- Review
6 Citations
5,159 Views
15 Pages
Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters
- H.M. Mazhar Asjad,
- Shahrooz Nasrollahi-Shirazi,
- Sonja Sucic,
- Michael Freissmuth and
- Christian Nanoff
Many diseases arise from mutations, which impair protein folding. The study of folding-deficient variants of G protein-coupled receptors and solute carrier 6 (SLC6) transporters has shed light on the folding trajectory, how it is monitored and how mi...