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Article

16 Citations

5,299 Views

18 Pages

The Phage-Encoded N-Acetyltransferase Rac Mediates Inactivation of Pseudomonas aeruginosa Transcription by Cleavage of the RNA Polymerase Alpha Subunit

Pieter-Jan Ceyssens,
Jeroen De Smet,
Jeroen Wagemans,
Natalia Akulenko,
Evgeny Klimuk,
Subray Hedge,
Marleen Voet,
Hanne Hendrix,
Jan Paeshuyse and
Rob Lavigne
+ 4 authors

Viruses2020, 12(9), 976;https://doi.org/10.3390/v12090976

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2 September 2020

In this study, we describe the biological function of the phage-encoded protein RNA polymerase alpha subunit cleavage protein (Rac), a predicted Gcn5-related acetyltransferase encoded by phiKMV-like viruses. These phages encode a single-subunit RNA p...

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Article

1 Citations

2,088 Views

18 Pages

Deletion of 82–85 N-Terminal Residues in SARS-CoV-2 Nsp1 Restricts Virus Replication

Gianni Gori Savellini,
Gabriele Anichini,
Fabrizio Manetti,
Claudia Immacolata Trivisani and
Maria Grazia Cusi

Viruses2024, 16(5), 689;https://doi.org/10.3390/v16050689

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26 April 2024

Non-structural protein 1 (Nsp1) represents one of the most crucial SARS-CoV-2 virulence factors by inhibiting the translation of host mRNAs and promoting their degradation. We selected naturally occurring virus lineages with specific Nsp1 deletions l...

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