Search Results (152)

This article traces the historical evolution of mural painting as a medium of cultural expression from prehistoric cave art to contemporary street interventions. Adopting a diachronic and interdisciplinary approach, it investigates how muralism has developed across civilizations in relation to techniques, symbolic systems, social function, and its embeddedness in architectural and urban contexts. The analysis is structured around key historical periods using emblematic case studies to examine the interplay between materiality, iconography, and socio-political meaning. From sacred enclosures and civic monuments to post-industrial walls and digital projections, murals reflect shifting cultural paradigms and spatial dynamics. This study emphasizes how mural painting, once integrated into sacred and imperial architecture, has become a tool for public participation, protests, and urban storytelling. Particular attention is paid to the evolving relationship between wall painting and the spaces it inhabits, highlighting the transition from permanence to ephemerality and from monumentality to immediacy. This article contributes to mural studies by offering a comprehensive framework for understanding the technical and symbolic transformations of the medium while proposing new directions for research in the context of digital urbanism and cultural memory. Full article

The determination of precise and reliable interior (IO) and relative (RO) orientation parameters for thermal infrared (TIR) cameras is critical for their subsequent use in photogrammetric processes. Although 2D calibration boards have become the predominant approach for TIR geometric calibration, these targets are susceptible to projective coupling and often introduce error through manual construction methods, necessitating the development of 3D targets tailored to TIR geometric calibration. Therefore, this paper evaluates TIR geometric calibration results obtained from 2D board and 3D field calibration approaches, documenting the construction, observation, and calculation of IO and RO parameters. This includes a comparative analysis of values derived from three popular commercial software packages commonly used for geometric calibration: MathWorks’ MATLAB, Agisoft Metashape, and Photometrix’s Australis. Furthermore, to assess the validity of derived parameters, two InfraRed Thermography 3D-Data Fusion (IRT-3DDF) methods are developed to model historic building façades and medieval frescoes. The results demonstrate the success of the proposed 3D field calibration targets for the calculation of both IO and RO parameters tailored to photogrammetric data fusion. Additionally, a novel combined TIR-RGB bundle block adjustment approach demonstrates the success of applying ‘out-of-the-box’ deep-learning neural networks for multi-modal image matching and thermal modelling. Considerations for the development of TIR geometric calibration approaches and the evolution of proposed IRT-3DDF methods are provided for future work. Full article

The first book of Kings succinctly evokes—in only thirteen verses—the mysterious figure of a queen who came from the distant land of Sheba to test Solomon’s wisdom (1 Kgs 10.1–13). Who would have predicted that this modest episode celebrating the glory of the ancient kings of Jerusalem would be so popular? The episode has spread far beyond the boundaries of the two Testaments, notably in painting. Piero della Francesca’s fresco cycle in Arezzo is a fine example in this respect. Inspired by the Golden Legend, the Florentine painter recreates the scenes of the discovery of the true Cross. Solomon and the Queen of Sheba meet against the backdrop of the fall of Constantinople in 1453. Whether intra- or extra-biblical, ancient or modern, rereading of the original episode reveals issues that are as much historical as they are theological. Full article

In recent decades, there has been an increase in the development of non-invasive and non-destructive analytical techniques in the field of cultural heritage. The present study aims to characterize the frescoes in the hypogeum environment of the San Pietro a Corte complex in Salerno (Campania, Italy) through a multi-analytical approach that couples Infrared Reflectography with X-Ray Fluorescence Spectrometry. Thermographic and hygrometric measurements were also performed to evaluate their state of conservation in relation to environmental parameters such as relative humidity and temperature at the frescoed walls. Spectroscopic investigations revealed a predominant use of natural pigments—chiefly iron-rich earths—and uncovered details invisible to the naked eye that aid art historians in refining stylistic attributions. Hygrometric data showed that the central zones of the frescoes retain the highest moisture levels, underscoring the need for a carefully tailored conservation plan. Overall, this multi-analytical methodology provides important information that enables conservators and restorers to understand both the materials and the preservation requirements of these artworks from a scientific and conservation perspective. Full article

Hybrid simulation integrates numerical and experimental techniques to analyze structural responses under static and dynamic loads. It physically tests components that are not fully characterized while modeling the rest of the structure numerically. Over the past two decades, hybrid testing platforms have become increasingly modular and versatile. This paper presents the development of a robust hybrid testing software framework at the National Laboratory for Civil Engineering (LNEC), Portugal, and evaluates the efficiency of its algorithms. The framework features a LabVIEW-based control and interface application that exchanges data with OpenSees via the OpenFresco middleware using a TCP/IP protocol. Designed for slow to real-time hybrid testing, it employs a predictor–corrector algorithm for motion control, enhanced by an adaptive time series (ATS)-based error tracking and delay compensation algorithm. Its modular design facilitates the integration of new simulation tools. The framework was first assessed through simulated hybrid tests, followed by validation via a hybrid test on a two-bay, one-story steel moment-resisting frame, where one exterior column was physically tested. The results emphasized the importance of the accurate system identification of the physical substructure and the precise calibration of the actuator control and delay compensation algorithms. Full article

Paint loss is one of the main forms of deterioration in historical wall paintings, generally restored by the application of chromatic reintegration. In the specific case of outdoor exposed paintings, it is essential to find a binder that will withstand diverse weather conditions. Since chromatic reintegrations have to be compatible with the original painting, fresco paint mock-ups were manufactured and compared to chromatic reintegrations made with an aqueous colloidal dispersion of silica nanoparticles as binder. The physical compatibility was studied by colour spectrophotometry and measurements of static contact angle, gloss, and roughness values, together with a peeling test, stereomicroscopy, and polarised light microscopy. They were also characterised from a mineralogical, chemical, and molecular point of view using X-ray diffraction, X-ray fluorescence and Fourier-transform infrared spectroscopy. The microtexture was studied by scanning electron microscopy with energy-dispersive X-ray spectroscopy. Chromatic reintegrations showed similar roughness and lower gloss values than frescoes, and the nano-silica binder ensured the natural breathability of the wall. Overall, the chemical nature of pigments was highly influential. The reintegrations with silicate-based pigments were more homogenous, with hardly any fissures, while those carried out with sulphide- or oxide-based pigments were severely cracked. The use of verdigris is discouraged due to the lack of affinity between the binder and the pigment. Full article

Communion Under Both Kinds in the Lublin Frescoes and Gregory Tsamblak’s Liturgy at the Council of Constance. The aim of this publication is to draw attention to the fact that a rather lengthy discussion of the peculiar depiction of the Communion of the Apostles in the krthodox paintings of the Roman Catholic chapel of Lublin Castle has overlooked the fact that the Orthodox Metropolitan of Kiev Gregory Tsamblak, who was an envoy of the founder of the frescoes, i.e., King Władysław Jagiełło of Poland, to the Council of Constance, gave Communion under two forms during the liturgy he celebrated there and that this was recorded in the annals of the Council. Several issues are worth considering here—the depiction of this Communion in a Roman Catholic Church, its unusual form and the fact that Tsamblak celebrated this liturgy at the Council, which gave separate attention to the question of Communion under both kinds. Metropolitan Tsamblak appeared at the Council in 1418, the same year in which the Lublin paintings were made. It is likely that it was Tsamblak who may have worked with King Władysław Jagiełło to set their programme, just as they both united their efforts to create a framework for Christians of different denominations to coexist within one state organism. Thus, it also seems important to recall this remarkable person and the role he played at a key moment after the unification of the Kingdom of Poland and the Grand Duchy of Lithuania. Full article

The treatment landscape of metastatic colorectal cancer (mCRC) has undergone significant evolution, with the introduction of targeted therapies and immunotherapy dramatically altering the management of microsatellite instability-high (MSI-H) tumors. However, the majority of patients, particularly those with microsatellite-stable (MSS) disease, remain refractory to immunotherapy, necessitating the exploration of alternative therapeutic strategies. This review summarizes the current treatment options for heavily pretreated mCRC patients who are not eligible for targeted therapies or clinical trials. Approved therapies for refractory mCRC, including regorafenib, trifluridine/tipiracil (FTD/TPI), and fruquintinib, demonstrate modest survival benefits but are often associated with significant toxicities. Additionally, innovative approaches targeting specific mutations such as KRAS G12C, HER2 amplification, and BRAF V600E are discussed, highlighting emerging combination regimens with immune checkpoint inhibitors and other agents to overcome resistance mechanisms. The potential of rechallenge strategies using previously administered therapies, such as oxaliplatin and anti-EGFR agents, is examined, supported by retrospective and prospective studies. Furthermore, the role of older drugs like mitomycin C in combination with capecitabine is revisited, offering insights into their viability in advanced treatment settings. Ongoing clinical trials with novel agents and combinations are expected to provide further clarity on optimizing sequential treatment regimens and personalizing therapy for mCRC patients. This review emphasizes the need for comprehensive molecular profiling and shared decision-making to improve outcomes and quality of life in this challenging patient population. Full article

The stone Ensemble from Corbii de Piatrǎ Romania arouses a continuous scientific interest, with the final goal being to obtain an exhaustive and multidisciplinary package of results that will become the support of an extensive restoration project. The cave painting stands out as the most important and most affected by the advanced degradation among the historical monuments in Romania. This article provides for the first time a radiocarbon dating of the first forms of painting by establishing the age of the mortar/plaster used as a pictorial support. Being a very complex context from the point of view of the type of datable material and the disappearance over time through degradation of other elements that would ensure a simpler and more reliable radiocarbon dating (such as the straws used to form the material), it was necessary to use a multidisciplinary approach for the selection of samples and for supporting the radiocarbon results. The set of analyses consisted of visualization techniques through microscopy and compositional analysis, providing information on the similarities/differences between the samples, the degradation mechanisms/impurities and the quality of the calcium carbonate dated by the Accelerator Mass Spectrometry (AMS) technique. The results supported each other, ensured the selection of reliable radiocarbon data and established the most probable moment of the early interventions, namely the two phases corresponding to the 14th century. Full article

In October 2021, a mural painting was discovered in the crypt of Parma Cathedral (Italy). It was covered by a wall, erasing it form historical memory. The painting, presumably from the 15th–16th century, depicts the Madonna and Child enthroned in the center, between Saints Peter and John. Before the restoration project, investigations were conducted with different techniques to identify the pigments and binders used, the nature of the surface finish and the efflorescence. Micro-Raman spectroscopy detected numerous pigments compatible with the presumed age. An interesting result concerns the presence of crocoite (lead chromate), an unusual and rare pigment for this period. These pigments were confirmed through investigation by means of Scanning Electron Microscopy coupled to Energy-Dispersive X-ray Spectroscopy (SEM-EDS). Fourier Transform Infrared Spectroscopy (FT–IR) and Gas Chromatography/Mass Spectroscopy (GC/MS) were used to identify the binder and the type of wax used in the finish layer. The rather widespread presence of egg, used to spread the paint, allows us to affirm that this mural painting was created as a fresco, with substantial parts a secco. Full article

Colorectal cancer (CRC) is one of the most common malignancies worldwide, with high morbidity and mortality rates. Conventional treatments, including surgery, radiotherapy, and chemotherapy, have limited effects on advanced and metastatic CRC (mCRC). Fruquintinib, a novel and highly selective vascular endothelial growth factor receptor (VEGFR) inhibitor, has shown significant efficacy and tolerance in treating mCRC. The FRESCO and FRESCO-2 trials demonstrated that fruquintinib significantly prolongs progression-free survival and the overall survival of refractory mCRC patients, establishing it as the standard third-line treatment strategy for mCRC. In addition, the combination of fruquintinib with other anticancer drugs and immune checkpoint inhibitors demonstrated potential for enhanced efficacy, which warrants further exploration. In this review, we aimed to systematically summarize the current knowledge about the pharmacological mechanisms, pharmacokinetic characteristics, adverse events, and corresponding treatment options of fruquintinib and provide an update on the clinical trials related to fruquintinib in CRC by conducting a comprehensive literature search of PubMed and consulting the relevant clinical trials via ClinicalTrials.gov and the ChiCTR website, aiming to offer new insights into the role of fruquintinib in the comprehensive treatment of CRC. Full article

The aim of the present research is to validate the combined use, through data fusion, of a Laser Induced Fluorescence (LIF) scanning system and a radar scanner (RGB-ITR, Red Green Blue Imaging Topological Radar system), as a unique tool to address the need for non-invasive, rapid, and low-cost techniques for both diagnostic and operational needs. The integrated system has been applied to the House of Diana complex in Ostia Antica. The main diagnostic objective of this research was to trace the materials used in different phases of restoration, from antiquity to modernity, on both masonry and pictorial surfaces, to reconstruct the history of the building. Due to the significant interest in this insula, other studies have been recently carried out on the House of Diana, but they once again highlighted the necessity of multiple approaches and non-invasive methods capable of providing quasi-real-time answers, delivering point-by-point information on very large surfaces to overcome the limits related to representativeness of sampling. The data acquired by the RGB-ITR system are quantitative, allowing for morphological and 3-colour analysis of the investigated artwork. In this work, the sensor has been used to create coloured 3D models useful for structural assessments and for locating different classes of materials. In fact, the LIF maps, which integrate knowledge about the original constituent materials and previous conservation interventions, have been used as additional layers of the tridimensional models. Therefore, the method can direct possible new investigations and restoration actions, piecing together the history of the House of Diana to build for it a safer future. Full article

The interior of Orthodox churches is entirely decorated with paintings, icons, and frescoes, to help create a special environment for the prayers and visitors. The paintings have religious, esthetic, and historical value, being created in the Byzantine tradition and following recommendations on style and materials according to old church canons. Particular importance is attributed to the Iconostasis decorated with icons on several registers, as well as to polychrome wooden ornaments and imperial doors. This work presents the scientific investigation results of three royal icons, theoretically dating to the 19th century, from the Iconostasis of the Runcu church, an important 19th-century Romanian historical monument, aiming to answer questions regarding their age and constituent materials, especially what were the mineral pigments used in the color palettes for their painting and if there were any old repainting interventions, in order to assist their restoration and conservation. Methods of characterization employed were optical microscopy, SEM-EDX spectrometry, ATR/FTIR spectroscopy, and X-ray fluorescence spectrometry. Results obtained allowed us to date, attribute, and evaluate the conservation state of the Royal icons; to our knowledge, this study is among the very few research studies carried out so far on the religious heritage conservation field in Romania. Full article

In this work, we consider the indoor and outdoor microclimatic conditions and the influence of the building on their relationship. Microclimatic indexes are a useful tool to characterize microclimatic environments, and they can be used to compare indoor and outdoor microclimate conditions and to evaluate the influence of the building itself on the microclimate. The case study refers to the ancient building of San Panfilo church in Tornimparte (Italy), preserving an important cycle of frescoes by depicted by Saturnino Gatti from 1491 to 1494. The microclimatic conditions were measured during a dedicated campaign at several sites in the church and two sites outside: one in a near-building position and one in an open-air site. In order to characterize the indoor and outdoor microclimatic conditions, some statistical indexes were applied. The results show the comparison in microclimatic conditions in the different sites in the church and between indoor and outdoor environments, allowing for the detection of the influence of the building in the microclimatic conditions. Full article

The paper presents the results of experiments on measuring cross-sections for the neutron transfer channels ⁹Be(³He, α)⁸Be_gs,3.03 in the reaction of the ³He (30 MeV) ions with the ⁹Be target. To describe the angular distributions, we use the Distorted Wave Born Approximation (DWBA) applying the FRESCO code. The results of the theoretical analysis are in agreement with the experimental data. In addition, we perform calculations based on the solution of the time-dependent Schrödinger equation (TDSE) for the weakly bound neutron of the ⁹Be nucleus. The TDSE approach allows us to determine the dynamics of the neutron transfer process and calculate the probabilities for the transfer and removal of the neutron of the ⁹Be nucleus in the ³He + ⁹Be reaction. Full article