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Keywords = failure envelopes

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21 pages, 16873 KiB  
Article
Enhancing Residential Building Safety: A Numerical Study of Attached Safe Rooms for Bushfires
by Sahani Hendawitharana, Anthony Ariyanayagam and Mahen Mahendran
Fire 2025, 8(8), 300; https://doi.org/10.3390/fire8080300 - 29 Jul 2025
Viewed by 325
Abstract
Early evacuation during bushfires remains the safest strategy; however, in many realistic scenarios, timely evacuation is challenging, making safe sheltering a last-resort option to reduce risk compared to late evacuation attempts. However, most Australian homes in bushfire-prone areas are neither designed nor retrofitted [...] Read more.
Early evacuation during bushfires remains the safest strategy; however, in many realistic scenarios, timely evacuation is challenging, making safe sheltering a last-resort option to reduce risk compared to late evacuation attempts. However, most Australian homes in bushfire-prone areas are neither designed nor retrofitted to provide adequate protection against extreme bushfires, raising safety concerns. This study addresses this gap by investigating the concept of retrofitting a part of the residential buildings as attached safe rooms for sheltering and protection of valuables, providing a potential last-resort solution for bushfire-prone communities. Numerical simulations were conducted using the Fire Dynamics Simulator to assess heat transfer and internal temperature conditions in a representative residential building under bushfire exposure conditions. The study investigated the impact of the placement of the safe room relative to the fire front direction, failure of vulnerable building components, and the effectiveness of steel shutters in response to internal temperatures. The results showed that the strategic placement of safe rooms inside the building, along with adequate protective measures for windows, can substantially reduce internal temperatures. The findings emphasised the importance of maintaining the integrity of openings and the external building envelope, demonstrating the potential of retrofitted attached safe rooms as a last-resort solution for existing residential buildings in bushfire-prone areas where the entire building was not constructed to withstand bushfire conditions. Full article
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22 pages, 12545 KiB  
Article
Denoised Improved Envelope Spectrum for Fault Diagnosis of Aero-Engine Inter-Shaft Bearing
by Danni Li, Longting Chen, Hanbin Zhou, Jinyuan Tang, Xing Zhao and Jingsong Xie
Appl. Sci. 2025, 15(15), 8270; https://doi.org/10.3390/app15158270 - 25 Jul 2025
Viewed by 221
Abstract
The inter-shaft bearing is an important component of aero-engine rotor systems. It works between a high-pressure rotor and a low-pressure rotor. Effective fault diagnosis of it is significant for an aero-engine. The casing vibration signals can promptly and intuitively reflect changes in the [...] Read more.
The inter-shaft bearing is an important component of aero-engine rotor systems. It works between a high-pressure rotor and a low-pressure rotor. Effective fault diagnosis of it is significant for an aero-engine. The casing vibration signals can promptly and intuitively reflect changes in the operational health status of an aero-engine’s support system. However, affected by a complex vibration transmission path and vibration of the dual-rotor, the intrinsic vibration information of the inter-shaft bearing is faced with strong noise and a dual-frequency excitation problem. This excitation is caused by the wide span of vibration source frequency distribution that results from the quite different rotational speeds of the high-pressure rotor and low-pressure rotor. Consequently, most existing fault diagnosis methods cannot effectively extract inter-shaft bearing characteristic frequency information from the casing signal. To solve this problem, this paper proposed the denoised improved envelope spectrum (DIES) method. First, an improved envelope spectrum generated by a spectrum subtraction method is proposed. This method is applied to solve the multi-source interference with wide-band distribution problem under dual-frequency excitation. Then, an improved adaptive-thresholding approach is subsequently applied to the resultant subtracted spectrum, so as to eliminate the influence of random noise in the spectrum. An experiment on a public run-to-failure bearing dataset validates that the proposed method can effectively extract an incipient bearing fault characteristic frequency (FCF) from strong background noise. Furthermore, the experiment on the inter-shaft bearing of an aero-engine test platform validates the effectiveness and superiority of the proposed DIES method. The experimental results demonstrate that this proposed method can clearly extract fault-related information from dual-frequency excitation interference. Even amid strong background noise, it precisely reveals the inter-shaft bearing’s fault-related spectral components. Full article
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17 pages, 3698 KiB  
Article
A Novel Fault Diagnosis Method for Rolling Bearings Based on Spectral Kurtosis and LS-SVM
by Lianyou Lai, Weijian Xu and Zhongzhe Song
Electronics 2025, 14(14), 2790; https://doi.org/10.3390/electronics14142790 - 11 Jul 2025
Viewed by 291
Abstract
As a core component of machining tools and vehicles, the load-bearing and transmission performance of rolling bearings is directly related to product processing quality and driving safety, highlighting the critical importance of fault detection. To address the nonlinearity, non-stationary modulation, and low signal-to-noise [...] Read more.
As a core component of machining tools and vehicles, the load-bearing and transmission performance of rolling bearings is directly related to product processing quality and driving safety, highlighting the critical importance of fault detection. To address the nonlinearity, non-stationary modulation, and low signal-to-noise ratio (SNR) observed in bearing vibration signals, we propose a fault feature extraction method based on spectral kurtosis and Hilbert envelope demodulation. First, spectral kurtosis is employed to determine the center frequency and bandwidth of the signal adaptively, and a bandpass filter is constructed to enhance the characteristic frequency components. Subsequently, the envelope spectrum is extracted through the Hilbert transform, allowing for the precise identification of fault characteristic frequencies. In the fault diagnosis stage, a multidimensional feature vector is formed by combining the kurtosis index with the amplitude ratios of inner/outer race characteristic frequencies, and fault pattern classification is accomplished using a Least-Squares Support Vector Machine (LS-SVM). To evaluate the effectiveness of the proposed method, experiments were conducted on the bearing datasets from Case Western Reserve University (CWRU) and the Machine Failure Prevention Technology (MFPT) Society. The experimental results demonstrate that the proposed method surpasses other comparative approaches, achieving identification accuracies of 95% and 100% for the CWRU and MFPT datasets, respectively. Full article
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39 pages, 3707 KiB  
Article
Real-Time Gas Path Fault Diagnosis for Aeroengines Based on Enhanced State-Space Modeling and State Tracking
by Siyan Cao, Hongfu Zuo, Xincan Zhao and Chunyi Xia
Aerospace 2025, 12(7), 588; https://doi.org/10.3390/aerospace12070588 - 29 Jun 2025
Viewed by 284
Abstract
Failures in gas path components pose significant risks to aeroengine performance and safety. Traditional fault diagnosis methods often require extensive data and struggle with real-time applications. This study addresses these critical limitations in traditional studies through physics-informed modeling and adaptive estimation. A nonlinear [...] Read more.
Failures in gas path components pose significant risks to aeroengine performance and safety. Traditional fault diagnosis methods often require extensive data and struggle with real-time applications. This study addresses these critical limitations in traditional studies through physics-informed modeling and adaptive estimation. A nonlinear component-level model of the JT9D engine is developed through aero-thermodynamic governing equations, enhanced by a dual-loop iterative cycle combining Newton–Raphson steady-state resolution with integration-based dynamic convergence. An augmented state-space model that linearizes nonlinear dynamic models while incorporating gas path health characteristics as control inputs is novelly proposed, supported by similarity-criterion normalization to mitigate matrix ill-conditioning. A hybrid identification algorithm is proposed, synergizing partial derivative analysis with least squares fitting, which uniquely combines non-iterative perturbation advantages with high-precision least squares. This paper proposes a novel enhanced Kalman filter through integral compensation and three-dimensional interpolation, enabling real-time parameter updates across flight envelopes. The experimental results demonstrate a 0.714–2.953% RMSE in fault diagnosis performance, a 3.619% accuracy enhancement over traditional sliding mode observer algorithms, and 2.11 s reduction in settling time, eliminating noise accumulation. The model maintains dynamic trend consistency and steady-state accuracy with errors of 0.482–0.039%. This work shows marked improvements in temporal resolution, diagnostic accuracy, and flight envelope adaptability compared to conventional approaches. Full article
(This article belongs to the Section Aeronautics)
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24 pages, 7285 KiB  
Article
From Several Puck-like Inter-Fiber Failure Criteria to Longitudinal Compressive Failure: An Extension and Application for UD Composites
by Jiongyao Shen, Zhongxu Liu and Junhua Guo
Polymers 2025, 17(12), 1613; https://doi.org/10.3390/polym17121613 - 10 Jun 2025
Viewed by 420
Abstract
The LaRC02 criterion is a classical criterion for determining fiber kinking failure of UD laminates under longitudinal compression (LC), but its basis for determining matrix cracking in a fiber kinking coordinate system is based on stress-invariant theory rather than on a physical mechanism. [...] Read more.
The LaRC02 criterion is a classical criterion for determining fiber kinking failure of UD laminates under longitudinal compression (LC), but its basis for determining matrix cracking in a fiber kinking coordinate system is based on stress-invariant theory rather than on a physical mechanism. Herein, three Puck-like physical-mechanism-based inter-fiber failure criteria are extended to LC failure of UD composites, and thus three failure criteria (denoted as LC-Guo, LC-Li, and LC-Puck failure criteria) are constructed for fiber kinking failure determination. The stresses in the global coordinate system are transformed to the fiber kinking coordinate system by a three-level coordinate system transformation, and then the failure determination is performed using the three Puck-like criteria. The results show that the overall accuracy of the three proposed criteria is higher than that of the LaRC02 criterion, especially the LC-Guo criterion. Additionally, an analysis of the influence of material properties shows that the failure envelope curves tend to be conservative, and the predicted off-axial compression strength decreases as the transverse compression strength and in-plane shear strength increase and the transverse tensile strength decreases. This work proposes a more reasonable assessment methodology for the determination of LC failure of UD composites, which has important theoretical significance and engineering value. Full article
(This article belongs to the Section Polymer Composites and Nanocomposites)
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17 pages, 3979 KiB  
Article
An Examination of the Failure Envelope of Finned Suction Anchors Subjected to Combined Vertical–Horizontal Loadings in Clay Through Numerical Modeling
by Angelica Gilo and Yun Wook Choo
J. Mar. Sci. Eng. 2025, 13(6), 1104; https://doi.org/10.3390/jmse13061104 - 30 May 2025
Viewed by 402
Abstract
The addition of fins to suction anchors has been proposed to enhance bearing capacity in combined loadings. This study examines the failure envelope of finned suction anchors subjected to combined vertical–horizontal loadings in normally and lightly over-consolidated clay using the finite element method, [...] Read more.
The addition of fins to suction anchors has been proposed to enhance bearing capacity in combined loadings. This study examines the failure envelope of finned suction anchors subjected to combined vertical–horizontal loadings in normally and lightly over-consolidated clay using the finite element method, focusing on fin capacity enhancement and fin efficiency against penetration resistance. Parameters considered include different length-to-diameter ratios of the suction anchor, as well as different fin-to-shaft-length ratios, to evaluate the effect on capacity. The addition of fins expands the vertical–horizontal failure envelope, minimally altering the shape of the failure envelope. The fin factor (the ratio of the finned suction anchor capacity to the conventional suction anchor capacity) increases with fin lengths but exhibits minimal dependence on length-to-diameter ratios. A nonlinear relationship between fin length and fin factor (both vertical and horizontal) with a distinct trend is observed in horizontal capacity. Fin efficiency (the ratio of capacity to penetration resistance) decreases with increasing fin length except at a fin length-to-shaft ratio of unity in horizontal capacity. Full article
(This article belongs to the Special Issue Marine Geotechnical Applications in Marine Structures)
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22 pages, 723 KiB  
Review
From Antibodies to Immunity: Assessing Correlates of Flavivirus Protection and Cross-Reactivity
by Hannah E. Flores, Eduar Fernando Pinzon Burgos, Sigrid Camacho Ortega, Alonso Heredia and Joel V. Chua
Vaccines 2025, 13(5), 449; https://doi.org/10.3390/vaccines13050449 - 24 Apr 2025
Viewed by 1323
Abstract
Flaviviruses are arthropod-borne RNA viruses that can cause a wide range of human diseases, from mild symptoms to severe illness with multiorgan failure and death. Effective prevention of these diseases relies on identifying reliable vaccine targets, typically measured by correlates of protection (CoPs), [...] Read more.
Flaviviruses are arthropod-borne RNA viruses that can cause a wide range of human diseases, from mild symptoms to severe illness with multiorgan failure and death. Effective prevention of these diseases relies on identifying reliable vaccine targets, typically measured by correlates of protection (CoPs), which help indicate host immunity after vaccination. Current vaccines primarily focus on neutralizing antibodies (nAbs) against the viral envelope E protein, though emerging evidence suggests other potential targets may also be effective in disease prevention. Additionally, there is growing evidence of cross-protection between different flaviviruses when immunity to one virus is achieved, although this can be limited by antibody-dependent enhancement. This review examines the current understanding of flavivirus immunity, CoPs, and the potential for cross-protection in the context of existing vaccine strategies. Full article
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20 pages, 1287 KiB  
Article
Integrated Approach to Marine Engine Maintenance Optimization: Weibull Analysis, Markov Chains, and DEA Model
by Damir Budimir, Dario Medić, Vlatka Ružić and Mateja Kulej
J. Mar. Sci. Eng. 2025, 13(4), 798; https://doi.org/10.3390/jmse13040798 - 16 Apr 2025
Viewed by 1009
Abstract
This study addresses the growing need for predictive maintenance in the maritime industry by proposing an optimized strategy for ship engine maintenance. The aim is to reduce unplanned failures that cause significant financial losses and disrupt global logistics flows. The methodology integrates Weibull [...] Read more.
This study addresses the growing need for predictive maintenance in the maritime industry by proposing an optimized strategy for ship engine maintenance. The aim is to reduce unplanned failures that cause significant financial losses and disrupt global logistics flows. The methodology integrates Weibull reliability analysis, Markov chains, and Data Envelopment Analysis (DEA). A dataset of 512 diesel engine components from container ships was analysed, where the Weibull distribution (β = 1.8; α = 18,500 h) accurately modelled failure patterns, and Markov chains captured transitions between operational states (normal, degraded, failure). DEA was used to evaluate the efficiency of different maintenance strategies. Results indicate that targeting interventions in the degraded state significantly reduces downtime and improves component reliability, particularly for high-pressure fuel pumps and turbochargers. Optimizing maintenance extended the Mean Time to Failure (MTTF) up to 22,000 h and reduced the proportion of failures in critical components from 64.3% to 40%. These findings support a transition from reactive to proactive maintenance models, contributing to enhanced fleet availability, safety, and cost-effectiveness. The approach provides a quantitative foundation for predictive maintenance planning, with potential application in fleet management systems and smart ship platforms. Full article
(This article belongs to the Section Ocean Engineering)
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21 pages, 6146 KiB  
Article
Impact and Post-Impact Compression Buckling Behavior of Symmetrical Foam-Filled Hat-Stiffened Panels
by Da Liu, Zhijia Zheng, Yuhao Shen, Xiao Wei, Dawei Wang, Zhongsheng Zhai, Zhenfei Guo, Wei Feng, Shanting Ding and Xuanze Wang
Symmetry 2025, 17(4), 570; https://doi.org/10.3390/sym17040570 - 9 Apr 2025
Viewed by 435
Abstract
This study investigates the mechanical behavior and failure mechanisms of SFHCPs under low-velocity impact and compression after impact (CAI) conditions. Symmetric foam-filled hat-stiffened composite panels (SFHCPs) are widely used in critical load-bearing structures such as vessels and aircraft due to their high strength-to-weight [...] Read more.
This study investigates the mechanical behavior and failure mechanisms of SFHCPs under low-velocity impact and compression after impact (CAI) conditions. Symmetric foam-filled hat-stiffened composite panels (SFHCPs) are widely used in critical load-bearing structures such as vessels and aircraft due to their high strength-to-weight ratio and integrated stiffener design. However, due to the material’s high sensitivity to impact, it is necessary to conduct a systematic evaluation of its application reliability. By integrating experimental testing and numerical simulation, the buckling modes characterized by symmetry and envelope number were adopted as key performance indicators. The integration of an optical buckling measurement method with iterative finite element model (FEM) updates significantly enhances model accuracy and computational efficiency. Experimental results indicate that for specimens impacted at the mid-section of the stiffener the residual compressive strength drops sharply from 106 kN to 40.6 kN (a reduction of 61.7%), with the buckling mode changing from a symmetric four-wave pattern in the undamaged state to localized buckling in the impact region, leading to brittle failure. The integration of FPP data improved the accuracy of the FEM, highlighting the critical influence of the symmetry of the buckling mode in optimizing impact-resistant composite structures. Full article
(This article belongs to the Special Issue Symmetry in Impact Mechanics of Materials and Structures)
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29 pages, 10470 KiB  
Article
Performance-Based Design Assessment of a Chilean Prescriptive R.C. Shear Wall Building Using Nonlinear Static Analysis
by Mario Gutiérrez, Juan C. Vielma-Quintero, Jorge Carvallo and Juan C. Vielma
Buildings 2025, 15(7), 1188; https://doi.org/10.3390/buildings15071188 - 5 Apr 2025
Cited by 1 | Viewed by 480
Abstract
Performance-based seismic design (PBD) has emerged as a key approach for rationalizing prescriptive code provisions and improving the explicit assessment of structural performance. In Chile, where reinforced concrete shear wall buildings are the predominant structural typology, evaluating their seismic response beyond traditional linear [...] Read more.
Performance-based seismic design (PBD) has emerged as a key approach for rationalizing prescriptive code provisions and improving the explicit assessment of structural performance. In Chile, where reinforced concrete shear wall buildings are the predominant structural typology, evaluating their seismic response beyond traditional linear methodologies is crucial. This study assesses the seismic performance of a representative Chilean shear wall residential building using the ACHISINA manual’s performance-based seismic design framework. A nonlinear static (pushover) analysis is performed to verify compliance with prescribed design criteria, incorporating capacity design principles and a moment envelope approach to prevent premature yielding in upper stories. The results confirm that the building meets the performance objectives for both Immediate Occupancy and Additional Deformation Capacity limit states. The application of capacity design effectively controls shear demand, preventing brittle failure, while the flexural design ensures the formation of the yielding mechanism (plastic hinge) at the intended critical section. Additionally, the study highlights the limitations of pushover analysis in capturing higher-mode effects and recommends complementary nonlinear time-history analysis (NLTHA) for a more comprehensive assessment. The computed response reduction factors exceed those used in the prescriptive design, suggesting a conservatively safe approach in current Chilean practice. This research reinforces the need to integrate performance-based methodologies into Chilean seismic design regulations, particularly for shear wall structures. It provides valuable insights into the advantages and limitations of current design practices and proposes improvements for future applications. Full article
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15 pages, 3579 KiB  
Article
Mechanical, Morphological, and Electrical Characteristics of Cu-Loaded Acrylic Paint on a Fused Deposition Modeling Printed Polylactic Acid Surface
by Sudhir Kumar, Pulkit Tiwari and Seyed Saeid Rahimian Koloor
Processes 2025, 13(4), 1059; https://doi.org/10.3390/pr13041059 - 2 Apr 2025
Viewed by 510
Abstract
Fused deposition modeling (FDM) printing has become increasingly popular for exploring advanced material matrices with a polymeric base. This study uses a low-energy method to investigate the metallization process on a surface created by 3D printing. This involves using an acrylic-paint-based solution to [...] Read more.
Fused deposition modeling (FDM) printing has become increasingly popular for exploring advanced material matrices with a polymeric base. This study uses a low-energy method to investigate the metallization process on a surface created by 3D printing. This involves using an acrylic-paint-based solution to disperse the copper (Cu) powder on a polylactic acid (PLA) substrate, allowing for an evaluation of the fabricated samples’ mechanical, morphological, absorbance, and capacitance properties. The study findings indicate a gradual increase in tensile strength as the content of Cu in the acrylic paint layer on the PLA substrate increases. There was a clear and consistent increase in the tensile strength of the specimen, ranging from 13.5 MPa (sample 1) to 15.6 MPa (sample 5). Similarly, the percentage of strain at failure also showed a noticeable increase, ranging from 4.2% (sample 1) to 8.6% (sample 5). The scanning electron microscopy (SEM) investigation revealed the presence of completely enveloped Cu particles in acrylic paint on the FDM-printed surface of the PLA. The Ultraviolet–Visible Diffuse Reflectance Spectroscopy (UV–Vis DRS) indicated a significant change in the absorbance pattern as the copper content in the layer increased. The augmented absorbance values serve as an advantage because they demonstrate enhanced UV light interaction, which correlates with the increase in capacitance measurements of 6 to 8 pF. This result suggests that the fabricated sample potentially leads to favorable alterations in material characteristics for applications that demand stable capacitance alongside improved mechanical properties. The SEM analysis supported the observed trends. Full article
(This article belongs to the Special Issue Development and Characterization of Advanced Polymer Nanocomposites)
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15 pages, 5021 KiB  
Article
Off-Axial Tensile Test and Analysis for Stratospheric Airship Envelope Material
by Zhanbo Li, Yanchu Yang, Rong Cai and Lin Song
Aerospace 2025, 12(4), 287; https://doi.org/10.3390/aerospace12040287 - 28 Mar 2025
Viewed by 374
Abstract
The mechanical properties of envelope materials play a critical role in determining the service life of stratospheric airships. This paper investigates the failure analysis and strength criteria of a plain-woven stratospheric envelope material. First, a series of off-axial tensile tests were conducted, revealing [...] Read more.
The mechanical properties of envelope materials play a critical role in determining the service life of stratospheric airships. This paper investigates the failure analysis and strength criteria of a plain-woven stratospheric envelope material. First, a series of off-axial tensile tests were conducted, revealing that the material exhibits significant nonlinearity and orthotropic behavior under off-axial loading. Notably, the failure strength of the material decreases dramatically at small off-axial angles. Second, finite element simulations were performed to analyze the failure mechanisms of specimens at various off-axial angles and a potential explanation for the sharp decline in failure strength is proposed. Third, the predictions of several existing strength criteria were compared with experimental results, showing limited agreement. To address this, a new strength criterion is introduced to more accurately predict the failure strength of the envelope material across different off-axial angles. The results demonstrate that the proposed criterion offers a significant improvement in predicting the mechanical behavior of plain-woven stratospheric envelope materials Full article
(This article belongs to the Section Aeronautics)
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21 pages, 8169 KiB  
Article
Dynamic Modeling and Numerical Analysis of Gear Transmission System with Localized Defects
by Yixuan Zeng, Junhui Zhu, Yaoyao Han, Donghua Qiu, Wei Huang and Minmin Xu
Machines 2025, 13(4), 272; https://doi.org/10.3390/machines13040272 - 26 Mar 2025
Cited by 1 | Viewed by 685
Abstract
Localized defects are common in gear transmission systems and can sometimes cause serious production problems or even catastrophic accidents. To reveal the failure mechanisms and study the localized defects in gear transmission systems, a 24-degree-of-freedom (DOF) dynamic coupling model is proposed considering shafts, [...] Read more.
Localized defects are common in gear transmission systems and can sometimes cause serious production problems or even catastrophic accidents. To reveal the failure mechanisms and study the localized defects in gear transmission systems, a 24-degree-of-freedom (DOF) dynamic coupling model is proposed considering shafts, bearings, and gears. The dynamic characteristics of the established model when defects appear on the raceways of bearings and surfaces of gears are analyzed. It can be found in the results that the response of the established model produces periodic shocks when localized defects appear on bearings or gears through numerical analysis. Sidebands generated by fault frequencies can be detected from the frequency spectrum. Especially, bearing-localized defects on the inner race and gear surface are similar in modulation form envelope analysis, and the increase in rotating frequency leads to difficulties in distinguishing defects on bearings and gears. The established coupling dynamic model was validated through experimentation and offers a theoretical basis for the fault diagnosis of gear transmission systems. Full article
(This article belongs to the Section Machine Design and Theory)
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28 pages, 3566 KiB  
Review
Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure
by Ivan Sherstnev, Aleksandra Judina, Giovanni Battista Luciani, Alessandra Ghigo, Emilio Hirsch and Julia Gorelik
Cells 2025, 14(6), 460; https://doi.org/10.3390/cells14060460 - 20 Mar 2025
Viewed by 1501
Abstract
Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium handling, and hypertrophic responses. PDE4 provides spatial and temporal precision to cAMP signalling, particularly under β-adrenergic stimulation, through its compartmentalised activity in subcellular nanodomains, including [...] Read more.
Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium handling, and hypertrophic responses. PDE4 provides spatial and temporal precision to cAMP signalling, particularly under β-adrenergic stimulation, through its compartmentalised activity in subcellular nanodomains, including the sarcoplasmic reticulum, plasma membrane and nuclear envelope. This review highlights the cardiac PDE4 isoforms PDE4A, PDE4B and PDE4D, focusing on their distinct localisation and contributions to cardiac physiology and pathophysiology, particularly in heart failure and arrhythmias. Although PDE4 plays a smaller role in overall cAMP hydrolysis in human hearts than in rodents, its compartmentalised function remains critical. Recent therapeutic advances have shifted from pan-PDE4 inhibitors to isoform-specific approaches to enhance efficacy while minimising systemic toxicity. We discuss the potential of selective PDE4 modulators, gene therapies and combination strategies in restoring cAMP compartmentation and preventing maladaptive cardiac remodelling. By integrating rodent and human studies, this review underscores the translational challenges and therapeutic opportunities surrounding PDE4, positioning it as both a key regulator of cardiac signalling and a promising target for heart failure therapies. Full article
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26 pages, 14127 KiB  
Article
Investigation of the Mechanical Properties of Calcareous Sand Improved by Polyurethane Foam Adhesive Under Fixed Principal Stress Axes Shearing
by Dan Chang, Yongjun Xie, Xinghua Zhang and Jiankun Liu
Polymers 2025, 17(5), 644; https://doi.org/10.3390/polym17050644 - 27 Feb 2025
Viewed by 785
Abstract
The mechanical properties and envelope curve predictions of polyurethane-improved calcareous sand are significantly influenced by the magnitude and direction of principal stress. This study conducted a series of directional shearing tests with varying polyurethane contents (c = 2.5%, 5%, and 7.5%), stress [...] Read more.
The mechanical properties and envelope curve predictions of polyurethane-improved calcareous sand are significantly influenced by the magnitude and direction of principal stress. This study conducted a series of directional shearing tests with varying polyurethane contents (c = 2.5%, 5%, and 7.5%), stress Lode angles (θσ  = −19.1°, 0°, 19.1°, and 30°), and major principal stress angles (α = 0°, 30°, 45°, 60°, and 90°) to investigate the strength and non-coaxial characteristics of calcareous sand improved by polyurethane foam adhesive (PFA). Key findings revealed that failure strength varied significantly with the major principal stress axis direction, initially decreasing to a minimum at α = 45° before increasing, with a 30% decrease and 25% increase observed at c = 5%. Non-coaxial characteristics between strain increment and stress directions became more pronounced, with angles varying up to 15°. Increasing polyurethane content from 2.5% to 7.5% enhanced sample strength by 20% at θσ = −19.1° and α = 60°. A generalized linear strength theory in the π-plane accurately described strength envelope variations, while a modified Lade criterion, incorporating polymer content, effectively predicted multiaxial strength characteristics with less than 10% deviation from experimental results. These contributions provide quantitative insights into failure strength and non-coaxial behavior, introduce a robust strength prediction framework, and enhance multiaxial strength prediction accuracy, advancing the understanding of polyurethane-improved calcareous sand for engineering applications. Full article
(This article belongs to the Section Polymer Applications)
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