Search Results (192)

The widespread use of portable electronic devices has increasingly promoted the prolonged maintenance of non-physiological postures, particularly anterior and downward head flexion. Therefore, this study aimed to analyze the condylar and incisor relationship displacement induced by this improper posture. A total of 20 adult subjects (9 F, 11 M; mean age 27 ± 5) were recruited at the Department of Dentistry, Vita-Salute San Raffaele University, Milan, Italy. Mandibular kinematics was recorded using JMA-Optic AG (Zebris Medical GmbH, Isny, Germany). The protocol adopted consisted of three phases: (1) Habitual occlusion with light clenching, (2) Neuromuscular rest position (RP) verified by surface electromyography (sEMG), (3) Anterior head flexion (40–60°) (HF), simulating the posture typically observed during portable digital device use. Millimetric measurements of condylar displacement from RP to HF and incisal plane changes were collected. Data were analyzed descriptively with Microsoft Excel, and inferentially with StatPlus Pro (AnalystSoft, StatPlus: mac Pro, version 8). The right condyle exhibited a mean displacement of 1.9 mm in the downward direction (p < 0.001), while the left condyle showed a downward displacement of 1.5 mm (p < 0.001). No significant difference was observed between the two sides. At the dental level, the lower incisor revealed a mean shift of 1.0 mm superiorly (p < 0.001) and 0.7 mm anteriorly (p < 0.001). The HF determines a significant condylar and incisal plane displacement, and may predispose individuals to TMJ disorders, supporting the hypothesis of an emerging cranio-cervico-mandibular condition linked to prolonged use of high-tech display terminals, here proposed as ED-TMD (Electronic Device-Induced Temporomandibular Disorder). Full article

Excessive alcohol consumption (EAC), defined as consuming more than 14 units per week, in the university population represents a significant health risk to students. Objective: The present research tested the impact of different attitude-salient messages to reduce the strength of habits towards consuming alcohol. Methods: Seven hundred and fifty-five university students were randomised to one of five conditions that varied in the content of attitude salience: short-term affective, short-term cognitive, long-term affective, long-term cognitive, and no message control. The habitual strength of participants’ alcohol consumption was measured at baseline and at follow-up using the Self-reported Habit Index. Results: ANCOVA controlling for the baseline assessed potential gender differences and several significant interactions were identified, demonstrating that the affective distal message reduced habitual strength towards EAC to a greater extent for men low in Need for Cognition (NfC; 95% CI [0.48, 2.12]), whereas, for women low in NfC, the affective proximal message was most effective. For both men and women high in NfC, the cognitive message was shown to be more effective at reducing the strength of habit towards EAC. Conclusion: The findings point to the value of distinguishing between health messages in terms of several factors, including affective and cognitive outcomes, the temporal nature of these outcomes (short-term or long-term), and gender. This has important ramifications for providing information to modify behaviour. Full article

Learning burnout, a prevalent condition among adolescents characterized by emotional exhaustion and academic disengagement, has been increasingly recognized as a critical risk factor for Internet Gaming Disorder. This study investigates the chain-mediating roles of self-control and peer alienation in this relationship. A longitudinal design was implemented with three waves of data collected from 759 Chinese middle school students. Chain mediation analyses were conducted to examine the dynamic pathways among these variables over time. Learning burnout not only directly predicted IGD but also exerted indirect effects through the mediating roles of self-control and peer alienation. The proportion of mediation effects showed an initial increase from T1 (48.18%) to T2 (60.98%), followed by a decrease at T3 (41.94%), suggesting a transition from conscious coping strategies to habitual addictive patterns. The longitudinal model (T1–T3) demonstrated that early learning burnout impaired self-control at T2, which subsequently led to increased peer alienation at T3, ultimately contributing to IGD, with this pathway accounting for 72.14% of the total effect. These findings support a dual-process mechanism involving resource depletion and compensatory need satisfaction, highlighting the importance of early interventions focused on enhancing self-regulation capabilities and improving peer relationships to prevent IGD development among adolescents. Full article

I defend a diachronic constraint on justification as a necessary condition for knowledge. In my view (JTB + D), a belief is knowledge-apt only if its justification is maintainable over a context-sensitive interval Δ under ordinary avenues of evidence-accrual, including reliable memory, testimony, and communal inquiry, with no accessible undefeated defeaters arising within that interval. This temporal, process-sensitive requirement mitigates Gettier-style luck by targeting “snapshot” justification that would easily collapse under minimal further scrutiny (as in Fake Barn County), while avoiding infallibilism and over-intellectualism. I calibrate Δ by stakes and domain volatility to avoid vagueness and moving goalposts, distinguish responsive stability from mere habituation, and show how the account handles no-new-evidence scenarios without undermining ordinary memorial and testimonial knowledge. Conceptually, the proposal integrates internalist and externalist insights as it preserves reason-responsiveness over time and serves as an actual-world temporal analogue of safety, not a standalone fourth ‘dimension’. I engage canonical cases and acknowledge Zagzebski’s challenge: the view does not promise full Gettier immunity, but it raises the bar for counterexamples in ordinary environments. The result is a principled, parameterised refinement of the justification condition that better captures knowledge as an enduring, responsibly supported true belief. Full article

Catecholamines are fundamental mediators of the stress response, regulating arousal, vigilance, and adaptive behavior. However, their dynamics under extreme real-life conditions remain insufficiently explored. Survival, Evasion, Resistance, and Escape (SERE) training provides a unique model for examining neuroendocrine mechanisms of adaptation during both the acute phase and the recovery period following intense psychological and physical stress. Serum norepinephrine (NE) and dopamine (DA) were measured in 47 special forces soldiers during peak stress in SERE and one month later, compared with 17 healthy controls. Samples were collected under standardized conditions and analyzed using validated ELISA kits. NE levels differed significantly among groups (p = 0.003), being higher during SERE training and in controls compared to the post-recovery condition. DA also showed a significant group effect (p < 0.001), with increased levels during recovery and in soldiers during SERE relative to controls. The post-recovery decline in norepinephrine suggests adaptive habituation of sympathetic activity following extreme stress exposure. Conversely, the sustained elevation of dopamine during recovery may reflect neuroadaptive mechanisms that promote motivational and cognitive restoration. Together, these findings indicate coordinated catecholaminergic regulation supporting long-term resilience in elite military personnel. Full article

Background/Objectives: Although screening for scoliosis is common among adolescents, little is known about its subtypes and their correlations in young adults. This study aimed to investigate the prevalence and classification of scoliosis (functional vs. structural) among female university students in Saudi Arabia and to examine associated factors. Methods: A cross-sectional study was conducted with 263 female students at Taibah University. Screening was performed using Adam’s forward bending test and a scoliometer. Data on age, body mass index, academic year, hand dominance, habitual sitting posture, backpack carriage method, leg-length discrepancy, painful conditions, and family history of scoliosis were collected. The association between scoliosis subtypes and contributing factors was analyzed using descriptive statistics, chi-square test, and Spearman’s correlation. Results: Scoliosis was identified in 94 students (prevalence, 35.7%). Of these, 26.2% had functional scoliosis, whereas 9.5% had structural scoliosis. Functional scoliosis was significantly associated with sitting posture, leg-length discrepancy, and age (p < 0.05), whereas structural scoliosis was associated with family history, habitual sitting posture, and painful conditions (p < 0.05). Conclusions: The high prevalence and differing profiles of scoliosis subtypes underscore the need for routine postural screening in universities. Early identification and ergonomic education may help in selecting appropriate targeted interventions for individuals with functional or structural scoliosis. Full article

Background: Sarcopenia is a clinical condition linked to various liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD includes a spectrum from steatosis to steatohepatitis, which may progress to fibrosis, cirrhosis, and hepatocellular carcinoma. The influence of dietary habits and nutrient intake on MASLD and its progression is well-established. However, the association between dietary consumption and sarcopenia in MASLD patients remains underexplored. This study evaluated whether there is an association between sarcopenia and habitual food consumption in MASLD patients. Methods: A cross-sectional study was conducted with outpatients diagnosed with MASLD. Sarcopenia was defined based on the 2019 EWGSOP2 criteria. Dietary intake was assessed using three 24 h recalls per patient, with intrapersonal variance corrected using the Multiple Source Method (MSM) software (Version 1.0.1). Steatosis was diagnosed via upper abdominal ultrasound, and the Fibrosis-4 Index (FIB-4) was used to assess hepatic fibrosis. Results: MASLD patients (n = 76) were evaluated. The mean age was 52.9 (SD, 12.0) years, and 75.0% were female. Two had sarcopenia, and 27.6% (n = 21) had probable sarcopenia (characterized by low muscle strength only). Among probable sarcopenia, F1-F2 were observed in 61.9%, and 23.8% had indeterminate FIB-4 grades. Calcium intake was lower among patients with probable sarcopenia than those no sarcopenia (p = 0.04). Conclusions: In these MASLD patients, only two patients were diagnosed with sarcopenia, and around a third had probable sarcopenia. The majority of MASLD patients with lower calcium, energy, and protein intake, but only lower calcium intake in those with probable sarcopenia. Full article

Background: Habitual breakfast skipping is associated with an increased risk of cardiovascular and cardiometabolic diseases. However, the effects of skipping breakfast regularly versus irregularly on vascular endothelial function (VEF), a key marker of cardiovascular health, remain unclear. This study aimed to investigate the effects of eight-Day regular or irregular breakfast skipping on brachial artery VEF in healthy habitual breakfast eaters using a three-condition, randomized controlled crossover trial. Methods: Ten young healthy adults (seven females, three males) completed three randomized nine-Day trials: (1) Eat (three meals per day), (2) Skip (breakfast skipped on days 1–8, consumed on Day 9), and (3) Eat/Skip (alternating breakfast consumption and skipping). Flow-mediated dilation (FMD) of the right brachial artery was assessed at 7:45–55 am on days 1, 2, 5, and 9, expressed as the percentage change in the brachial artery diameter normalized to the shear rate area under the curve (Δ%FMD/SR_AUC). Blood samples were collected before and 30 min after breakfast or lunch for glucose, insulin, free fatty acids, and triglyceride analyses. Insulin resistance was estimated using the homeostasis model assessment of insulin resistance calculated from fasting glucose and fasting insulin values. Objective measurements of sleep, physical activity, and continuous glucose monitoring were obtained. Results: On Day 9, the Skip and Eat/Skip trials had significantly lower %FMD/SR_AUC and significantly higher levels of fasting plasma insulin than the Eat trial. Exploratory analyses within the Skip and Eat/Skip trials suggested a weak negative association between changes in %FMD/SR_AUC and fasting blood glucose and insulin from day 1 to day 9. Conclusions: These findings suggest that both regular and irregular breakfast skipping may impair early morning VEF, possibly through alterations in glucose metabolism, whereas regular breakfast consumption may help preserve VEF and support cardiovascular health. Clinical Trial Registry: Clinical Trial Registry: University Hospital Medical Information Network (UMIN000053117, registered 20 December 2023). Full article

Introduced species of trees and shrubs used in landscaping of cities in the steppe zone are exposed to the combined negative impact of the ever-increasing load of various anthropogenic factors and unfavorable zonal natural and climatic conditions. In this regard, the assessment of the degree of plant resistance to unfavorable factors in the urban ecosystems of the steppe zone is a necessary condition for rationalizing the selection of the assortment and improving the condition of green spaces. This paper presents the results of the analysis of the vital state of 5509 representatives of 78 introduced species of trees and shrubs growing along the road and transport network in the territory with increased anthropogenic pressure. The age structure of plantings, as well as a number of biological and ecological characteristics of the species composition, are analyzed. The variation in the level of vitality in groups united by individual characteristics—taxonomic affiliation, geographical origin, morphobiological characteristics (habitus), growth rate and age of plants—is shown, and groups with the highest level of vitality are identified. As a result, a number of criteria are selected that can serve as indirect markers of plant adaptability to the ecological conditions of steppe zone cities when forming an assortment for landscaping. Using the examples of the features “plant height” and “plant age”, the species-specific reaction of plants is shown, expressed in the limitation of growth and development, as well as the reduction of life expectancy under conditions of increased anthropogenic and climatic loads. The data obtained can be used to adjust the species composition of urban trees and shrubs, optimize their ratio and spatial and functional placement, and thereby optimize the operational characteristics of green spaces and increase the duration of their use. Full article

This research proposed a feasibility study for a qualitative and semiquantitative analysis of sheep serum using Raman Spectroscopy analysis as an alternative to standard methodologies. Raman Spectroscopy was used to obtain information about molecular vibrations that can provide information about the behavior of specific variations in the protein network. This study was conducted during the traditional vernal shearing procedure in Sicilian sheep breeding. Twenty female sheep were randomly chosen from a one-hundred Comisana-bred flock habituated to the handling required for shearing and venipuncture. Animals had a mean body weight of 52.35 ± 4.55 kg, were aged between 2 and 3 years old, and were clinically healthy with no evidence of disease and free from internal and external parasites. All animals were shorn on the same day by hand using traditional shearing scissors in a 15 m × 10 m pen. The animals were released into an adjacent pen at the end of the shearing procedure. For each animal, blood samples were collected through jugular venipuncture into a vacutainer tube with a clot activator (Terumo Corporation, Japan) immediately before and 5 and 60 min after the end of the shearing procedure. On the obtained sera, ELISA and Raman spectroscopy analyses were performed to evaluate cortisol concentrations. The band area corresponding to the cortisol vibration mode was identified in the 1300–1366 cm⁻¹ band. The Raman spectra obtained during the various protocol data points showed the same trend, with differences in the intensity of the band area 1300–1366 cm⁻¹. A positive correlation was found between ELISA and Raman assessment in all experimental conditions. The obtained results demonstrate that Raman spectroscopy analysis could be a suitable tool for biomolecule identification. This study demonstrated that this technique provides useful information for understanding sheep responses to stress induced by management conditions. Full article

This study evaluated the impact of vocal loudness on bilabial contact pressure (BCP) during the production of bilabial English consonants in adults with Parkinson’s disease (PD). Twelve adults with PD produced sentences with the phonemes /b, p, m/ initiating a linguistically meaningful word within the sentence, while BCP was sensed with a miniature pressure transducer positioned at the midline between the upper and lower lips. Stimuli were produced at two loudness levels: Habitual and twice as loud as habitual loudness (Loud). A linear mixed model (LMM) indicated a statistically significant main effect of Condition (F (1, 714) = 16.210, p < 0.001) with Loud having greater BCP than Habitual (mean difference of 0.593 kPa). The main effect of Phoneme was also significant (F (1, 714) = 31.905, p < 0.001), with post hoc tests revealing that BCP was significantly higher for /p/ compared to /m/ (p = 0.007), and for /b/ compared to /m/ (p = 0.002). An additional LMM of the magnitude of the percent change in BCP in the Loud condition relative to the Habitual condition had a significant main effect of Phoneme (F (2, 22.3) = 5.871, p = 0.006). The percent change in BCP was the greatest for /p/ (47.7%), followed by /b/ (35.7%) and /m/ (27.4%), with statistically significant differences for both /p/ and /b/ compared to /m/ in post hoc tests. The results indicated that changes in vocal loudness cause changes in BCP in individuals with PD. A louder voice was associated with higher BCP for all three phonemes, although the increase was the greatest on bilabial stops compared to nasal stops. These results provide initial insights regarding the mechanism by which therapeutic interventions focused on increasing loudness in people with PD alter oral articulatory behaviors. Future work that details potential aerodynamic (e.g., oral air pressure build-up) and articulatory acoustics (e.g., burst intensity) is needed to better explain the mechanistic actions of increased loudness that can explain why loud-focused speech treatments for people with PD may improve speech intelligibility. Full article

People often turn to sweet foods for comfort during times of stress, as energy imbalance is implicated in several neuropsychiatric disorders including post-traumatic stress disorder (PTSD). Although acute sucrose consumption may improve cognitive capabilities, its long-term effectiveness has been debated. Objectives: In a widely used mouse model, we examined the effect of sucrose drinking on conditioned fear-induced freezing (as a model of PTSD), with emphasis on the concentrations and timing of the intervention as well as sex differences. We aimed to develop a low-cost, widely accessible therapeutic option. Methods: A short electric foot shock was used for trauma, and freezing was detected 24 h (mimicking acute stress disorder, ASD) or 14 days (PTSD-like symptoms) later in the trauma context and with trauma cues. Results: First, we confirmed that our trauma increased freezing, independent of previous habituation to sucrose drinking. Next, we confirmed that 16% and 32%, but not 2% sucrose drinking for 24 h (but not 3 h) immediately after trauma, diminished freezing behavior the next day. However, the same intervention did not influence behavior 14 days later. Moreover, we could not find any curative effect of 24 h of 16% sucrose consumption before testing remote fear memory 14 days after trauma. Conclusions: Consuming a high-calorie solution immediately following trauma for 24 h may influence ASD but does not necessarily alter the development of PTSD symptoms. Here, we offer a new perspective on energy regulation in neuropsychiatric disorders. Full article

Background/Objectives: Hypertension is a growing public health concern in Saudi Arabia, driven by rapid socioeconomic changes. This study investigated the interplay between habitual, behavioral, and dietary risk factors associated with hypertension among Saudi adults. Methods: A cross-sectional survey was conducted among 3312 Saudi adults using multistage stratified random sampling. The data were collected via validated questionnaires assessing sociodemographic, anthropometric indicators, lifestyle behaviors, dietary patterns, and medical history. Hypertension status was determined through self-reported diagnosis. Bivariate analyses and multiple logistic regression identified independent predictors (p < 0.05). Results: Hypertension prevalence was 13% (mean age: 34 ± 15 years; 50% male). The strongest predictors were age (OR = 1.08/year; 95% CI: 1.07–1.10; p < 0.001), increased body mass index (OR = 1.03; 95% CI: 1.01–1.06; p = 0.011), smoking (OR = 1.55; 95% CI: 1.04–2.29; p = 0.030), and family history of hypertension (OR = 7.71; 95% CI: 5.61–10.75; p < 0.001). Participants with diabetes mellitus had 89% higher odds of hypertension (OR = 1.89; 95% CI: 1.42–2.51; p < 0.001), and those with dyslipidemia had more than double the odds (OR = 2.45; 95% CI: 1.38–4.22; p = 0.002). Protective factors included higher income (≥15,000 SAR; OR = 0.54; 95% CI: 0.36–0.81; p = 0.003) and regular whole grain consumption (OR = 0.60; 95% CI: 0.46–0.77; p < 0.001). Conclusions: Hypertension risk in Saudi adults is shaped by age, obesity, smoking, comorbid metabolic conditions (diabetes and dyslipidemia), and genetic pre-disposition. In contrast, higher income and whole grain intake may offer protection. These findings underscore the need for comprehensive prevention strategies that address both lifestyle and cardiometabolic comorbidities, in alignment with Saudi Vision 2030 health priorities. Full article

Background/Objectives: Nurses play a vital role in healthcare, yet their demanding working conditions, including long hours, shift work, and stress, can negatively impact health behaviors. In Poland, empirical data on nurses’ eating habits and body composition remain limited. Therefore, this study aimed to evaluate body composition and dietary habits among nurses, and to identify significant relationships and associations between these variables. Methods: A cross-sectional observational study was conducted among 460 Polish nurses. The mean age of the respondents was 45.07 years (SD ± 11.98). Body composition was assessed using the Tanita MC-780 PLUS MA analyzer, and eating behaviors were measured with the standardized My Eating Habits questionnaire (MEH). Advanced statistical analyses including k-means clustering, ANOVA, chi-square tests, Spearman’s correlation, ROC curves, decision tree modeling, and heatmap visualization were used to identify associations. Results: The MEH scores among nurses indicated average eating behavior. However, excess body fat, overweight/obesity, shift work, and holding multiple jobs were significantly associated with emotional overeating, habitual overeating, and restrictive eating. Decision tree analysis identified Body Mass Index (BMI), fat-free mass (FFM) and comorbidities as key predictors of problematic eating patterns. Interaction effects showed that shift work combined with higher BMI further increased the risk of maladaptive behaviors. Heatmaps confirmed the strongest MEH scores in participants with elevated BMI and FFM. Conclusions: The findings underscore the need for targeted workplace interventions promoting healthy eating and weight control among nurses. Recognizing risk factors such as excess weight or multiple job holding can aid in designing effective prevention and health promotion strategies tailored to healthcare professionals. Full article

Background and Clinical Significance: This case report highlights the rare but potentially sight-threatening presentation of corneal ulcers associated with methamphetamine abuse. Identifying the signs of illicit drug use is critical, as ocular complications may be overlooked without proper social history or lab confirmation. Case Presentation: A 48-year-old Hispanic male presented with progressive bilateral vision loss over four weeks, describing his condition as “blind vision.” Two weeks earlier, he had visited the emergency room after a fall caused by impaired vision and was prescribed insulin, metronidazole, and fluoroquinolone drops. At ophthalmology follow-up, visual acuity was 20/400 OD and 20/800 OS. Examination revealed bilateral stromal corneal ulcers with infiltrates. Notable systemic signs—pockmarks, poor dentition, thin body habitus, and jittery behavior—raised suspicion for methamphetamine use. He was treated with bandage contact lenses, dehydrated amniotic membranes, and a steroid-antibiotic combination drop. Conclusions: This case underscores the importance of recognizing physical signs of methamphetamine abuse, even in the absence of disclosed history. Emergency room laboratory testing confirmed methamphetamine use. Awareness of drug-induced ocular effects allows for appropriate patient education, timely intervention, and referral to addiction services. Patients should be warned that continued drug use may result in irreversible vision loss. Full article