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Synthesis of (S)- and (R)-β-Tyrosine by Redesigned Phenylalanine Aminomutase
- Fei Peng,
- Habibu Aliyu,
- André Delavault,
- Ulrike Engel and
- Jens Rudat
Phenylalanine aminomutase from Taxus chinensis (TchPAM) is employed in the biosynthesis of the widely used antitumor drug paclitaxel. TchPAM has received substantial attention due to its strict enantioselectivity towards (R)-β-phenylalanine, in...