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Aptamer–Gemcitabine Conjugates with Enzymatically Cleavable Linker for Targeted Delivery and Intracellular Drug Release in Cancer Cells
- Jianjun Qi,
- Zihua Zeng,
- Zhenghu Chen,
- Cole Nipper,
- Xiaohui Liu,
- Quanyuan Wan,
- Jian Chen,
- Ching-Hsuan Tung and
- Youli Zu
Gemcitabine is a chemotherapeutic used clinically to treat a variety of cancers. However, because it lacks tumor cell specificity, gemcitabine may cause off-target cytotoxicity and adversely impact patients. To impart cancer cell specificity to gemci...