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Keywords = fiber-optic imaging

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17 pages, 2744 KiB  
Article
Experimental Crack Width Quantification in Reinforced Concrete Using Ultrasound and Coda Wave Interferometry
by Noah Sträter, Felix Clauß, Mark Alexander Ahrens and Peter Mark
Materials 2025, 18(15), 3684; https://doi.org/10.3390/ma18153684 - 6 Aug 2025
Abstract
For the first time, comprehensive investigations into the tensile load-bearing behavior and crack formation of reinforced concrete based on ultrasound are presented. Uniaxial tensile tests are performed on reinforced concrete tension members equipped with embedded ultrasonic transducers. Key mechanical parameters across all ranges [...] Read more.
For the first time, comprehensive investigations into the tensile load-bearing behavior and crack formation of reinforced concrete based on ultrasound are presented. Uniaxial tensile tests are performed on reinforced concrete tension members equipped with embedded ultrasonic transducers. Key mechanical parameters across all ranges of tensile behavior are continuously quantified by recording ultrasonic signals and evaluated with coda wave interferometry. The investigations include member configurations of different lengths to cover different numbers of cracks. For reference, crack patterns and crack widths are analyzed using digital image correlation, while the strain in the reinforcement is monitored with distributed fiber optic sensors. For the first time, a direct proportional relationship between the relative velocity change in ultrasonic signals and crack widths is established in the ranges of crack formation and stabilized cracking. In the non-cracked state, linear correlations are found between the velocity change and the average strain, as well as the length of the specimens. The experimental results significantly enhance the general understanding of the phenomena related to ultrasonic signals in flexural reinforced concrete members, particularly concerning cracking in the tensile zone. Consequently, this study contributes to the broader objective of employing coda wave interferometry to evaluate the condition of infrastructure. Full article
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23 pages, 25086 KiB  
Article
U-Net Segmentation with Bayesian-Optimized Weight Voting for Worn Surface Analysis of a PEEK-Based Tribological Composite
by Yuxiao Zhao and Leyu Lin
Lubricants 2025, 13(8), 324; https://doi.org/10.3390/lubricants13080324 - 24 Jul 2025
Viewed by 343
Abstract
This study presents a U-Net-based automatic segmentation framework for quantitative analysis of surface morphology in a PEEK-based composite following tribological testing. Controlled Pin-on-Disc tests were conducted to characterize tribological performance, worn surfaces were captured by laser scanning microscopy to acquire optical images and [...] Read more.
This study presents a U-Net-based automatic segmentation framework for quantitative analysis of surface morphology in a PEEK-based composite following tribological testing. Controlled Pin-on-Disc tests were conducted to characterize tribological performance, worn surfaces were captured by laser scanning microscopy to acquire optical images and height maps, and the model produced pixel-level segmentation masks distinguishing different regions, enabling high-throughput, objective analysis of worn surface morphology. Sixty-three manually annotated image sets—with labels for fiber, third-body patch, and matrix regions—formed the training corpus. A 70-layer U-Net architecture with four-channel input was developed and rigorously evaluated using five-fold cross-validation. To enhance performance on the challenging patch and fiber classes, the top five model instances were ensembled through Bayesian-optimized weighted voting, achieving significant improvements in class-specific F1 metrics. Segmentation outputs on unseen data confirmed the method’s robustness and generalizability across complex surface topographies. This approach establishes a scalable, accurate tool for automated morphological analysis, with potential extensions to real-time monitoring and other composite systems. Full article
(This article belongs to the Special Issue New Horizons in Machine Learning Applications for Tribology)
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16 pages, 3372 KiB  
Article
Monitoring the Time-Lagged Response of Land Subsidence to Groundwater Fluctuations via InSAR and Distributed Fiber-Optic Strain Sensing
by Qing He, Hehe Liu, Lu Wei, Jing Ding, Heling Sun and Zhen Zhang
Appl. Sci. 2025, 15(14), 7991; https://doi.org/10.3390/app15147991 - 17 Jul 2025
Viewed by 302
Abstract
Understanding the time-lagged response of land subsidence to groundwater level fluctuations and subsurface strain variations is crucial for uncovering its underlying mechanisms and enhancing disaster early warning capabilities. This study focuses on Dangshan County, Anhui Province, China, and systematically analyzes the spatio-temporal evolution [...] Read more.
Understanding the time-lagged response of land subsidence to groundwater level fluctuations and subsurface strain variations is crucial for uncovering its underlying mechanisms and enhancing disaster early warning capabilities. This study focuses on Dangshan County, Anhui Province, China, and systematically analyzes the spatio-temporal evolution of land subsidence from 2018 to 2024. A total of 207 Sentinel-1 SAR images were first processed using the Small Baseline Subset Interferometric Synthetic Aperture Radar (SBAS-InSAR) technique to generate high-resolution surface deformation time series. Subsequently, the seasonal-trend decomposition using the LOESS (STL) model was applied to extract annual cyclic deformation components from the InSAR-derived time series. To quantitatively assess the delayed response of land subsidence to groundwater level changes and subsurface strain evolution, time-lagged cross-correlation (TLCC) analysis was performed between surface deformation and both groundwater level data and distributed fiber-optic strain measurements within the 5–50 m depth interval. The strain data was collected using a borehole-based automated distributed fiber-optic sensing system. The results indicate that land subsidence is primarily concentrated in the urban core, with annual cyclic amplitudes ranging from 10 to 18 mm and peak values reaching 22 mm. The timing of surface rebound shows spatial variability, typically occurring in mid-February in residential areas and mid-May in agricultural zones. The analysis reveals that surface deformation lags behind groundwater fluctuations by approximately 2 to 3 months, depending on local hydrogeological conditions, while subsurface strain changes generally lead surface subsidence by about 3 months. These findings demonstrate the strong predictive potential of distributed fiber-optic sensing in capturing precursory deformation signals and underscore the importance of integrating InSAR, hydrological, and geotechnical data for advancing the understanding of subsidence mechanisms and improving monitoring and mitigation efforts. Full article
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11 pages, 2180 KiB  
Article
Impact of Mild Acid and Alkali Treatments on Cotton Fibers with Nonlinear Optical Imaging and SEM Analysis
by Huipeng Gao, Xiaoxiao Li, Rui Li, Chao Wang, Hsiang-Chen Chui and Quan Zhang
Photonics 2025, 12(7), 688; https://doi.org/10.3390/photonics12070688 - 8 Jul 2025
Viewed by 274
Abstract
This study investigates the structural effects of dilute acid and alkali treatments on cotton fibers, aiming to understand the influence of chemical pretreatment on cellulose morphology. Cotton samples were exposed to 1% sulfuric acid and 1% sodium hydroxide at 90 °C, and the [...] Read more.
This study investigates the structural effects of dilute acid and alkali treatments on cotton fibers, aiming to understand the influence of chemical pretreatment on cellulose morphology. Cotton samples were exposed to 1% sulfuric acid and 1% sodium hydroxide at 90 °C, and the resulting changes were evaluated using scanning electron microscopy and nonlinear optical imaging techniques. The results indicate that sulfuric acid causes significant fiber degradation, leading to fragmentation and reduced fiber thickness. In contrast, sodium hydroxide treatment results in a roughened, flaky surface while preserving the overall structural integrity, with fibers appearing fluffier and more accessible to enzymatic processes. Untreated cotton fibers maintained a smooth and uniform surface, confirming the chemical specificity of the observed changes. These findings are crucial for optimizing biomass pretreatment methods, demonstrating that dilute chemical treatments primarily affect macrostructural features without significantly disrupting the cellulose microfibrils. The study provides valuable insights for the development of efficient biorefining processes and sustainable bio-based materials, highlighting the importance of selecting appropriate chemical conditions to enhance enzymatic hydrolysis and biomass conversion while maintaining the core structure of cellulose. This research contributes to advancing the understanding of cellulose’s structural resilience under mild chemical pretreatment conditions. Full article
(This article belongs to the Section Optical Interaction Science)
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19 pages, 2744 KiB  
Article
Chaotic Behaviour, Sensitivity Assessment, and New Analytical Investigation to Find Novel Optical Soliton Solutions of M-Fractional Kuralay-II Equation
by J. R. M. Borhan, E. I. Hassan, Arafa Dawood, Khaled Aldwoah, Amani Idris A. Sayed, Ahmad Albaity and M. Mamun Miah
Mathematics 2025, 13(13), 2207; https://doi.org/10.3390/math13132207 - 6 Jul 2025
Viewed by 372
Abstract
The implementation of chaotic behavior and a sensitivity assessment of the newly developed M-fractional Kuralay-II equation are the foremost objectives of the present study. This equation has significant possibilities in control systems, electrical circuits, seismic wave propagation, economic dynamics, groundwater flow, image and [...] Read more.
The implementation of chaotic behavior and a sensitivity assessment of the newly developed M-fractional Kuralay-II equation are the foremost objectives of the present study. This equation has significant possibilities in control systems, electrical circuits, seismic wave propagation, economic dynamics, groundwater flow, image and signal denoising, complex biological systems, optical fibers, plasma physics, population dynamics, and modern technology. These applications demonstrate the versatility and advantageousness of the stated model for complex systems in various scientific and engineering disciplines. One more essential objective of the present research is to find closed-form wave solutions of the assumed equation based on the (GG+G+A)-expansion approach. The results achieved are in exponential, rational, and trigonometric function forms. Our findings are more novel and also have an exclusive feature in comparison with the existing results. These discoveries substantially expand our understanding of nonlinear wave dynamics in various physical contexts in industry. By simply selecting suitable values of the parameters, three-dimensional (3D), contour, and two-dimensional (2D) illustrations are produced displaying the diagrammatic propagation of the constructed wave solutions that yield the singular periodic, anti-kink, kink, and singular kink-shape solitons. Future improvements to the model may also benefit from what has been obtained as well. The various assortments of solutions are provided by the described procedure. Finally, the framework proposed in this investigation addresses additional fractional nonlinear partial differential equations in mathematical physics and engineering with excellent reliability, quality of effectiveness, and ease of application. Full article
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18 pages, 2702 KiB  
Article
Real-Time Depth Monitoring of Air-Film Cooling Holes in Turbine Blades via Coherent Imaging During Femtosecond Laser Machining
by Yi Yu, Ruijia Liu, Chenyu Xiao and Ping Xu
Photonics 2025, 12(7), 668; https://doi.org/10.3390/photonics12070668 - 2 Jul 2025
Viewed by 362
Abstract
Given the exceptional capabilities of femtosecond laser processing in achieving high-precision ablation for air-film cooling hole fabrication on turbine blades, it is imperative to develop an advanced monitoring methodology that enables real-time feedback control to automatically terminate the laser upon complete penetration detection, [...] Read more.
Given the exceptional capabilities of femtosecond laser processing in achieving high-precision ablation for air-film cooling hole fabrication on turbine blades, it is imperative to develop an advanced monitoring methodology that enables real-time feedback control to automatically terminate the laser upon complete penetration detection, thereby effectively preventing backside damage. To tackle this issue, a spectrum-domain coherent imaging technique has been developed. This innovative approach adapts the fundamental principle of fiber-based Michelson interferometry by integrating the air-film hole into a sample arm configuration. A broadband super-luminescent diode with a 830 nm central wavelength and a 26 nm spectral bandwidth serves as the coherence-optimized illumination source. An optimal normalized reflectivity of 0.2 is established to maintain stable interference fringe visibility throughout the drilling process. The system achieves a depth resolution of 11.7 μm through Fourier transform analysis of dynamic interference patterns. With customized optical path design specifically engineered for through-hole-drilling applications, the technique demonstrates exceptional sensitivity, maintaining detection capability even under ultralow reflectivity conditions (0.001%) at the hole bottom. Plasma generation during laser processing is investigated, with plasma density measurements providing optical thickness data for real-time compensation of depth measurement deviations. The demonstrated system represents an advancement in non-destructive in-process monitoring for high-precision laser machining applications. Full article
(This article belongs to the Special Issue Advances in Laser Measurement)
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34 pages, 6553 KiB  
Review
Recent Advances in Photonic Crystal Fiber-Based SPR Biosensors: Design Strategies, Plasmonic Materials, and Applications
by Ayushman Ramola, Amit Kumar Shakya, Vinay Kumar and Arik Bergman
Micromachines 2025, 16(7), 747; https://doi.org/10.3390/mi16070747 - 25 Jun 2025
Viewed by 1075
Abstract
This article presents a comprehensive overview of recent advancements in photonic crystal fiber (PCF)-based sensors, with a particular focus on the surface plasmon resonance (SPR) phenomenon for biosensing. With their ability to modify core and cladding structures, PCFs offer exceptional control over light [...] Read more.
This article presents a comprehensive overview of recent advancements in photonic crystal fiber (PCF)-based sensors, with a particular focus on the surface plasmon resonance (SPR) phenomenon for biosensing. With their ability to modify core and cladding structures, PCFs offer exceptional control over light guidance, dispersion management, and light confinement, making them highly suitable for applications in refractive index (RI) sensing, biomedical imaging, and nonlinear optical phenomena such as fiber tapering and supercontinuum generation. SPR is a highly sensitive optical phenomenon, which is widely integrated with PCFs to enhance detection performance through strong plasmonic interactions at metal–dielectric interfaces. The combination of PCF and SPR technologies has led to the development of innovative sensor geometries, including D-shaped fibers, slotted-air-hole structures, and internal external metal coatings, each optimized for specific sensing goals. These PCF-SPR-based sensors have shown promising results in detecting biomolecular targets such as excess cholesterol, glucose, cancer cells, DNA, and proteins. Furthermore, this review provides an in-depth analysis of key design parameters, plasmonic materials, and sensor models used in PCF-SPR configurations, highlighting their comparative performance metrics and application prospects in medical diagnostics, environmental monitoring, and chemical analysis. Thus, an exhaustive analysis of various sensing parameters, plasmonic materials, and sensor models used in PCF-SPR sensors is presented and explored in this article. Full article
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13 pages, 4704 KiB  
Article
Freshwater Thin Ice Sheet Monitoring and Imaging with Fiber Optic Distributed Acoustic Sensing
by Meghan Quinn, Adrian K. Doran, Constantine Coclin, Levi Cass and Heath Turner
Glacies 2025, 2(3), 7; https://doi.org/10.3390/glacies2030007 - 21 Jun 2025
Viewed by 690
Abstract
Fiber optic distributed acoustic sensing (DAS) technology can monitor vibrational strain of vast areas with fine spatial resolution at high sampling rates. The fiber optic cable portion of DAS may directly monitor, measure, and map potentially unsafe areas such as thin ice sheets. [...] Read more.
Fiber optic distributed acoustic sensing (DAS) technology can monitor vibrational strain of vast areas with fine spatial resolution at high sampling rates. The fiber optic cable portion of DAS may directly monitor, measure, and map potentially unsafe areas such as thin ice sheets. Once the fiber optic cable is emplaced, DAS can provide “rapid-response” information along the cable’s length through remote sampling. A field campaign was performed to test the sensitivity of DAS to spatial variations within thin ice sheets. A pilot field study was conducted in the northeastern United States in which fiber-optic cable was deployed on the surface of a freshwater pond. Phase velocity transformations were used to analyze the DAS response to strike testing on the thin ice sheet. The study results indicated that the ice sheet was about 5 cm thick generally, tapering to about 3.5 cm within 2 m of the pond’s edge and then disappearing at the margins. After validation of the pilot study’s methodology, a follow-up experiment using DAS to collect on a rapidly deployed, surface-laid cable atop a larger freshwater pond was conducted. Using phase velocity transformations, the ice thickness along the fiber optic cable was estimated to be between 25.5 and 28 cm and confirmed via ice auger measurements along the fiber optic cable. This field campaign demonstrates the feasibility of employing DAS systems to remotely assess spatially variable properties on thin freshwater ice sheets. Full article
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11 pages, 7908 KiB  
Article
Poly(Methyl Methacrylate)-Based Core-Shell Electrospun Fibers: Structural and Morphological Analysis
by Ivana Stajcic, Vesna Radojevic, Zorica Lazarevic, Milica Curcic, Branka Hadzic, Aleksandar Kojovic and Aleksandar Stajcic
Coatings 2025, 15(6), 727; https://doi.org/10.3390/coatings15060727 - 18 Jun 2025
Viewed by 763
Abstract
Dicyclopentadiene (DCPD)–poly(methyl methacrylate) (PMMA) core–shell fibers were fabricated via coaxial electrospinning to develop a self-healing polymer composite. A PMMA shell containing a first-generation Grubbs catalyst was co-spun with a DCPD core at 0.5 mL h−1 and 28 kV, yielding smooth, cylindrical fibers. [...] Read more.
Dicyclopentadiene (DCPD)–poly(methyl methacrylate) (PMMA) core–shell fibers were fabricated via coaxial electrospinning to develop a self-healing polymer composite. A PMMA shell containing a first-generation Grubbs catalyst was co-spun with a DCPD core at 0.5 mL h−1 and 28 kV, yielding smooth, cylindrical fibers. The diameter range of nanofibers was 300–900 nm, with 95% below 800 nm, as confirmed by FESEM image analysis. FTIR spectroscopy monitored shell integrity via the PMMA C=O stretch and core polymerization via the trans-C=C bands. The high presence of the 970 cm−1 band in the healed nanofiber mat and the minor appearance in the uncut core–shell mat demonstrated successful DCPD polymerization mostly where the intended damage was. The optical clarity of PMMA enabled the direct monitoring of healing progress via optical microscopy. The presented findings demonstrate that PMMA can retain a liquid active core and catalyst to form a polymer layer on a damaged site and could be used as a model material for other self-healing systems that require healing monitoring. Full article
(This article belongs to the Special Issue Advances in Optical Coatings and Thin Films)
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17 pages, 2351 KiB  
Article
The Value of Optical Coherence Tomography in Patients with Pituitary Adenoma and Its Association with Clinical Features: A Pilot Study
by Monika Duseikaite, Alvita Vilkeviciute, Igne Dumbliauskaite, Brigita Glebauskiene, Indre Zostautiene, Vita Rovite, Sheng-Nan Wu, Arimantas Tamasauskas and Rasa Liutkeviciene
J. Clin. Med. 2025, 14(12), 4318; https://doi.org/10.3390/jcm14124318 - 17 Jun 2025
Viewed by 1027
Abstract
Background: The main mechanism of optic nerve damage in patients with pituitary adenoma (PA) is the pressure of optic chiasm. The retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL)+, and GCL++ thickness measurement by optical coherence tomography (OCT), visual function [...] Read more.
Background: The main mechanism of optic nerve damage in patients with pituitary adenoma (PA) is the pressure of optic chiasm. The retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL)+, and GCL++ thickness measurement by optical coherence tomography (OCT), visual function evaluation, and magnetic resonance imaging (MRI) can be used to predict visual function recovery. In our study, we investigated the associations between visual acuity (VA), visual field (VF), RNFL, GCL changes, and the findings of MRI in patients with PA. Methods: This study was conducted in the Departments of Ophthalmology and Neurosurgery of the Lithuanian University of Health Sciences Hospital. A total of 25 patients diagnosed with PA were included in the study group, and 27 healthy subjects were included in the control group. The thickness of the RNFL and ganglion cell layer (GCL+, GCL++) and optic nerve disc diameter was analysed with OCT. Moreover, an MRI was performed for patients with PA. Results: The RNFL thickness around the optic disk measured preoperatively was reduced significantly in the temporal quadrant in PA patients compared with the control group (median (min; max); mean rank: 73.5 (52; 109); 58.39 vs. 69.5 (16; 168); 46.14; p = 0.038). We found that it was reduced significantly only in the inferior quadrant of the macro-PA group compared to the micro-PA group (median (min; max); mean rank: 99.5 (61; 115); 21.07 vs. 106.5 (90; 121); 32.15), p = 0.008, respectively). The RNFL thickness was reduced significantly only in the inferior quadrant of the non-active PA group compared to the active PA group (median (min; max); mean rank: 118.5 (49; 144); 17.42 vs. 130.5 (77; 156); 28.05), p = 0.028, respectively). RNFL thickness was reduced significantly only in the temporal quadrant in the PA with suprasellar extension group compared to the PA without suprasellar extension group (median (min; max); mean rank: 67.5 (16; 99); 21.66 vs. 72 (58; 168); 30.39), p = 0.036, respectively). Furthermore, GCL++ thickness was reduced significantly in total and in superior and inferior sectors of the PA with suprasellar extension group compared to the PA without suprasellar extension group (median (min; max); mean rank: 98.5 (57; 113); 21.8; 101 (61; 121); 21.48 and 102.5 (59; 116); 21.71 vs. 103.5 (95; 115); 30.2; 106.5 (90; 115); 30.61 and 104.5 (95; 113); 30.32), p = 0.043; p = 0.028 and p = 0.038, respectively). In the control group, significant positive correlations were found between optic disc area and the total RNFL thickness (r = 0.440, p < 0.001). In the PA group, significant correlations were observed between optic rim area and total RNFL thickness (r = 0.493, p < 0.001) and all quadrants, with the strongest in the nasal quadrant (r = 0.503, p < 0.001). A moderate to strong negative correlation was found between visual field (VF) defects and RNFL thickness, with the strongest correlation observed in the superior quadrant. Conclusions: OCT offers a detailed insight into the microscopic structural and functional changes throughout the entire visual pathway in patients with PA. Our findings demonstrate a significant negative correlation between RNFL thickness and visual field defects, highlighting the clinical relevance of OCT measurements in visual function assessment. Moreover, the results suggest that optic rim area may be a more reliable indicator of RNFL thickness variations than optic disc area in patients with PA. Full article
(This article belongs to the Section Clinical Neurology)
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24 pages, 2772 KiB  
Article
Harnessing the Unique Nature of Evanescent Waves: Optimizing FOEW LSPR Sensors with Absorption-Focused Nanoparticle Design
by Omar Awad, AbdulRahman Ghannoum and Patricia Nieva
Fibers 2025, 13(6), 81; https://doi.org/10.3390/fib13060081 - 17 Jun 2025
Viewed by 551
Abstract
This work presents a novel and comprehensive framework for optimizing fiber optic evanescent wave (FOEW) localized surface plasmon resonance (LSPR) sensors by investigating the unique interaction between evanescent waves and plasmonic nanoparticles. Unlike propagating light, the evanescent wave is a localized, non-propagating field [...] Read more.
This work presents a novel and comprehensive framework for optimizing fiber optic evanescent wave (FOEW) localized surface plasmon resonance (LSPR) sensors by investigating the unique interaction between evanescent waves and plasmonic nanoparticles. Unlike propagating light, the evanescent wave is a localized, non-propagating field that interacts exclusively with absorbing media near the fiber surface. This characteristic highlights the importance of prioritizing nanoparticle absorption over total extinction in FOEW sensor design. The optical response of silver nanoparticles was modeled across a size range of 10–100 nm, showing that absorption increases with particle number. Among the sizes tested, 30 nm silver nanoparticles exhibited the highest absorption efficiency, which was confirmed experimentally. An analytical adsorption kinetics model based on diffusion transport further predicted that smaller nanoparticles yield higher surface coverage, a result validated through atomic force microscopy (AFM) and scanning electron microscopy (SEM) imaging. Refractive index (RI) sensitivity tests conducted on sensors fabricated with 10 nm, 20 nm, and 30 nm silver nanoparticles revealed that while smaller nanoparticles produced higher initial absorption due to greater surface density, the 30 nm particles ultimately provided superior RI sensitivity due to their enhanced absorption efficiency. These findings underscore the significance of absorption-centered nanoparticle design in maximizing FOEW LSPR sensor performance. Full article
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14 pages, 822 KiB  
Article
Optical Coherence Tomography (OCT) Findings in Post-COVID-19 Healthcare Workers
by Sanela Sanja Burgić, Mirko Resan, Milka Mavija, Saša Smoljanović Skočić, Sanja Grgić, Daliborka Tadić and Bojan Pajic
J. Imaging 2025, 11(6), 195; https://doi.org/10.3390/jimaging11060195 - 12 Jun 2025
Viewed by 1018
Abstract
Recent evidence suggests that SARS-CoV-2 may induce subtle anatomical changes in the retina, detectable through advanced imaging techniques. This retrospective case–control study utilized optical coherence tomography (OCT) to assess medium-term retinal alterations in 55 healthcare workers, including 25 individuals with PCR-confirmed COVID-19 and [...] Read more.
Recent evidence suggests that SARS-CoV-2 may induce subtle anatomical changes in the retina, detectable through advanced imaging techniques. This retrospective case–control study utilized optical coherence tomography (OCT) to assess medium-term retinal alterations in 55 healthcare workers, including 25 individuals with PCR-confirmed COVID-19 and 30 non-COVID-19 controls, all of whom had worked in COVID-19 clinical settings. Comprehensive ophthalmological examinations, including OCT imaging, were conducted six months after infection. The analysis considered demographic variables, comorbidities, COVID-19 severity, risk factors, and treatments received. Central macular thickness (CMT) was significantly increased in the post-COVID-19 group (p < 0.05), with a weak but statistically significant positive correlation between CMT and disease severity (r = 0.245, p < 0.05), suggesting potential post-inflammatory retinal responses. No significant differences were observed in retinal nerve fiber layer (RNFL) or ganglion cell complex (GCL + IPL) thickness. However, mild negative trends in inferior RNFL and average GCL+IPL thickness may indicate early neurodegenerative changes. Notably, patients with comorbidities exhibited a significant reduction in superior and inferior RNFL thickness, pointing to possible long-term neurovascular impairment. These findings underscore the value of OCT imaging in identifying subclinical retinal alterations following COVID-19 and highlight the need for continued surveillance in recovered patients, particularly those with pre-existing systemic conditions. Full article
(This article belongs to the Special Issue Learning and Optimization for Medical Imaging)
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16 pages, 4359 KiB  
Article
Nonlinear Imaging Detection of Organ Fibrosis in Minute Samples for Early Stage Utilizing Dual-Channel Two-Photon and Second-Harmonic Excitation
by Bo-Song Yu, Qing-Di Cheng, Yi-Zhou Liu, Rui Zhang, Da-Wei Li, Ai-Min Wang, Li-Shuang Feng and Xiao Jia
Biosensors 2025, 15(6), 357; https://doi.org/10.3390/bios15060357 - 4 Jun 2025
Viewed by 2867
Abstract
Histopathological staining remains the fibrosis diagnostic gold standard yet suffers from staining artifacts and variability. Nonlinear optical techniques (e.g., spontaneous fluorescence, Second Harmonic Generation) enhance accuracy but struggle with rapid trace-level detection of fibrosis. To address these limitations, a dual-channel nonlinear optical imaging [...] Read more.
Histopathological staining remains the fibrosis diagnostic gold standard yet suffers from staining artifacts and variability. Nonlinear optical techniques (e.g., spontaneous fluorescence, Second Harmonic Generation) enhance accuracy but struggle with rapid trace-level detection of fibrosis. To address these limitations, a dual-channel nonlinear optical imaging system with excitation wavelengths at 780 nm and 820 nm was developed, enabling simultaneous spontaneous fluorescence and second-harmonic generation imaging through grid localization. This study applies dual-modality nonlinear imaging to achieve label-free, high-resolution visualization of pulmonary and renal fibrosis at the ECM microstructure scale. Through leveraging this system, it is demonstrated that collagen can be rapidly detected via spontaneous fluorescence at 780 nm, whereas the spatial distribution of collagen fibrils is precisely mapped using Second Harmonic Generation at 820 nm. This approach allows for the rapid and sensitive detection of trace fibrosis in a 5-day unilateral ureteral obstruction mouse model. Additionally, we identify that the elastic fibers, which can also be visualized, provide a foundation for staging diagnosis and delivering accurate and quantitative data for pathological studies and analysis. The research findings underscore the potential of this dual-channel nonlinear optical imaging system as a powerful tool for rapid, precise, and noninvasive fibrosis detection and staging. Full article
(This article belongs to the Section Optical and Photonic Biosensors)
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16 pages, 4355 KiB  
Review
Swept-Source Optical Coherence Tomography in the Diagnosis and Monitoring of Optic Nerve Neuropathy in Patients with Wernicke’s Encephalopathy Due to Hyperemesis Gravidarum
by Magdalena Kal, Michał Brzdęk, Justyna Tracz, Paweł Szadkowski and Dorota Zarębska-Michaluk
J. Clin. Med. 2025, 14(11), 3849; https://doi.org/10.3390/jcm14113849 - 30 May 2025
Viewed by 519
Abstract
Objectives: This review explores the role of swept-source optical coherence tomography (OCT) in diagnosing and monitoring optic nerve neuropathy in Wernicke’s encephalopathy (WE) due to hyperemesis gravidarum, including a case of neuropathy from intractable vomiting in pregnancy. Methods: A literature search [...] Read more.
Objectives: This review explores the role of swept-source optical coherence tomography (OCT) in diagnosing and monitoring optic nerve neuropathy in Wernicke’s encephalopathy (WE) due to hyperemesis gravidarum, including a case of neuropathy from intractable vomiting in pregnancy. Methods: A literature search was conducted in the PubMed database to select high-quality reviews and original articles on the use of swept-source OCT for assessing optic nerve involvement in WE due to hyperemesis gravidarum. Results: WE is a potentially fatal neuropsychiatric syndrome caused by thiamine deficiency due to various causes, like alcoholism, malnutrition, and prolonged parenteral nutrition. This condition can cause neurological disorders such as imbalance, altered mental status, nystagmus, and ophthalmoplegia. Sometimes, there is also a deterioration of visual acuity with swelling of the optic disc. OCT is a non-invasive imaging tool that can detect optic nerve involvement in WE by assessing peripapillary retinal nerve fiber layer (pRNFL) thickness. In the acute phase, optic disc edema and increased pRNFL thickness may be observed, while chronic-phase changes include optic nerve atrophy and pRNFL thinning. WE may occur in the course of hyperemesis gravidarum in pregnant women. We present a case of a 23-year-old woman at 14 weeks of gestation with WE due to severe hyperemesis gravidarum, manifesting as visual impairment and neurological deficits. MRI confirmed the diagnosis, while OCT revealed transient pRNFL thickening followed by optic nerve atrophy. Conclusions: Early diagnosis and thiamine supplementation are crucial to preventing severe complications. OCT is a valuable tool for detecting and tracking optic nerve changes in WE. Full article
(This article belongs to the Section Nuclear Medicine & Radiology)
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22 pages, 2497 KiB  
Article
Identification and Characterization of Fiber Optic Imaging Bundle Structures in Endoscopic Fringe Projection Systems
by Jannis Drangmeister, Markus Kästner and Eduard Reithmeier
Sensors 2025, 25(11), 3305; https://doi.org/10.3390/s25113305 - 24 May 2025
Viewed by 362
Abstract
Endoscopic fringe projection is used to perform inspections of hard-to-reach areas. In order to transfer fringe patterns from a projector to the specimens’ surface, fiber optic imaging bundles (FOIB) can be employed. To ensure maximum accessibility, a highly flexible FOIB is needed. Therefore, [...] Read more.
Endoscopic fringe projection is used to perform inspections of hard-to-reach areas. In order to transfer fringe patterns from a projector to the specimens’ surface, fiber optic imaging bundles (FOIB) can be employed. To ensure maximum accessibility, a highly flexible FOIB is needed. Therefore, the number of individual fibers has to be minimized, which affects the quality of the fringe pattern. This paper presents methods and results for projecting a high frequency pattern despite a small number of fibers by adapting the FOIBs’ structure. First, the spatial structure of the FOIB is identified with regard to the projector pixels. By determining their center, it is possible to address individual fibers. It will be shown that the peak values of spots produced by individual fibers behave nonlinearly according to the modulated intensity. Furthermore, the intensity distribution within the spots changes. By recording the intensity curves, the presented algorithm is able to adapt the fringe pattern in orientation and intensity. This leads, especially for high frequency patterns, to an improved amplitude and signal-to-noise ratio. Full article
(This article belongs to the Section Industrial Sensors)
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