Search Results (29,953)

Wikidata provides extensive coverage of tourism-related Points of Interest (POIs), yet its heterogeneous type system and uneven metadata limit its direct use in smart tourism applications. This paper presents an end-to-end pipeline that transforms Wikidata POIs into a compact and interpretable tourism-oriented representation supporting multi-category assignments. We collect POIs from six countries—Greece, Italy, Spain, Norway, Sweden, and Denmark—and construct a dataset that integrates core identifiers with textual descriptions, type information, heritage indicators, geographic coordinates, and Wikipedia sitelinks. We introduce an eight-category tourism taxonomy capturing key themes, including cultural venues, archaeological and historic sites, monuments, fortifications, religious sites, protected areas, natural features, and coastal or water locations. As a reproducible baseline, category likelihoods are estimated using sentence embeddings and similarity to category anchor descriptions, producing a probability vector for each POI. Building on this baseline, we propose a fuzzy inference layer that integrates embedding-based probabilities with structured Wikidata signals to generate interpretable membership degrees across categories and enable principled multi-category classification. This fusion is particularly valuable for smart tourism applications, as it supports robust faceted exploration and personalized recommendations (e.g., “historic + coastal”), while providing evidence-based explanations that enhance user trust and facilitate curator oversight when POI metadata is sparse or ambiguous. The resulting pipeline produces ranked POI catalogs by country and category, country-level tourism profiles, and diagnostic views for examining uncertain cases. The approach is fully reproducible and readily adaptable to other geographic regions or domain taxonomies. Full article

Atopic dermatitis (AD) is increasingly interpreted through frameworks emphasizing barrier dysfunction, type 2 cytokine signaling, pruritus pathways, and microbial dysbiosis, often relegating IgE-mediated mechanisms to secondary roles. In this narrative review, we synthesize historical, clinical, immunologic, and histopathologic evidence to propose a conceptual model in which IgE-bearing antigen-presenting cells (APCs)—including Langerhans cells, inflammatory dermal dendritic cells, and inflammatory dendritic epidermal cells (IDECs)—participate in an IgE-dependent amplification loop that may contribute to the chronicity of extrinsic (IgE-associated) AD. Evidence from human studies indicates that FcεRI-expressing APCs can acquire environmental allergens through IgE, enhancing antigen uptake and T-cell activation, while mast cells and basophils further reinforce type 2 inflammation through IgE-dependent and IgE-augmented pathways. Although these mechanisms have been described across distinct experimental and clinical contexts, their integration into a unified pathogenic circuit remains hypothesis-driven. We therefore present an interpretive framework that organizes these partially validated mechanisms into a coherent model linking cutaneous sensitization, allergen capture, APC activation, Th2 polarization, and spongiosis formation. This conceptual synthesis aims to reposition IgE-mediated processes within the broader pathophysiology of extrinsic AD and to highlight potential therapeutic implications for targeting IgE–FcεRI signaling and IgE-dependent APC biology. Full article

Introduction: The fish fauna in the Yucatan Peninsula exhibit a unique composition, shaped by the region’s complex geological and hydrological history. Thorichthys meeki is a widely distributed cichlid species that has been the subject of morphological, behavioral, and phylogenetic studies. Nevertheless, the historical and biogeographical processes that have shaped its diversification and genetic structure remain unexplored. Objective: The objective of this study was to identify phylogeographic patterns and assess the genetic diversity of T. meeki in southeastern Mexico. Methodology: Genomic DNA was extracted from the muscle tissue of specimens preserved in 90% ethanol. DNA was amplified using a polymerase chain reaction (PCR) and sequences were obtained from two molecular markers: cytochrome oxidase 1 (CO1) and S7 intron 1. Phylogeographic analyses included genetic diversity indices molecular variance analyses to assess population structure and haplotype networks. Results: A total of 60 CO1 and 40 S7 intron 1 sequences were obtained from 26 sampling sites. For CO1, 14 haplotypes were identified, with high haplotype diversity (Hd = 0.84), and low nucleotide diversity (π = 0.0048). For S7 intron 1, 16 haplotypes were recovered with lower haplotype diversity (Hd = 0.543) and π = 0.021. A hierarchical AMOVA (2 groups) showed the greatest variation; 72.3% in CO1 and 79.8% in S7 within population groups with significant ΦST values. Haplotype networks identified three haplogroups for each gene. A single CO1 haplotype was found in 26 sequences from 13 sampling sites. For S7 intron 1, one haplotype was identified in 22 sequences and was shered from all populations. Conclusions: A widely distributed haplotype for CO1 and S7 reflects historical connectivity among hydrological systems. These preliminary results provide an interesting insights into the processesthat have influenced the distribution of T. meeki on the Yucatán Peninsula. Full article

This paper addresses the contemporary challenge of religious disaffiliation and the “supermarket mentality” of liquid religion by proposing a prophetic paradigm shift in evangelisation and catechesis. Utilising Richard Osmer’s practical theological framework as a structure, the study identifies a historical shift from the lived apostolic kerygma (fides qua) toward an over-reliance on formal conciliar definitions and Magisterial formulae (fides quae). This diachronic analysis suggests that the current “apparent failure” of institutional engagement is rooted in a linguistic and methodological disconnect. Drawing on the visionary models of St Augustine and St Benedict, and grounded in Karl Rahner’s transcendental theology, the paper proposes a normative way forward: an inductive pedagogy of the heart. This model prioritises the art of accompaniment and the return to elementary, foundational concepts that address the experiential core of the human person. Ultimately, the study argues that restoring the balance between the lived tradition and the contents of the faith is a theological requirement for helping contemporary believers to live their faith in daily life. Full article

This study evaluates the accuracy of various preprocessing methods applied to scanned archival aerial photographs for reconstructing historical terrain in the Czech Republic. Seven workflows were tested on identical imagery and control points, varying parameters such as resolution unification, brightness normalization, focal length calibration, and AI-based denoising. Accuracy was assessed using GNSS checkpoints and high-resolution LiDAR data. Results show that basic brightness correction reduced the vertical RMSE by 59% (to 5.69 m). In contrast, standalone AI preprocessing was associated with increased geometric instability (RMSE 16.48 m) due to over-smoothing and the loss of essential micro-texture. However, the evaluated “Fusion AI” workflow—combining AI enhancement with strict focal length constraints—successfully mitigated this degradation. By restricting the internal orientation, it stabilized the vertical accuracy at 6.48 m, closely matching the best traditional approaches. Statistical analysis revealed strong spatial autocorrelation and non-normal error distributions, highlighting the need for robust validation. Ultimately, this study confirms that AI can be effectively utilized to enhance visual clarity in data-scarce historical reconstruction without sacrificing spatial reliability, provided it is strictly geometrically constrained. This offers an optimal compromise and a tested, reproducible workflow that supports heritage preservation and long-term environmental analysis. Full article

Background: Benzimidazole (BZ) resistance in the gastrointestinal nematode Haemonchus contortus is a major constraint to sheep production worldwide. However, data on the prevalence and molecular mechanisms of resistance in Yili Prefecture, Xinjiang—a key livestock region in Northwestern China—remain limited. This study aimed to determine the frequency of BZ resistance-associated single nucleotide polymorphisms (SNPs) in H. contortus populations from Zhaosu and Tekesi counties. Methods: Adult male worms (n = 150) were collected from naturally infected sheep at local abattoirs. Species identity was confirmed morphologically by sequencing the internal transcribed spacer 2 (ITS-2) region. A 385 bp fragment of the isotype-1 β-tubulin gene was amplified and sequenced to detect SNPs at codons 167 (F167Y), 198 (E198A), and 200 (F200Y). Results: The F167Y mutation was absent in all individuals. In contrast, the E198A mutation occurred at exceptionally high frequencies, with resistant allele frequencies (RAF) of 64.7% in Zhaosu and 52.7% in Tekesi. The F200Y mutation showed clear geographical variation: it remained low in Zhaosu (RAF = 9.3%) but was substantially higher in Tekesi (RAF = 33.3%). Haplotype analysis revealed that resistance in Zhaosu was driven primarily by the E198A mutation, whereas the Tekesi population exhibited complex patterns of co-selection of both E198A and F200Y, with a high proportion of double-heterozygous individuals (29.3%). Conclusions: This study provides comprehensive molecular evidence of severe BZ resistance in H. contortus populations from Zhaosu and Tekesi counties, Yili Prefecture. The marked predominance of the E198A mutation, together with the emergence of multi-locus resistance in Tekesi, indicates a rapid escalation of resistance beyond historical levels. These findings suggest that benzimidazoles are likely ineffective in this region and highlight the urgent need to revise local parasite control strategies. Full article

The large-scale integration of wind and solar power introduces significant volatility into electricity markets, posing challenges for accurate day-ahead price forecasting for generation companies. This paper proposes a hybrid forecasting model, CEEMD-SE-IBA-LSTM, based on hyperparameter adaptation to improve prediction accuracy. First, a similar-day selection method integrating Random Forest and an Improved Grey Ideal Value approximation identifies the most relevant historical days. Second, Complete Ensemble Empirical Mode Decomposition with Sample Entropy (CEEMD-SE) decomposes and reconstructs the price series into stable components. Third, an Improved Bat Algorithm (IBA), incorporating differential evolution and adaptive weighting, is developed to optimize two key LSTM hyperparameters: the number of hidden layer neurons, which is treated as a model architecture hyperparameter, and the learning rate, which is treated as a training hyperparameter. The number of LSTM layers and the number of training epochs are kept fixed as model settings to ensure reproducibility. Using data from the US PJM market, the proposed model is validated against six benchmarks. The results show that CEEMD-SE-IBA-LSTM achieves superior performance, with a Mean Absolute Percentage Error (MAPE) of 3.73%, a Root Mean Square Error (RMSE) of 3.57 $/MWh, and a Mean Absolute Error (MAE) of 1.95 $/MWh. The method provides accurate price trends, offering effective decision support for new energy enterprises in price bidding to enhance revenue. Full article

Historic blue bricks are fundamental to Beijing’s architectural heritage, yet cross-site compositional data for guiding material-compatible restoration remain scarce. This study applies WD-XRF, XRD, SEM, thermal expansion measurement, and physical property testing to 21 blue brick specimens from four Beijing-area sites spanning the Tang through Qing dynasties, with PCA and K-means clustering used to explore compositional grouping structures. Within this exploratory dataset, a compositional distinction separates the Ming and Qing Great Wall bricks: CaO falls from 7.7 to 1.5 wt.% as anorthite gives way to albite, while Qing specimens are denser (1.79 vs. 1.65 g·cm⁻³) with lower water absorption (15.9% vs. 20.9%). Two Wanping City bricks are strongly sulfate-enriched (SO₃ up to 9.8%), and WP-SE3 additionally carries a heavy chloride load (Cl 2.1%), masking their original clay signatures and illustrating how unrecognized weathering can distort compositional grouping and source-related interpretation from bulk chemistry. K-means clustering yields compositional types that overlap only partially with site boundaries, capturing raw material variation rather than site-specific manufacturing fingerprints. Despite constraints in sample size and physical property coverage, the integrated dataset offers preliminary compositional benchmarks and limited performance data to inform period-specific brick replacement at these heritage sites. Full article

Medical intervention for ischemic heart disease began approximately 150 years ago with nitrates, and for nearly a century thereafter, little fundamental progress was made. With the advent of the left internal thoracic artery to the left anterior descending artery (LITA-LAD) bypass in the 1960s, treatment entered a new stage; however, its essential significance remained insufficiently recognized for many years. Numerous studies were subsequently conducted to evaluate alternative or parallel treatment strategies, but these investigations also helped bring the durable capacity of LITA-LAD to perfuse ischemic myocardium into sharper focus. Over the past quarter century, the treatment of ischemic heart disease has remained in a state of uncertainty, and its central prognostic foundation has often been obscured, although in recent years this uncertainty has begun to resolve. In this review, we reexamine the historical process by which the significance of LITA-LAD remained incompletely appreciated in parts of the cardiology and cardiac surgical communities. We further outline how the principal basis of the long-term prognostic benefit conferred by LITA-LAD gradually became evident and define the contemporary roles of medical therapy and percutaneous coronary intervention in relation to LITA-LAD-based coronary artery bypass grafting (CABG). Full article

The city of Bologna (Italy) boasts an outstanding hydraulic heritage linked to the development of the silk industry, embodied in an extensive and valuable canal network. These public works, such as the Canale di Reno and the Canale Navile, were fundamental to the urban and economic shaping of the city from the Middle Ages onwards; however, many were concealed or dismantled from the 19th century. This article analyses recent heritage engagement and dissemination strategies regarding Bologna’s historic canals and proposes new tools to overcome their spatial fragmentation and enhance their interpretation as a continuous network. The methodology combines analysis, fieldwork or valorisation of the hydraulic system, proposing two complementary promotion actions: the design of a mobile application and the development of a straightforward urban intervention consisting of linear pavement marking of the underground canals layout. The proposed operational hypotheses suggest that integrating digital resources with on-site signage brings invisible heritage to light, improves the spatial understanding of the hydraulic system, and fosters both community and tourist engagement. The study concludes that these strategies reinforce the territorial understanding and social awareness of civil engineering heritage, offering a transferable approach for the outreach of hydraulic networks. Full article

Bacterial canker caused by different phytopathogenic pseudomonads continues to be a significant issue in stone fruit production worldwide, affecting all major fruit-growing regions. Among stone fruits, apricot and sweet and sour cherry are particularly susceptible to this disease. Over many decades, it has been consistently reported as a major problem, especially in young orchards, where infections can lead to serious economic losses, followed by tree death. Several pathogens have been identified within the Pseudomonas syringae species complex associated with stone fruits, including P. syringae pv. syringae, pv. morsprunorum (race 1 and 2), pv. persicae, pv. avii, and pv. cerasicola, as well as other pseudomonads such as Pseudomonas cerasi and P. viridiflava. Among these, pv. syringae and pv. morsprunorum are of the greatest economic importance, while pv. persicae is classified in the EU as a regulated non-quarantine pathogen. The aim of this paper is to provide an overview of the historical perspectives of bacterial canker of stone fruits, its economic importance, the taxonomic position of Pseudomonas syringae, disease symptoms, and the biology and epidemiology of the pathogens. In addition, we address bacteriological characteristics, as well as serological and molecular methods for the identification of P. syringae complex strains, and outline currently available control measures. Full article

Background: Hypotonic–hyporesponsive episode (HHE) is a recognised adverse event following immunisation (AEFI) in infants, characterised by sudden hypotonia, hyporesponsiveness, and pallor or cyanosis. Although considered benign, its abrupt and often dramatic presentation often leads to acute medical evaluation. Contemporary data on HHE are limited, and awareness among healthcare professionals needs attention. Methods: We conducted a retrospective analysis of all spontaneous reports of HHE submitted to the national pharmacovigilance centre Lareb between 1 January 2012 and 22 July 2025. Cases were included only when meeting Brighton Collaboration (BC) Level 1 criteria, requiring clear documentation of hypotonia, hyporesponsiveness, and pallor or cyanosis in children younger than 24 months. Demographic and clinical characteristics, vaccine combinations, latency, duration, seriousness, and medical care utilisation were described. Results: A total of 294 Level 1 HHE cases were identified. Most episodes followed combinations of hexavalent vaccines with pneumococcal conjugate vaccines. The median age at onset was 9 weeks, with slightly more reports involving boys. The median latency to onset was 5 h (range 4–8 h), and the median episode duration was 10 min (range 3–30 min), aligning with the historical literature. All children recovered fully, and no long-term sequelae were reported. Although HHE is clinically benign, 27% of cases were classified as serious, primarily due to hospital admission. Among non-serious cases, one third involved medical assessment or emergency services. Healthcare professionals submitted 44% of reports, notably community child health physicians. Conclusions: Contemporary Dutch pharmacovigilance data confirm that the clinical characteristics of HHE remain highly consistent with long-standig evidence. Despite its benign and self-limiting nature, HHE frequently triggers substantial medical care consumption. Improved awareness of the typical presentation, course, and prognosis, supported by the Brighton Collaboration criteria, may help clinicians recognise HHE more readily, reduce unnecessary medical consumption, and provide reassurance to caregivers. Full article

Real-time scheduling in large-scale electric vehicle charging stations is challenged by stochastic vehicle arrivals, dynamic departures, limited charging resources, and station-level power constraints. To address this problem, this paper proposes a two-stage Supervised Service Matching and Reinforcement Power Dispatch (SMPD) framework, termed SMPD, which decomposes the original coupled scheduling problem into supervised service matching and reinforcement learning-based power dispatch. In the first stage, a supervised matching network learns EV-charger service suitability from historical charging-session records and determines service access decisions for feasible EV–charger pairs. In the second stage, a Soft Actor-Critic-based controller allocates continuous charging power to connected EVs under EV-side charging limits, charger capacity constraints, and the station-level total power constraint. The proposed framework is evaluated using public charging-session data from the ElaadNL dataset. Experimental results show that SMPD achieves lower average waiting time, higher average revenue, lower composite penalty, and comparable demand satisfaction compared with rule-based, single-stage reinforcement learning, and multi-agent baselines. Sensitivity and robustness analyses further indicate that SMPD maintains favorable scheduling performance and acceptable online decision time under the tested charger-scale settings and operational disturbance scenarios. These results suggest that the proposed two-stage design provides an effective and computationally tractable approach for real-time scheduling in large-scale EV charging stations. Full article

The Chishui River Basin, a core production area for Chinese sauce-aroma Baijiu (exemplified by Moutai), supports sorghum cultivation critical to the liquor’s distinctive quality. The soil environment quality within this region, therefore, directly impacts the safety and quality of both raw material and the final distilled spirit. To underpin the safe production and sustainable development of this iconic beverage, it is essential to assess soil heavy metal contamination in the soils and quantify the contributions from various sources. In this study, 172 surface soil samples were collected from typical sorghum planting bases in the Renhuai area. Concentrations of eight heavy metals (loids) (As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) were determined. The contamination status was evaluated using the geostatistical inverse distance weighting interpolation, the Nemerow pollution index (P_N), and the potential ecological risk index (RI). Source identification and quantification were performed using the positive matrix factorization receptor model (PMF). Results revealed significant enrichment of Cd and Hg in the soil, with mean concentrations 2.07 times and 2.54 times the soil background values for Guizhou Province, respectively. Pollution index results (P_i, P_N) indicated that soil Cd contamination is relatively severe, whereas contamination from other elements is minimal. Overall, approximately 86.5% of the study area was classified as clean or only slightly polluted. Cd poses a moderate ecological risk and was the primary contributor to the total ecological hazard. Other elements exhibited lower risk, resulting in a slight overall potential ecological risk. The soil environmental quality in certified organic sorghum bases was generally favorable. PMF analysis identified three principal sources: historic industrial emissions and traffic-related sources (contributing 46%), weathering of carbonate rocks combined with agricultural activities (37%), and natural background coupled with organic fertilizer application (17%). In conclusion, while the overall soil heavy metal pollution level in the sorghum planting areas is low, the notable enrichment and higher ecological risk of Cd necessitate enhanced dynamic monitoring and targeted risk control measures to ensure long-term soil health and product safety. Full article

The expansion of remote work has transformed labour market conditions across the developed world, yet access to home-based work remains unequally distributed along occupational, sectoral, regional, and organisational lines. Post-pandemic evidence on the persistence of these inequalities is particularly scarce in Central and Eastern European economies, where historically low remote work prevalence, manufacturing-intensive industrial structures, and pronounced regional disparities create a distinctive structural context. Drawing on primary survey data collected from 390 employees in Slovakia in 2025, this study pursues two interrelated empirical goals: to identify the factors predicting a mismatch between the structural feasibility of working from home and its actual availability to employees, and to examine the determinants of experienced work discomfort. Binary logistic regression, multiple linear regression, and a battery of group difference tests were employed across the two analytical strands. The results reveal a pronounced capital–periphery gradient in remote work access, with employees outside the capital city facing dramatically higher odds of mismatch, and identify organisational support as the most practically actionable determinant of work discomfort. Notably, experiencing a mismatch between remote work feasibility and access was not associated with higher discomfort, a finding that challenges assumptions common in the Western European literature and points to the moderating role of contextual expectations in post-communist labour markets. The findings offer directly applicable evidence for employers seeking to reduce work-related strain through targeted support measures, and for policymakers designing regulatory frameworks to promote equitable access to flexible work arrangements across regions and sectors. Full article