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Search Results (1,362)

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Keywords = four-dimensional (4D)

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19 pages, 28819 KiB  
Article
Dynamical Analysis, Feedback Control Circuit Implementation, and Fixed-Time Sliding Mode Synchronization of a Novel 4D Chaotic System
by Huaigu Tian, Xifeng Yi, Yang Zhang, Zhen Wang, Xiaojian Xi and Jindong Liu
Symmetry 2025, 17(8), 1252; https://doi.org/10.3390/sym17081252 - 6 Aug 2025
Abstract
This paper presents a novel four-dimensional (4D) chaotic system exhibiting parametric symmetry breaking and multistability. Through equilibrium stability analysis, attractor reconstruction, Lyapunov Exponent spectra (LEs), and bifurcation diagrams, we reveal a continuous transition from symmetric period attractors to asymmetric chaotic states and rich [...] Read more.
This paper presents a novel four-dimensional (4D) chaotic system exhibiting parametric symmetry breaking and multistability. Through equilibrium stability analysis, attractor reconstruction, Lyapunov Exponent spectra (LEs), and bifurcation diagrams, we reveal a continuous transition from symmetric period attractors to asymmetric chaotic states and rich dynamical behaviors. Additionally, considering the potential of this system in practical applications, a feedback control simulation circuit is designed and implemented to ensure its stability and effectiveness under real-world conditions. Finally, among various control strategies, this paper proposes an innovative Fixed-Time Sliding Mode Synchronization (FTSMS) strategy, determines its synchronization convergence time, and provides an important theoretical foundation for the practical application of the system. Full article
(This article belongs to the Special Issue Symmetry/Asymmetry in Chaos Theory and Application)
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28 pages, 6199 KiB  
Article
Dual Chaotic Diffusion Framework for Multimodal Biometric Security Using Qi Hyperchaotic System
by Tresor Lisungu Oteko and Kingsley A. Ogudo
Symmetry 2025, 17(8), 1231; https://doi.org/10.3390/sym17081231 - 4 Aug 2025
Viewed by 11
Abstract
The proliferation of biometric technology across various domains including user identification, financial services, healthcare, security, law enforcement, and border control introduces convenience in user identity verification while necessitating robust protection mechanisms for sensitive biometric data. While chaos-based encryption systems offer promising solutions, many [...] Read more.
The proliferation of biometric technology across various domains including user identification, financial services, healthcare, security, law enforcement, and border control introduces convenience in user identity verification while necessitating robust protection mechanisms for sensitive biometric data. While chaos-based encryption systems offer promising solutions, many existing chaos-based encryption schemes exhibit inherent shortcomings including deterministic randomness and constrained key spaces, often failing to balance security robustness with computational efficiency. To address this, we propose a novel dual-layer cryptographic framework leveraging a four-dimensional (4D) Qi hyperchaotic system for protecting biometric templates and facilitating secure feature matching operations. The framework implements a two-tier encryption mechanism where each layer independently utilizes a Qi hyperchaotic system to generate unique encryption parameters, ensuring template-specific encryption patterns that enhance resistance against chosen-plaintext attacks. The framework performs dimensional normalization of input biometric templates, followed by image pixel shuffling to permutate pixel positions before applying dual-key encryption using the Qi hyperchaotic system and XOR diffusion operations. Templates remain encrypted in storage, with decryption occurring only during authentication processes, ensuring continuous security while enabling biometric verification. The proposed system’s framework demonstrates exceptional randomness properties, validated through comprehensive NIST Statistical Test Suite analysis, achieving statistical significance across all 15 tests with p-values consistently above 0.01 threshold. Comprehensive security analysis reveals outstanding metrics: entropy values exceeding 7.99 bits, a key space of 10320, negligible correlation coefficients (<102), and robust differential attack resistance with an NPCR of 99.60% and a UACI of 33.45%. Empirical evaluation, on standard CASIA Face and Iris databases, demonstrates practical computational efficiency, achieving average encryption times of 0.50913s per user template for 256 × 256 images. Comparative analysis against other state-of-the-art encryption schemes verifies the effectiveness and reliability of the proposed scheme and demonstrates our framework’s superior performance in both security metrics and computational efficiency. Our findings contribute to the advancement of biometric template protection methodologies, offering a balanced performance between security robustness and operational efficiency required in real-world deployment scenarios. Full article
(This article belongs to the Special Issue New Advances in Symmetric Cryptography)
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13 pages, 2643 KiB  
Review
Primary Hyperparathyroidism: 18F-Fluorocholine PET/CT vs. 4D-CT for Parathyroid Identification: Toward a Comprehensive Diagnostic Framework—An Updated Review and Recommendations
by Gregorio Scerrino, Nunzia Cinzia Paladino, Giuseppa Graceffa, Giuseppina Melfa, Giuseppina Orlando, Renato Di Vuolo, Chiara Lo Cicero, Alessandra Murabito, Stefano Radellini, Pierina Richiusa and Antonio Lo Casto
J. Clin. Med. 2025, 14(15), 5468; https://doi.org/10.3390/jcm14155468 - 4 Aug 2025
Viewed by 41
Abstract
Introduction: Primary hyperparathyroidism (pHPT) is an endocrine disorder characterized by excessive parathyroid hormone production, typically due to adenomas, hyperplasia, or carcinoma. Preoperative imaging plays a critical role in guiding surgical planning, particularly in selecting patients for minimally invasive procedures. While first-line imaging [...] Read more.
Introduction: Primary hyperparathyroidism (pHPT) is an endocrine disorder characterized by excessive parathyroid hormone production, typically due to adenomas, hyperplasia, or carcinoma. Preoperative imaging plays a critical role in guiding surgical planning, particularly in selecting patients for minimally invasive procedures. While first-line imaging techniques, such as ultrasound and 99mTc-sestamibi scintigraphy, are standard, advanced second-line imaging modalities like 18F-fluorocholine PET/CT (FCH-PET) and four-dimensional computed tomography (4D-CT) have emerged as valuable tools when initial diagnostics are inconclusive. Methods: This article provides an updated review and recommendations of the role of these advanced imaging techniques in localizing parathyroid adenomas. Results: FCH-PET has shown exceptional sensitivity (94% per patient, 96% per lesion) and is particularly useful in detecting small or ectopic adenomas. Despite its higher sensitivity, it can yield false positives, particularly in the presence of thyroid disease. On the other hand, 4D-CT offers detailed anatomical imaging, aiding in the identification of parathyroids in challenging cases, including recurrent disease and ectopic glands. Studies suggest that FCH-PET and 4D-CT exhibit similar diagnostic performance and could be complementary in preoperative planning of most difficult situations. Conclusions: This article also emphasizes a multimodal approach, where initial imaging is followed by advanced techniques only in cases of uncertainty. Although 18F-fluorocholine PET/CT is favored as a second-line option, 4D-CT remains invaluable for its high spatial resolution and ability to guide surgery in complex cases. Despite limitations in evidence, these imaging modalities significantly enhance the accuracy of parathyroid localization, contributing to more targeted and minimally invasive surgery. Full article
(This article belongs to the Section General Surgery)
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23 pages, 3153 KiB  
Article
Research on Path Planning Method for Mobile Platforms Based on Hybrid Swarm Intelligence Algorithms in Multi-Dimensional Environments
by Shuai Wang, Yifan Zhu, Yuhong Du and Ming Yang
Biomimetics 2025, 10(8), 503; https://doi.org/10.3390/biomimetics10080503 - 1 Aug 2025
Viewed by 202
Abstract
Traditional algorithms such as Dijkstra and APF rely on complete environmental information for path planning, which results in numerous constraints during modeling. This not only increases the complexity of the algorithms but also reduces the efficiency and reliability of the planning. Swarm intelligence [...] Read more.
Traditional algorithms such as Dijkstra and APF rely on complete environmental information for path planning, which results in numerous constraints during modeling. This not only increases the complexity of the algorithms but also reduces the efficiency and reliability of the planning. Swarm intelligence algorithms possess strong data processing and search capabilities, enabling them to efficiently solve path planning problems in different environments and generate approximately optimal paths. However, swarm intelligence algorithms suffer from issues like premature convergence and a tendency to fall into local optima during the search process. Thus, an improved Artificial Bee Colony-Beetle Antennae Search (IABCBAS) algorithm is proposed. Firstly, Tent chaos and non-uniform variation are introduced into the bee algorithm to enhance population diversity and spatial searchability. Secondly, the stochastic reverse learning mechanism and greedy strategy are incorporated into the beetle antennae search algorithm to improve direction-finding ability and the capacity to escape local optima, respectively. Finally, the weights of the two algorithms are adaptively adjusted to balance global search and local refinement. Results of experiments using nine benchmark functions and four comparative algorithms show that the improved algorithm exhibits superior path point search performance and high stability in both high- and low-dimensional environments, as well as in unimodal and multimodal environments. Ablation experiment results indicate that the optimization strategies introduced in the algorithm effectively improve convergence accuracy and speed during path planning. Results of the path planning experiments show that compared with the comparison algorithms, the average path planning distance of the improved algorithm is reduced by 23.83% in the 2D multi-obstacle environment, and the average planning time is shortened by 27.97% in the 3D surface environment. The improvement in path planning efficiency makes this algorithm of certain value in engineering applications. Full article
(This article belongs to the Section Biological Optimisation and Management)
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24 pages, 29785 KiB  
Article
Multi-Scale Feature Extraction with 3D Complex-Valued Network for PolSAR Image Classification
by Nana Jiang, Wenbo Zhao, Jiao Guo, Qiang Zhao and Jubo Zhu
Remote Sens. 2025, 17(15), 2663; https://doi.org/10.3390/rs17152663 - 1 Aug 2025
Viewed by 215
Abstract
Compared to traditional real-valued neural networks, which process only amplitude information, complex-valued neural networks handle both amplitude and phase information, leading to superior performance in polarimetric synthetic aperture radar (PolSAR) image classification tasks. This paper proposes a multi-scale feature extraction (MSFE) method based [...] Read more.
Compared to traditional real-valued neural networks, which process only amplitude information, complex-valued neural networks handle both amplitude and phase information, leading to superior performance in polarimetric synthetic aperture radar (PolSAR) image classification tasks. This paper proposes a multi-scale feature extraction (MSFE) method based on a 3D complex-valued network to improve classification accuracy by fully leveraging multi-scale features, including phase information. We first designed a complex-valued three-dimensional network framework combining complex-valued 3D convolution (CV-3DConv) with complex-valued squeeze-and-excitation (CV-SE) modules. This framework is capable of simultaneously capturing spatial and polarimetric features, including both amplitude and phase information, from PolSAR images. Furthermore, to address robustness degradation from limited labeled samples, we introduced a multi-scale learning strategy that jointly models global and local features. Specifically, global features extract overall semantic information, while local features help the network capture region-specific semantics. This strategy enhances information utilization by integrating multi-scale receptive fields, complementing feature advantages. Extensive experiments on four benchmark datasets demonstrated that the proposed method outperforms various comparison methods, maintaining high classification accuracy across different sampling rates, thus validating its effectiveness and robustness. Full article
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29 pages, 2309 KiB  
Systematic Review
The Influence of Printing Orientation on the Properties of 3D-Printed Polymeric Provisional Dental Restorations: A Systematic Review and Meta-Analysis
by Firas K. Alqarawi
J. Funct. Biomater. 2025, 16(8), 278; https://doi.org/10.3390/jfb16080278 - 31 Jul 2025
Viewed by 345
Abstract
Three-dimensional printing is commonly used to fabricate provisional dental restorations. Studies have reported that changes in printing orientation affect the physical and mechanical properties of 3D-printed polymeric provisional restorations; however the findings have been inconsistent. Therefore, this systematic review and meta-analysis aims to [...] Read more.
Three-dimensional printing is commonly used to fabricate provisional dental restorations. Studies have reported that changes in printing orientation affect the physical and mechanical properties of 3D-printed polymeric provisional restorations; however the findings have been inconsistent. Therefore, this systematic review and meta-analysis aims to analyze the articles evaluating the influence of printing orientation on the physical and mechanical properties of 3D-printed polymeric provisional dental restorations. Recommendations provided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to structure and compose the review. The PICO (Participant, Intervention, Comparison, Outcome) question ordered was: ‘Do 3D-printed provisional dental restorations (P) printed at various orientations (except 0°) (I) exhibit similar physical and mechanical properties (O) when compared to those printed at a 0° orientation (C)?’. An electronic search was conducted on 28 and 29 April 2025, by two independent researchers across four databases (MEDLINE/PubMed, Scopus, Cochrane Library, and Web of Science) to systematically collect relevant articles published up to March 2025. After removing duplicate articles and applying predefined inclusion and exclusion criteria, twenty-one articles were incorporated into this review. Self-designed Performa’s were used to tabulate all relevant information. For the quality analysis, the modified CONSORT scale was utilized. The quantitative analysis was performed on only fifteen out of twenty-one articles. It can be concluded that the printing orientation affects some of the tested properties, which include fracture strength (significantly higher for specimens printed at 0° when compared to 90°), wear resistance (significantly higher for specimens printed at 90° when compared to 0°), microhardness (significantly higher for specimens printed at 90°and 45° when compared to 0°), color stability (high at 0°), and surface roughness (significantly higher for specimens printed at 45° and 90° when compared to 0°). There were varied outcomes in terms of flexural strength and elastic modulus. Full article
(This article belongs to the Special Issue Advances in Restorative Dentistry Materials)
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12 pages, 456 KiB  
Article
From Variability to Standardization: The Impact of Breast Density on Background Parenchymal Enhancement in Contrast-Enhanced Mammography and the Need for a Structured Reporting System
by Graziella Di Grezia, Antonio Nazzaro, Luigi Schiavone, Cisternino Elisa, Alessandro Galiano, Gatta Gianluca, Cuccurullo Vincenzo and Mariano Scaglione
Cancers 2025, 17(15), 2523; https://doi.org/10.3390/cancers17152523 - 30 Jul 2025
Viewed by 462
Abstract
Introduction: Breast density is a well-recognized factor in breast cancer risk assessment, with higher density linked to increased malignancy risk and reduced sensitivity of conventional mammography. Background parenchymal enhancement (BPE), observed in contrast-enhanced imaging, reflects physiological contrast uptake in non-pathologic breast tissue. [...] Read more.
Introduction: Breast density is a well-recognized factor in breast cancer risk assessment, with higher density linked to increased malignancy risk and reduced sensitivity of conventional mammography. Background parenchymal enhancement (BPE), observed in contrast-enhanced imaging, reflects physiological contrast uptake in non-pathologic breast tissue. While extensively characterized in breast MRI, the role of BPE in contrast-enhanced mammography (CEM) remains uncertain due to inconsistent findings regarding its correlation with breast density and cancer risk. Unlike breast density—standardized through the ACR BI-RADS lexicon—BPE lacks a uniform classification system in CEM, leading to variability in clinical interpretation and research outcomes. To address this gap, we introduce the BPE-CEM Standard Scale (BCSS), a structured four-tiered classification system specifically tailored to the two-dimensional characteristics of CEM, aiming to improve consistency and diagnostic alignment in BPE evaluation. Materials and Methods: In this retrospective single-center study, 213 patients who underwent mammography (MG), ultrasound (US), and contrast-enhanced mammography (CEM) between May 2022 and June 2023 at the “A. Perrino” Hospital in Brindisi were included. Breast density was classified according to ACR BI-RADS (categories A–D). BPE was categorized into four levels: Minimal (< 10% enhancement), Light (10–25%), Moderate (25–50%), and Marked (> 50%). Three radiologists independently assessed BPE in a subset of 50 randomly selected cases to evaluate inter-observer agreement using Cohen’s kappa. Correlations between BPE, breast density, and age were examined through regression analysis. Results: BPE was Minimal in 57% of patients, Light in 31%, Moderate in 10%, and Marked in 2%. A significant positive association was found between higher breast density (BI-RADS C–D) and increased BPE (p < 0.05), whereas lower-density breasts (A–B) were predominantly associated with minimal or light BPE. Regression analysis confirmed a modest but statistically significant association between breast density and BPE (R2 = 0.144), while age showed no significant effect. Inter-observer agreement for BPE categorization using the BCSS was excellent (κ = 0.85; 95% CI: 0.78–0.92), supporting its reproducibility. Conclusions: Our findings indicate that breast density is a key determinant of BPE in CEM. The proposed BCSS offers a reproducible, four-level framework for standardized BPE assessment tailored to the imaging characteristics of CEM. By reducing variability in interpretation, the BCSS has the potential to improve diagnostic consistency and facilitate integration of BPE into personalized breast cancer risk models. Further prospective multicenter studies are needed to validate this classification and assess its clinical impact. Full article
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14 pages, 3346 KiB  
Article
DES-Mediated Mild Synthesis of Synergistically Engineered 3D FeOOH-Co2(OH)3Cl/NF for Enhanced Oxygen Evolution Reaction
by Bingxian Zhu, Yachao Liu, Yue Yan, Hui Wang, Yu Zhang, Ying Xin, Weijuan Xu and Qingshan Zhao
Catalysts 2025, 15(8), 725; https://doi.org/10.3390/catal15080725 - 30 Jul 2025
Viewed by 207
Abstract
Hydrogen energy is a pivotal carrier for achieving carbon neutrality, requiring green and efficient production via water electrolysis. However, the anodic oxygen evolution reaction (OER) involves a sluggish four-electron transfer process, resulting in high overpotentials, while the prohibitive cost and complex preparation of [...] Read more.
Hydrogen energy is a pivotal carrier for achieving carbon neutrality, requiring green and efficient production via water electrolysis. However, the anodic oxygen evolution reaction (OER) involves a sluggish four-electron transfer process, resulting in high overpotentials, while the prohibitive cost and complex preparation of precious metal catalysts impede large-scale commercialization. In this study, we develop a FeCo-based bimetallic deep eutectic solvent (FeCo-DES) as a multifunctional reaction medium for engineering a three-dimensional (3D) coral-like FeOOH-Co2(OH)3Cl/NF composite via a mild one-step impregnation approach (70 °C, ambient pressure). The FeCo-DES simultaneously serves as the solvent, metal source, and redox agent, driving the controlled in situ assembly of FeOOH-Co2(OH)3Cl hybrids on Ni(OH)2/NiOOH-coated nickel foam (NF). This hierarchical architecture induces synergistic enhancement through geometric structural effects combined with multi-component electronic interactions. Consequently, the FeOOH-Co2(OH)3Cl/NF catalyst achieves a remarkably low overpotential of 197 mV at 100 mA cm−2 and a Tafel slope of 65.9 mV dec−1, along with 98% current retention over 24 h chronopotentiometry. This study pioneers a DES-mediated strategy for designing robust composite catalysts, establishing a scalable blueprint for high-performance and low-cost OER systems. Full article
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19 pages, 3294 KiB  
Article
Rotation- and Scale-Invariant Object Detection Using Compressed 2D Voting with Sparse Point-Pair Screening
by Chenbo Shi, Yue Yu, Gongwei Zhang, Shaojia Yan, Changsheng Zhu, Yanhong Cheng and Chun Zhang
Electronics 2025, 14(15), 3046; https://doi.org/10.3390/electronics14153046 - 30 Jul 2025
Viewed by 181
Abstract
The Generalized Hough Transform (GHT) is a powerful method for rigid shape detection under rotation, scaling, translation, and partial occlusion conditions, but its four-dimensional accumulator incurs prohibitive computational and memory demands that prevent real-time deployment. To address this, we propose a framework that [...] Read more.
The Generalized Hough Transform (GHT) is a powerful method for rigid shape detection under rotation, scaling, translation, and partial occlusion conditions, but its four-dimensional accumulator incurs prohibitive computational and memory demands that prevent real-time deployment. To address this, we propose a framework that compresses the 4-D search space into a concise 2-D voting scheme by combining two-level sparse point-pair screening with an accelerated lookup. In the offline stage, template edges are extracted using an adaptive Canny operator with Otsu-determined thresholds, and gradient-direction differences for all point pairs are quantized to retain only those in the dominant bin, yielding rotation- and scale-invariant descriptors that populate a compact 2-D reference table. During the online stage, an adaptive grid selects only the highest-gradient pixels per cell as a base points, while a precomputed gradient-direction bucket table enables constant-time retrieval of compatible subpoints. Each valid base–subpoint pair is mapped to indices in the lookup table, and “fuzzy” votes are cast over a 3 × 3 neighborhood in the 2-D accumulator, whose global peak determines the object center. Evaluation on 200 real industrial parts—augmented to 1000 samples with noise, blur, occlusion, and nonlinear illumination—demonstrates that our method maintains over 90% localization accuracy, matches the classical GHT, and achieves a ten-fold speedup, outperforming IGHT and LI-GHT variants by 2–3×, thereby delivering a robust, real-time solution for industrial rigid object localization. Full article
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19 pages, 26478 KiB  
Article
Three-Dimensional Numerical Simulation of Flow Around a Spur Dike in a Meandering Channel Bend
by Yan Xing, Congfang Ai, Hailong Cui and Zhangling Xiao
Fluids 2025, 10(8), 198; https://doi.org/10.3390/fluids10080198 - 29 Jul 2025
Viewed by 219
Abstract
This paper presents a three-dimensional (3D) free surface model to predict incompressible flow around a spur dike in a meandering channel bend, which is highly 3D due to the presence of curvature effects. The model solves the Reynolds-averaged Navier–Stokes (RANS) equations using an [...] Read more.
This paper presents a three-dimensional (3D) free surface model to predict incompressible flow around a spur dike in a meandering channel bend, which is highly 3D due to the presence of curvature effects. The model solves the Reynolds-averaged Navier–Stokes (RANS) equations using an explicit projection method. The 3D grid system is built from a two-dimensional grid by adding dozens of horizontal layers in the vertical direction. Numerical simulations consider four test cases with different spur dike locations in the same meandering channel bend with the same Froude numbers as 0.22. Four turbulence models, the standard k-ε model, the k-ω model, the RNG k-ε model and a nonlinear k-ε model, are implemented in our three-dimensional free surface model. The performance of these turbulence models within the RANS framework is assessed. Comparisons between the model results and experimental data show that the nonlinear k-ε model behaves better than the three other models in general. Based on the results obtained by the nonlinear k-ε model, the highly 3D flow field downstream of the spur dike was revealed by presenting velocity vectors at representative cross-sections and streamlines at the surface and bottom layers. Meanwhile, the 3D characteristics of the downstream separation zone were also investigated. In addition, to highlight the advantage of the nonlinear turbulence model, comparisons of velocity vectors at representative cross-sections between the results obtained by the linear and nonlinear k-ε models are also presented. Full article
(This article belongs to the Special Issue Computational Fluid Dynamics Applied to Transport Phenomena)
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22 pages, 1781 KiB  
Article
Analyzing Heart Rate Variability for COVID-19 ICU Mortality Prediction Using Continuous Signal Processing Techniques
by Guilherme David, André Lourenço, Cristiana P. Von Rekowski, Iola Pinto, Cecília R. C. Calado and Luís Bento
J. Clin. Med. 2025, 14(15), 5312; https://doi.org/10.3390/jcm14155312 - 28 Jul 2025
Viewed by 261
Abstract
Background/Objectives: Heart rate variability (HRV) has been widely investigated as a predictor of disease and mortality across diverse patient populations; however, there remains no consensus on the optimal set or combination of time and frequency domain nor on nonlinear features for reliable prediction [...] Read more.
Background/Objectives: Heart rate variability (HRV) has been widely investigated as a predictor of disease and mortality across diverse patient populations; however, there remains no consensus on the optimal set or combination of time and frequency domain nor on nonlinear features for reliable prediction across clinical contexts. Given the relevance of the COVID-19 pandemic and the unique clinical profiles of these patients, this retrospective observational study explored the potential of HRV analysis for early prediction of in-hospital mortality using ECG signals recorded during the initial moments of ICU admission in COVID-19 patients. Methods: HRV indices were extracted from four ECG leads (I, II, III, and aVF) using sliding windows of 2, 5, and 7 min across observation intervals of 15, 30, and 60 min. The raw data posed significant challenges in terms of structure, synchronization, and signal quality; thus, from an original set of 381 records from 321 patients, after data pre-processing steps, a final dataset of 82 patients was selected for analysis. To manage data complexity and evaluate predictive performance, two feature selection methods, four feature reduction techniques, and five classification models were applied to identify the optimal approach. Results: Among the feature aggregation methods, compiling feature means across patient windows (Method D) yielded the best results, particularly for longer observation intervals (e.g., using LDA, the best AUC of 0.82±0.13 was obtained with Method D versus 0.63±0.09 with Method C using 5 min windows). Linear Discriminant Analysis (LDA) was the most consistent classification algorithm, demonstrating robust performance across various time windows and further improvement with dimensionality reduction. Although Gradient Boosting and Random Forest also achieved high AUCs and F1-scores, their performance outcomes varied across time intervals. Conclusions: These findings support the feasibility and clinical relevance of using short-term HRV as a noninvasive, data-driven tool for early risk stratification in critical care, potentially guiding timely therapeutic decisions in high-risk ICU patients and thereby reducing in-hospital mortality. Full article
(This article belongs to the Section Cardiology)
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17 pages, 8549 KiB  
Article
A Fully Automated Analysis Pipeline for 4D Flow MRI in the Aorta
by Ethan M. I. Johnson, Haben Berhane, Elizabeth Weiss, Kelly Jarvis, Aparna Sodhi, Kai Yang, Joshua D. Robinson, Cynthia K. Rigsby, Bradley D. Allen and Michael Markl
Bioengineering 2025, 12(8), 807; https://doi.org/10.3390/bioengineering12080807 - 27 Jul 2025
Viewed by 341
Abstract
Four-dimensional (4D) flow MRI has shown promise for the assessment of aortic hemodynamics. However, data analysis traditionally requires manual and time-consuming human input at several stages. This limits reproducibility and affects analysis workflows, such that large-cohort 4D flow studies are lacking. Here, a [...] Read more.
Four-dimensional (4D) flow MRI has shown promise for the assessment of aortic hemodynamics. However, data analysis traditionally requires manual and time-consuming human input at several stages. This limits reproducibility and affects analysis workflows, such that large-cohort 4D flow studies are lacking. Here, a fully automated artificial intelligence (AI) 4D flow analysis pipeline was developed and evaluated in a cohort of over 350 subjects. The 4D flow MRI analysis pipeline integrated a series of previously developed and validated deep learning networks, which replaced traditionally manual processing tasks (background-phase correction, noise masking, velocity anti-aliasing, aorta 3D segmentation). Hemodynamic parameters (global aortic pulse wave velocity (PWV), peak velocity, flow energetics) were automatically quantified. The pipeline was evaluated in a heterogeneous single-center cohort of 379 subjects (age = 43.5 ± 18.6 years, 118 female) who underwent 4D flow MRI of the thoracic aorta (n = 147 healthy controls, n = 147 patients with a bicuspid aortic valve [BAV], n = 10 with mechanical valve prostheses, n = 75 pediatric patients with hereditary aortic disease). Pipeline performance with BAV and control data was evaluated by comparing to manual analysis performed by two human observers. A fully automated 4D flow pipeline analysis was successfully performed in 365 of 379 patients (96%). Pipeline-based quantification of aortic hemodynamics was closely correlated with manual analysis results (peak velocity: r = 1.00, p < 0.001; PWV: r = 0.99, p < 0.001; flow energetics: r = 0.99, p < 0.001; overall r ≥ 0.99, p < 0.001). Bland–Altman analysis showed close agreement for all hemodynamic parameters (bias 1–3%, limits of agreement 6–22%). Notably, limits of agreement between different human observers’ quantifications were moderate (4–20%). In addition, the pipeline 4D flow analysis closely reproduced hemodynamic differences between age-matched adult BAV patients and controls (median peak velocity: 1.74 m/s [automated] or 1.76 m/s [manual] BAV vs. 1.31 [auto.] vs. 1.29 [manu.] controls, p < 0.005; PWV: 6.4–6.6 m/s all groups, any processing [no significant differences]; kinetic energy: 4.9 μJ [auto.] or 5.0 μJ [manu.] BAV vs. 3.1 μJ [both] control, p < 0.005). This study presents a framework for the complete automation of quantitative 4D flow MRI data processing with a failure rate of less than 5%, offering improved measurement reliability in quantitative 4D flow MRI. Future studies are warranted to reduced failure rates and evaluate pipeline performance across multiple centers. Full article
(This article belongs to the Special Issue Recent Advances in Cardiac MRI)
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34 pages, 3431 KiB  
Article
Evaluation of Hierarchical Clustering Methodologies for Identifying Patterns in Timeout Requests in EuroLeague Basketball
by José Miguel Contreras, Elena Molina Portillo and Juan Manuel Fernández Luna
Mathematics 2025, 13(15), 2414; https://doi.org/10.3390/math13152414 - 27 Jul 2025
Viewed by 203
Abstract
This study evaluates hierarchical clustering methodologies to identify patterns associated with timeout requests for EuroLeague basketball games. Using play-by-play data from 3743 games spanning the 2008–2023 seasons (over 1.9 million instances), we applied Principal Component Analysis to reduce dimensionality and tested multiple agglomerative [...] Read more.
This study evaluates hierarchical clustering methodologies to identify patterns associated with timeout requests for EuroLeague basketball games. Using play-by-play data from 3743 games spanning the 2008–2023 seasons (over 1.9 million instances), we applied Principal Component Analysis to reduce dimensionality and tested multiple agglomerative and divisive clustering techniques (e.g., Ward and DIANA) with different distance metrics (Euclidean, Manhattan, and Minkowski). Clustering quality was assessed using internal validation indices such as Silhouette, Dunn, Calinski–Harabasz, Davies–Bouldin, and Gap statistics. The results show that Ward.D and Ward.D2 methods using Euclidean distance generate well-balanced and clearly defined clusters. Two clusters offer the best overall quality, while four clusters allow for meaningful segmentation of game situations. The analysis revealed that teams that did not request timeouts often exhibited better scoring efficiency, particularly in the advanced game phases. These findings offer data-driven insights into timeout dynamics and contribute to strategic decision-making in professional basketball. Full article
(This article belongs to the Section E: Applied Mathematics)
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19 pages, 7674 KiB  
Article
Development of Low-Cost Single-Chip Automotive 4D Millimeter-Wave Radar
by Yongjun Cai, Jie Bai, Hui-Liang Shen, Libo Huang, Bing Rao and Haiyang Wang
Sensors 2025, 25(15), 4640; https://doi.org/10.3390/s25154640 - 26 Jul 2025
Viewed by 445
Abstract
Traditional 3D millimeter-wave radars lack target height information, leading to identification failures in complex scenarios. Upgrading to 4D millimeter-wave radars enables four-dimensional information perception, enhancing obstacle detection and improving the safety of autonomous driving. Given the high cost-sensitivity of in-vehicle radar systems, single-chip [...] Read more.
Traditional 3D millimeter-wave radars lack target height information, leading to identification failures in complex scenarios. Upgrading to 4D millimeter-wave radars enables four-dimensional information perception, enhancing obstacle detection and improving the safety of autonomous driving. Given the high cost-sensitivity of in-vehicle radar systems, single-chip 4D millimeter-wave radar solutions, despite technical challenges in imaging, are of great research value. This study focuses on developing single-chip 4D automotive millimeter-wave radar, covering system architecture design, antenna optimization, signal processing algorithm creation, and performance validation. The maximum measurement error is approximately ±0.2° for azimuth angles within the range of ±30° and around ±0.4° for elevation angles within the range of ±13°. Extensive road testing has demonstrated that the designed radar is capable of reliably measuring dynamic targets such as vehicles, pedestrians, and bicycles, while also accurately detecting static infrastructure like overpasses and traffic signs. Full article
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10 pages, 1873 KiB  
Article
Stacking Order-Dependent Electronic and Optical Properties of h-BP/Borophosphene Van Der Waals Heterostructures
by Kejing Ren, Quan Zhang, Shengli Zhang and Yang Zhang
Nanomaterials 2025, 15(15), 1155; https://doi.org/10.3390/nano15151155 - 25 Jul 2025
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Abstract
Van der Waals (vdW) heterostructures, typically composed of two-dimensional (2D) atomic layers, have attracted significant attention over the past few decades. Their performance is closely dependent on their composition and interlayer interactions. In this study, we constructed four types of 2D hexagonal BP [...] Read more.
Van der Waals (vdW) heterostructures, typically composed of two-dimensional (2D) atomic layers, have attracted significant attention over the past few decades. Their performance is closely dependent on their composition and interlayer interactions. In this study, we constructed four types of 2D hexagonal BP monolayer (h-BP)/borophosphene vdW heterostructures with different stacking orders: (i) B-B stacking, (ii) P-P stacking, (iii) moire-I, and (iv) moire-II. Their structural stability and their electronic and optical properties were explored by using first-principles calculations. The results show that h-BP/borophosphene heterostructures can maintain their configurations with good structural stability and minimal lattice mismatch. All vdW heterostructures exhibit semiconducting characteristics, and their band gaps are highly dependent on interlayer stacking orders. Due to the regular atomic arrangement and enhanced interlayer dipole interactions, the B-B stacking bilayer opens a relatively large band gap of 0.157 eV, while the moire-II bilayer exhibits a very small band gap of 0.045 eV because of its irregular atom arrangements. By calculating the complex dielectric function, optical absorption spectra of B-B and P-P stacking bilayers were discussed. This study suggests that h-BP/borophosphene heterostructures have desirable optical properties, broadening the potential applications of the constituent monolayers. Full article
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