You are currently on the new version of our website. Access the old version .

2 Results Found

  • Review
  • Open Access
6 Citations
5,159 Views
15 Pages

Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters

  • H.M. Mazhar Asjad,
  • Shahrooz Nasrollahi-Shirazi,
  • Sonja Sucic,
  • Michael Freissmuth and
  • Christian Nanoff

14 November 2017

Many diseases arise from mutations, which impair protein folding. The study of folding-deficient variants of G protein-coupled receptors and solute carrier 6 (SLC6) transporters has shed light on the folding trajectory, how it is monitored and how mi...

  • Article
  • Open Access
11 Citations
2,837 Views
11 Pages

Microbe-derived factors trigger innate immune responses through the production of inflammatory mediators, including pentraxin 3 (PTX3). PTX3 is a soluble pattern recognition molecule that stimulates the clearance of clinically important bacterial pat...