Search Results (17,506)

This article presents a performance assessment of an electrical power and cooling system powered by a parabolic dish collector and using refrigerants with low global warming potential. The study was conducted using energy and mass balances for each component and system. The simulation includes various parameters, such as solar radiation, the focal temperature of the solar collector, the ambient temperature, the power cycle pressure ratio, and the chiller’s evaporation temperature. The results show that the efficiency of the organic Rankine cycle with the refrigerant R1233zd(E) is similar to that of the refrigerants R123 and R245fa and is up to 11 and 50 times lower than with R290 and R744, respectively. The solar absorption chiller using the refrigerant R717 can achieve cooling with a supply temperature up to 5 °C lower than that of R718. The dynamic simulation results show that the energy efficiency of the proposed solar-powered generator–chiller is 14% higher than that of a standard solar-powered absorption chiller. Furthermore, the same solar-powered generator–chiller reduces the primary energy required by a conventional system by 60% (PESr = 0.60). The presented results may be useful for the design of sustainable generator–chillers for rural areas or for autonomous housing in tropical climates. Full article

We analysed the formal inspection reports of 108 licensed British zoos covering three consecutive formal inspections, equivalent to a licensing period, under the Zoo Licensing Act 1981 (ZLA). We examined the compliance of zoos against animal welfare standards, animal escape protocols and engagement in conservation measures, as well as the effects of licence type, zoo association membership, and collection type. Of the 324 inspection reports analysed, 59 (18%) reported that the zoo had passed every assessed question. Failure to undertake the necessary number of escape drills was the most reported area of non-compliance in 134 (41%) of the reports. Across a total of 15,876 welfare assessment criteria, 14,067 (89%) were scored as compliant, but only 83 inspection reports (26%) recorded that the zoo had met all welfare standards. Zoos were commonly found to fall into one of three classes, which predicted their probability of participating in each of the five conservation measures within the ZLA. Farm parks were identified as the collection type performing least well across inspection categories. With British zoos being required to meet new standards from May 2027, we propose a number of changes which could aid inspection consistency and legislative enforcement and drive improvements. Full article

Sheep welfare outcomes vary depending on production systems, breeds, and environmental conditions. This study examined the effects of extensive, semi-extensive, and semi-intensive sheep production systems on animal welfare in Serbia, using the AWIN Welfare Protocol to evaluate 30 farms. Welfare indicators were categorised into resource-based, management-based, and animal-based metrics. The results indicated that there was no significant difference in space allowance among the production systems (p > 0.05). This suggests that the space provided was adequate for semi-intensive farms and suitable for both semi-extensive and extensive farms. However, management practices showed significant variations (p < 0.05), indicating diverse impacts on sheep welfare. No ocular discharge or stereotypic behaviours were observed, while respiratory issues, social withdrawal, and excessive itching were found to have a very low prevalence across all farms. The primary welfare concern identified in the extensive farms was the use of painful mutilations. Semi-extensive and semi-intensive farms had significantly higher rates of tail docking (p < 0.05) and poorer fleece cleanliness. These findings highlight the necessity of addressing the root causes of poor welfare to improve sheep welfare standards. Therefore, achieving sustainable welfare outcomes requires an integrated approach that combines genetic suitability, adequate housing, and effective management practices. Full article

Livestock production systems are considered some of the most environmentally degrading due to greenhouse gas (GHG) emissions and their contribution to poor air, soil and water quality, amongst other impacts. Advanced manure treatment technologies are required in response to intensification of dairy production worldwide, and the considerably greater volumes of manure generated that require collection and management. Similarly, in Australian dairy systems cows spend more time off pasture, with increased collection of larger manure volumes from a range of contained housing facilities. Adoption of advanced treatment is required to capture nutrients at risk of loss, and ideally to valorise manure to support uptake of these technologies. This review describes the generation of manure and the manure sources found in commercial Australian systems, including grazing-based and intensive dairy farms, supporting zero grazing. The review draws on manure data from pasture-based industries elsewhere and summarises their properties for comparison with Australian systems. Manure treatments that recover and retain nutrients, water and energy are reviewed. These include additives, mechanical/chemical/membrane separation, thermochemical and biological treatments which produce organic and inorganic soil amendments, clarified or potable water, gases (N₂, H₂), biofuels and energy. The review describes the technical and operational details of the technologies, and where there are opportunities for the Australian dairy industry. Treatment technologies need to be validated for Australian systems based on the collated data of local manure properties, as differences with international manure data have been observed. The relative costs, technological maturity, and the benefits and challenges associated with adoption are discussed. Many advanced technologies are ready for adoption, but others are experimental or at pilot stage and relative costs range from low to very high. However, to accurately assess feasibility of manure treatments, environmental, and production benefits should be balanced against capital and operating expenses and account for costs associated with current management. For large intensive farms, implementing advanced manure technologies may be required to ensure approval to operate/expand and to meet regulatory compliance. Future research for the Australian industry should investigate nutrient retention and further develop separation treatments incorporating chemical and mechanical technologies. Bioconversion of manure through insect composting as well as investigating co-digestion opportunities to enhance biogas production would support famers currently using these systems. Full article

Rural property rights reform is considered paramount for mobilizing land resources and promoting rural entrepreneurship. However, the outcomes of tenure clarification depend on the role of the land in household livelihoods. The study focuses on China’s homestead rights confirmation and examines its effects on farmer entrepreneurship. The analysis is based on data from 2337 households in Jiangsu Province from the 2020 China Land Economic Survey. The application of Probit and endogenous switching Probit models yielded the following finding: confirming homestead rights reduces the probability of farmer entrepreneurship by approximately 11.4 percentage points. This decline can be attributed to several factors, including a decrease in homestead utilization, a shift towards lower-investment-risk preferences, an increase in entrepreneurial risk perception, and a contraction in entrepreneurial social networks. Collectively, these factors contribute to a reshaping of households’ risk evaluation and asset allocation. The negative impact is primarily observed among households with higher dependency ratios, poorer housing conditions, older heads of household, and those residing in less developed areas. The findings indicate that the consequences of property rights confirmation are characterized by institutional and functional specificity, thereby underscoring the necessity for measures that promote land transfer, exit, and risk-sharing to harmonize tenure reform with entrepreneurship. Full article

Housing prices exert a notable impact on labor force sustainability, a key component of socioeconomic sustainable development. Skyrocketing housing costs tend to postpone young adults’ marriage and childbearing schedules, reduce their fertility intentions, and eventually lead to a shrinking labor force. It is therefore essential to explore the intrinsic links between housing prices, fertility intentions, and labor force sustainability. Based on data on China’s commercial housing prices, fertility rates, and related socioeconomic indicators from 2005 to 2024, this paper analyzes the theoretical mechanisms of how housing prices affect fertility intentions. It examines the trends of housing prices, housing price-to-income ratios, and disposable income growth at the national level, and further discusses the heterogeneous characteristics of these indicators in eastern, central, western, and northeastern China. In addition, this study analyzes the overall trends and regional disparities of fertility rates, conducts regression analyses combined with mortality rates and population growth rates, and implements correlation analyses between housing prices and fertility rates at national and regional levels. Using 2018 and 2022 CFPS data with control variables including education years, household registration type, employment nature, gender, and number of siblings, an improved interaction terms fixed-effects model is adopted to empirically examine the impact of housing prices on fertility intentions. The reliability of the results is verified by three methods: parallel trend test, alternative estimation method, and data source replacement. Full article

Background: This study evaluated the inter-method agreement of an in-house qualitative CMV real-time PCR assay for the detection of cytomegalovirus (CMV) DNA in various non-plasma clinical specimen types, in comparison with a commercially available comparator assay. Methods: In this prospective comparative study, 186 clinical specimens—including bronchoalveolar lavage fluid (BALF), stool, urine, colonoscopic biopsy, amniotic fluid, and intraocular fluid—were analyzed. A total of 166 samples with valid results from both test systems were included in the inter-method comparison. CMV DNA was detected using the in-house qualitative PCR assay in parallel with the comparator assay (artus^® CMV QS-RGQ kit). Agreement was assessed using positive percent agreement (PPA), negative percent agreement (NPA), overall percent agreement (OPA), and Cohen’s kappa coefficient (κ), in accordance with CLSI EP12-A2 recommendations. Results: Substantial overall inter-method agreement was observed when all specimens were evaluated collectively (κ = 0.66). Agreement metrics were highest in stool, urine, and invasive specimens, whereas BALF samples demonstrated comparatively lower agreement, reflecting potential matrix-related analytical variability. Conclusion: The laboratory-developed qualitative CMV PCR assay demonstrated substantial inter-method agreement with the comparator assay across multiple non-plasma specimen types. The findings highlight specimen-specific variability in qualitative CMV DNA detection and represent analytical concordance between two molecular assays rather than definitive clinical diagnostic accuracy or viral load quantification. Full article

A wide range of Leishmania species, transmitted by phlebotomine, cause leishmaniasis, which presents diverse clinical manifestations. Leishmaniasis has a high impact on vulnerable communities, primarily affecting people suffering from malnutrition or poor housing. Because leishmaniasis is associated with poverty, access to treatment is limited. In addition, high drug toxicity and therapeutic failure, related to drug resistance, remain major challenges. Therefore, there is a need to develop new therapeutic approaches that are safer and more effective. Drug combinations and repurposing are two strategies used in the development of treatments. The combination of drugs with different mechanisms of action can minimise resistance and allow dose reduction, increasing the likelihood of successful drug repurposing. This study evaluated the antileishmanial effects of combining antitumoral agents (paclitaxel and docetaxel) with standard drugs (miltefosine and paromomycin). Results demonstrated synergistic effects at higher doses. Furthermore, the antitumoral compounds enhanced the host immune response by promoting macrophage polarisation toward the M1 phenotype, essential for parasite control. These findings highlight a promising approach that could improve efficacy and reduce resistance. Full article

Leptospirosis is a globally widespread zoonosis, with wildlife species playing a key role in the maintenance and environmental dissemination of Leptospira spp. Wild boar (Sus scrofa) are increasingly recognized as potential reservoir; however, molecular data on renal carriage of Leptospira spp. in Europe and particularly in Germany, remain scarce. In this study, 1281 wild boar kidney samples collected in the federal state of Saxony-Anhalt were analyzed by real-time PCR to investigate the presence of pathogenic and intermediate Leptospira DNA. Pathogenic Leptospira DNA was detected in 3.1% (95% CI = 2.3–4.2) of the samples, whereas intermediate Leptospira DNA was identified in 0.6% (95% CI = 0.3–1.2). Pathogenic Leptospira showed a widespread distribution across the study area, with a significantly higher prevalence in the district of Salzlandkreis (p = 0.04, OR = 3.4, CI = 0.8–10.3). Evaluation of host-related and environmental factors revealed a significant association between pathogenic Leptospira DNA detection and both sub-adult age class (χ² = 13.1, df = 2, p = 0.0014) and autumn season (χ² = 12.3, df = 3, p = 0.0066), whereas no significant association was observed for sex. Neither of these factors showed a significant relation with intermediate Leptospira spp. Sequence analyses of rrs and 16S rRNA genes predominantly identified as L. interrogans (62.5%), followed by L. borgpetersenii (20.0%) and L. kirschneri (5.0%). All intermediate Leptospira sequences were identified as L. fainei. Notably, this study provides the first molecular evidence of intermediate L. fainei DNA in wild boar kidneys in Germany. Overall, these findings suggest that wild boar may act as renal carriers of Leptospira spp. and support their potential relevance in the epidemiology of leptospirosis within wildlife populations in Saxony-Anhalt. Full article

Climate change is expected to impact rainfall amount, seasonality, and dry/wet patterns, with direct implications for rainwater harvesting systems. This study aims to quantify how future rainfall may affect rainwater harvesting systems across Brazil by combining multi-model climate projections with a daily water balance model. A single-family social housing archetype (60 m² roof area; four occupants; 150 L/day/person; non-potable demand equal to 30% of total demand) was simulated for 652 Brazilian cities, using bias-corrected daily rainfall from the CLIMBra dataset and nineteen climate models. Historical conditions were compared with near-future and far-future projections under the SSP2-4.5 and SSP5-8.5 scenarios. Historically, the greater potential for potable water savings has occurred in wetter, less seasonal climates, such as those in the North. In contrast, more seasonal and drought-prone areas, such as the Northeast, showed lower reliability. In future climates, most models indicate relative reductions in the potential for potable water savings in the North, Northeast, and Centre–West, with larger reductions under SSP5-8.5 and in the far-future scenarios. The South shows the most significant divergence between models and may increase the potential for potable water savings in some projections. On the other hand, in the South, the volume of rainwater harvesting system overflow increases under future scenarios. This work contributes to the literature by delivering a national-scale, multi-model, uncertainty-aware evaluation of rainwater harvesting performance under non-stationary rainfall regimes. Full article

Enriching bakery products with highly nutritious ingredients, such as microalgae and insect powder, is a promising strategy for developing functional foods. This study aimed to evaluate the effects of spirulina, chlorella, and cricket powder on the quality of sponge cakes. The assessed parameters included color, nutritional value, mineral composition, antioxidant activity, predicted glycemic index (pGI), and sensory properties. The addition of microalgae significantly reduced the L* value and altered the color shade of the sponge cakes, while the insect powder caused milder color changes. The enriched samples contained higher levels of protein (by up to 14%) and minerals, including calcium, magnesium, iron, and zinc. Antioxidant activity was enhanced across all variations, particularly in sponge cakes with insect powder, which showed the highest TPC (47.96 mg GAE), DPPH· (0.107 mM TE), and ABTS·⁺ (0.208 mM TE) levels. Cakes containing spirulina exhibited the highest total flavonoid content (63.95 mg EPI). Additionally, the enriched samples demonstrated a statistically significant reduction in the pGI. Among all the supplemented samples, the sponge cake with cricket powder received the highest consumer acceptance. Overall, enriching sponge cakes with microalgae and cricket powder improved their nutritional value and antioxidant properties, with insect powder offering the best balance between sensory quality and functionality. Full article

This study evaluated the effects of different environmental enrichment tools on broiler chickens from 1 to 21 days of age. A total of 120,000 one-day-old broiler chicks were randomly assigned to five treatments, each consisting of four replicates with 6000 birds per replicate. Replicates were housed in pens measuring approximately 362 m². The treatments included: T1, green balls (approximately 40 balls per pen); T2, hanging toys (8–10 toys per pen); T3, hanging strings (8–10 string bundles per pen); T4, rotational use of green balls, hanging toys, and strings at equivalent densities; and T5, a control group without enrichment. Data were collected on growth performance, foot health, behavioral activity, serum biochemical parameters, and carcass and meat quality traits. Birds provided with hanging enrichment tools showed significantly improved growth performance (p ≤ 0.05) compared with the control group. Among enriched treatments, T2 yielded the highest body weight and weight gain, as well as the lowest feed conversion ratio. Enrichment treatments also resulted in significant improvements (p ≤ 0.05) in carcass characteristics and selected meat quality parameters, including lightness (L*) and pH stability. Behavioral observations indicated substantially higher activity levels in enriched groups relative to the control. Toe damage scores differed significantly among treatments (p = 0.004), with the lowest scores observed in T1 and the highest in T4; however, no significant differences were detected in footpad dermatitis or hock burn scores (p > 0.05). In conclusion, hanging environmental enrichment tools, particularly hanging toys, can effectively enhance growth performance, behavioral activity, and selected carcass and meat quality traits in broiler production systems, while their effects on footpad health appear limited under the conditions of this study. Full article

Understanding the influence of structural parameters on the seismic response of wooden houses is essential for improving structural performance and model reliability. However, conducting extensive parametric studies using nonlinear time-history analysis is computationally expensive. To address this issue, this study proposes a machine learning (ML) surrogate framework for efficiently evaluating the seismic response of a wooden house and interpreting the importance of structural parameters. A dataset consisting of 289 nonlinear structural simulations was used to train the surrogate model, enabling efficient evaluation of parameter importance through multiple sensitivity analysis methods. A Gradient Boosting regression model was developed to approximate the results of nonlinear structural analyses. The surrogate model predicted the maximum inter-story drift with high accuracy, achieving a coefficient of determination of R² = 0.90. Using the trained surrogate model, six sensitivity analysis methods were applied: SHAP, Structural Perturbation, Drop-column Importance, Permutation Importance, Sobol sensitivity analysis, and the Morris method. The results showed that most sensitivity analysis methods consistently identified wall-related parameters, particularly W1, W3, and W4, as the dominant factors influencing structural response. This tendency was observed in both elastic and nonlinear response ranges, although the influence of these parameters became more pronounced under nonlinear conditions. While the Morris method produced slightly different sensitivity magnitudes due to its screening-based formulation, it still identified the same dominant parameters as the other approaches. The results demonstrate that the proposed ML surrogate framework, combined with explainable AI techniques, can effectively identify key structural parameters governing the seismic response of wooden structures. This approach provides a computationally efficient tool for structural sensitivity analysis and may support improved structural modeling and seismic performance evaluation. Full article

To reduce the time and computational cost of vibro-acoustic simulations in gear reducer noise evaluation, this study develops a simulation-driven surrogate modeling framework for a three-stage helical gear reducer. A high-fidelity “vibration–acoustic radiation” simulation chain is established, where the housing vibration responses computed in Romax Designer are mapped into ACTRAN to obtain the radiated noise. Using Optimal Latin Hypercube Sampling, 300 designs are generated by varying the first-stage pinion micro-modification parameters (tooth drum, tooth slope, and tooth profile), and the average RMS sound pressure level over six field points is adopted as the noise metric. A BP neural network (BPNN) surrogate is then constructed, in which Bayesian Optimization (BOA) is used to tune hidden layer nodes and learning rate, and an improved Sparrow Search Algorithm (ISSA) is employed to optimize the initial weights and biases, forming the proposed BOA-ISSA-BPNN model. On the test set, the proposed model achieves R² = 0.97499, RMSE = 0.91385, and MAE = 0.6547, with an average prediction time of 32.35s. Meanwhile, comparisons with SVM, BPNN, BOA-BPNN, SSA-BPNN, and ISSA-BPNN demonstrate superior prediction accuracy; moreover, relative to the hour-level computational cost of high-fidelity simulations, the proposed surrogate enables rapid noise evaluation on the order of tens of seconds, enabling fast micro-modification design iteration and practical engineering decision-making. Full article

Objective: To evaluate the diagnostic performance of an in-house-developed IgG Western blot (WB) for congenital toxoplasmosis and its complementary role with other serological markers. Methodology: For this purpose, the study utilized 42 mother–child pairs, evaluating the WB in comparison with a Composite Reference Standard (CRS). Cohen’s Kappa coefficient measured agreement, while McNemar’s test compared WB with Combined Serology (neonatal IgG titers higher than the mother’s (IgG↑), IgM, IgA). Results: The WB demonstrated a sensitivity of 75.0% and a specificity of 100.0%. Kappa indicated substantial agreement with the CRS (κ = 0.67; 95% CI: 0.44–0.89). McNemar’s test found no statistically significant difference between WB and Combined Serology (p = 0.7516). Crucially, WB detected 4 unique cases missed by Combined Serology, and Combined Serology detected 6 cases missed by WB. This complementarity increased the overall diagnostic rate from 82.14% to 96.43%. Conclusions: IgG-WB is a crucial complementary diagnostic tool, especially for asymptomatic newborns. Its integration significantly improves diagnostic certainty, allowing for more timely treatment for congenital toxoplasmosis. Full article