in the Kela 2 gas field reservoir accounts for 63.4%. The stress sensitivity causes the permeability to decrease by less than or equal to 40%, and the overall stress sensitivity is not strong. (2) Post-test observations showed fracture development in some cores after the experiment, indicating that during the gas reservoir mining process, the stress cycle changes will cause some closed cracks in the core to reopen or produce new cracks, which will play a role in increasing permeability. After the crack is opened, the comprehensive recovery degree at the end of the stable production period increases by 21.7 percentage points, and 9.9 percentage points increase the comprehensive recovery degree at the end of the abandoned production. (3) The new understanding of this experiment has changed the traditional understanding that stress sensitivity can only lead to reservoir damage, and also pointed out a new technical direction for the field to improve reservoir physical properties and enhance oil recovery by changing stress effects such as heating-condensation, intermittent gas injection, and directional blasting. Full article

Background: Osteoporosis is a chronic bone disease characterized by reduced bone mass and structural deterioration, increasing fracture risk and affecting patients’ quality of life (QoL). Pharmacological treatments are essential in managing osteoporosis; however, suboptimal prescribing patterns and poor medication adherence can limit therapeutic outcomes. This study primarily aimed to assess medication adherence among patients with osteoporosis using the MMAS-8, as well as prescribing patterns and patient beliefs. Methods: We conducted a single-center cross-sectional observational study at Saqr Hospital, Ras al Khaimah, UAE, between October 2024 and May 2025, enrolling 300 adults with clinically diagnosed osteoporosis and/or a bone mineral density T-score ≤ −2.5. Data were collected through structured interviews and medical-record review. Medication adherence was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8), and beliefs about medicines were measured using the Beliefs about Medicines Questionnaire (BMQ). Prescribing patterns were characterized by drug class, dose, and frequency, and prescribing appropriateness was evaluated using prescribed daily dose/defined daily dose (PDD/DDD) ratios based on WHO ATC/DDD standards. Predictors of adherence were examined using univariate and multivariable Firth penalized logistic regression. Results: The median age was 70 years (IQR 63–76), 89.0% of participants were female, and 32.0% had a prior fracture history. Denosumab was the most frequently prescribed anti-osteoporotic therapy (59.0%), followed by romosozumab (30.7%), whereas bisphosphonates and parathyroid hormone analogues were infrequently used (2.7% and 4.7%, respectively). Prescribed dosing closely aligned with WHO standards for all evaluated agents. Overall, 40.7% of patients were classified as adherent and 59.3% as non-adherent. Adherence was not significantly associated with age, gender, nationality, fracture history, polypharmacy, or most comorbidities. In contrast, medication beliefs demonstrated a strong relationship with adherence. In multivariable Firth regression, stronger medication concerns were independently associated with lower odds of adherence (adjusted OR 0.033, 95% CI 0.003–0.355; p = 0.0049), while having more than two comorbidities was also associated with reduced adherence (adjusted OR 0.076, 95% CI 0.008–0.688; p = 0.022). Conclusions: In this UAE real-world cohort, osteoporosis pharmacotherapy was dominated by injectable biologic agents and was prescribed in close agreement with standard dosing recommendations. However, medication adherence remained suboptimal. Patient beliefs, particularly treatment-related concerns, emerged as a more important determinant of adherence than demographic or most clinical characteristics. These findings highlight the need for belief-sensitive, patient-centered adherence interventions alongside optimized pharmacotherapy to improve osteoporosis outcomes in routine practice. Full article

Addressing the problem of limited methane (CH₄) recovery degree under different production conditions in a target low-permeability carbonate gas reservoir, this study intends to further investigate the effect of carbon dioxide (CO₂) injection on enhanced gas recovery (EGR). A group of long-core physical simulation experiments of CO₂ injection for EGR was adopted. Field injection–production parameters were converted to laboratory conditions through similarity criteria to simulate the actual production process of gas wells. Systematic experiments on CH₄ depletion and CO₂ displacement were carried out under different irreducible water saturation, gas injection timing pressure and injection rates. The influence laws of each key parameter on the CO₂ breakthrough time and CH₄ recovery degree were analyzed emphatically, and the optimal injection–production scheme was obtained. For the target low-permeability carbonate gas reservoir (permeability < 1 mD), the optimal CO₂ injection scheme is as follows: for layers with medium to high irreducible water saturation (≥40%), CO₂ injection at a rate of 36,000 m³/d per well after the end of stable production (formation pressure > 7.38 MPa) can increase the CH₄ recovery degree by 3–5%. This study provides experimental support for the optimization of CO₂ injection schemes for enhanced recovery in gas reservoirs and the adjustment of gas reservoir development strategies under different irreducible water saturation conditions. Full article

Induced seismicity is a recognized challenge in hot dry rock (HDR) geothermal development. Based on a systematic review of previous studies on induced seismicity mechanisms, characteristics, risk assessment, and mitigation measures, we compiled publicly available data from 13 HDR projects worldwide. Our statistical analysis shows that felt earthquakes occurred in 62% of the projects, and a post-injection “tailing effect” was observed in 54% of the projects. The spatial influence range of induced seismicity is typically within 2 km of the injection well, and the duration of the “Kaiser effect” varies from months to years depending on local conditions. A cross-site comparison of injection parameters suggests that the maximum wellhead pressure may be a more useful indicator than injected volume for estimating the largest possible earthquake magnitude, especially when comparing different tectonic settings. Furthermore, we examine the applicability and limitations of b-value trends, seismogenic indices, and existing maximum magnitude prediction models in seismic risk assessment. Dynamic adjustment of injection parameters based on real-time risk indicators, combined with safer injection schemes, may represent an important research direction for improving the conventional traffic light system. These findings provide a data-driven basis for site-specific safety management of HDR development. Full article

Microscopic pore structure strongly controls hydrocarbon storage and flow in carbonate reservoirs, but objective and continuous pore-type classification remains difficult because carbonate pore systems are multiscale, heterogeneous, and commonly interpreted using experience-based criteria. This study develops a reproducible workflow that integrates 912 mercury-intrusion capillary pressure (MICP) datasets from 34 wells with 474 paired thin-section and core-photograph observations from the S oilfield. Principal component analysis (PCA) reduces eight pore-structure parameters to three interpretable components that describe pore-throat scale, distribution uniformity, and connectivity/displacement behavior, retaining 87.63% of the total variance. K-means clustering identifies four pore types for dolomite and four for limestone, with k = 4 selected using the elbow criterion, silhouette coefficient, centroid interpretability, and petrographic consistency. Modified injection-to-final-state analysis (MIFA) is used as an internal MICP-based consistency check rather than as a fully independent validation; paired micro-observations provide cross-scale validation with 81.22% agreement. Lithology-constrained GR, SP, and AC response windows are then used for intra-field upscaling to uncored intervals, and field-scale back-checking shows 87% agreement with existing geological interpretations. The workflow reduces interpreter subjectivity, provides physically interpretable pore-type criteria, and is applicable to carbonate reservoirs with comparable MICP, petrographic, and logging constraints. Full article