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21 pages, 3870 KiB  
Article
The Impact of Drilling Parameters on Drilling Temperature in High-Strength Steel Thin-Walled Parts
by Yupu Zhang, Ruyu Li, Yihan Liu, Chengwei Liu, Shutao Huang, Lifu Xu and Haicheng Shi
Appl. Sci. 2025, 15(15), 8568; https://doi.org/10.3390/app15158568 (registering DOI) - 1 Aug 2025
Abstract
High-strength steel has high strength and low thermal conductivity, and its thin-walled parts are very susceptible to residual stress and deformation caused by cutting heat during the drilling process, which affects the machining accuracy and quality. High-strength steel thin-walled components are widely used [...] Read more.
High-strength steel has high strength and low thermal conductivity, and its thin-walled parts are very susceptible to residual stress and deformation caused by cutting heat during the drilling process, which affects the machining accuracy and quality. High-strength steel thin-walled components are widely used in aerospace and other high-end sectors; however, systematic investigations into their temperature fields during drilling remain scarce, particularly regarding the evolution characteristics of the temperature field in thin-wall drilling and the quantitative relationship between drilling parameters and these temperature variations. This paper takes the thin-walled parts of AF1410 high-strength steel as the research object, designs a special fixture, and applies infrared thermography to measure the bottom surface temperature in the thin-walled drilling process in real time; this is carried out in order to study the characteristics of the temperature field during the thin-walled drilling process of high-strength steel, as well as the influence of the drilling dosage on the temperature field of the bottom surface. The experimental findings are as follows: in the process of thin-wall drilling of high-strength steel, the temperature field of the bottom surface of the workpiece shows an obvious temperature gradient distribution; before the formation of the drill cap, the highest temperature of the bottom surface of the workpiece is distributed in the central circular area corresponding to the extrusion of the transverse edge during the drilling process, and the highest temperature of the bottom surface can be approximated as the temperature of the extrusion friction zone between the top edge of the drill and the workpiece when the top edge of the drill bit drills to a position close to the bottom surface of the workpiece and increases with the increase in the drilling speed and the feed volume; during the process of drilling, the highest temperature of the bottom surface of the workpiece is approximated as the temperature of the top edge of the drill bit and the workpiece. The maximum temperature of the bottom surface of the workpiece in the drilling process increases nearly linearly with the drilling of the drill, and the slope of the maximum temperature increases nearly linearly with the increase in the drilling speed and feed, in which the influence of the feed on the slope of the maximum temperature increases is larger than that of the drilling speed. Full article
(This article belongs to the Special Issue Machine Automation: System Design, Analysis and Control)
20 pages, 5076 KiB  
Article
Brackish Water Desalination Using Electrodialysis: Influence of Operating Parameters on Energy Consumption and Scalability
by Angie N. Medina-Toala, Priscila E. Valverde-Armas, Jonathan I. Mendez-Ruiz, Kevin Franco-González, Steeven Verdezoto-Intriago, Tomas Vitvar and Leonardo Gutiérrez
Membranes 2025, 15(8), 227; https://doi.org/10.3390/membranes15080227 - 31 Jul 2025
Viewed by 70
Abstract
Groundwater is one of the main water sources for consumption, domestic use, agriculture, and tourism in coastal communities. However, high total dissolved solids (TDS) levels in the water (700–2000 mg L−1 TDS) and electrical conductivity (3000–5000 µS cm−1) threaten the [...] Read more.
Groundwater is one of the main water sources for consumption, domestic use, agriculture, and tourism in coastal communities. However, high total dissolved solids (TDS) levels in the water (700–2000 mg L−1 TDS) and electrical conductivity (3000–5000 µS cm−1) threaten the health and economic growth opportunities for residents. This research aims to evaluate the performance of a laboratory-scale electrodialysis system as a technology for desalinating brackish water. For this purpose, water samples were collected from real groundwater sources. Batch experiments were conducted with varying operational parameters, such as voltage (2–10 V), feed volume (100–1600 mL), recovery rate (50–80%), and cros-flow velocity (1.3–5.1 cm s−1) to determine the electrodialysis system setup that meets the requirements for drinking water in terms of TDS and energy efficiency. A total specific energy consumption of 1.65 kWh m−3, including pumping energy, was achieved at a laboratory scale. The conditions were as follows: flow velocity of 5.14 cm s−1, applied voltage of 6 V, feed volume of 1.6 L, and a water recovery of 66%. Furthermore, increasing the flow velocity and the applied voltage enhanced the desalination kinetics and salt removal. Additionally, the system presented opportunities for scalability. This research aims to evaluate a sustainable membrane-based treatment technology for meeting the growing demand for water resources in coastal communities, particularly in developing countries in South America. Full article
(This article belongs to the Section Membrane Applications for Water Treatment)
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11 pages, 469 KiB  
Article
Breastfeeding in Preterm Infants Is Not Compromised by Early Discharge and Home Nasogastric Tube Feeding up to 3 Months Postmenstrual Age: A Prospective Cohort Study
by Rahel Schuler, Alice Louise Kreidler, Markus Waitz, Birgit Kampschulte, Jutta Petzinger, Tina Frodermann, Andreas Hahn and Walter A. Mihatsch
Nutrients 2025, 17(15), 2444; https://doi.org/10.3390/nu17152444 - 26 Jul 2025
Viewed by 362
Abstract
Background/Objectives: Breastmilk offers numerous benefits for the health and development of preterm infants, while prolonged hospitalization may impair neurodevelopment. At our institution, the implementation of enhanced family-centered care (FCC) has enabled earlier discharge of preterm infants. This study aimed to assess the [...] Read more.
Background/Objectives: Breastmilk offers numerous benefits for the health and development of preterm infants, while prolonged hospitalization may impair neurodevelopment. At our institution, the implementation of enhanced family-centered care (FCC) has enabled earlier discharge of preterm infants. This study aimed to assess the impact of early discharge on breastfeeding and breastmilk provision. Methods: This analysis is based on data from a prospective single-center longitudinal cohort study conducted from October 2020 to November 2023, involving six consecutive cohorts (one baseline and five intervention cohorts; n = 184). FCC was progressively enhanced across cohorts. The primary outcome of the main study was postmenstrual age (PMA) at discharge. In this secondary analysis, breastfeeding and breastmilk provision were assessed at four time points: 4 weeks postnatal age, at discharge, 4 weeks post-discharge, and at 3 months PMA. Results: From baseline to intervention cohort 5, the PMA at discharge declined significantly from 37.8 ± 2.1 to 35.7 ± 0.91 weeks (p = 0.03), while the percentage of infants necessitating home nasogastric tube feeding increased from 6.3% to 66.7% (p < 0.01). The proportion of breastmilk of daily feeding volume remained unchanged at 4 weeks postnatal age (0.66 ± 0.42 vs. 0.9 ± 0.28) and at discharge (0.6 ± 0.45 vs. 0.79 ± 0.36). At 4 weeks post-discharge, 65.8% vs. 62.5% of the infants were on partial or exclusive breastmilk (p = 0.91) feeding. Similarly, the percentage of exclusively breastfed infants at 4 weeks post-discharge (23.7% vs. 19.8%) and at 3 months PMA (20% vs. 28.6%) did not differ significantly between baseline and intervention cohort 5. Conclusions: Early discharge did not reduce breastmilk supply or exclusive breastfeeding. However, the persistently low rate of exclusive breastfeeding post-discharge highlights the need for additional support strategies during and after hospitalization. Full article
(This article belongs to the Section Pediatric Nutrition)
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14 pages, 1255 KiB  
Article
Right and Left Side-Lying Positioning During Bottle-Feeding in Premature Infants—A Randomized Crossover Pilot Study
by Anna Raczyńska, Magdalena Suda-Całus, Tomasz Talar and Ewa Gulczyńska
J. Clin. Med. 2025, 14(14), 5108; https://doi.org/10.3390/jcm14145108 - 18 Jul 2025
Viewed by 312
Abstract
Background/Objectives: Optimal feeding position may contribute to improving the quality and safety of bottle-feeding in premature infants. The aim of this study was to compare the advantages of right side-lying (R-SLP) and left side-lying (L-SLP) positioning during the bottle-feeding of preterm infants. Methods: [...] Read more.
Background/Objectives: Optimal feeding position may contribute to improving the quality and safety of bottle-feeding in premature infants. The aim of this study was to compare the advantages of right side-lying (R-SLP) and left side-lying (L-SLP) positioning during the bottle-feeding of preterm infants. Methods: The randomized study included eight neonates (n = 8) born at ≤34 weeks of gestational age (GA). Four bottle-feeding sessions were conducted for each newborn: two in the R-SLP and two in the L-SLP position. Levels of oxygen saturation (SpO2) and heart rate (HR) were measured as indicators of physiological stability. The qualitative aspects of feeding included total time of SpO2 declines to ≤85%, the newborn’s alertness level based on the Neonatal Behavioral Assessment Scale (NBAS), and the number of possetings, regurgitations, and choking episodes. The volume of milk consumed and the duration of each feeding session were also recorded. Results: The L-SLP position was characterized with higher SpO2 (p = 0.042) at the 10th minute after feeding and lower HR (p = 0.022) at the end of feeding. Greater milk intake (p = 0.042), shorter feeding duration (p = 0.021), and shorter duration of SpO2 declines to ≤85% (p = 0.025) were also observed in L-SLP. No differences were found in alertness level, or in the number of choking episodes, possetings, or regurgitations compared to R-SLP. Conclusions: This pilot study suggests the potential efficacy of the L-SLP position during bottle-feeding of premature infants. The results require the need for larger studies to confirm the potential benefits of using L-SLP. Full article
(This article belongs to the Section Clinical Pediatrics)
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24 pages, 8216 KiB  
Article
Application of Dueling Double Deep Q-Network for Dynamic Traffic Signal Optimization: A Case Study in Danang City, Vietnam
by Tho Cao Phan, Viet Dinh Le and Teron Nguyen
Mach. Learn. Knowl. Extr. 2025, 7(3), 65; https://doi.org/10.3390/make7030065 - 14 Jul 2025
Viewed by 498
Abstract
This study investigates the application of the Dueling Double Deep Q-Network (3DQN) algorithm to optimize traffic signal control at a major urban intersection in Danang City, Vietnam. The objective is to enhance signal timing efficiency in response to mixed traffic flow and real-world [...] Read more.
This study investigates the application of the Dueling Double Deep Q-Network (3DQN) algorithm to optimize traffic signal control at a major urban intersection in Danang City, Vietnam. The objective is to enhance signal timing efficiency in response to mixed traffic flow and real-world traffic dynamics. A simulation environment was developed using the Simulation of Urban Mobility (SUMO) software version 1.11, incorporating both a fixed-time signal controller and two 3DQN models trained with 1 million (1M-Step) and 5 million (5M-Step) iterations. The models were evaluated using randomized traffic demand scenarios ranging from 50% to 150% of baseline traffic volumes. The results demonstrate that the 3DQN models outperform the fixed-time controller, significantly reducing vehicle delays, with the 5M-Step model achieving average waiting times of under five minutes. To further assess the model’s responsiveness to real-time conditions, traffic flow data were collected using YOLOv8 for object detection and SORT for vehicle tracking from live camera feeds, and integrated into the SUMO-3DQN simulation. The findings highlight the robustness and adaptability of the 3DQN approach, particularly under peak traffic conditions, underscoring its potential for deployment in intelligent urban traffic management systems. Full article
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18 pages, 3287 KiB  
Article
Evaluation of the Application Effects of Siniperca chuatsi in Biofloc Systems: A Comparative Study on the Use of Bamboo Flour and Rice Straw as Carbon Sources
by Huiling Zhang, Zhaojie Deng, Shijun Chen, Xi Xiong, Wenhui Zeng, Fang Chen, Huanjiao Tan, Xuran Chen, Canmin Yang, Yuhui He, Dizhi Xie and Lian Gan
Microorganisms 2025, 13(7), 1631; https://doi.org/10.3390/microorganisms13071631 - 10 Jul 2025
Viewed by 328
Abstract
A 56-day trial was conducted to assess the effects of rice straw (RS) and bamboo flour (BF) on growth performance, water quality, gill histology, and the bacterial community of water and the intestine of mandarin fish (Siniperca chuatsi) in biofloc technology [...] Read more.
A 56-day trial was conducted to assess the effects of rice straw (RS) and bamboo flour (BF) on growth performance, water quality, gill histology, and the bacterial community of water and the intestine of mandarin fish (Siniperca chuatsi) in biofloc technology systems. The results showed that mandarin fish in the RS and BF groups had comparable survival rates of 100.00 ± 0.00 and 93.33 ± 3.85%; feed conversion ratios of 1.13 ± 0.02 and 1.40 ± 0.15; and weight gain rates of 112.21 ± 1.56 and 100.92 ± 6.45%, respectively. From days 11 to 56 of the farming period, the BF group was more effective than the RS group in removing total ammonia nitrogen (TAN) and NO2-N, maintaining TAN levels below 0.24 ± 0.05 mg/L. During the early stage of the experiment, the TAN level in the RS group was higher; however, with the supplementation of a carbon source, it gradually decreased and eventually stabilized at 0.13 ± 0.03 mg/L later in the farming period. The secondary gill lamella in the RS group was curved and showed hyperplasia, and the basal gill lamellae showed an increase in the volume of interlamellar cell mass in the BF group. Genes related to denitrification (narG, napA, nirS, nirK, and nosZ) and anammox showed higher expression levels in the BF group than in the RS group, although the differences were not statistically significant (p > 0.05). The results of 16S rRNA sequencing research showed that both treatment groups’ intestinal and water bacterial communities had comparable levels of richness and diversity. Pseudomonas mosselii was the dominant bacterial species in the water. In the BF group, the dominant intestinal species were Bacillus halodurans and Caldalkalibacillus thermarum, while in the RS group, the dominant species was Plesiomonas shigelloides. In conclusion, rice straw and bamboo flour are applicable in BFT systems for mandarin fish culture, with good growth performance and water quality. The BF group showed higher nitrogen removal efficiency and denitrification gene expression than the RS group. Full article
(This article belongs to the Special Issue Microbiome in Fish and Their Living Environment)
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18 pages, 5419 KiB  
Article
Nanoporous Carbons from Hydrothermally Treated Alga: Role in Batch and Continuous Capacitive Deionization (CDI)
by Dipendu Saha, Ryan Schlosser, Lindsay Lapointe, Marisa L. Comroe, John Samohod, Elijah Whiting and David S. Young
Molecules 2025, 30(13), 2848; https://doi.org/10.3390/molecules30132848 - 3 Jul 2025
Viewed by 371
Abstract
This study presents a sustainable approach for synthesizing high-performance activated carbon from Spirulina Alga through hydrothermal carbonization followed by chemical activation using potassium hydroxide. The resulting activated carbon exhibited a high Brunauer–Emmett–Teller (BET) surface area of 1747 m2/g and a total [...] Read more.
This study presents a sustainable approach for synthesizing high-performance activated carbon from Spirulina Alga through hydrothermal carbonization followed by chemical activation using potassium hydroxide. The resulting activated carbon exhibited a high Brunauer–Emmett–Teller (BET) surface area of 1747 m2/g and a total pore volume of 1.147 cm3/g, with micropore volume accounting for 0.4 cm3/g. Characterization using Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy (SEM-EDS), X-ray Photoelectron Spectroscopy (XPS), and gas adsorption analyses confirmed the presence of hierarchical micro- and mesoporosity as well as favorable surface functional groups. The synthesized carbon was used to fabricate electrodes for membrane capacitive deionization (MCDI) along with cation and anion-selective membranes, which were then tested with saline water (500–5000 ppm) and synthetic hard water (898 ppm of total salts). The salt adsorption capacity (SAC) reached 25 (batch) to 40 (continuous) mg/g, while rapid adsorption rates with average salt adsorption rates (ASARs) values exceeding 10 (batch) to 30 (continuous) mg·g−1·min−1 during early stages were obtained. Batch MCDI experiments demonstrated a higher SAC compared to continuous operation, with non-monotonic trends in SAC observed as a function of feed concentration. Ion adsorption kinetics were influenced by ion valency, membrane selectivity, and pore structure. The specific energy consumption (SEC) was calculated as 8–21 kJ/mol for batch and 0.1–0.5 kJ/mol for continuous process. These performance metrics are on par with or surpass those reported in the recent literature for similar single-electrode CDI configurations. The results demonstrate the viability of using Alga-derived carbon as an efficient and eco-friendly electrode material for water desalination technologies. Full article
(This article belongs to the Special Issue Carbon-Based Materials for Sustainable Chemistry: 2nd Edition)
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12 pages, 911 KiB  
Article
Estimation of Milk Casein Content Using Machine Learning Models and Feeding Simulations
by Bence Tarr, János Tőzsér, István Szabó and András Revoly
Dairy 2025, 6(4), 35; https://doi.org/10.3390/dairy6040035 - 3 Jul 2025
Viewed by 327
Abstract
Milk quality has a growing importance for farmers as component-based pricing becomes more widespread. Food quality and precision manufacturing techniques demand consistent milk composition. Udder health, general cow condition, environmental factors, and especially feed composition all influence milk quality. The large volume of [...] Read more.
Milk quality has a growing importance for farmers as component-based pricing becomes more widespread. Food quality and precision manufacturing techniques demand consistent milk composition. Udder health, general cow condition, environmental factors, and especially feed composition all influence milk quality. The large volume of routinely collected milk data can be used to build prediction models that estimate valuable constituents from other measured parameters. In this study, casein was chosen as the target variable because of its high economic value. We developed a multiple linear-regression model and a feed-forward neural network model to estimate casein content from twelve commonly recorded milk traits. Evaluated on an independent test set, the regression model achieved R2 = 0.86 and RMSE = 0.018%, with mean bias = +0.003% and slope bias = −0.10, whereas the neural network improved performance to R2 = 0.924 and RMSE = 0.084%. In silico microgreen inclusion from 0% to 100% of dietary dry matter raised the predicted casein concentration from 2.662% to 3.398%, a relative increase of 27.6%. To extend practical applicability, a simulation module was created to explore how microgreen supplementation might modify milk casein levels, enabling virtual testing of dietary strategies before in vivo trials. Together, the predictive models and the microgreen simulation form a cost-effective, non-invasive decision-support tool that can accelerate diet optimization and improve casein management in precision dairy production. Full article
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24 pages, 15100 KiB  
Article
Sugarcane Feed Volume Detection in Stacked Scenarios Based on Improved YOLO-ASM
by Xiao Lai and Guanglong Fu
Agriculture 2025, 15(13), 1428; https://doi.org/10.3390/agriculture15131428 - 2 Jul 2025
Viewed by 263
Abstract
Improper regulation of sugarcane feed volume can lead to harvester inefficiency or clogging. Accurate recognition of feed volume is therefore critical. However, visual recognition is challenging due to sugarcane stacking during feeding. To address this, we propose YOLO-ASM (YOLO Accurate Stereo Matching), a [...] Read more.
Improper regulation of sugarcane feed volume can lead to harvester inefficiency or clogging. Accurate recognition of feed volume is therefore critical. However, visual recognition is challenging due to sugarcane stacking during feeding. To address this, we propose YOLO-ASM (YOLO Accurate Stereo Matching), a novel detection method. At the target detection level, we integrate a Convolutional Block Attention Module (CBAM) into the YOLOv5s backbone network. This significantly reduces missed detections and low-confidence predictions in dense stacking scenarios, improving detection speed by 28.04% and increasing mean average precision (mAP) by 5.31%. At the stereo matching level, we enhance the SGBM (Semi-Global Block Matching) algorithm through improved cost calculation and cost aggregation, resulting in Opti-SGBM (Optimized SGBM). This double-cost fusion approach strengthens texture feature extraction in stacked sugarcane, effectively reducing noise in the generated depth maps. The optimized algorithm yields depth maps with smaller errors relative to the original images, significantly improving depth accuracy. Experimental results demonstrate that the fused YOLO-ASM algorithm reduces sugarcane volume error rates across feed volumes of one to six by 3.45%, 3.23%, 6.48%, 5.86%, 9.32%, and 11.09%, respectively, compared to the original stereo matching algorithm. It also accelerates feed volume detection by approximately 100%, providing a high-precision solution for anti-clogging control in sugarcane harvester conveyor systems. Full article
(This article belongs to the Section Agricultural Technology)
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15 pages, 4173 KiB  
Article
Optimization of Chip Morphology in Deep Hole Trepanning of Titanium Alloy
by Fan Xie, Xiaolan Han, Lipeng Qiu and Haikuan Ma
Processes 2025, 13(7), 2082; https://doi.org/10.3390/pr13072082 - 1 Jul 2025
Viewed by 253
Abstract
Deep hole trepanning of large-diameter titanium alloy rods presents several challenges, including chip breaking, chip clogging, tool wear, and chipping. To address these issues, an optimized multi-tooth trepanning design was developed. An L9 orthogonal experimental array was employed to assess the influence of [...] Read more.
Deep hole trepanning of large-diameter titanium alloy rods presents several challenges, including chip breaking, chip clogging, tool wear, and chipping. To address these issues, an optimized multi-tooth trepanning design was developed. An L9 orthogonal experimental array was employed to assess the influence of cutting speed, feed rate, and cutting fluid pressure on the chip volume ratio and to determine optimal process parameters. Results indicate that the impact of process parameters on the chip volume ratio of the first and third cutting teeth follows the order of cutting speed, feed rate, and cutting fluid pressure. Optimal chip morphology for internal chip removal is achieved with a cutting speed of 63.3 m·min−1, a feed rate of 0.18 mm·r−1, and a cutting fluid pressure of 4 MPa. Conversely, improper parameter matching can result in numerous long spiral chips, causing adhesive wear, diffusion wear of the multi-tooth drill, and severe chipping of the cutting edge. Full article
(This article belongs to the Section Manufacturing Processes and Systems)
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14 pages, 1134 KiB  
Article
Analyzing the Caloric Variability of Bites in a Semi-Naturalistic Dietary Setting
by Mohammad Junayed Bhuyan, Luca Vedovelli, Corrado Lanera, Daniele Gasparini, Paola Berchialla, Ileana Baldi and Dario Gregori
Nutrients 2025, 17(13), 2192; https://doi.org/10.3390/nu17132192 - 30 Jun 2025
Viewed by 304
Abstract
Background: Obesity is a major public health issue in developed countries, primarily managed through dietary interventions and physical activity. Food portion sizes influence the estimation of energy intake, particularly through bites, of which characteristics remain insufficiently defined. This study investigates the variability in [...] Read more.
Background: Obesity is a major public health issue in developed countries, primarily managed through dietary interventions and physical activity. Food portion sizes influence the estimation of energy intake, particularly through bites, of which characteristics remain insufficiently defined. This study investigates the variability in bite energy content. Methods: This observational study was conducted over 14 months. Thirteen types of packaged food were provided to 30 Italian healthy volunteers (mean age 26.8 ± 8.5 years) in a semi-naturalistic dietary feeding setting. Participants’ anthropometric measurements were recorded. A total of 1850 bites were weighed and 420 bites were assessed for volume and energy content. Results: Bite volume and mass explained bite energy content at different rates. The most influential anthropometric feature was waist circumference. Gender modified the association between waist circumference and bite characteristics; males showed increased bite volume, mass, and energy content as waist circumference increased, whereas females showed little or no association. Age was inversely associated with bite volume and mass, with younger participants having larger bites. Gender significantly influenced average bite size, with females showing lower values than males. The use of a fork was associated with higher bite volume, mass, and energy compared to a spoon. Food eaten with bare hands had lower mass but higher energy content compared to food eaten with a spoon. The variability in bite energy was considerably greater per bite than per gram, reflecting the combined influence of food texture, bite size, and cutlery used. Conclusions: Bite energy variability, influenced by intrinsic factors (gender, age, waist circumference) and extrinsic factors (cutlery, food texture), significantly impacts portion size effect. Future bite counters should consider these elements for accurate dietary assessment. Full article
(This article belongs to the Section Nutrition and Public Health)
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11 pages, 2494 KiB  
Case Report
Prenatal Phenotype in a Neonate with Prader–Willi Syndrome and Literature Review
by Libing Luo, Mary Hoi Yin Tang, Shengmou Lin, Anita Sik-Yau Kan, Cindy Ka Yee Cheung, Xiaoying Dai, Ting Zeng, Yanyan Li, Lilu Nong, Haibo Huang, Chunchun Chen, Yue Xu and Kelvin Yuen Kwong Chan
Diagnostics 2025, 15(13), 1666; https://doi.org/10.3390/diagnostics15131666 - 30 Jun 2025
Viewed by 361
Abstract
Background and Clinical Significance: Prader–Willi syndrome (PWS) is a rare genetic disease caused by imprinted gene dysfunction, typically involving deletion of the chromosome 15q11.2-q13 region, balanced translocation, or related gene mutations in this region. PWS presents with complex and varied clinical manifestations. Abnormalities [...] Read more.
Background and Clinical Significance: Prader–Willi syndrome (PWS) is a rare genetic disease caused by imprinted gene dysfunction, typically involving deletion of the chromosome 15q11.2-q13 region, balanced translocation, or related gene mutations in this region. PWS presents with complex and varied clinical manifestations. Abnormalities can be observed from the fetal stage and change with age, resulting in growth, developmental, and metabolic issues throughout different life stages. Case Presentation: We report the prenatal characteristics observed from the second to third trimester of pregnancy in a neonate with PWS. Prenatal ultrasound findings included a single umbilical artery, poor abdominal circumference growth from 26 weeks, normal head circumference and femur length growth, increased amniotic fluid volume after 30 weeks, undescended fetal testicles in the third trimester, small kidneys, and reduced fetal movement. The male infant was born at 38 weeks of gestation with a birth weight of 2580 g. He had a weak cry; severe hypotonia; small eyelid clefts; bilateral cryptorchidism; low responsiveness to medical procedures such as blood drawing; and poor sucking, necessitating tube feeding. Blood methylation-specific multiple ligation-dependent probe amplification (MS-MLPA) showed paternal deletion PWS. Notably, this case revealed two previously unreported prenatal features in PWS: a single umbilical artery and small kidneys. Conclusions: Through literature review and our case presentation, we suggest that a combination of specific sonographic features, including these newly identified markers, may aid clinicians in the early diagnosis of PWS. Full article
(This article belongs to the Section Clinical Diagnosis and Prognosis)
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15 pages, 741 KiB  
Article
Development of Nifedipine Phytantriol-Based Cubosomes and In Vitro Simulation of Administration Through Pediatric Feeding Tubes
by Lorena Almeida Lima, Euler Eduardo Lisboa de Moura, Schauana Freitas Fraga, Renata Vidor Contri and Irene Clemes Külkamp-Guerreiro
Pharmaceutics 2025, 17(7), 828; https://doi.org/10.3390/pharmaceutics17070828 - 25 Jun 2025
Viewed by 372
Abstract
Background/Objectives: This study focused on developing an organic solvent-free formulation of phytantriol-based cubosomes for nifedipine delivery. It assessed the physicochemical properties and in vitro administration performance in pediatric nasogastric tubes and preliminarily evaluated toxicity in a brine shrimp lethality model. Methods: The nanocarrier [...] Read more.
Background/Objectives: This study focused on developing an organic solvent-free formulation of phytantriol-based cubosomes for nifedipine delivery. It assessed the physicochemical properties and in vitro administration performance in pediatric nasogastric tubes and preliminarily evaluated toxicity in a brine shrimp lethality model. Methods: The nanocarrier formulation was characterized in terms of the particle size and drug release properties and was compared with extemporaneous formulations prepared using nifedipine tablets in flow rate tests through pediatric feeding tubes. The recovery efficiency was evaluated across different tube sizes and rinsing volumes. A preliminary toxicity study was conducted using a brine shrimp lethality model. Results: Compared with nifedipine tablets, the nanocarrier formulation demonstrated favorable physicochemical properties, including controlled release and superior flow rates, in the pediatric tubes. Full recovery of the nifedipine content was achieved with the nanocarrier formulation, whereas extemporaneous formulation of the nifedipine recovery depended on the tube dimensions and rinsing protocols. Conclusions: Compared with the traditional formulations, the nanocarrier formulation represents a promising alternative for administering nifedipine via pediatric feeding tubes, offering an enhanced administration recovery. Full article
(This article belongs to the Special Issue Customized Pharmaceutics: Innovations for Diverse Populations)
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14 pages, 10262 KiB  
Article
A Trident-Fed Wine Glass UWB Antenna Based on Bézier Curve Optimization
by Chheang Ly and Jae-Young Chung
Electronics 2025, 14(13), 2560; https://doi.org/10.3390/electronics14132560 - 24 Jun 2025
Viewed by 256
Abstract
This work introduces a wine glass-shaped planar ultra-wideband (UWB) antenna. The antenna achieves a compact form factor by reducing lateral width through Bézier curve shaping and a trident feed, while maintaining length for low-frequency operation. The wine-glass-shaped radiator increases shunt capacitance and enhances [...] Read more.
This work introduces a wine glass-shaped planar ultra-wideband (UWB) antenna. The antenna achieves a compact form factor by reducing lateral width through Bézier curve shaping and a trident feed, while maintaining length for low-frequency operation. The wine-glass-shaped radiator increases shunt capacitance and enhances midband impedance matching, as demonstrated by equivalent circuit analysis, while the trident feed improves matching at higher frequencies. This design yields a 92% fractional bandwidth (3.2–8.7 GHz) within a compact volume of 0.37λ0×0.13λ0×0.0013λ0. The prototype is fabricated on two 50-μm-thick polyimide flexible copper-clad laminates (FCCL), and its performance is evaluated in an anechoic chamber. The measured results demonstrate omnidirectional radiation with an efficiency of over 80% across the UWB band. With broad operational range and compactness, the antenna is well-suited for IoT and wearable sensing applications. Full article
(This article belongs to the Section Microwave and Wireless Communications)
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17 pages, 6509 KiB  
Article
Operation of Vacuum Arc Thruster Arrays with Multiple Isolated Current Sources
by Benjamin Kanda and Minkwan Kim
Aerospace 2025, 12(6), 549; https://doi.org/10.3390/aerospace12060549 - 16 Jun 2025
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Abstract
Vacuum arc thrusters (VATs) have recently gained significant interest as a micro-propulsion system due to their scalability, low cost, storability, and small form factor. While VATs offer an attractive propulsion solution for CubeSats, conventional propellant feed systems used in VATs require intricate mechanical [...] Read more.
Vacuum arc thrusters (VATs) have recently gained significant interest as a micro-propulsion system due to their scalability, low cost, storability, and small form factor. While VATs offer an attractive propulsion solution for CubeSats, conventional propellant feed systems used in VATs require intricate mechanical moving parts, increasing overall system complexity and mission risk. A promising alternative is the use of VAT arrays, where multiple thin-layer VATs are arranged in a regularly spaced grid, thus enhancing reliability, increasing total impulse without a mechanical propellant feed system, and enabling integrated attitude control via off-axis thruster placement. However, VAT arrays require a larger power processing unit (PPU) and additional control system, posing challenges within CubeSat volume constraints. To address this, this study proposes a novel PPU design that enables the simultaneous operation of multiple VATs while minimising system mass and volume. Experimental results demonstrate the successful operation of VAT pairs using the proposed PPU concept, validating its feasibility as an efficient propulsion solution for CubeSats. Full article
(This article belongs to the Special Issue Space Propulsion: Advances and Challenges (3rd Volume))
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