Search Results (356)

Sensorimotor integration along the gastrointestinal (GI) tract is crucial for normal gut function yet remains poorly understood in the context of neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD). The genetic tractability of zebrafish allows investigators to generate molecularly defined models that provide a means of studying the functional circuits of digestion in vivo. Optical transparency during development allows for the use of optogenetics and calcium imaging to elucidate the mechanisms underlying GI-related symptoms associated with ASD. The array of commonly reported symptoms implicates altered sensorimotor integration at various points along the GI tract, from the pharynx to the anus. We will examine the reflex arcs that facilitate swallowing, nutrient-sensing, absorption, peristalsis, and evacuation. The high level of conservation of these processes across vertebrates also enables us to explore potential therapeutic avenues to mitigate GI distress in ASD and other NDDs. Full article

Emergency preparedness training in organizations frequently involves simple evacuation drills triggered by fire alarms, limiting the opportunities for broader skill development. Digital technologies, particularly virtual reality (VR), offer promising methods to enhance learning for handling incidents and evacuations. However, implementing VR-based training remains challenging due to unclear integration strategies within organizational practices and a lack of empirical evidence of VR’s effectiveness. This paper explores how VR-based training tools can be implemented in schools to enhance emergency preparedness among students, teachers, and staff. Following a design science research process, data were collected from a questionnaire-based study involving 12 participants and an exploratory study with 13 participants. The questionnaire-based study investigates initial attitudes and willingness to adopt VR training, while the exploratory study assesses the VR prototype’s usability, realism, and perceived effectiveness for emergency preparedness training. Despite a limited sample size and technical constraints of the early prototype, findings indicate strong student enthusiasm for gamified and immersive learning experiences. Teachers emphasized the need for technical and instructional support to regularly utilize VR training modules, while firefighters acknowledged the potential of VR tools, but also highlighted the critical importance of regular drills and professional validation. The relevance of the results of utilizing VR in this context is further discussed in terms of how it can be integrated into university curricula and aligned with other accessible digital preparedness tools. Full article

Chemical leakage accidents in chemical industrial parks pose significant threats to personnel safety, particularly during evacuation processes, where individual behavior and evacuation strategies have a considerable impact on overall efficiency. This study takes a leakage incident at an alkylation unit as a case study. First, ALOHA5.4.7 software was used to simulate the influence of meteorological conditions across different seasons on the dispersion range of toxic gases, thereby generating an annual comprehensive risk zone distribution map. Subsequently, different evacuation scenarios were constructed in Pathfinder2024.1.0605, with the integration of trigger mechanisms to simulate individual behaviors during evacuation, such as variations in risk perception and peer influence. Furthermore, this study expanded the conventional application scope of Pathfinder—typically limited to small-scale building evacuations—by successfully adapting it for large-scale evacuation simulations in chemical industrial parks. The feasibility of such simulations was thereby demonstrated, highlighting the software’s potential. According to the simulation results, exit configuration, shelter placement, and individual behavior modeling significantly affect the total evacuation time. This study provides both theoretical insights and practical guidance for emergency response planning in chemical industrial parks. Full article

In recent decades, climate change has led to more frequent episodes of extreme rainfall, increasing the risk of river flooding. Streams and rivers characterized by short flow times are subject to rapid and impressive floods; for this reason, the modeling of their beds is of fundamental importance for the execution of hydraulic calculations capable of predicting the flow rates and identifying the points where floods may occur. In the context of studies conducted on three watercourses in Calabria (Italy), different survey and restitution techniques were used (aerial LiDAR, terrestrial laser scanner, GNSS, photogrammetry). By integrating these methodologies, multi-resolution models were generated, featuring a horizontal accuracy of ±16 cm and a vertical accuracy of ±15 cm. These models form the basis for the hydraulic calculations performed. The results demonstrate the feasibility of producing accurate models that are compatible with the memory and processing capabilities of modern computers. Furthermore, the technique set up and implemented for the refined representation of both the models and the effects predicted by hydraulic calculations in the event of exceptional rainfall (such as flow, speed, flooded areas, and critical points along riverbanks) serves as a valuable tool for improving hydrogeological planning, designing appropriate defense works, and preparing evacuation plans in case of emergency, all with the goal of mitigating hydrogeological risk. Full article

The fire resistance performance of steel beams is of utmost importance to the fire safety of building structures and personnel evacuation. To address the deviation in the assumption of uniform temperature distribution in traditional studies, this study conducted multiple simulation tests. It was found that when the size of the vent was reduced by 50%, the difference in the heating rate in the early stage of the fire was 30% to 50%. Increasing the load ratio from 0.2 to 0.8 can significantly reduce the critical temperature of the steel beam by 15% to 20%, and the corresponding critical temperature is reduced from 670 °C to 565 °C. Based on parametric analysis, a simplified evaluation model of critical temperature for Q460 high-strength steel beams is proposed. The calculation error of the model is less than 5%, which provides a theoretical basis for the whole process of fire protection design. The research achievements break through the limitations of traditional methods and offer innovative approaches to predicting the fire resistance performance of steel beams and their optimized design. Full article

This article discusses and compares approaches to the visualization of the danger zone formed as a result of spreading toxic substances during a fire at an industrial enterprise, to create predictive models and scenarios for evacuation and environmental protection measures. The purpose of this study is to analyze the features and conditions for the application of algorithms for predicting the spread of a danger zone, based on the Gauss equation and the probabilistic algorithm of a cellular automaton. The research is also aimed at the analysis of the consequences of a fire at an industrial enterprise, taking into account natural and climatic conditions, the development of the area, and the scale of the fire. The subject of this study is the development of software and algorithmic support for the visualization of the danger zone and analysis of the consequences of a fire, which can be confirmed by comparing a computational experiment and actual measurements of toxic substance concentrations. The main research methods include a Gaussian model and probabilistic, frontal, and empirical cellular automation. The results of the study represent the development of algorithms for a cellular automation model for the visual forecasting of a dangerous zone. They are characterized by taking into consideration the rules for filling the dispersion ellipse, as well as determining the effects of interaction with obstacles, which allows for a more accurate mathematical description of the spread of a cloud of toxic combustion products in densely built-up areas. Since the main problems of the cellular automation approach to modeling the dispersion of pollutants are the problems of speed and numerical diffusion, in this article the frontal cellular automation algorithm with a 16-point neighborhood pattern is used, which takes into account the features of the calculation scheme for finding the shortest path. Software and algorithmic support for an integrated system for the visualization and analysis of fire consequences at an industrial enterprise has been developed; the efficiency of the system has been confirmed by computational analysis and actual measurement. It has been shown that the future development of the visualization of dangerous zones during fires is associated with the integration of the Bayesian approach and stochastic forecasting algorithms based on Markov chains into the simulation model of a dangerous zone for the efficient assessment of uncertainties associated with complex atmospheric processes. Full article

This study investigates hazardous emissions from foundry binder systems, comparing organic resins (phenolic urethane, furan, and alkaline-phenolic) and clay-bonded green sand with inorganic alternatives (sodium silicate and geopolymer). The research was conducted at the Fundaciόn Azterlan pilot plant (Spain), involving controlled chamber tests for the production of 60 kg iron alloy castings in 110 kg sand molds. The molds were evaluated under two configurations: homogeneous systems, where both mold and cores were manufactured using the same binder (five trials), and heterogeneous systems, where different binders were used for mold and cores (four trials). Each mold was placed in a metallic box fitted with a lid and an integrated gas extraction duct. The lid remained open during pouring and was closed immediately afterward to enable efficient evacuation of casting gases through the extraction system. Although the box was not completely airtight, it was designed to direct most exhaust gases through the duct. Along the extraction system line, different sampling instruments were strategically located for the precise measurement of contaminants: volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs), phenol, multiple forms of particulate matter (including crystalline silica content), and gases produced during pyrolysis. Across the nine trials, inorganic binders demonstrated significant reductions in gas emissions and priority pollutants, achieving decreases of over 90% in BTEX compounds (benzene, toluene, ethylbenzene, and xylene) and over 94% in PAHs compared to organic systems. Gas emissions were also substantially reduced, with CO emissions lowered by over 30%, NO_x by more than 98%, and SO₂ by over 75%. Conducted under the Greencasting LIFE project (LIFE 21 ENV/FI/101074439), this work provides empirical evidence supporting sodium silicate and geopolymer binders as viable, sustainable solutions for minimizing occupational and ecological risks in metal casting processes. Full article

This work—mixing an original experimental approach, as well as numerical simulations—proposes to study film boiling modes around a small nickel sphere. While dealing with a simple looking phenomenon that is found in many industrial processes and has been solved for basic quenching regimes, we focus on describing precisely how vapor formation and film thicknesses, as well as vapor bubble evacuation, affect cooling kinetics. As instrumenting small spheres may lead to experimental inaccuracies, we optically captured, using a high-speed camera, the vapor film thickness at mid height, the vapor bubble volume, and the bubble detachment frequency, along with the heat flux. More precisely, an estimation of the instant sphere temperature, in different conditions, was obtained through cooling time measurement before the end of the film boiling mode, subsequently facilitating heat flux evaluation. We encountered a nearly linear decrease in both the vapor film thickness and vapor bubble volume as the sphere temperature decreased. Notably, the detachment frequency remained constant across the whole temperature range. The estimation of the heat fluxes confirmed the prevalence of conduction as the primary heat transfer mode; a major portion of the energy was spent increasing the liquid temperature. The results were then compared to finite element simulations using an in-house multiphysics solver, including thermic phase changes (liquid to vapor) and their hydrodynamics, and we also captured the interfaces. While presenting a challenge due to the contrast in densities and viscosities between phases, the importance of the small circulations along them, which improve the heat removal in the liquid phase, was highlighted; we also assessed the suitability of the model and the numerical code for the simulation of such quenching cases when subcooling in the vicinity of a saturation temperature. Full article

The safety of pipeline transportation technology is the key to guaranteeing the development and application of CCUS. In the process of CO₂ pipeline transportation, manual pressure relief may be required due to equipment failure, overpressure, or other reasons. However, the sharp temperature drop in the evacuation process may lead to the formation of dry ice, which may cause a pipeline blockage and equipment damage. Although the multi-stage throttling method of pressure relief can effectively control the stability of the equipment, the effect on the low temperature of the pipeline needs to be further investigated. Therefore, in order to evaluate the safety of multi-stage throttling pressure relief, a comparative experiment of dense-phase venting with double-stage throttling was carried out based on an industrial-scale pipeline experimental device. The results show that the double-stage throttling pressure relief scheme can significantly reduce the pressure drop rate and improve the stability of the pressure relief structure. Moreover, the temperature drop limit upstream of the main pipeline is controlled under the double-stage throttling scheme, but it exacerbates the low temperature level downstream, which is not conducive to mitigating the risk of freeze-plugging of the pressure relief valve. Therefore, it is recommended that the double-stage throttling relief scheme be used to close the valve in time to return to the temperature and to adopt an intermittent means of pressure relief. Full article

Based on the regional disaster system theory, this study constructed a comprehensive flood risk indicator system for small reservoirs, covering the entire flood disaster process from three dimensions: hazard, vulnerability, and exposure. The analytic hierarchy process (AHP) and entropy weight method (EW) were used to determine indicator weights, and a risk assessment was conducted for small reservoirs in Huangshan City, Anhui Province, China. The results indicate that most reservoirs exhibit medium–low overall risk, yet distinct localized high-risk zones exist. High-economic-density areas such as Tunxi District, the central–eastern parts of Huangshan District, and the central and eastern parts of Qimen County have become high-risk clusters due to prominent exposure indicators (numbers of villages and medical facilities). Reservoirs in western and northern regions exhibit higher hazard levels, primarily driven by rainfall and catchment areas. Dam height and reservoir capacity are the main factors affecting vulnerability, with no significant spatial clustering for high-vulnerability reservoirs. Through the decoupling of three-dimensional indicators, this study reveals the differentiated driving mechanisms of “hazard–vulnerability–exposure,” providing a scientific basis for optimizing flood control engineering (e.g., reservoir capacity expansion, dam reinforcement) and risk zoning management (e.g., emergency evacuation planning in high-exposure areas) for small reservoirs. Full article

Engineered laminated bamboo frame structures have seen notable advancements in China, driven by their potential in sustainable construction. However, accurately predicting their seismic performance remains a pivotal challenge. Structural and non-structural damage caused by earthquakes can severely compromise building operability, lead to substantial economic losses, and disrupt safe evacuation processes, collectively exacerbating disaster impacts. To address this, three laminated bamboo frame models (3-, 4-, and 5-story) were developed, integrating energy-dissipating T-shaped steel plate beam–column connections. Two engineering demand parameters—peak inter-story drift ratio (PIDR) and peak floor acceleration (PFA)—were selected to quantify seismic responses under near-field and far-field ground motions. The study systematically evaluates suitable intensity measures for these parameters, emphasizing efficiency and sufficiency criteria. Regarding efficiency, the applicable intensity measures for PFA differ from those for PIDR. The measures for PFA tend to focus more on acceleration amplitude-related measures such as peak ground accelerations (PGA), sustained maximum acceleration (SMA), effective design acceleration (EDA), and A₉₅ (the acceleration at 95% Arias intensity), while the measures for PIDR are primarily based on spectral acceleration-related measures such as S_a(T₁) (spectral acceleration at fundamental period), etc. Concerning sufficiency, significant differences exist in the applicable measures for PFA and PIDR, and they are greatly influenced by ground motion characteristics. Full article

As the attention to using hydrogen as a potential energy storage medium for power generation and mobility increases, hydrogen production, storage, and transportation safety should be considered. For instance, hydrogen’s extreme physical and chemical properties and the wide range of flammable concentrations raise many concerns about the current safety measures in processing other flammable gases. Hydrogen cloud accumulation in the case of leakage in confined spaces can lead to reaching the hydrogen lower flammability limit (LFL) within seconds if the hydrogen is not properly evacuated from the space. At Jülich Research Centre, hydrogen mixed with natural gas is foreseen to be used as a fuel for the central heating system of the campus. In this work, the release, dispersion, formation, and spread of the hydrogen cloud in the case of hydrogen leakage inside the central utility building of the campus are numerically simulated using the OpenFOAM-based containmentFOAM CFD codes. Additionally, different ventilation scenarios are simulated to investigate the behavior of the hydrogen cloud. The results show that locating exhaust openings close to the ceiling and the potential leakage source can be the most effective way to safely evacuate hydrogen from the building. Additionally, locating the exhaust outlets near the ceiling can decrease the combustible cloud volume by more than 25% compared to side openings far below the ceiling. Also, hydrogen concentrations can reach the LFL in case of improper forced ventilation after only 8 s, while it does not exceed 0.15% in the case of natural ventilation under certain conditions. The results of this work show the significant effect of locating exhaust outlets near the ceiling and the importance of natural ventilation to mitigate the effects of hydrogen leakage. The approach illustrated in this study can be used to study hydrogen dispersion in closed buildings in case of leakage and the proper design of the ventilation outlets for closed spaces with hydrogen systems. Full article

Carbon fiber reinforced polymers (CFRPs) are significantly vital for industries. However, the drilling process of a CFRP is considered a challenge due to its nature, which causes delamination, fiber pull-out, peel-up, high friction, and a decrease in cutting tool life. Wet drilling is necessary for minimizing defects, and lubricants are very costly. In the current work, ultrasonic-assisted drilling (UAD) with a longitudinal vibration of 39.7 kHz was applied to the drill bit in the feed direction, used for CFRPs, and compared with conventional drilling (CD). Low spindle speeds under 5000 rpm were applied with different feed rates. The morphology, delamination factor, and cutting forces were investigated through the specific input machining parameters for CD and UAD. SEM was applied to study the morphology of the hole entrance and exit as well as the burr heights of evacuated chips. UAD with 39.7 kHz succeeded in minimizing the surface roughness by 50% compared with the surface roughness resulting from CD and could drill high-precision holes for CFRPs with a trade-off concept, besides achieving near-zero delamination (K ≃ 1) in the absence of a lubricant, which is being extended for industrial application. Full article

Landslide hazard chains pose significant threats in mountainous areas worldwide, yet their cascading effects remain insufficiently studied. This study proposes an integrated framework to systematically assess the landslide-landslide dam-outburst flood hazard chain in mountainous river systems. First, landslide susceptibility is assessed through a random forest model incorporating 11 static environmental and geological factors. The surface deformation rate derived from SABS-InSAR technology is incorporated as a dynamic factor to improve classification accuracy. Second, motion trajectories of rock masses in high-risk zones are identified by Rockfall Analyst model to predict potential river blockages by landslide dams, and key geometric parameters of the landslide dams are predicted using a predictive model. Third, the 2D HEC-RAS model is used to simulate outburst flood evolution. Results reveal that: (1) incorporating surface deformation rate as a dynamic factor significantly improves the predictive accuracy of landslide susceptibility assessment; (2) landslide-induced outburst floods exhibit greater destructive potential and more complex inundation dynamics than conventional mountain flash floods; and (3) the outburst flood propagation process exhibits three sequential phases defined by the Outburst Flood Arrival Time (FAT): initial rapid advancement phase, intermediate lateral diffusion phase, and mature floodplain development phase. These phases represent critical temporal thresholds for initiating timely downstream evacuation. This study contributes to the advancement of early warning systems aimed at protecting downstream communities from outburst floods triggered by landslide hazard chains. It enables researchers to better analyze the complex dynamics of such cascading events and to develop effective risk reduction strategies applicable in vulnerable regions. Full article

Existing studies on ontology evolution lack automated mechanisms to balance semantic coherence and adaptability under real-time uncertainties, particularly in resolving spatiotemporal asymmetry and multidimensional coupling imbalances in dam-break scenarios. Traditional methods such as WordNet’s tree symmetry and FrameNet’s frame symmetry fail to formalize dynamic adjustments through quantitative metrics, leading to path dependency and delayed responses. This study addresses this gap by introducing a novel symmetry-entropy-constrained matrix fusion algorithm, which integrates algebraic direct sum operations and Hadamard product with entropy-driven adaptive weighting. The original contribution lies in the symmetry entropy metric, which quantifies structural deviations during fusion to systematically balance semantic stability and adaptability. This work formalizes ontology evolution as a symmetry-driven optimization process. Experimental results demonstrate that shared concepts between ontologies (s = 3) reduce structural asymmetry by 25% compared to ontologies (s = 1), while case studies validate the algorithm’s ability to reconcile discrepancies between theoretical models and practical challenges in evacuation efficiency and crowd dynamics. This advancement promotes the evolution of traditional emergency management systems towards an adaptive intelligent form. Full article