Search Results (227)

Modern lifestyles are increasingly plagued by physical inactivity, social disconnection, digital addiction, and excessive time indoors—factors that negatively impact the health and well-being of both humans and their companion dogs (Canis familiaris). Evidence shows that nature exposure, physical activity, and human–animal bond (HAB) each enhance physical, mental, and social well-being, yet these domains have rarely been examined together as an integrated therapeutic triad. We introduce a new conceptual framework of bonded green exercise, defined as shared physical activity between a bonded human and dog in natural environments. Synthesizing existing evidence across human and canine sciences into a testable conceptual integration, we posit that bonded green exercise may plausibly activate evolutionarily conserved, synergistic mechanisms of physiological, behavioural, and affective co-regulation. Four testable hypotheses are proposed: (H1) triadic synergy: combined domains produce greater benefits than additive effects; (H2) heterospecific benefit: parallel health gains occur in both species; (H3) behavioural amplification: dogs acts as catalysts to drive human participation in nature-based activity; and (H4) scalable health promotion: bonded green exercise represents a low-cost, accessible, One Health approach with population-level potential. This framework highlights how intentional, shared physical activity in nature may potentially offer a novel low-cost and accessible model for enhancing health, lifespan, welfare, and ecological stewardship across species. Full article

Communication in mammals constitutes a complex, multimodal system that integrates visual, acoustic, tactile, and chemical signals whose functions extend beyond simple information transfer to include the regulation of social relationships, coordination of behaviour, and expression of emotional states. This article examines the fundamental mechanisms of communication from biological, neuroethological, and behavioural perspectives, with particular emphasis on domesticated and farmed species. Analysis of sensory signals demonstrates that their perception and interpretation are closely linked to the physiology of sensory organs as well as to social experience and environmental context. In companion animals such as dogs and cats, domestication has significantly modified communicative repertoires ranging from the development of specialised facial musculature in dogs to adaptive diversification of vocalisations in cats. The neurobiological foundations of communication, including the activity of the amygdala, limbic structures, and mirror-neuron systems, provide evidence for homologous mechanisms of emotion recognition across species. The article also highlights the role of communication in shaping social structures and the influence of husbandry conditions on the behaviour of farm animals. In intensive production environments, acoustic, visual, and chemical signals are often shaped or distorted by crowding, noise, and chronic stress, with direct consequences for welfare. Furthermore, the growing importance of multimodal technologies such as Precision Livestock Farming (PLF) and Animal–Computer Interaction (ACI) is discussed, particularly their role in enabling objective monitoring of emotional states and behaviour and supporting individualised care. Overall, the analysis underscores that communication forms the foundation of social functioning in mammals, and that understanding this complexity is essential for ethology, animal welfare, training practices, and the design of modern technologies facilitating human–animal interaction. Full article

Dog ownership may be an effective nonpharmacological, rehabilitative approach to improve veterans’ mental health and well-being. For three functional types of dogs—service, emotional support, and companion—little is known about the demographic and health characteristics of veterans and the dog types they own. This study examined veteran demographics and health characteristics stratified by functional dog type and intensity of the relationship. A cross-sectional online survey with several reliable/valid health and well-being instruments was administered to veterans with a service, emotional support, or companion dog. A convenience sample of veterans (N = 242) with a mean age of 46.9 (SD = 13.4) participated in this study. There were 143 males, 95 females, and 2 participants with another identity. The majority were white (71%). The Army (48.3%) was the most represented branch. Significant differences were found between veteran health characteristics [suicidal ideation, PTSD, anxiety, and physical well-being based on the functional dog type owned]. Service dog owners had a significantly more intense relationship with their dog. This study provides insight into the role dogs may play in improving mental health and well-being in veterans. To prevent further disability in veterans, clinicians should consider incorporating the right functional dog type in personalized care plans. Full article

Low-dose psychedelics have shown potential in modulating chronic pain in humans, yet their application in veterinary medicine remains unexplored. This study protocol proposes to investigate the therapeutic potential of low-dose oral administration of 1-cyclopropionyl-D-lysergic acid diethylamide (1cp-LSD), a legal LSD analogue in certain countries, for the management of chronic pain in privately owned dogs with osteoarthritis. The study will employ a randomized, placebo-controlled design with caregivers blinded to treatment allocation. A cohort of about 24 dogs previously diagnosed with osteoarthritis, will orally receive sub-perceptual, intermittent doses of 1cp-LSD over a 30-day period, while maintaining their standard analgesic regimens to safeguard animal welfare. Outcome measures will include the Canine Brief Pain Inventory and caregiver-reported assessments, including the Treatment Expectation Questionnaire (TEX-Q), to evaluate both pharmacological efficacy and the influence of caregiver expectations as an indirect indicator of placebo effects as a secondary aim. The study anticipates a reduction in pain scores among treated dogs, potentially modulated by caregiver expectations. However, the sustained effect of 1cp-LSD in osteoarthritis remains uncertain due to interactions with inflammatory mediators. Limitations include the lack of established dose–response relationships, small cohort size, and variability in caregiver perceptions, which will be analyzed descriptively. The protocol establishes a comprehensive and methodologically framework to evaluate both the pharmacological therapeutic effects of low-dose psychedelics in managing chronic osteoarthritic pain and the psychological factors that may influence perceived outcomes. Full article

In humans, iron deficiency is commonly associated with reactive thrombocytosis, which has clinically relevant consequences. To investigate the relationship between serum iron parameters and platelet indices in dogs and to assess for associations between iron parameters and disease pathology, the clinical records of 141 dogs with concurrent serum iron panel and complete blood count (CBC) from 2010 to 2023 were retrospectively reviewed. In total, 86 (61%) dogs had low serum iron concentrations, with 56/86 (65%) having functional and 30/86 (35%) having absolute iron deficiency. Seventy-seven (91.7%) of the dogs with iron deficiency were anaemic and 22% (19/86) had thrombocytosis. Dogs with serum iron < 10 μmol/L had higher platelet count distributions (p = 0.003) and were more likely to have platelet counts >400 × 10⁹/L (p = 0.013). Platelet counts did not differ between dogs with functional versus absolute iron deficiency. Dogs with neoplasia had lower serum iron distributions than those with inflammatory or other disease pathologies (p = 0.001) and dogs with serum iron <10 μmol/L were more likely to have neoplasia (p = 0.001, OR 5.1). In conclusion, both functional and absolute iron deficiency appear to be associated with thrombocytosis in dogs, as seen in humans. Additional studies are required to assess whether iron-deficiency-related thrombocytosis carries diagnostic, monitoring, prognostic, or therapeutic utility in dogs. Full article

Background/Objectives: In the present study, the changes in oxytocin (OXT) and serotonin (5-HT), as hormones involved in social relationships and mood regulation, respectively, were measured in dialysis patients involved in Animal Assisted Activity (AAA) interventions. Methods: Thirty patients (15 men and 15 women) with chronic kidney disease, undergoing hemodialysis three times per week, for 4 h, were enrolled. The patients were divided into three groups: two experimental groups who received the AAA intervention and a control group that never received the AAA intervention. A specific dog-zootherapist vet pair was assigned for each experimental group. All sessions of the two experimental groups were performed weekly, for a total period of 3 months (12 sessions). Blood samples were collected at the beginning and end of each session (T₀ and T₁), lasting about one hour. The interaction time with the dog was approximately 40 min. The samples were then analyzed to measure the levels of oxytocin and serotonin and processed using analysis of variance with mixed effects models. Results: The results obtained showed that both dog-zootherapist vet dyads caused a statistically significant overall effect of both oxytocin and serotonin, increasing during the sessions, compared to the control group. In addition, it was observed progressively increasing effect between two consecutive weeks. Conclusions: The results from this study showed that the AAA represents a positive stimulus for patients on dialysis. Thus, our study suggests that structured AAA intervention in a hemodialysis center can improve patients’ quality of life during the dialysis cycle. Full article

Sentinel animals may play a key role in the surveillance of arbovirus circulation, particularly in developing countries. This study aimed to assess the relevance of using dogs as sentinel animals for Rift Valley fever virus (RVFV) surveillance in Madagascar. Serological surveys were conducted on 513 dogs and 135 cattle in the Ifanadiana district, southeastern Madagascar. In addition, 486 human dry blood samples available from the same area were used. Antibodies against RVFV were detected in 23 of 513 dogs, in 86 of 486 humans, and in 33 of 135 cattle. Serocatalytic models fitted to age-stratified serological data were developed to estimate the RVFV force of infection (FOI) under several hypotheses, ranging from no relationship to proportional RVFV FOIs between humans, cattle, and dogs. The best supported model indicated that RVFV FOI in humans and cattle was proportional to RVFV FOI in dogs. Proportionality parameters were estimated at 2.6 (95% credible interval: [1.4–5.1]) for humans and 3.5 (95% credible interval: [1.3–6.4]) for cattle. Our findings suggested that dog blood samples could be used to identify RVFV circulation in RVF endemic areas and infer the exposure of humans and cattle in these areas in Madagascar. Full article

Family dogs stand out with regard to their special (human-like) attachment behavior towards their owners. This dog–owner attachment bond, analogous to the human infant–mother relationship, has been extensively documented at the behavioral level. Capitalizing on the fully non-invasive polysomnography protocol, the current study compares family dogs’ sleep structure when sleeping in the company of their owners versus an experimenter (a friendly stranger human). Subjects (N = 9) participated in three recording sessions, each lasting 3 h. The first session served as an adaptation to the recording environment, while the second and third were the test sessions analyzed for the present paper. On these two occasions, dogs slept, in a counterbalanced order, once in the company of their owner, while on the other occasion they slept in the company of an experimenter, while the owner was outside the room. Polysomnography recordings were used to extract high-resolution information (in 20 s epochs) on the time dogs spend awake and in each of the sleep stages (drowsiness, non-REM, and REM). Our results show a robust difference between dogs’ sleep structure with and without the owner. In addition to an increased sleep latency and worsened sleep efficiency, dogs spent considerably less time in deep sleep (non-REM) when their owner was absent. These findings add to the increasing body of literature dealing with dog-to-owner attachment and provide unique physiological evidence for the phenomenon, complementing the widely reproduced behavioral data. Full article

Does the head tilt observed in many domesticated dogs index lateralized language processing? To answer this question, the present study evaluated household dogs responding to four conditions in which owners provided an increasing number of communicative cues. These cues ranged from no communicative/affective cues to rich affective cues coupled with dog-directed speech. Dogs’ facial responses were first coded manually using the Dog Facial Action Coding System (DogFACS), followed by an in-depth investigation of head tilt behavior, in which AI-based automated analysis of head tilt and audio analysis of acoustic features extracted from communicative cues were implemented. In a sample of 103 dogs representing seven breed groups and mixed-breed dogs, we found significant differences in the number of head tilts occurring between conditions, with the most communicative (last) condition eliciting the most head tilts. There were also significant differences in the direction of the head tilts and between sex groups. Dogs were more likely to tilt their heads to the right, and neutered male dogs were more likely to tilt their heads than spayed female dogs. The right-tilt bias is consistent with left-hemisphere language processing in humans, with males processing language in a more lateralized manner, and females processing language more bilaterally—a pattern also observed in humans. Understanding the canine brain is important to both evolutionary research through a comparative lens, and in understanding our interspecies relationship. Full article

Heartworm disease, caused by Dirofilaria immitis and transmitted by mosquitoes, represents a major veterinary and zoonotic concern. Beyond its recognized cardiopulmonary effects in dogs, increasing evidence suggests that parasite-derived antigens may contribute to allergic disease in humans. Gran Canaria (Canary Islands, Spain) is a hyperendemic region for heartworm disease, offering a unique setting to explore this potential relationship. Therefore, the aim was to analyze the association between canine infection with D. immitis and the occurrence of allergic conditions in their owners on Gran Canaria. This cross-sectional study included 644 dogs and their respective owners. Dogs were tested for circulating D. immitis antigens using a commercial rapid test. Owners provided information on allergy through medical anamnesis. Associations between canine infection status, animal-related variables (age, sex, breed, habitat), and owner-reported allergies (age, sex) were analyzed using chi-square and Fisher’s exact tests with Bonferroni correction. The results showed that 46.4% of dogs tested positive for D. immitis and 43.8% of owners reported allergic diseases. However, 24.64% of dog owners who tested negative for heartworm disease and 65.89% of owners with positive pets reported allergic diseases. In fact, owners of infected dogs exhibited a significantly higher prevalence of allergies compared to those of uninfected dogs. Canine age, sex, breed, and owner demographics were not associated with infection or allergies. However, dog habitat was significantly associated with both outcomes: dogs living indoors had lower infection rates, while owners of infected dogs in mixed indoor–outdoor environments reported the highest rates of allergy. This study provides the first epidemiological evidence of an association between canine heartworm infection and allergies in owners within a hyperendemic European region. The findings suggest that cohabitation with infected dogs may represent a novel risk factor for atopy, reinforcing the importance of integrated preventive measures and highlighting the relevance of a One Health approach. Full article

Dyadic co-construction, the mutual adaptation that occurs between dogs and their owners, is often discussed in terms of cooperation and participation, yet it remains poorly defined and under-conceptualized in the literature. This review proposed that self-determination theory (SDT), with its three core psychological needs—autonomy, competence, and relatedness (attachment)—offers a valuable framework for understanding this phenomenon within a dyadic context. The objectives of this review were twofold: (1) to conceptualize co-construction in owner–dog interactions through the lens of SDT, and (2) to propose methodological approaches for studying this process, while acknowledging their current limitations. Dyadic co-construction emerges as a dynamic, evolving process of mutual influence, shaped by biopsychosocial factors, individual and shared experiences, and the physical and social environments of both human and dog, as well as the dyad as a unit. Depending on the nature of the interaction, co-construction can be beneficial or detrimental. Positive training practices and secure attachment patterns in both humans and dogs tend to foster more harmonious co-construction, whereas aversive methods and insecure attachment may hinder it. Although existing methodologies offer promising insights into this process, they often lack standardization, statistical robustness, and true bidirectionality. This review underscores the need for more integrative, longitudinal, and empirically grounded approaches to fully capture the complexity and clinical relevance of owner–dog dyadic co-construction. Full article

Truffle hunting in the Piedmontese landscapes of Northern Italy is not merely a foraging practice but a deeply embodied and multispecies relationship grounded in intergenerational knowledge, sensory attunement, and emotional connection to forest ecologies. This study draws on qualitative interviews with local truffle hunters (Trifulau) to examine how socio-ecological transformations driven by land privatization, vineyard expansion, monocultural hazelnut plantations, and tourism disrupt these traditional practices. Thematic analysis reveals five dimensions of transformation: ecological estrangement, dispossession and exclusion, erosion of knowledge transmission, commodification and spectacularizing, emotional and ontological loss. Hunters describe a loss of sensory orientation, access to ancestral commons, and a breakdown of the human–dog forest relational web, accompanied by feelings of grief, alienation, and identity erosion. We argue that these changes undermine ecological sustainability and threaten emotional, cultural, and epistemological sustainability. The findings call for a broadened understanding of sustainability, one that recognizes affective, multispecies, and place-based knowledge systems as vital to sustaining cultural landscapes. This study contributes to debates on rural transformation, non-material heritage, and the invisible costs of commodifying traditional ecological practices in globalizing economies. Full article

Attending puppy training classes may help to improve the human–dog relationship and the overall behaviour and trainability of the dog, yet class attendance and the structure and content of classes are not well known. This study aimed to describe the size and structure of classes attended and reasons for non-attendance, and to identify factors associated with training class attendance, by owners of puppies under 19-weeks-old. In a sample of 2187 owners participating in the ‘Generation Pup’ study, 67% reported attending at least one training class. Factors associated with increased odds of class attendance were higher household income, previous intention to attend, first-time ownership, and/or those who received a puppy information pack at acquisition. The likelihood of attending decreased as the acquisition age of the puppy increased. Classes were reported to vary in relation to the number, age, and size of puppies. Class content also varied, for example, in relation to opportunities for puppies to play with each other and training advice given. Common reasons for non-attendance included owners wanting to work with the puppy themselves and/or no suitable classes being available. These data may help to better understand training class attendance for young dogs and could inform strategies to encourage attendance amongst the dog-owning population. Full article

Oral malignant melanoma (OMM) is a highly aggressive malignancy in dogs. The development of effective systemic therapies is urgently required to improve the treatment of canine OMM. Immunotherapy using immune checkpoint inhibitors (ICIs) has been investigated in canines following their dramatic success in human cancer treatment; however, there is still a need for extensive veterinary clinical studies to clarify and optimize their clinical benefits. Among the ICIs under development for canine cancer immunotherapy, c4G12 (HFC-L1), a canine chimeric anti-PD-L1 antibody, has shown promising efficacy in dogs with pulmonary metastatic OMM in previous clinical studies. However, the optimal dose of HFC-L1/c4G12 has not yet been determined. To explore the dose–response relationship of HFC-L1, a multicenter, randomized clinical study was conducted using three different doses (2, 5, or 10 mg/kg via intravenous infusion every 2 weeks) to treat dogs with pulmonary metastatic OMM (n = 8–9 per group). The safety profiles were similar among the dose groups, and numerically longer median overall survival was achieved in the higher dose groups (5 and 10 mg/kg) than in the 2 mg/kg group. Although the study was exploratory in nature with a small sample size, 5–10 mg/kg should be considered the preferred dose in future clinical studies using HFC-L1. Full article

Dog parents have a strong attachment to their pets and treat them as children. Similarly to the guilt experienced by the parents of human children, dog parents feel guilty when they have to travel or work long hours and leave their dogs at home alone. This study examined the empathic tendencies among dog parents and how they are related to dog parent guilt and other mental health symptoms. A sample of 332 dog owners from the United States, stratified by age and sex, was recruited for this study. The sample comprised 168 female and 164 male participants. The Guilt About Dog Parenting Scale (GAPS-D), Depression Anxiety and Stress Scale-21, Interpersonal Reactivity Index, and Dog Anthropomorphism Scale were administered via an online survey. Demographic variables, such as age, sex, race, education level, household income, relationship, and parental status, were also collected. Data were analyzed using descriptive statistics, correlation, and linear regression. As predicted, this study found that empathic tendencies in dog parents are related to guilt, anthropomorphizing, and mental health symptoms. This is the first study to examine empathetic tendencies among dog parents in relation to dog parent guilt. Researchers, educators, social workers, mental health professionals, and veterinarians should inform and educate pet owners about dog parent guilt. This will increase the knowledge of professionals, organizations, and pet owners suffering from such guilt. Cognitive behavior therapy (CBT) may offer a promising approach for helping pet parents identify, normalize, and better understand their thoughts, feelings, and behaviors related to empathic and anthropomorphic tendencies. By addressing these cognitive patterns, CBT could potentially help reduce associated feelings of guilt, depression, anxiety, and stress. Full article