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Search Results (1,432)

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Keywords = generalized linear mixed models

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16 pages, 2714 KiB  
Article
Early Succession Across Boreal Forest Transitions After Linear Disturbance and Wildfire
by Colleen M. Sutheimer and Scott E. Nielsen
Forests 2025, 16(8), 1333; https://doi.org/10.3390/f16081333 (registering DOI) - 16 Aug 2025
Abstract
Anthropogenic disturbances interact with wildfire, altering successional dynamics across North America’s boreal forest. Linear disturbances, including seismic lines used for oil and gas exploration, dissect forests, while wildfire is a fundamental agent of forest succession. However, little is known about early succession dynamics [...] Read more.
Anthropogenic disturbances interact with wildfire, altering successional dynamics across North America’s boreal forest. Linear disturbances, including seismic lines used for oil and gas exploration, dissect forests, while wildfire is a fundamental agent of forest succession. However, little is known about early succession dynamics after both seismic line creation and wildfire, especially across transitions from uplands to peatlands. To address this, we characterized and compared regeneration and recruitment after individual and successive disturbances in peatland, transitional, and mesic upland forests across the oil sands region of Alberta, Canada. We used non-metric multidimensional scaling to compare composition and mixed-effects generalized linear models to compare densities of trees and tall shrubs 10 to 24 years after disturbance. Compositionally, regeneration was similar within forest types and between transitional and peatland forests, while patterns in recruitment were more influenced by past disturbances. Overall, we found evidence of dominant, additive, and interactive effects on early successional patterns within linear disturbances in boreal forests. In transitional and peatland forests, disturbances influenced tree and tall shrub regeneration and recruitment in complex ways. Early successional dynamics after disturbance influence forest structure and composition and are vital to understanding recovery in boreal forests, especially across boreal forest transitions. Full article
(This article belongs to the Special Issue Impact of Disturbance on Forest Regeneration and Recruitment)
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20 pages, 835 KiB  
Article
Automated and Optimized Scheduling for CNC Machines
by Guilherme Sousa Silva Martins, M. Fernanda P. Costa and Filipe Alves
Mathematics 2025, 13(16), 2621; https://doi.org/10.3390/math13162621 - 15 Aug 2025
Abstract
This work presents the design and implementation of an automated, digital, and modular system to address a real-world industrial challenge: the automation and optimization of production schedules for Computer Numerical Control (CNC) machines in a factory in Portugal. The goal is to replicate [...] Read more.
This work presents the design and implementation of an automated, digital, and modular system to address a real-world industrial challenge: the automation and optimization of production schedules for Computer Numerical Control (CNC) machines in a factory in Portugal. The goal is to replicate and enhance the existing manual scheduling process by integrating multiple data sources and formulating a general Mixed-Integer Linear Programming (MILP) model with constraints. This model can be solved using MILP optimization methods to produce efficient scheduling solutions that minimize machine downtime, reduce tool change frequency, and lower operator workload. The proposed system is implemented using open-source Python abstraction interfaces (Python-MIP), employing state-of-the-art of MILP optimization solvers such as CBC and HiGHS for solution validation. The system is designed to accommodate a wide range of constraints and operational factors, which can be switched on or off as needed, thereby enhancing its flexibility and decision-support capabilities. Additionally, a user-friendly graphical application is developed to facilitate the input of specific scheduling data and constraints, enabling flexible and efficient formulation of diverse scheduling scenarios. The proposed system is validated through multiple case studies, demonstrating its effectiveness in optimizing industrial CNC scheduling tasks and providing a scalable, practical tool for real-world factory operations. Full article
(This article belongs to the Special Issue Operations Research and Optimization, 2nd Edition)
12 pages, 3778 KiB  
Article
Effects of Drainage Maintenance on Tree Radial Increment in Hemiboreal Forests of Latvia
by Kārlis Bičkovskis, Guntars Šņepsts, Jānis Donis, Āris Jansons, Diāna Jansone, Ieva Jaunslaviete and Roberts Matisons
Forests 2025, 16(8), 1318; https://doi.org/10.3390/f16081318 - 13 Aug 2025
Viewed by 158
Abstract
Under cool and moist climates, timely implementation of ditch network maintenance (DNM) is crucial for sustaining productivity of drained forests, thus reducing operational costs, while mitigating environmental risks. This underscores the need to understand tree growth responses to DNM. This study evaluated the [...] Read more.
Under cool and moist climates, timely implementation of ditch network maintenance (DNM) is crucial for sustaining productivity of drained forests, thus reducing operational costs, while mitigating environmental risks. This underscores the need to understand tree growth responses to DNM. This study evaluated the effects of DNM on tree radial increment in sites with both organic and mineral drained soils, focusing on regionally commercially important species: Scots pine (Pinus sylvestris), Norway spruce (Picea abies), and silver birch (Betula pendula). Responses of relative growth changes over eight years post-DNM to site and tree characteristics were assessed using a linear mixed-effects model. Species- and site-specific growth responses to DNM were indicated by significant interactions between tree species, site type, and distance from the drainage ditch. While growth responses were generally neutral (non-significant), variability among sites and species suggests that both organic and mineral soils might be prone to site-level moisture depletion near drainage infrastructure in the post-DNM period. The effect of stand age and density suggested higher responsiveness of older and less dense stands, hence positive effects of thinning to resilience of stands to DNM. These findings highlight the importance of adapting DNM strategies to local site conditions and stand characteristics to minimize drought-related growth limitations. Full article
(This article belongs to the Special Issue Effects of Climate Change on Tree-Ring Growth—2nd Edition)
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14 pages, 574 KiB  
Article
Impact of Chromosomal Structural Rearrangements on IVF Laboratory Outcomes in PGT-SR Cycles: A Propensity Score Matching-Based Study
by Daria Marzanati, Sara D’Alessandro, Davide Gentilini, Elisa Rabellotti, Laura Privitera, Sonia Faulisi, Francesca Spinella, Anil Biricik, Ettore Cotroneo, Massimo Candiani, Luca Pagliardini, Enrico Papaleo and Alessandra Alteri
Life 2025, 15(8), 1266; https://doi.org/10.3390/life15081266 - 11 Aug 2025
Viewed by 223
Abstract
Chromosomal structural rearrangements (SR) can impair gametogenesis, increasing the risk of embryos carrying unbalanced chromosomal content (i.e., with a gain or loss of chromosomal material). In such cases, assisted reproduction technologies (ARTs) with preimplantation genetic testing for structural rearrangements (PGT-SR) is recommended to [...] Read more.
Chromosomal structural rearrangements (SR) can impair gametogenesis, increasing the risk of embryos carrying unbalanced chromosomal content (i.e., with a gain or loss of chromosomal material). In such cases, assisted reproduction technologies (ARTs) with preimplantation genetic testing for structural rearrangements (PGT-SR) is recommended to identify embryos with a normal or balanced karyotype. However, data on IVF laboratory outcomes in this context remain limited. This retrospective cohort study analyzed 548 ART cycles, comprising 129 with PGT-SR and 419 with PGT-A, conducted at a single university-affiliated center. Following propensity score matching, laboratory outcomes were compared using logistic regression. The fertilization rate was comparable between groups, but the PGT-SR group had significantly lower blastocyst development (36.7% vs. 47.1%) and top-quality blastocyst development rates (9.6% vs. 21.1%). No significant differences were found either in the blastocyst development rate on days 5, 6, 7, or in euploidy rates. In the PGT-SR cohort, the generalized linear mixed-effects model indicated no significant effect of carrier gender on the normal/balanced blastocyst rate, while the type of SR was strongly associated with it: non-reciprocal SRs yielded a higher rate of normal/balanced blastocysts (89.9%) compared to reciprocal translocations (45.7%). These findings indicate that patients undergoing PGT-SR generate fewer blastocysts available for biopsy, and that in cases involving reciprocal translocations, the proportion of normal/balanced blastocysts suitable for transfer is significantly reduced. These results underscore the importance of personalized counseling in managing expectations and supporting informed clinical decision-making. Full article
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17 pages, 1451 KiB  
Article
Temporal–Spatial Acceleration Framework for Full-Year Operational Simulation of Power Systems with High Renewable Penetration
by Chen Wang, Zhiqiang Lu, Chunmiao Zhang, Mingyu Yan, Yirui Zhao and Yijia Zhou
Processes 2025, 13(8), 2502; https://doi.org/10.3390/pr13082502 - 8 Aug 2025
Viewed by 296
Abstract
With the rapid growth of renewable energy integration, power systems are facing increasing uncertainty and variability in operation. The intermittent and uncontrollable nature of wind and solar generation requires operational decisions to anticipate future fluctuations, creating strong temporal coupling across days. This leads [...] Read more.
With the rapid growth of renewable energy integration, power systems are facing increasing uncertainty and variability in operation. The intermittent and uncontrollable nature of wind and solar generation requires operational decisions to anticipate future fluctuations, creating strong temporal coupling across days. This leads to large-scale mixed-integer linear programming (MILP) with a large number of binary variables, which is computationally intensive—especially in year-long simulations. As a result, there is a growing need for efficient modeling approaches that can reduce complexity while preserving key temporal features. This paper proposes a temporal–spatial acceleration framework for long-term power system operation simulation. In the temporal dimension, a monthly K-means clustering algorithm is applied to reconstruct typical scenario days from 8760 h time series, preserving the characteristics of seasonal and intraday variability. In the spatial dimension, thermal units with similar characteristics are aggregated, and binary decision variables are relaxed into continuous variables, transforming the MILP into a tractable LP model, and thereby reducing computational burden. Case studies are performed based on the six-bus and the IEEE RTS-79 systems to validate the framework, being able to provide a practical solution for renewable-integrated power system planning and dispatch applications. Full article
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31 pages, 5099 KiB  
Article
Scalable Energy Management Model for Integrating V2G Capabilities into Renewable Energy Communities
by Niccolò Pezzati, Eleonora Innocenti, Lorenzo Berzi and Massimo Delogu
World Electr. Veh. J. 2025, 16(8), 450; https://doi.org/10.3390/wevj16080450 - 7 Aug 2025
Viewed by 276
Abstract
To promote a more decentralized energy system, the European Commission introduced the concept of Renewable Energy Communities (RECs). Meanwhile, the increasing penetration of Electric Vehicles (EVs) may significantly increase peak power demand and consumption ramps when charging sessions are left uncontrolled. However, by [...] Read more.
To promote a more decentralized energy system, the European Commission introduced the concept of Renewable Energy Communities (RECs). Meanwhile, the increasing penetration of Electric Vehicles (EVs) may significantly increase peak power demand and consumption ramps when charging sessions are left uncontrolled. However, by integrating smart charging strategies, such as Vehicle-to-Grid (V2G), EV storage can actively support the energy balance within RECs. In this context, this work proposes a comprehensive and scalable model for leveraging smart charging capabilities in RECs. This approach focuses on an external cooperative framework to optimize incentive acquisition and reduce dependence on Medium Voltage (MV) grid substations. It adopts a hybrid strategy, combining Mixed-Integer Linear Programming (MILP) to solve the day-ahead global optimization problem with local rule-based controllers to manage power deviations. Simulation results for a six-month case study, using historical demand data and synthetic charging sessions generated from real-world events, demonstrate that V2G integration leads to a better alignment of overall power consumption with zonal pricing, smoother load curves with a 15.5% reduction in consumption ramps, and enhanced cooperation with a 90% increase in shared power redistributed inside the REC. Full article
(This article belongs to the Special Issue Power and Energy Systems for E-Mobility, 2nd Edition)
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28 pages, 4311 KiB  
Article
Sustainable Integration of Prosumers’ Battery Energy Storage Systems’ Optimal Operation with Reduction in Grid Losses
by Tomislav Markotić, Damir Šljivac, Predrag Marić and Matej Žnidarec
Sustainability 2025, 17(15), 7165; https://doi.org/10.3390/su17157165 - 7 Aug 2025
Viewed by 290
Abstract
Driven by the need for sustainable and efficient energy systems, the optimal management of distributed generation, including photovoltaic systems and battery energy storage systems within prosumer households, is of crucial importance. This requires a comprehensive cost–benefit analysis to assess their viability. In this [...] Read more.
Driven by the need for sustainable and efficient energy systems, the optimal management of distributed generation, including photovoltaic systems and battery energy storage systems within prosumer households, is of crucial importance. This requires a comprehensive cost–benefit analysis to assess their viability. In this study, an optimization model formulated as a mixed-integer linear programming problem is proposed to evaluate the integration of battery storage systems for 10 prosumers on the radial feeder in Croatia and to quantify the benefits both from the prosumers’ perspective and that of the reduction in grid losses. The results show significant annual cost reductions for prosumers, totaling EUR 1798.78 for the observed feeder, with some achieving a net profit. Grid losses are significantly reduced by 1172.52 kWh, resulting in an annual saving of EUR 216.25 for the distribution system operator. However, under the current Croatian market conditions, the integration of battery storage systems is not profitable over the entire lifetime due to the high initial investment costs of EUR 720/kWh. The break-even analysis reveals that investment cost needs to decrease by 52.78%, or an inflation rate of 4.87% is required, to reach prosumer profitability. This highlights the current financial barriers to the widespread adoption of battery storage systems and emphasizes the need for significant cost reductions or targeted incentives. Full article
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26 pages, 10480 KiB  
Article
Monitoring Chlorophyll Content of Brassica napus L. Based on UAV Multispectral and RGB Feature Fusion
by Yongqi Sun, Jiali Ma, Mengting Lyu, Jianxun Shen, Jianping Ying, Skhawat Ali, Basharat Ali, Wenqiang Lan, Yiwa Hu, Fei Liu, Weijun Zhou and Wenjian Song
Agronomy 2025, 15(8), 1900; https://doi.org/10.3390/agronomy15081900 - 7 Aug 2025
Viewed by 300
Abstract
Accurate prediction of chlorophyll content in Brassica napus L. (rapeseed) is essential for monitoring plant nutritional status and precision agricultural management. The current study focuses on single cultivars, limiting general applicability. This study used unmanned aerial vehicle (UAV)-based RGB and multispectral imagery to [...] Read more.
Accurate prediction of chlorophyll content in Brassica napus L. (rapeseed) is essential for monitoring plant nutritional status and precision agricultural management. The current study focuses on single cultivars, limiting general applicability. This study used unmanned aerial vehicle (UAV)-based RGB and multispectral imagery to evaluate six rapeseed cultivars chlorophyll content across mixed-growth stages, including seedling, bolting, and initial flowering stages. The ExG-ExR threshold segmentation was applied to remove background interference. Subsequently, color and spectral indices were extracted from segmented images and ranked according to their correlations with measured chlorophyll content. Partial Least Squares Regression (PLSR), Multiple Linear Regression (MLR), and Support Vector Regression (SVR) models were independently established using subsets of the top-ranked features. Model performance was assessed by comparing prediction accuracy (R2 and RMSE). Results demonstrated significant accuracy improvements following background removal, especially for the SVR model. Compared to data without background removal, accuracy increased notably with background removal by 8.0% (R2p improved from 0.683 to 0.763) for color indices and 3.1% (R2p from 0.835 to 0.866) for spectral indices. Additionally, stepwise fusion of spectral and color indices further improved prediction accuracy. Optimal results were obtained by fusing the top seven color features ranked by correlation with chlorophyll content, achieving an R2p of 0.878 and an RMSE of 52.187 μg/g. These findings highlight the effectiveness of background removal and feature fusion in enhancing chlorophyll prediction accuracy. Full article
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16 pages, 2440 KiB  
Article
Dog–Stranger Interactions Can Facilitate Canine Incursion into Wilderness: The Role of Food Provisioning and Sociability
by Natalia Rojas-Troncoso, Valeria Gómez-Silva, Annegret Grimm-Seyfarth and Elke Schüttler
Biology 2025, 14(8), 1006; https://doi.org/10.3390/biology14081006 - 6 Aug 2025
Viewed by 593
Abstract
Most research on domestic dog (Canis familiaris) behavior has focused on pets with restricted movement. However, free-ranging dogs exist in diverse cultural contexts globally, and their interactions with humans are less understood. Tourists can facilitate unrestricted dog movement into wilderness areas, [...] Read more.
Most research on domestic dog (Canis familiaris) behavior has focused on pets with restricted movement. However, free-ranging dogs exist in diverse cultural contexts globally, and their interactions with humans are less understood. Tourists can facilitate unrestricted dog movement into wilderness areas, where they may negatively impact wildlife. This study investigated which stimuli—namely, voice, touch, or food—along with inherent factors (age, sex, sociability) motivate free-ranging dogs to follow a human stranger. We measured the distance (up to 600 m) of 129 free-ranging owned and stray dogs from three villages in southern Chile as they followed an experimenter who presented them one of the above stimuli or none (control). To evaluate the effect of dog sociability (i.e., positive versus stress-related or passive behaviors), we performed a 30 s socialization test (standing near the dog without interacting) before presenting a 10 s stimulus twice. We also tracked whether the dog was in the company of other dogs. Each focus dog was video-recorded and tested up to three times over five days. Generalized linear mixed-effects models revealed that the food stimulus significantly influenced dogs’ motivation to follow a stranger, as well as a high proportion of sociable behaviors directed towards humans and the company of other dogs present during the experiment. Juveniles tended to follow a stranger more than adults or seniors, but no effects were found for the dog’s sex, whether an owner was present, the repetition of trials, the location where the study was performed, or for individuals as a random variable. This research highlights that sociability as an inherent factor shapes dog–stranger interactions in free-ranging dogs when food is given. In the context of wildlife conservation, we recommend that managers promote awareness among local communities and tourists to avoid feeding dogs, especially in the context of outdoor activities close to wilderness. Full article
(This article belongs to the Special Issue Biology, Ecology, Management and Conservation of Canidae)
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13 pages, 418 KiB  
Article
Depression and Hypomagnesemia as Independent and Synergistic Predictors of Cognitive Impairment in Older Adults Post-COVID-19: A Prospective Cohort Study
by José Guzmán-Esquivel, Brando S. Becerra-Galindo, Gustavo A. Hernández-Fuentes, Marco A. Ramos-Rojas, Osiris G. Delgado-Enciso, Hannah P. Guzmán-Solórzano, Janet Diaz-Martinez, Verónica M. Guzmán-Sandoval, Carmen A. Sanchez-Ramirez, Valery Melnikov, Héctor Ochoa-Diaz-Lopez, Daniel Montes-Galindo, Fabian Rojas-Larios and Iván Delgado-Enciso
Med. Sci. 2025, 13(3), 114; https://doi.org/10.3390/medsci13030114 - 6 Aug 2025
Viewed by 179
Abstract
Background/Objectives: Cognitive impairment in older adults has emerged as a growing public health concern, particularly in relation to COVID-19 infection and its associated neuropsychiatric symptoms. The identification of modifiable risk factors may contribute to the development of targeted preventive strategies. This study aimed [...] Read more.
Background/Objectives: Cognitive impairment in older adults has emerged as a growing public health concern, particularly in relation to COVID-19 infection and its associated neuropsychiatric symptoms. The identification of modifiable risk factors may contribute to the development of targeted preventive strategies. This study aimed to assess predictors of cognitive impairment in older adults with and without recent SARS-CoV-2 infection. Methods: A prospective cohort study was conducted from June 2023 to March 2024 at a tertiary hospital in western Mexico. Adults aged 65 years or older with confirmed SARS-CoV-2 infection within the previous six months, along with uninfected controls, were enrolled. Cognitive function (Mini-Mental State Examination), depression (PHQ-9), anxiety (Geriatric Anxiety Inventory), insomnia (Insomnia Severity Index), functional status (Katz Index and Lawton–Brody Scale), and laboratory markers were evaluated at baseline, three months, and six months. The primary outcome was cognitive impairment at six months. Independent predictors were identified using a multivariable generalized linear mixed-effects model. Results: Among the 111 participants, 20 (18.8%) developed cognitive impairment within six months. Low serum magnesium (adjusted risk ratio [aRR] 2.73; 95% CI 1.04–7.17; p = 0.041) and depression (aRR 5.57; 95% CI 1.88–16.48; p = 0.002) were independently associated with a higher risk. A significant synergistic among COVID-19, depression, and hypomagnesemia was observed (RR 44.30; 95% CI 9.52–206.21; p < 0.001), corresponding to the group with simultaneous presence of all three factors compared to the group with none. Conclusions: Depression and hypomagnesemia appear to be independent predictors of cognitive impairment in older adults with recent COVID-19 infection. These findings suggest potential targets for prevention and support the implementation of routine neuropsychiatric and biochemical assessments in this population. Full article
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12 pages, 840 KiB  
Article
Baseline Knee Osteoarthritis and Chronic Obstructive Pulmonary Disease as Predictors of Physical Activity Decline: A Five-Year Longitudinal Study in U.S. Adults Using the Disablement Process Framework
by Saad A. Alhammad and Vishal Vennu
Healthcare 2025, 13(15), 1902; https://doi.org/10.3390/healthcare13151902 - 5 Aug 2025
Viewed by 237
Abstract
Background/Objective: Understanding how chronic conditions such as knee osteoarthritis (OA) and chronic obstructive pulmonary disease (COPD) influence long-term physical activity (PA) is essential for developing condition-specific rehabilitation strategies. This study aimed to examine whether baseline diagnoses of knee OA and COPD are independently [...] Read more.
Background/Objective: Understanding how chronic conditions such as knee osteoarthritis (OA) and chronic obstructive pulmonary disease (COPD) influence long-term physical activity (PA) is essential for developing condition-specific rehabilitation strategies. This study aimed to examine whether baseline diagnoses of knee OA and COPD are independently associated with the trajectories of PA decline over five years in U.S. adults, informed by the disablement process model. Methods: We analyzed data from 855 adults aged ≥45 years enrolled in the Osteoarthritis Initiative (OAI). The participants were categorized into three baseline groups, control (n = 122), knee OA (n = 646), and COPD (n = 87), based on self-reports and prior clinical assessments. PA was measured annually for five years using the Physical Activity Scale for the Elderly (PASE). General linear mixed models assessed changes in PA over time, adjusting for demographic, behavioral, and clinical covariates. Results: Compared to the controls, participants with knee OA had a significant decline in PA over time (β = −6.62; 95% CI: −15.4 to −2.19; p = 0.014). Those with COPD experienced an even greater decline compared to the knee OA group (β = −11.2; 95% CI: −21.7 to −0.67; p = 0.037). These associations persisted after adjusting for age, sex, body mass index, comorbidities, and smoking. Conclusions: Baseline knee OA and COPD were independently associated with long-term reductions in PA. These findings underscore the importance of early, tailored rehabilitation strategies, particularly pulmonary rehabilitation, in preserving functional independence among older adults with chronic conditions. Full article
(This article belongs to the Special Issue Association Between Physical Activity and Chronic Condition)
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20 pages, 357 KiB  
Article
The Association Between Physical Activity and Frailty: China Health and Retirement Longitudinal Study (CHARLS)
by Wupeng Yin, Ximeng Zhao, Ayodele Tyndall and Nan Hu
Int. J. Environ. Res. Public Health 2025, 22(8), 1219; https://doi.org/10.3390/ijerph22081219 - 4 Aug 2025
Viewed by 490
Abstract
Background: With China’s rapidly aging population, frailty has become a growing concern among older adults. Physical activity (PA) is known to mitigate frailty-related decline, yet few studies have examined these associations longitudinally. Methods: Using five waves (2011–2020) of CHARLS data, we analyzed Chinese [...] Read more.
Background: With China’s rapidly aging population, frailty has become a growing concern among older adults. Physical activity (PA) is known to mitigate frailty-related decline, yet few studies have examined these associations longitudinally. Methods: Using five waves (2011–2020) of CHARLS data, we analyzed Chinese adults aged 60+ to assess the association between frailty—measured by a frailty index (FI)—and PA across various types (light, moderate, vigorous, total, and leisure). A generalized linear mixed-effects model was used, adjusting for demographic, socioeconomic, and health-related factors. Results: All PA types were significantly associated with lower odds of concurrent frailty, including light (OR = 0.37), moderate (OR = 0.37), vigorous (OR = 0.40), total (OR = 0.23), and leisure PA (OR = 0.56). Lagged PA also predicted reduced frailty risk over time, except for light PA. Conclusion: Regular PA is linked to a lower risk of frailty among older Chinese adults. These findings underscore the importance of sustained PA as a strategy to promote healthy aging and inform public health interventions for this population. Full article
14 pages, 1282 KiB  
Systematic Review
Actinic Cheilitis: A Systematic Review and Meta-Analysis of Interventions, Treatment Outcomes, and Adverse Events
by Matthäus Al-Fartwsi, Anne Petzold, Theresa Steeb, Lina Amin Djawher, Anja Wessely, Anett Leppert, Carola Berking and Markus V. Heppt
Biomedicines 2025, 13(8), 1896; https://doi.org/10.3390/biomedicines13081896 - 4 Aug 2025
Viewed by 432
Abstract
Introduction: Actinic cheilitis (AC) is a common precancerous condition affecting the lips, primarily caused by prolonged ultraviolet radiation exposure. Various treatment options are available. However, the optimal treatment approach remains a subject of debate. Objective: To summarize and compare practice-relevant interventions for AC. [...] Read more.
Introduction: Actinic cheilitis (AC) is a common precancerous condition affecting the lips, primarily caused by prolonged ultraviolet radiation exposure. Various treatment options are available. However, the optimal treatment approach remains a subject of debate. Objective: To summarize and compare practice-relevant interventions for AC. Materials and Methods: A pre-defined protocol was registered in PROSPERO (CRD42021225182). Systematic searches in Medline, Embase, and Central, along with manual trial register searches, identified studies reporting participant clearance rates (PCR) or recurrence rates (PRR). Quality assessment for randomized controlled trials (RCTs) was conducted using the Cochrane Risk of Bias tool 2. Uncontrolled studies were evaluated using the tool developed by the National Heart, Lung, and Blood Institute. The generalized linear mixed model was used to pool proportions for uncontrolled studies. A pairwise meta-analysis for RCTs was applied, using the odds ratio (OR) as the effect estimate and the GRADE approach to evaluate the quality of the evidence. Adverse events were analyzed qualitatively. Results: A comprehensive inclusion of 36 studies facilitated an evaluation of 614 participants for PCR, and 430 patients for PRR. Diclofenac showed the lowest PCR (0.53, 95% confidence interval (CI) [0.41; 0.66]), while CO2 laser showed the highest PCR (0.97, 95% CI [0.90; 0.99]). For PRR, Er:YAG laser showed the highest rates (0.14, 95% CI [0.08; 0.21]), and imiquimod the lowest (0.00, 95% CI [0.00; 0.06]). In a pairwise meta-analysis, the OR indicated a lower recurrence rate for Er:YAG ablative fractional laser (AFL)-primed methyl-aminolevulinate photodynamic therapy (MAL-PDT) (Er:YAG AFL-PDT) compared to methyl-aminolevulinate photodynamic therapy (MAL-PDT) alone (OR = 0.22, 95% CI [0.06; 0.82]). The CO2 laser showed fewer local side effects than the Er:YAG laser, while PDTs caused more skin reactions. Due to qualitative data, comparability was limited, highlighting the need for individualized treatment. Conclusions: This study provides a complete and up-to-date evidence synthesis of practice-relevant interventions for AC, identifying the CO2 laser as the most effective treatment and regarding PCR and imiquimod as most effective concerning PRR. Full article
(This article belongs to the Special Issue Skin Diseases and Cell Therapy)
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21 pages, 9010 KiB  
Article
Dual-Branch Deep Learning with Dynamic Stage Detection for CT Tube Life Prediction
by Zhu Chen, Yuedan Liu, Zhibin Qin, Haojie Li, Siyuan Xie, Litian Fan, Qilin Liu and Jin Huang
Sensors 2025, 25(15), 4790; https://doi.org/10.3390/s25154790 - 4 Aug 2025
Viewed by 310
Abstract
CT scanners are essential tools in modern medical imaging. Sudden failures of their X-ray tubes can lead to equipment downtime, affecting healthcare services and patient diagnosis. However, existing prediction methods based on a single model struggle to adapt to the multi-stage variation characteristics [...] Read more.
CT scanners are essential tools in modern medical imaging. Sudden failures of their X-ray tubes can lead to equipment downtime, affecting healthcare services and patient diagnosis. However, existing prediction methods based on a single model struggle to adapt to the multi-stage variation characteristics of tube lifespan and have limited modeling capabilities for temporal features. To address these issues, this paper proposes an intelligent prediction architecture for CT tubes’ remaining useful life based on a dual-branch neural network. This architecture consists of two specialized branches: a residual self-attention BiLSTM (RSA-BiLSTM) and a multi-layer dilation temporal convolutional network (D-TCN). The RSA-BiLSTM branch extracts multi-scale features and also enhances the long-term dependency modeling capability for temporal data. The D-TCN branch captures multi-scale temporal features through multi-layer dilated convolutions, effectively handling non-linear changes in the degradation phase. Furthermore, a dynamic phase detector is applied to integrate the prediction results from both branches. In terms of optimization strategy, a dynamically weighted triplet mixed loss function is designed to adjust the weight ratios of different prediction tasks, effectively solving the problems of sample imbalance and uneven prediction accuracy. Experimental results using leave-one-out cross-validation (LOOCV) on six different CT tube datasets show that the proposed method achieved significant advantages over five comparison models, with an average MSE of 2.92, MAE of 0.46, and R2 of 0.77. The LOOCV strategy ensures robust evaluation by testing each tube dataset independently while training on the remaining five, providing reliable generalization assessment across different CT equipment. Ablation experiments further confirmed that the collaborative design of multiple components is significant for improving the accuracy of X-ray tubes remaining life prediction. Full article
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15 pages, 428 KiB  
Article
Biodiversity Patterns and Community Construction in Subtropical Forests Driven by Species Phylogenetic Environments
by Pengcheng Liu, Jiejie Jiao, Chuping Wu, Weizhong Shao, Xuesong Liu and Liangjin Yao
Plants 2025, 14(15), 2397; https://doi.org/10.3390/plants14152397 - 2 Aug 2025
Viewed by 554
Abstract
To explore the characteristics of species diversity and phylogenetic diversity, as well as the dominant processes of community construction, in different forest types (deciduous broad-leaved forest, mixed coniferous and broad-leaved forest, and Chinese fir plantation) in subtropical regions, analyze the specific driving patterns [...] Read more.
To explore the characteristics of species diversity and phylogenetic diversity, as well as the dominant processes of community construction, in different forest types (deciduous broad-leaved forest, mixed coniferous and broad-leaved forest, and Chinese fir plantation) in subtropical regions, analyze the specific driving patterns of soil nutrients and other environmental factors on the formation of forest diversity in different forest types, and clarify the differences in response to environmental heterogeneity between natural forests and plantation forests. Based on 48 fixed monitoring plots of 50 m × 50 m in Shouchang Forest Farm, Jiande City, Zhejiang Province, woody plants with a diameter at breast height ≥5 cm were investigated. Species diversity indices (Margalef index, Shannon–Wiener index, Simpson index, and Pielou index), phylogenetic structure index (PD), and environmental factors were used to analyze the relationship between diversity characteristics and environmental factors through variance analysis, correlation analysis, and generalized linear models. Phylogenetic structural indices (NRI and NTI) were used, combined with a random zero model, to explore the mechanisms of community construction in different forest types. Research has found that (1) the deciduous broad-leaved forest had the highest species diversity (Margalef index of 4.121 ± 1.425) and phylogenetic diversity (PD index of 21.265 ± 7.796), significantly higher than the mixed coniferous and broad-leaved forest and the Chinese fir plantation (p < 0.05); (2) there is a significant positive correlation between species richness and phylogenetic diversity, with the best fit being AIC = 70.5636 and R2 = 0.9419 in broad-leaved forests; however, the contribution of evenness is limited; (3) the specific effects of soil factors on different forest types: available phosphorus (AP) is negatively correlated with the diversity of deciduous broad-leaved forests (p < 0.05), total phosphorus (TP) promotes the diversity of coniferous and broad-leaved mixed forests, while the diversity of Chinese fir plantations is significantly negatively correlated with total nitrogen (TN); (4) the phylogenetic structure of three different forest types shows a divergent pattern in deciduous broad-leaved forests, indicating that competition and exclusion dominate the construction of deciduous broad-leaved forests; the aggregation mode of Chinese fir plantation indicates that environmental filtering dominates the construction of Chinese fir plantation; the mixed coniferous and broad-leaved forest is a transitional model, indicating that the mixed coniferous and broad-leaved forest is influenced by both stochastic processes and ecological niche processes. In different forest types in subtropical regions, the species and phylogenetic diversity of broad-leaved forests is significantly higher than in other forest types. The impact of soil nutrients on the diversity of different forest types varies, and the characteristics of community construction in different forest types are also different. This indicates the importance of protecting the original vegetation and provides a scientific basis for improving the ecological function of artificial forest ecosystems through structural adjustment. The research results have important practical guidance value for sustainable forest management and biodiversity conservation in the region. Full article
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